The Experts below are selected from a list of 1971 Experts worldwide ranked by ideXlab platform
Maria Valletregi - One of the best experts on this subject based on the ideXlab platform.
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an optimized β tricalcium phosphate and agarose Scaffold Fabrication Technique
Journal of Biomedical Materials Research Part A, 2008Co-Authors: J. Román, M.v. Cabañas, J. Peña, Juan C. Doadrio, Maria ValletregiAbstract:Biodegradable Scaffolds composed of β-tricalcium phosphate, and a natural hydrogel, agarose, were prepared by a shaping method based on the thermal gelation of the polymeric component. This Technique was modified to facilitate the inclusion, during the Scaffold preparation stage, of therapeutic agents that could improve the graft performance. Vancomycin was included in materials containing different amounts of agarose and ceramic without affecting the Scaffold consolidation process. These materials, easily injectable, behave like a reinforced hydrogel whose swelling behavior and drug release rate depend on their composition. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
J. Román - One of the best experts on this subject based on the ideXlab platform.
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An optimized β‐tricalcium phosphate and agarose Scaffold Fabrication Technique
Journal of biomedical materials research. Part A, 2008Co-Authors: J. Román, M.v. Cabañas, J. Peña, Juan C. Doadrio, María Vallet-regíAbstract:Biodegradable Scaffolds composed of β-tricalcium phosphate, and a natural hydrogel, agarose, were prepared by a shaping method based on the thermal gelation of the polymeric component. This Technique was modified to facilitate the inclusion, during the Scaffold preparation stage, of therapeutic agents that could improve the graft performance. Vancomycin was included in materials containing different amounts of agarose and ceramic without affecting the Scaffold consolidation process. These materials, easily injectable, behave like a reinforced hydrogel whose swelling behavior and drug release rate depend on their composition. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
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an optimized β tricalcium phosphate and agarose Scaffold Fabrication Technique
Journal of Biomedical Materials Research Part A, 2008Co-Authors: J. Román, M.v. Cabañas, J. Peña, Juan C. Doadrio, Maria ValletregiAbstract:Biodegradable Scaffolds composed of β-tricalcium phosphate, and a natural hydrogel, agarose, were prepared by a shaping method based on the thermal gelation of the polymeric component. This Technique was modified to facilitate the inclusion, during the Scaffold preparation stage, of therapeutic agents that could improve the graft performance. Vancomycin was included in materials containing different amounts of agarose and ceramic without affecting the Scaffold consolidation process. These materials, easily injectable, behave like a reinforced hydrogel whose swelling behavior and drug release rate depend on their composition. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
Magali Saint-geniez - One of the best experts on this subject based on the ideXlab platform.
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A novel porous Scaffold Fabrication Technique for epithelial and endothelial tissue engineering
Journal of Materials Science: Materials in Medicine, 2013Co-Authors: Kevin J. Mchugh, Sarah L. Tao, Magali Saint-geniezAbstract:Porous Scaffolds have the ability to minimize transport barriers for both two- (2D) and three-dimensional tissue engineering. However, current porous Scaffolds may be non-ideal for 2D tissues such as epithelium due to inherent Fabrication-based characteristics. While 2D tissues require porosity to support molecular transport, pores must be small enough to prevent cell migration into the Scaffold in order to avoid non-epithelial tissue architecture and compromised function. Though electrospun meshes are the most popular porous Scaffolds used today, their heterogeneous pore size and intense topography may be poorly-suited for epithelium. Porous Scaffolds produced using other methods have similar unavoidable limitations, frequently involving insufficient pore resolution and control, which make them incompatible with 2D tissues. In addition, many of these Techniques require an entirely new round of process development in order to change material or pore size. Herein we describe “pore casting,” a Fabrication method that produces flat Scaffolds with deterministic pore shape, size, and location that can be easily altered to accommodate new materials or pore dimensions. As proof-of-concept, pore-cast poly(ε-caprolactone) (PCL) Scaffolds were fabricated and compared to electrospun PCL in vitro using canine kidney epithelium, human colon epithelium, and human umbilical vein endothelium. All cell types demonstrated improved morphology and function on pore-cast Scaffolds, likely due to reduced topography and universally small pore size. These results suggest that pore casting is an attractive option for creating 2D tissue engineering Scaffolds, especially when the application may benefit from well-controlled pore size or architecture.
