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Michael P Stern - One of the best experts on this subject based on the ideXlab platform.
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a quantitative trait locus on chromosome 5p influences d dimer levels in the San Antonio family heart study
International Journal of Vascular Medicine, 2010Co-Authors: Valenzuela Patricio Diego, David L Rainwater, Laura Almasy, Michael P Stern, Jean W Maccluer, Shelley A. Cole, Russell P Tracy, Anthony G. Comuzzie, Michael C. Mahaney, John BlangeroAbstract:Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM. Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.
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national cholesterol education program versus world health organization metabolic syndrome in relation to all cause and cardiovascular mortality in the San Antonio heart study
Circulation, 2004Co-Authors: Kelly J Hunt, Ken Williams, Roy G Resendez, S M Haffner, Michael P SternAbstract:Background— To assess the utility of clinical definitions of the metabolic syndrome (MetS) to identify individuals with increased cardiovascular risk, we examined the relation between the MetS, using both the National Cholesterol Education Program (NCEP) and the World Health Organization definitions, and all-cause and cardiovascular mortality in San Antonio Heart Study participants enrolled between 1984 and 1988. Methods and Results— Among 2815 participants, 25 to 64 years of age at enrollment, 509 met both criteria, 197 met NCEP criteria only, and 199 met WHO criteria only. Over an average of 12.7 years, 229 deaths occurred (117 from cardiovascular disease). Moreover, in the primary prevention population of 2372 participants (ie, those without diabetes or cardiovascular disease at baseline), 132 deaths occurred (50 from cardiovascular disease). In the primary prevention population, the only significant association adjusted for age, gender, and ethnic group was between NCEP-MetS and cardiovascular mortali...
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the genetics of obesity in mexican americans the evidence from genome scanning efforts in the San Antonio family heart study
Human Biology, 2003Co-Authors: Anthony G. Comuzzie, David L Rainwater, Laura Almasy, Michael P Stern, Shelley A. Cole, Lisa J Martin, Bratxton D Mitchell, Wenchi Hsueh, James E Hixson, Jean W MaccluerAbstract:1 Abstract Recent estimates indicate that approximately 18% of the popu- lation in the United States can be considered obese (defined as a body mass index (BMI) ≥ 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic dis- eases including type 2 diabetes mellitus and coronary heart disease. The search for genes involved in the expression of obesity has been one of the fo- cal points of the San Antonio Family Heart Study (SAFHS), a large, family- based study to examine the genetics of risk for atherosclerosis in Mexican Americans. To date, our genome scanning effort has reported two quantita- tive trait loci (QTLs) with pronounced effects on the expression of a variety of obesity—related phenotypes (e.g., leptin levels, fat mass, and BMI) locat- ed on chromosomes 2 and 8. We are currently working to further refine these signals and to identify the genes and allelic variants involved. Here, we sum- marize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study.
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the metabolic syndrome as predictor of type 2 diabetes the San Antonio heart study
Diabetes Care, 2003Co-Authors: Carlos Lorenzo, Michael P Stern, Mayor Okoloise, Ken Williams, Steven M. HaffnerAbstract:OBJECTIVE —The oral glucose tolerance test identifies high-risk subjects for diabetes, but it is costly and inconvenient. To find better predictors of type 2 diabetes, we evaluated two different definitions of the metabolic syndrome because insulin resistance, which is commonly associated with this clustering of metabolic factors, frequently precedes the onset of type 2 diabetes. RESEARCH DESIGN AND METHODS —We compared the ability of the National Cholesterol Education Program (NCEP) definition, a modified version of the 1999 World Health Organization (WHO) definition that excludes the 2-h glucose requirement, and impaired glucose tolerance (IGT) to predict incident type 2 diabetes. In the San Antonio Heart Study, 1,734 participants completed a 7- to 8-year follow-up examination. RESULTS —IGT and the NCEP definition had higher sensitivity than the modified WHO definition (51.9, 52.8, and 42.8%, respectively). IGT had a higher positive predictive value than the NCEP and modified WHO definitions (43.0, 30.8, and 30.4%, respectively). The combination of the IGT and NCEP definitions increased the sensitivity to 70.8% with an acceptable positive predictive value of 29.7%. Risk for incidence of type 2 diabetes using the NCEP definition was independent of other risk factors, including IGT and fasting insulin (odds ratio 3.30, 95% CI 2.27-4.80). The NCEP definition performed better with fasting glucose ≥5.4 mmol/l (sensitivity 62.0% and positive predictive value 30.9%). CONCLUSIONS —The metabolic syndrome predicts diabetes independently of other factors. However, the NCEP definition performs better than the modified 1999 WHO definition. Lowering the fasting glucose cutoff to 5.4 mmol/l improves the prediction of diabetes by the metabolic syndrome.
