The Experts below are selected from a list of 2907 Experts worldwide ranked by ideXlab platform
Solmaz Abdolrahimzadeh - One of the best experts on this subject based on the ideXlab platform.
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an androgen receptor positive carcinoma of the lacrimal drainage system resembling Salivary Duct carcinoma case report and review of the literature
Applied Immunohistochemistry & Molecular Morphology, 2016Co-Authors: Siavash Rahimi, Alessandro Lambiase, Peter A Brennan, Solmaz AbdolrahimzadehAbstract:: Carcinomas of the lacrimal drainage apparatus are rare and due to their aggressive behavior, they usually require extensive surgical treatment. We report a unique case of a 60-year-old man presenting with proptosis found to have a mass in the lacrimal drainage system on magnetic resonance imaging. Histology revealed a high-grade carcinoma with morphologic features of Salivary Gland Duct carcinoma. Immunohistochemistry showed an extensive positive staining to androgen receptor. This is the first report of Salivary Gland-like Duct carcinoma of the lacrimal drainage apparatus. Androgen receptor should be included in the immunohistochemical panel for the diagnostic work-up of lacrimal drainage system carcinomas, which resemble Salivary Gland Duct carcinoma. This finding could have important diagnostic and therapeutic implications.
Chuanqing Ding - One of the best experts on this subject based on the ideXlab platform.
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New insight into lacrimal Gland function: Role of the Duct epithelium in tear secretion.
The ocular surface, 2020Co-Authors: Edit Tóth-molnár, Chuanqing DingAbstract:Abstract Tear secretion is a complex process with the involvement of the main and accessory lacrimal Glands, corneal and conjunctival epithelial cells and the Meibomian Glands. The lacrimal Gland is the main source of fluid, electrolytes and proteins in tear fluid. Deficient ion and water secretion results in aqueous deficient dry eye with serious consequences on the integrity of the ocular surface. Functions of acinar cells are widely studied, whereas less information is available about the Duct system of the lacrimal Gland. Secretory mechanisms of Duct epithelium may play an important role in tear proDuction, but only limited studies have tried to elucidate the role of the Duct system in tear secretion. Significant progress has been made in the past few years, resulting in new insight into lacrimal Gland Duct function. New experimental techniques were introduced, which contributed to the exploration of the role of lacrimal Gland Ducts in more detail. Therefore, the aim of this review is to summarize our present knowledge about the role of Ducts in lacrimal Gland function and tear secretion, which appears to be the first review with a focus on this topic. Short outline of pancreatic and Salivary Gland Duct functions is also given for the purposes of comparison.
Siavash Rahimi - One of the best experts on this subject based on the ideXlab platform.
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an androgen receptor positive carcinoma of the lacrimal drainage system resembling Salivary Duct carcinoma case report and review of the literature
Applied Immunohistochemistry & Molecular Morphology, 2016Co-Authors: Siavash Rahimi, Alessandro Lambiase, Peter A Brennan, Solmaz AbdolrahimzadehAbstract:: Carcinomas of the lacrimal drainage apparatus are rare and due to their aggressive behavior, they usually require extensive surgical treatment. We report a unique case of a 60-year-old man presenting with proptosis found to have a mass in the lacrimal drainage system on magnetic resonance imaging. Histology revealed a high-grade carcinoma with morphologic features of Salivary Gland Duct carcinoma. Immunohistochemistry showed an extensive positive staining to androgen receptor. This is the first report of Salivary Gland-like Duct carcinoma of the lacrimal drainage apparatus. Androgen receptor should be included in the immunohistochemical panel for the diagnostic work-up of lacrimal drainage system carcinomas, which resemble Salivary Gland Duct carcinoma. This finding could have important diagnostic and therapeutic implications.
Edit Tóth-molnár - One of the best experts on this subject based on the ideXlab platform.
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New insight into lacrimal Gland function: Role of the Duct epithelium in tear secretion.
The ocular surface, 2020Co-Authors: Edit Tóth-molnár, Chuanqing DingAbstract:Abstract Tear secretion is a complex process with the involvement of the main and accessory lacrimal Glands, corneal and conjunctival epithelial cells and the Meibomian Glands. The lacrimal Gland is the main source of fluid, electrolytes and proteins in tear fluid. Deficient ion and water secretion results in aqueous deficient dry eye with serious consequences on the integrity of the ocular surface. Functions of acinar cells are widely studied, whereas less information is available about the Duct system of the lacrimal Gland. Secretory mechanisms of Duct epithelium may play an important role in tear proDuction, but only limited studies have tried to elucidate the role of the Duct system in tear secretion. Significant progress has been made in the past few years, resulting in new insight into lacrimal Gland Duct function. New experimental techniques were introduced, which contributed to the exploration of the role of lacrimal Gland Ducts in more detail. Therefore, the aim of this review is to summarize our present knowledge about the role of Ducts in lacrimal Gland function and tear secretion, which appears to be the first review with a focus on this topic. Short outline of pancreatic and Salivary Gland Duct functions is also given for the purposes of comparison.
Robert P Coppes - One of the best experts on this subject based on the ideXlab platform.
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Rescue of Salivary Gland function after stem cell transplantation in irradiated Glands.
PloS one, 2008Co-Authors: Isabelle M.a. Lombaert, Jeanette F. Brunsting, Pieter K. Wierenga, Hette Faber, Monique A. Stokman, Tineke Kok, Willy H. Visser, Harm H. Kampinga, Gerald De Haan, Robert P CoppesAbstract:Head and neck cancer is the fifth most common malignancy and accounts for 3% of all new cancer cases each year. Despite relatively high survival rates, the quality of life of these patients is severely compromised because of radiation-induced impairment of Salivary Gland function and consequential xerostomia (dry mouth syndrome). In this study, a clinically applicable method for the restoration of radiation-impaired Salivary Gland function using Salivary Gland stem cell transplantation was developed. Salivary Gland cells were isolated from murine submandibular Glands and cultured in vitro as salispheres, which contained cells expressing the stem cell markers Sca-1, c-Kit and Musashi-1. In vitro, the cells differentiated into Salivary Gland Duct cells and mucin and amylase producing acinar cells. Stem cell enrichment was performed by flow cytrometric selection using c-Kit as a marker. In vitro, the cells differentiated into amylase producing acinar cells. In vivo, intra-Glandular transplantation of a small number of c-Kit+ cells resulted in long-term restoration of Salivary Gland morphology and function. Moreover, donor-derived stem cells could be isolated from primary recipients, cultured as secondary spheres and after re-transplantation ameliorate radiation damage. Our approach is the first proof for the potential use of stem cell transplantation to functionally rescue Salivary Gland deficiency.
