The Experts below are selected from a list of 3918 Experts worldwide ranked by ideXlab platform
Janne J Jokinen - One of the best experts on this subject based on the ideXlab platform.
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natural coniferous resin Salve used to treat complicated surgical wounds pilot clinical trial on healing and costs
International Journal of Dermatology, 2012Co-Authors: Arno Sipponen, Opri Kuokkanen, Raine Tiihonen, Harri Kauppinen, Janne J JokinenAbstract:: Resin is a natural product of coniferous trees. Salves manufactured from spruce resin (Picea abies) have been used for centuries to treat wounds and skin infections. We report a pilot clinical trial designed to investigate healing rates, factors that contribute to delayed wound healing, cost-effectiveness, and incidence of allergic reactions when resin Salve is used to treat complicated surgical wounds. The trial involved 23 patients in whom wound healing after surgery was delayed. These patients were assigned to resin Salve treatment. The primary outcome measure was the number of days to complete wound healing. Secondary objectives included an assessment of factors contributing to delayed wound healing, an estimation of associated costs, and an investigation into the occurrence of allergic reactions related to resin Salve therapy. The study achieved a healing rate of 100%. The mean ± SD healing time was 43 ± 24 days. The mean ± SD wound size (length × width × depth) was (29 ± 19) × (12 ± 7) × (4 ± 3) mm. Wound size, use of corticosteroids or other immunosuppressants, and immobilization were statistically significant (P < 0.05) contributors to delayed wound healing and impaired re-epithelialization. The total mean ± SD costs of the resin Salve treatment were €45.0 ± 26.0 per patient during the entire treatment period and €1.2 ± 0.5 per treatment day. The rate of allergic reactions was 0%. The results of this pilot trial indicate that complicated surgical wounds may be treated successfully with resin Salve. The treatment method is clinically effective and cost-effective, and the rate of allergic reactions is low.
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Natural coniferous resin Salve used to treat complicated surgical wounds: pilot clinical trial on healing and costs.
International Journal of Dermatology, 2012Co-Authors: Arno Sipponen, Opri Kuokkanen, Raine Tiihonen, Harri Kauppinen, Janne J JokinenAbstract:: Resin is a natural product of coniferous trees. Salves manufactured from spruce resin (Picea abies) have been used for centuries to treat wounds and skin infections. We report a pilot clinical trial designed to investigate healing rates, factors that contribute to delayed wound healing, cost-effectiveness, and incidence of allergic reactions when resin Salve is used to treat complicated surgical wounds. The trial involved 23 patients in whom wound healing after surgery was delayed. These patients were assigned to resin Salve treatment. The primary outcome measure was the number of days to complete wound healing. Secondary objectives included an assessment of factors contributing to delayed wound healing, an estimation of associated costs, and an investigation into the occurrence of allergic reactions related to resin Salve therapy. The study achieved a healing rate of 100%. The mean ± SD healing time was 43 ± 24 days. The mean ± SD wound size (length × width × depth) was (29 ± 19) × (12 ± 7) × (4 ± 3) mm. Wound size, use of corticosteroids or other immunosuppressants, and immobilization were statistically significant (P
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resin Salve from norway spruce a potential method to treat infected chronic skin ulcers
Drug Metabolism Letters, 2007Co-Authors: Arno Sipponen, Merja Rautio, Janne J Jokinen, Tapio Laakso, Pekka Saranpaa, Jouni LohiAbstract:The home-made resin Salve from Norway spruce is traditionally and widely used in folk medicine to heal various skin infections and wounds in Northern Finland. We have performed laboratory studies to solve the mechanism of resin Salve. The resin Salve exhibited a bacteriostatic effect against all tested Gram-positive bacteria important in human medicine including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE), but was not effective against Gram-negative bacteria. An exception among the Gram-negative bacteria was Proteus vulgaris against which resin Salve was effective. High amounts of lipophilic extractives, like resin acids were dissolved into water from the resin Salve. Also, a large proportion of lignans and cinnamic acid were found in the water extract.
Arno Sipponen - One of the best experts on this subject based on the ideXlab platform.
