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Steven S Witkin - One of the best experts on this subject based on the ideXlab platform.

  • epizootics due to yellow fever virus in Sao Paulo state brazil viral dissemination to new areas 2016 2017
    Scientific Reports, 2019
    Co-Authors: Mariana Sequetin Cunha, Fabiana Cristina Pereira Dos Santos, Antonio Charlys Da Costa, Natalia Coelho Couto De Azevedo Fernandes, Juliana Mariotti Guerra, Juliana Silva Nogueira, Leandro Guariglia Dagostino, Shirley Vasconcelos Komninakis, Steven S Witkin
    Abstract:

    Beginning in late 2016 Brazil faced the worst outbreak of Yellow Fever in recent decades, mainly located in southeastern rural regions of the country. In the present study we characterize the Yellow Fever Virus (YFV) associated with this outbreak in Sao Paulo State, Brazil. Blood or tissues collected from 430 dead monkeys and 1030 pools containing a total of 5,518 mosquitoes were tested for YFV by quantitative RT-PCR, immunohistochemistry (IHC) and indirect immunofluorescence. A total of 67 monkeys were YFV-positive and 3 pools yielded YFV following culture in a C6/36 cell line. Analysis of five nearly full length genomes of YFV from collected samples was consistent with evidence that the virus associated with the Sao Paulo outbreak originated in Minas Gerais. The phylogenetic analysis also showed that strains involved in the 2016–2017 outbreak in distinct Brazilian states (i.e., Minas Gerais, Rio de Janeiro, Espirito Santo) intermingled in maximum-likelihood and Bayesian trees. Conversely, the strains detected in Sao Paulo formed a monophyletic cluster, suggesting that they were local-adapted. The finding of YFV by RT-PCR in five Callithrix monkeys who were all YFV-negative by histopathology or immunohistochemistry suggests that this YFV lineage circulating in Sao Paulo is associated with different outcomes in Callithrix when compared to other monkeys.

Alexandre Magno Sebbenn - One of the best experts on this subject based on the ideXlab platform.

Pitágoras Da Conceição Bispo - One of the best experts on this subject based on the ideXlab platform.

  • hydropsychidae curtis e leptoceridae leach insecta trichoptera do parque estadual intervales serra de paranapiacaba estado de Sao Paulo brasil
    EntomoBrasilis, 2015
    Co-Authors: Rafael Alberto Moretto, Pitágoras Da Conceição Bispo
    Abstract:

    Este estudo teve como objetivo realizar um levantamento das familias Hydropsychidae e Leptoceridae (Trichoptera) do Parque Estadual Intervales, um dos ultimos remanescentes florestais de Mata Atlântica do Estado de Sao Paulo. As coletas foram realizadas em diferentes riachos do Parque entre julho de 2010 e agosto de 2013. Foram coletados 2.319 individuos machos, totalizando 29 especies, 17 da familia Hydropsychidae e 12 de Leptoceridae. Dentre essas especies, duas nao possuiam registro para o Estado de Sao Paulo. Hydropsychidae Curtis and Leptoceridae Leach (Insecta, Trichoptera) from Parque Estadual Intervales, Serra de Paranapiacaba, Sao Paulo State, Brazil Abstract. This study aimed to survey the caddisfly families Hydropsychidae and Leptoceridae from Intervales State Park, one of the last remaining of the Atlantic Rain Forest of Sao Paulo State. The collections were carried out in several streams between July 2010 and August 2013. Were collected 2,319  males, totaling 29 species, 17 of the Hydropsychidae and 12 of Leptoceridae. Among these species, two had no record for the State of Sao Paulo.

  • hydropsychidae curtis e leptoceridae leach insecta trichoptera do parque estadual intervales serra de paranapiacaba estado de Sao Paulo brasil
    EntomoBrasilis, 2015
    Co-Authors: Rafael Alberto Moretto, Pitágoras Da Conceição Bispo
    Abstract:

    Este estudo teve como objetivo realizar um levantamento das familias Hydropsychidae e Leptoceridae (Trichoptera) do Parque Estadual Intervales, um dos ultimos remanescentes florestais de Mata Atlântica do Estado de Sao Paulo. As coletas foram realizadas em diferentes riachos do Parque entre julho de 2010 e agosto de 2013. Foram coletados 2.319 individuos machos, totalizando 29 especies, 17 da familia Hydropsychidae e 12 de Leptoceridae. Dentre essas especies, duas nao possuiam registro para o Estado de Sao Paulo. Hydropsychidae Curtis and Leptoceridae Leach (Insecta, Trichoptera) from Parque Estadual Intervales, Serra de Paranapiacaba, Sao Paulo State, Brazil Abstract. This study aimed to survey the caddisfly families Hydropsychidae and Leptoceridae from Intervales State Park, one of the last remaining of the Atlantic Rain Forest of Sao Paulo State. The collections were carried out in several streams between July 2010 and August 2013. Were collected 2,319  males, totaling 29 species, 17 of the Hydropsychidae and 12 of Leptoceridae. Among these species, two had no record for the State of Sao Paulo.