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A novel porous Scaffold Fabrication Technique for epithelial and endothelial tissue engineering
Journal of Materials Science: Materials in Medicine, 2013Co-Authors: Kevin J. Mchugh, Sarah L. Tao, Magali Saint-geniezAbstract:Porous Scaffolds have the ability to minimize transport barriers for both two- (2D) and three-dimensional tissue engineering. However, current porous Scaffolds may be non-ideal for 2D tissues such as epithelium due to inherent Fabrication-based characteristics. While 2D tissues require porosity to support molecular transport, pores must be small enough to prevent cell migration into the Scaffold in order to avoid non-epithelial tissue architecture and compromised function. Though electrospun meshes are the most popular porous Scaffolds used today, their heterogeneous pore size and intense topography may be poorly-suited for epithelium. Porous Scaffolds produced using other methods have similar unavoidable limitations, frequently involving insufficient pore resolution and control, which make them incompatible with 2D tissues. In addition, many of these Techniques require an entirely new round of process development in order to change material or pore size. Herein we describe “pore casting,” a Fabrication method that produces flat Scaffolds with deterministic pore shape, size, and location that can be easily altered to accommodate new materials or pore dimensions. As proof-of-concept, pore-cast poly(e-caprolactone) (PCL) Scaffolds were fabricated and compared to electrospun PCL in vitro using canine kidney epithelium, human colon epithelium, and human umbilical vein endothelium. All cell types demonstrated improved morphology and function on pore-cast Scaffolds, likely due to reduced topography and universally small pore size. These results suggest that pore casting is an attractive option for creating 2D tissue engineering Scaffolds, especially when the application may benefit from well-controlled pore size or architecture.
M Wang - One of the best experts on this subject based on the ideXlab platform.
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a novel Technique for the Fabrication of 3d nanofibrous Scaffolds using simultaneous positive voltage electrospinning and negative voltage electrospinning
Materials Letters, 2013Co-Authors: Howang Tong, M WangAbstract:Abstract Electrospinning is a very attractive technology for fabricating nanofibrous structures. However, for potential tissue engineering applications, the conventional electrospinning Technique can only produce 2D nanofibrous membranes with limited thickness. In this investigation, a novel Technique, which involved simultaneous positive voltage electrospinning (PVES) and negative voltage electrospinning (NVES), was developed for constructing 3D nanofibrous Scaffolds with greatly increased thickness. Using a specially designed electrospinning device, the problem of attraction and agglomeration of oppositely charged fibers in mid-air during simultaneous PVES and NVES could be avoided. As a demonstration and for comparison, two types of polymers, polyvinyl alcohol and poly( d,l -lactic acid), were processed into fibrous Scaffolds using conventional and novel electrospinning Techniques, respectively. For each polymer, the novel Technique rendered the formation of 3D fibrous Scaffolds that could not be achieved via conventional electrospinning. The polymer type, applied voltage and Scaffold Fabrication Technique were critical factors affecting the thickness of nanofibrous Scaffolds. The mechanism for 3D Scaffold formation was proposed.
Juan C. Doadrio - One of the best experts on this subject based on the ideXlab platform.
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An optimized β‐tricalcium phosphate and agarose Scaffold Fabrication Technique
Journal of biomedical materials research. Part A, 2008Co-Authors: J. Román, M.v. Cabañas, J. Peña, Juan C. Doadrio, María Vallet-regíAbstract:Biodegradable Scaffolds composed of β-tricalcium phosphate, and a natural hydrogel, agarose, were prepared by a shaping method based on the thermal gelation of the polymeric component. This Technique was modified to facilitate the inclusion, during the Scaffold preparation stage, of therapeutic agents that could improve the graft performance. Vancomycin was included in materials containing different amounts of agarose and ceramic without affecting the Scaffold consolidation process. These materials, easily injectable, behave like a reinforced hydrogel whose swelling behavior and drug release rate depend on their composition. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
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an optimized β tricalcium phosphate and agarose Scaffold Fabrication Technique
Journal of Biomedical Materials Research Part A, 2008Co-Authors: J. Román, M.v. Cabañas, J. Peña, Juan C. Doadrio, Maria ValletregiAbstract:Biodegradable Scaffolds composed of β-tricalcium phosphate, and a natural hydrogel, agarose, were prepared by a shaping method based on the thermal gelation of the polymeric component. This Technique was modified to facilitate the inclusion, during the Scaffold preparation stage, of therapeutic agents that could improve the graft performance. Vancomycin was included in materials containing different amounts of agarose and ceramic without affecting the Scaffold consolidation process. These materials, easily injectable, behave like a reinforced hydrogel whose swelling behavior and drug release rate depend on their composition. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008