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natural coniferous resin Salve used to treat complicated surgical wounds pilot clinical trial on healing and costs
International Journal of Dermatology, 2012Co-Authors: Arno Sipponen, Opri Kuokkanen, Raine Tiihonen, Harri Kauppinen, Janne J JokinenAbstract:: Resin is a natural product of coniferous trees. Salves manufactured from spruce resin (Picea abies) have been used for centuries to treat wounds and skin infections. We report a pilot clinical trial designed to investigate healing rates, factors that contribute to delayed wound healing, cost-effectiveness, and incidence of allergic reactions when resin Salve is used to treat complicated surgical wounds. The trial involved 23 patients in whom wound healing after surgery was delayed. These patients were assigned to resin Salve treatment. The primary outcome measure was the number of days to complete wound healing. Secondary objectives included an assessment of factors contributing to delayed wound healing, an estimation of associated costs, and an investigation into the occurrence of allergic reactions related to resin Salve therapy. The study achieved a healing rate of 100%. The mean ± SD healing time was 43 ± 24 days. The mean ± SD wound size (length × width × depth) was (29 ± 19) × (12 ± 7) × (4 ± 3) mm. Wound size, use of corticosteroids or other immunosuppressants, and immobilization were statistically significant (P < 0.05) contributors to delayed wound healing and impaired re-epithelialization. The total mean ± SD costs of the resin Salve treatment were €45.0 ± 26.0 per patient during the entire treatment period and €1.2 ± 0.5 per treatment day. The rate of allergic reactions was 0%. The results of this pilot trial indicate that complicated surgical wounds may be treated successfully with resin Salve. The treatment method is clinically effective and cost-effective, and the rate of allergic reactions is low.
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Natural coniferous resin Salve used to treat complicated surgical wounds: pilot clinical trial on healing and costs.
International Journal of Dermatology, 2012Co-Authors: Arno Sipponen, Opri Kuokkanen, Raine Tiihonen, Harri Kauppinen, Janne J JokinenAbstract:: Resin is a natural product of coniferous trees. Salves manufactured from spruce resin (Picea abies) have been used for centuries to treat wounds and skin infections. We report a pilot clinical trial designed to investigate healing rates, factors that contribute to delayed wound healing, cost-effectiveness, and incidence of allergic reactions when resin Salve is used to treat complicated surgical wounds. The trial involved 23 patients in whom wound healing after surgery was delayed. These patients were assigned to resin Salve treatment. The primary outcome measure was the number of days to complete wound healing. Secondary objectives included an assessment of factors contributing to delayed wound healing, an estimation of associated costs, and an investigation into the occurrence of allergic reactions related to resin Salve therapy. The study achieved a healing rate of 100%. The mean ± SD healing time was 43 ± 24 days. The mean ± SD wound size (length × width × depth) was (29 ± 19) × (12 ± 7) × (4 ± 3) mm. Wound size, use of corticosteroids or other immunosuppressants, and immobilization were statistically significant (P
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resin Salve from norway spruce a potential method to treat infected chronic skin ulcers
Drug Metabolism Letters, 2007Co-Authors: Arno Sipponen, Merja Rautio, Janne J Jokinen, Tapio Laakso, Pekka Saranpaa, Jouni LohiAbstract:The home-made resin Salve from Norway spruce is traditionally and widely used in folk medicine to heal various skin infections and wounds in Northern Finland. We have performed laboratory studies to solve the mechanism of resin Salve. The resin Salve exhibited a bacteriostatic effect against all tested Gram-positive bacteria important in human medicine including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococcus (VRE), but was not effective against Gram-negative bacteria. An exception among the Gram-negative bacteria was Proteus vulgaris against which resin Salve was effective. High amounts of lipophilic extractives, like resin acids were dissolved into water from the resin Salve. Also, a large proportion of lignans and cinnamic acid were found in the water extract.
Weili Peng - One of the best experts on this subject based on the ideXlab platform.
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Study on slave side of interventional surgery robotic system focused on the feed-back force detection
2016 IEEE International Conference on Mechatronics and Automation, 2016Co-Authors: Yuan Wang, Guangxuan Li, Weili PengAbstract:Minimally invasive interventional surgery shows its advantages compared to traditional operation. The master-slave robotic system technology can further significantly improve the accuracy, efficiency and safety of this complicated and high risk operation. However, one of the critical issues in the robotic system, guide wire force feed-back, needs more research. The mechanical structure of the Salve robot is designed basing on modularizing design principle. Ball spline pair, guide pair and herringbone gear pair are adopted in the structure concept. The experimental equipment is developed and the verifying experiments are conducted. The guide wire detected feedback force matches well with the detected resistance force. It indicates that the designed slave part and design method is rational from the point of feedback force detection.
Byung-ju Yi - One of the best experts on this subject based on the ideXlab platform.
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Image-Guided Dual Master–Slave Robotic System for Maxillary Sinus Surgery
IEEE Transactions on Robotics, 2018Co-Authors: Hyun Soo Yoon, Jin Hyeok Jeong, Byung-ju YiAbstract:The pathway to the maxillary sinus is anatomically curved and narrow. Thus, the conventional approach using a straight endoscope and surgical tools is difficult to diagnose and treat some blind regions of the maxillary sinus through the nostrils. Such cases are usually dealt with by an approach with an external incision that causes large invasive surgery. In order to approach the blind regions without any external incision, a new bendable device and an image-guided robotic approach for the maxillary sinus surgery are required. This work reports design, development, and validation of an image-guided dual master-slave robotic system for the maxillary sinus surgery. Initially, specifications of the robotic system for sinus surgery are decided by analysis of the anatomical structure of the sinus. A method for determining the design parameters of continuum type Salve robot is also presented. Based on the specifications and the design parameter determining method, a compact design of bendable dual slave robotic system for inspection and biopsy operation of the maxillary sinus area is devised and workspace analysis for verifying the robot design is conducted. The performance of the dual master-slave system equipped with flexible devices is validated through several phantom tests. The results suggest that bendable end-effectors and navigation software are useful to navigate and treat blind regions inside general sinus areas as well as the maxillary sinus.