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homeostasis model assessment of insulin resistance in relation to the incidence of cardiovascular disease the San Antonio heart study
Diabetes Care, 2002Co-Authors: Anthony J G Hanley, Michael P Stern, Kenneth C Williams, Steven M. HaffnerAbstract:OBJECTIVE —The prospective association between insulin levels and risk of cardiovascular disease (CVD) is controversial. The objective of the present study was to investigate the relationship of the homeostasis model assessment of insulin resistance (HOMA-IR), as well as insulin levels, with risk of nonfatal and fatal CVD over the 8-year follow-up of the San Antonio Heart Study. RESEARCH DESIGN AND METHODS —Between 1984 and 1988, randomly selected Mexican-American and non-Hispanic white residents of San Antonio participated in baseline examinations that included fasting blood samples for glucose, insulin, and lipids, a glucose tolerance test, anthropometric measurements, and a lifestyle questionnaire. Between 1991 and 1996, 2,569 subjects who were free of diabetes at baseline were reexamined using the same protocol. RESULTS —Over the follow-up period, 187 subjects experienced an incident cardiovascular event (heart attack, stroke, heart surgery, angina, or CVD death). Logistic regression analysis indicated that risk of a CVD event increased across quintiles of HOMA-IR after adjustment for age, sex, and ethnicity ( P for trend P for trend 0.02; quintile 5 vs. quintile 1, OR 1.94, 95% CI 1.05–3.59). Furthermore, there were no significant interactions between HOMA-IR and ethnicity, sex, hypertension, dyslipidemia, glucose tolerance (impaired glucose tolerance versus normal glucose tolerance), or obesity. The magnitude and direction of the relationship between insulin concentration and incident CVD were similar. CONCLUSIONS —We found a significant association between HOMA-IR and risk of CVD after adjustment for multiple covariates. The topic remains controversial, however, and additional studies are required, particularly among women and minority populations.
Anthony G. Comuzzie - One of the best experts on this subject based on the ideXlab platform.
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a quantitative trait locus on chromosome 5p influences d dimer levels in the San Antonio family heart study
International Journal of Vascular Medicine, 2010Co-Authors: Valenzuela Patricio Diego, David L Rainwater, Laura Almasy, Michael P Stern, Jean W Maccluer, Shelley A. Cole, Russell P Tracy, Anthony G. Comuzzie, Michael C. Mahaney, John BlangeroAbstract:Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM. Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.