Mariana Sequetin Cunha - One of the best experts on this subject based on the ideXlab platform.

  • genomic surveillance of yellow fever virus epizootic in Sao Paulo brazil 2016 2018
    PLOS Pathogens, 2020
    Co-Authors: Sarah C Hill, Renato De Souza, Julien Theze, Ingra Morales Claro, Renato S Aguiar, Leandro Abade, Fabiana Cristina Pereira Dos Santos, Mariana Sequetin Cunha
    Abstract:

    Sao Paulo, a densely inhabited state in southeast Brazil that contains the fourth most populated city in the world, recently experienced its largest yellow fever virus (YFV) outbreak in decades. YFV does not normally circulate extensively in Sao Paulo, so most people were unvaccinated when the outbreak began. Surveillance in non-human primates (NHPs) is important for determining the magnitude and geographic extent of an epizootic, thereby helping to evaluate the risk of YFV spillover to humans. Data from infected NHPs can give more accurate insights into YFV spread than when using data from human cases alone. To contextualise human cases, identify epizootic foci and uncover the rate and direction of YFV spread in Sao Paulo, we generated and analysed virus genomic data and epizootic case data from NHPs in Sao Paulo. We report the occurrence of three spatiotemporally distinct phases of the outbreak in Sao Paulo prior to February 2018. We generated 51 new virus genomes from YFV positive cases identified in 23 different municipalities in Sao Paulo, mostly sampled from NHPs between October 2016 and January 2018. Although we observe substantial heterogeneity in lineage dispersal velocities between phylogenetic branches, continuous phylogeographic analyses of generated YFV genomes suggest that YFV lineages spread in Sao Paulo at a mean rate of approximately 1km per day during all phases of the outbreak. Viral lineages from the first epizootic phase in northern Sao Paulo subsequently dispersed towards the south of the state to cause the second and third epizootic phases there. This alters our understanding of how YFV was introduced into the densely populated south of Sao Paulo state. Our results shed light on the sylvatic transmission of YFV in highly fragmented forested regions in Sao Paulo state and highlight the importance of continued surveillance of zoonotic pathogens in sentinel species.

  • epizootics due to yellow fever virus in Sao Paulo state brazil viral dissemination to new areas 2016 2017
    Scientific Reports, 2019
    Co-Authors: Mariana Sequetin Cunha, Fabiana Cristina Pereira Dos Santos, Antonio Charlys Da Costa, Natalia Coelho Couto De Azevedo Fernandes, Juliana Mariotti Guerra, Juliana Silva Nogueira, Leandro Guariglia Dagostino, Shirley Vasconcelos Komninakis, Steven S Witkin
    Abstract:

    Beginning in late 2016 Brazil faced the worst outbreak of Yellow Fever in recent decades, mainly located in southeastern rural regions of the country. In the present study we characterize the Yellow Fever Virus (YFV) associated with this outbreak in Sao Paulo State, Brazil. Blood or tissues collected from 430 dead monkeys and 1030 pools containing a total of 5,518 mosquitoes were tested for YFV by quantitative RT-PCR, immunohistochemistry (IHC) and indirect immunofluorescence. A total of 67 monkeys were YFV-positive and 3 pools yielded YFV following culture in a C6/36 cell line. Analysis of five nearly full length genomes of YFV from collected samples was consistent with evidence that the virus associated with the Sao Paulo outbreak originated in Minas Gerais. The phylogenetic analysis also showed that strains involved in the 2016–2017 outbreak in distinct Brazilian states (i.e., Minas Gerais, Rio de Janeiro, Espirito Santo) intermingled in maximum-likelihood and Bayesian trees. Conversely, the strains detected in Sao Paulo formed a monophyletic cluster, suggesting that they were local-adapted. The finding of YFV by RT-PCR in five Callithrix monkeys who were all YFV-negative by histopathology or immunohistochemistry suggests that this YFV lineage circulating in Sao Paulo is associated with different outcomes in Callithrix when compared to other monkeys.

Euripedes Morais - One of the best experts on this subject based on the ideXlab platform.

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