Andrew Croaker - One of the best experts on this subject based on the ideXlab platform.
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black Salve composition an evaluation of the potential for normal tissue toxicity and treatment failure from black Salve products
Journal of Herbal Medicine, 2019Co-Authors: Andrew Croaker, Graham J W King, John H Pyne, Shailendra AnoopkumardukieAbstract:Abstract Black Salve, used as an alternative skin cancer therapy, contains both herbal and chemical constituents, including extracts of the rhizomes of Sanguinaria canadensis and zinc chloride. Black Salves may be ordered online and have been associated with cases of extensive tissue necrosis and treatment failures that have resulted in patient fatalities. Despite these adverse outcomes and continued use by patients, black Salve products have not been quantitatively assessed to determine their constituent concentrations. Thirteen different black Salve products from eight manufacturers were analysed using validated HPLC-MS and ICP-MS methods to assess S. canadensis alkaloid and zinc chloride concentrations. This analysis revealed a dramatic variation in constituent concentrations between manufacturers of black Salve products. The alkaloid sanguinarine was found at concentrations significantly exceeding the cytotoxic IC50 of normal human epidermal keratinocytes in the majority of black Salve products, with one black Salve examined having a concentration 900 times the IC50 level. The majority of products contained zinc chloride at concentrations known to kill normal human tissue, while one black Salve product was found to contain an elevated lead level of 258 ppm, which exceeds the 10 ppm FDA determined lead limit for cosmetic products. Whilst some of the black Salve products were found to contain high concentrations of constituents cytotoxic to normal tissue, others were found to contain insufficient cytotoxic constituents to be reasonably expected to exert any anti-cancer activity. In their current formulations, the majority of black Salves analysed pose a significant risk of harm to patients and should not be available for unregulated clinical use. Further black Salve toxicity testing is urgently required.
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black Salve in a nutshell
Journal of general practice, 2018Co-Authors: Andrew Croaker, Cliff RosendahlAbstract:Background: Black Salve is an alternative therapy increasingly chosen by patients to self-manage their skin lesions. It is promoted as an effective, safe and natural skin cancer treatment, but such claims are not evidence-based, and serious complications have been reported. The sale of black Salve in Australia is illegal. Objective: The aim of this article is to educate general practitioners (GPs) about black Salve, enabling informed discussion with patients considering using black Salve. An overview of the scientific literature is presented. Discussion: Case reports have described significant morbidity and even mortality associated with the use of black Salve. Despite this, black Salve is readily accessible to the public online; a simple internet search yields multiple links to websites endorsing black Salve as an effective natural skin cancer remedy. As GPs are often called on in the initial presentation of skin complaints, they are well positioned to ask patients about their use of black Salve and educate them about its risks.
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carcinogenic potential of sanguinarine a phytochemical used in therapeutic black Salve and mouthwash
Mutation Research, 2017Co-Authors: Andrew Croaker, Graham J W King, John H Pyne, Shailendra Anoopkumardukie, Vilim SimanekAbstract:Black Salves are escharotic skin cancer therapies in clinical use since the mid 19th century. Sanguinaria canadensis, a major ingredient of black Salve formulations, contains a number of bioactive phytochemicals including the alkaloid sanguinarine. Despite its prolonged history of clinical use, conflicting experimental results have prevented the carcinogenic potential of sanguinarine from being definitively determined. Sanguinarine has a molecular structure similar to known polyaromatic hydrocarbon carcinogens and is a DNA intercalator. Sanguinarine also generates oxidative and endoplasmic reticulum stress resulting in the unfolded protein response and the formation of 8-hydroxyguanine genetic lesions. Sanguinarine has been the subject of contradictory in vitro and in vivo genotoxicity and murine carcinogenesis test results that have delayed its carcinogenic classification. Despite this, epidemiological studies have linked mouthwash that contains sanguinarine with the development of oral leukoplakia. Sanguinarine is also proposed as an aetiological agent in gallbladder carcinoma. This literature review investigates the carcinogenic potential of sanguinarine. Reasons for contradictory genotoxicity and carcinogenesis results are explored, knowledge gaps identified and a strategy for determining the carcinogenic potential of sanguinarine especialy relating to black Salve are discussed. As patients continue to apply black Salve, especially to skin regions suffering from field cancerization and skin malignancies, an understanding of the genotoxic and carcinogenic potential of sanguinarine is of urgent clinical relevance.