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principal component for metabolic syndrome risk maps to chromosome 4p in mexican americans the San Antonio family heart study
Human Biology, 2004Co-Authors: Guowen Cai, Jean W Maccluer, Shelley A. Cole, John Blangero, Jeanne H Freelandgraves, Anthony G. ComuzzieAbstract:Metabolic syndrome refers to the clustering of disease condi- tions such as insulin resistance, hyperinsulinemia, dyslipidemia, hyperten- sion, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The sub- jects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Antonio Family Heart Study. The factor scores ob- tained from these 14 phenotypes were used in multipoint linkage analysis using SOLAR. Factors were identiÞed that accounted for 73% of the total variance of the original variables: body size-adiposity, insulin-glucose, blood pressure, and lipid levels. Each factor exhibited evidence for either signiÞcant or suggestive linkage involving four factor-speciÞc chromosomal regions relating to chromosomes 1, 3, 4, and 6. SigniÞcant evidence for linkage of the lipid factor was found on chromosome 4 near marker D4S403 (LOD 3.52), where the cholecystokinin A receptor (CCKAR) and ADP- ribosyl cyclase 1 (CD38) genes are located. Suggestive evidence for linkage of the body size-adiposity factor to chromosome 1 near marker D1S1597 (LOD 2.53) in the region containing the nuclear receptor subfamily 0, group B, member 2 gene (NROB2) also was observed. The insulin-glucose and blood pressure factors were linked suggestively to regions on chromo- some 3 near marker D3S1595 (LOD 2.20) and on chromosome 6 near marker D6S1031 (LOD 2.08), respectively. In summary, our Þndings sug- gest that the factor structures for the risk of metabolic syndrome are insu- enced by multiple distinct genes across the genome.
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the genetics of obesity in mexican americans the evidence from genome scanning efforts in the San Antonio family heart study
Human Biology, 2003Co-Authors: Anthony G. Comuzzie, David L Rainwater, Laura Almasy, Michael P Stern, Shelley A. Cole, Lisa J Martin, Bratxton D Mitchell, Wenchi Hsueh, James E Hixson, Jean W MaccluerAbstract:1 Abstract Recent estimates indicate that approximately 18% of the popu- lation in the United States can be considered obese (defined as a body mass index (BMI) ≥ 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic dis- eases including type 2 diabetes mellitus and coronary heart disease. The search for genes involved in the expression of obesity has been one of the fo- cal points of the San Antonio Family Heart Study (SAFHS), a large, family- based study to examine the genetics of risk for atherosclerosis in Mexican Americans. To date, our genome scanning effort has reported two quantita- tive trait loci (QTLs) with pronounced effects on the expression of a variety of obesity—related phenotypes (e.g., leptin levels, fat mass, and BMI) locat- ed on chromosomes 2 and 8. We are currently working to further refine these signals and to identify the genes and allelic variants involved. Here, we sum- marize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study.
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genetic and environmental contributions to cardiovascular risk factors in mexican americans the San Antonio family heart study
Circulation, 1996Co-Authors: Braxton D Mitchell, David L Rainwater, John Blangero, Michael C. Mahaney, James E Hixson, Candace M Kammerer, Bennett Dyke, Richard D Henkel, Mark R Sharp, Anthony G. ComuzzieAbstract:Background The familial aggregation of coronary heart disease can be in large part accounted for by a clustering of cardiovascular disease risk factors. To elucidate the determinants of cardiovascular disease, many epidemiological studies have focused on the behavioral and lifestyle determinants of these risk factors, whereas others have examined whether specific candidate genes influence quantitative variation in these phenotypes. Methods and Results Among Mexican Americans from San Antonio (Tex), we quantified the relative contributions of both genetic and environmental influences to a large panel of cardiovascular risk factors, including serum levels of lipids, lipoproteins, glucose, hormones, adiposity, and blood pressure. Members of 42 extended families were studied, including 1236 first-, second-, and third-degree relatives of randomly ascertained probands and their spouses. In addition to the phenotypic assessments, information was obtained regarding usual dietary and physical activity patterns, me...
John Blangero - One of the best experts on this subject based on the ideXlab platform.
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a quantitative trait locus on chromosome 5p influences d dimer levels in the San Antonio family heart study
International Journal of Vascular Medicine, 2010Co-Authors: Valenzuela Patricio Diego, David L Rainwater, Laura Almasy, Michael P Stern, Jean W Maccluer, Shelley A. Cole, Russell P Tracy, Anthony G. Comuzzie, Michael C. Mahaney, John BlangeroAbstract:Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM. Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.
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principal component for metabolic syndrome risk maps to chromosome 4p in mexican americans the San Antonio family heart study
Human Biology, 2004Co-Authors: Guowen Cai, Jean W Maccluer, Shelley A. Cole, John Blangero, Jeanne H Freelandgraves, Anthony G. ComuzzieAbstract:Metabolic syndrome refers to the clustering of disease condi- tions such as insulin resistance, hyperinsulinemia, dyslipidemia, hyperten- sion, and obesity. To explore the genetic predispositions of this complex syndrome, we conducted a principal components analysis using data on 14 phenotypes related to the risk of developing metabolic syndrome. The sub- jects were 566 nondiabetic Mexican Americans, distributed in 41 extended families from the San Antonio Family Heart Study. The factor scores ob- tained from these 14 phenotypes were used in multipoint linkage analysis using SOLAR. Factors were identiÞed that accounted for 73% of the total variance of the original variables: body size-adiposity, insulin-glucose, blood pressure, and lipid levels. Each factor exhibited evidence for either signiÞcant or suggestive linkage involving four factor-speciÞc chromosomal regions relating to chromosomes 1, 3, 4, and 6. SigniÞcant evidence for linkage of the lipid factor was found on chromosome 4 near marker D4S403 (LOD 3.52), where the cholecystokinin A receptor (CCKAR) and ADP- ribosyl cyclase 1 (CD38) genes are located. Suggestive evidence for linkage of the body size-adiposity factor to chromosome 1 near marker D1S1597 (LOD 2.53) in the region containing the nuclear receptor subfamily 0, group B, member 2 gene (NROB2) also was observed. The insulin-glucose and blood pressure factors were linked suggestively to regions on chromo- some 3 near marker D3S1595 (LOD 2.20) and on chromosome 6 near marker D6S1031 (LOD 2.08), respectively. In summary, our Þndings sug- gest that the factor structures for the risk of metabolic syndrome are insu- enced by multiple distinct genes across the genome.
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genetic and environmental contributions to cardiovascular risk factors in mexican americans the San Antonio family heart study
Circulation, 1996Co-Authors: Braxton D Mitchell, David L Rainwater, John Blangero, Michael C. Mahaney, James E Hixson, Candace M Kammerer, Bennett Dyke, Richard D Henkel, Mark R Sharp, Anthony G. ComuzzieAbstract:Background The familial aggregation of coronary heart disease can be in large part accounted for by a clustering of cardiovascular disease risk factors. To elucidate the determinants of cardiovascular disease, many epidemiological studies have focused on the behavioral and lifestyle determinants of these risk factors, whereas others have examined whether specific candidate genes influence quantitative variation in these phenotypes. Methods and Results Among Mexican Americans from San Antonio (Tex), we quantified the relative contributions of both genetic and environmental influences to a large panel of cardiovascular risk factors, including serum levels of lipids, lipoproteins, glucose, hormones, adiposity, and blood pressure. Members of 42 extended families were studied, including 1236 first-, second-, and third-degree relatives of randomly ascertained probands and their spouses. In addition to the phenotypic assessments, information was obtained regarding usual dietary and physical activity patterns, me...
Felix Rodriguez Michael Frank - One of the best experts on this subject based on the ideXlab platform.
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Aprendizaje significativo en el Área de Educación Religiosa y uso de TICs en estudiantes de 5to de secundaria en la I.E. San Antonio de Jicamarca, Jicarmarca-2019
'Universidad Cesar Vallejo', 2019Co-Authors: Felix Rodriguez Michael FrankAbstract:El trabajo de investigación titulado aprendizaje significativo en el Área de Educción Religiosa y uso de TICs, tuvo como población a estudiantes de quinto grado de secundaria, fue realizada en la Institución Educativa San Antonio de Jicamarca, ubicado en el distrito de Jicamarca, provincia de Huarochiri, Lima Provincia. La finalidad fue determinar la relación del aprendizaje significativo en el Área de Educción Religiosa y el uso de Tics en estudiante de 5to de secundaria en la I.E. San Antonio de Jicamarca, Jicarmarca-2019. El trabajo de investigación tiene dos variables y atores bases. Rodríguez Palermo, Luz para aprendizaje significativo y Ministerio de Educación para las dimensiones; y Ministerio de Educación, Arras Vota, Ana, Torres Gastelú, Carlos, Muñoz Repiso, Ana para el uso de Tecnologías de la Información y Comunicación y Gutiérrez Castillo, Juan, Cabrero Almenara, Julio y Estrada Vidal, Ligia para las dimensiones. La tesis fue desarrolla con el método cuantitativo, diseño no experimental, tipo transversal y descripción básicas. Asimismo, se empleó la descriptiva correlacional por los tipos de variables y la interpretación de los datos estadísticos, con una población y muestra de 110 estudiantes. Para el recojo de datos se empleó la técnica y el instrumento fue un cuestionario politónico, con escala de Likert. La primera variable consta de 30 preguntas; la variable 2, 36 preguntas. El procesamiento estadístico se realizó con el Rho de Spaerman. La tesis mostró un el valor de Rho Spearman de r = -,021 (p-valor = ,830 > 0,5), indicando la ausencia de correlación entre las variables y un valor de significancia que sobrepasa el valor señalado del 05 %. Por lo tanto el aprendizaje significativo no se relaciona con el uso de las TICs
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Aprendizaje significativo en el Área de Educación Religiosa y uso de TICs en estudiantes de 5to de secundaria en la I.E. San Antonio de Jicamarca, Jicarmarca-2019
'Universidad Cesar Vallejo', 2019Co-Authors: Felix Rodriguez Michael FrankAbstract:TesisLima EsteEscuela Profesional de Posgradovaluación y aprendizajeEl trabajo de investigación titulado aprendizaje significativo en el Área de Educción Religiosa y uso de TICs, tuvo como población a estudiantes de quinto grado de secundaria, fue realizada en la Institución Educativa San Antonio de Jicamarca, ubicado en el distrito de Jicamarca, provincia de Huarochiri, Lima Provincia. La finalidad fue determinar la relación del aprendizaje significativo en el Área de Educción Religiosa y el uso de Tics en estudiante de 5to de secundaria en la I.E. San Antonio de Jicamarca, Jicarmarca-2019. El trabajo de investigación tiene dos variables y atores bases. Rodríguez Palermo, Luz para aprendizaje significativo y Ministerio de Educación para las dimensiones; y Ministerio de Educación, Arras Vota, Ana, Torres Gastelú, Carlos, Muñoz Repiso, Ana para el uso de Tecnologías de la Información y Comunicación y Gutiérrez Castillo, Juan, Cabrero Almenara, Julio y Estrada Vidal, Ligia para las dimensiones. La tesis fue desarrolla con el método cuantitativo, diseño no experimental, tipo transversal y descripción básicas. Asimismo, se empleó la descriptiva correlacional por los tipos de variables y la interpretación de los datos estadísticos, con una población y muestra de 110 estudiantes. Para el recojo de datos se empleó la técnica y el instrumento fue un cuestionario politónico, con escala de Likert. La primera variable consta de 30 preguntas; la variable 2, 36 preguntas. El procesamiento estadístico se realizó con el Rho de Spaerman. La tesis mostró un el valor de Rho Spearman de r = -,021 (p-valor = ,830 > 0,5), indicando la ausencia de correlación entre las variables y un valor de significancia que sobrepasa el valor señalado del 05 %. Por lo tanto el aprendizaje significativo no se relaciona con el uso de las TICs
David L Rainwater - One of the best experts on this subject based on the ideXlab platform.
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a quantitative trait locus on chromosome 5p influences d dimer levels in the San Antonio family heart study
International Journal of Vascular Medicine, 2010Co-Authors: Valenzuela Patricio Diego, David L Rainwater, Laura Almasy, Michael P Stern, Jean W Maccluer, Shelley A. Cole, Russell P Tracy, Anthony G. Comuzzie, Michael C. Mahaney, John BlangeroAbstract:Background. D-dimer is associated with increasing severity of atherosclerosis and with increased risk of a cardiovascular disease (CVD). Methods and Results. To better understand this risk factor, we performed a genome scan on 803 (301 males and 502 females) Mexican Americans in the San Antonio Family Heart Study (SAFHS). The SAFHS is ideal for the discovery of quantitative trait loci (QTLs) influencing CVD because CVD risk factors are prevalent in Mexican Americans of San Antonio and because the study design involves large families, which is optimal for QTL discovery. D-dimer levels were normalized in our study. We found that D-dimer levels were heritable, at about 23% heritability (). In a linkage analysis employing 432 microsatellite markers, we found strong evidence of a QTL on chromosome 5p with a lod score of 3.32 at 21 centiMorgans (cM). We also found suggestive evidence of a QTL on chromosome 2q with a lod score of 2.33 at 207 cM. Conclusions. To our knowledge, the putative QTL on chromosome 5p is novel. The possible QTL on chromosome 2q is discussed in relation to a recent report of linkage of a related hemostatic factor to the same location. These results warrant further investigation.
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the genetics of obesity in mexican americans the evidence from genome scanning efforts in the San Antonio family heart study
Human Biology, 2003Co-Authors: Anthony G. Comuzzie, David L Rainwater, Laura Almasy, Michael P Stern, Shelley A. Cole, Lisa J Martin, Bratxton D Mitchell, Wenchi Hsueh, James E Hixson, Jean W MaccluerAbstract:1 Abstract Recent estimates indicate that approximately 18% of the popu- lation in the United States can be considered obese (defined as a body mass index (BMI) ≥ 30), and this rate is even higher among ethnic populations such as Mexican Americans. This figure becomes very significant given the strong evidence for obesity as a major risk factor for a variety of chronic dis- eases including type 2 diabetes mellitus and coronary heart disease. The search for genes involved in the expression of obesity has been one of the fo- cal points of the San Antonio Family Heart Study (SAFHS), a large, family- based study to examine the genetics of risk for atherosclerosis in Mexican Americans. To date, our genome scanning effort has reported two quantita- tive trait loci (QTLs) with pronounced effects on the expression of a variety of obesity—related phenotypes (e.g., leptin levels, fat mass, and BMI) locat- ed on chromosomes 2 and 8. We are currently working to further refine these signals and to identify the genes and allelic variants involved. Here, we sum- marize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study.
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genetic and environmental contributions to cardiovascular risk factors in mexican americans the San Antonio family heart study
Circulation, 1996Co-Authors: Braxton D Mitchell, David L Rainwater, John Blangero, Michael C. Mahaney, James E Hixson, Candace M Kammerer, Bennett Dyke, Richard D Henkel, Mark R Sharp, Anthony G. ComuzzieAbstract:Background The familial aggregation of coronary heart disease can be in large part accounted for by a clustering of cardiovascular disease risk factors. To elucidate the determinants of cardiovascular disease, many epidemiological studies have focused on the behavioral and lifestyle determinants of these risk factors, whereas others have examined whether specific candidate genes influence quantitative variation in these phenotypes. Methods and Results Among Mexican Americans from San Antonio (Tex), we quantified the relative contributions of both genetic and environmental influences to a large panel of cardiovascular risk factors, including serum levels of lipids, lipoproteins, glucose, hormones, adiposity, and blood pressure. Members of 42 extended families were studied, including 1236 first-, second-, and third-degree relatives of randomly ascertained probands and their spouses. In addition to the phenotypic assessments, information was obtained regarding usual dietary and physical activity patterns, me...
