The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Lincoln C Gray - One of the best experts on this subject based on the ideXlab platform.
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pressed Scar Tissue for tympanic membrane grafting in revision tympanoplasty
Otolaryngology-Head and Neck Surgery, 2005Co-Authors: C Joseph Y Chang, Lincoln C GrayAbstract:OBJECTIVECompare the efficacy of pressed Scar Tissue grafts to standard fascia and areolar Tissue grafts for use in tympanoplasty.STUDY DESIGNA retrospective review of a prospective computerized database of tympanoplasty and mastoid surgeries at an academic, tertiary care practice was performed. Search parameters were set to find all patients who underwent tympanoplasty with or without mastoidectomy with use of various grafting materials for repair of tympanic membrane perforation from 1996 to 2002. All ages were included. Patients with cholesteatoma at the time of surgery were excluded. The short-term graft take rate was evaluated at 30 to 90 days to identify any differences in results using the standard fascia and areolar grafts vs. pressed Scar Tissue grafts. Other parameters that may have an influence on outcome were analyzed including mastoidectomy, infection, perforation size, perforation location, age of patient, primary vs. revision surgery, number of previous surgeries, postauricular vs. transcan...
Magda M. W. Ulrich - One of the best experts on this subject based on the ideXlab platform.
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wound healing in a fetal adult and Scar Tissue model a comparative study
Wound Repair and Regeneration, 2010Co-Authors: Neeltje A. Coolen, Kelly C. W. M. Schouten, Bouke K. H. L. Boekema, Esther Middelkoop, Magda M. W. UlrichAbstract:Early gestation fetal wounds heal without Scar formation. Understanding the mechanism of this Scarless healing may lead to new therapeutic strategies for improving adult wound healing. The aims of this study were to develop a human fetal wound model in which fetal healing can be studied and to compare this model with a human adult and Scar Tissue model. A burn wound (10 × 2 mm) was made in human ex vivo fetal, adult, and Scar Tissue under controlled and standardized conditions. Subsequently, the skin samples were cultured for 7, 14, and 21 days. Cells in the skin samples maintained their viability during the 21-day culture period. Already after 7 days, a significantly higher median percentage of wound closure was achieved in the fetal skin model vs. the adult and Scar Tissue model (74% vs. 28 and 29%, respectively, p<0.05). After 21 days of culture, only fetal wounds were completely reepithelialized. Fibroblasts migrated into the wounded dermis of all three wound models during culture, but more fibroblasts were present earlier in the wound area of the fetal skin model. The fast reepithelialization and prompt presence of many fibroblasts in the fetal model suggest that rapid healing might play a role in Scarless healing.
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Wound healing in a fetal, adult, and Scar Tissue model: A comparative study
Wound Repair and Regeneration, 2010Co-Authors: Neeltje A. Coolen, Kelly C. W. M. Schouten, Bouke K. H. L. Boekema, Esther Middelkoop, Magda M. W. UlrichAbstract:Early gestation fetal wounds heal without Scar formation. Understanding the mechanism of this Scarless healing may lead to new therapeutic strategies for improving adult wound healing. The aims of this study were to develop a human fetal wound model in which fetal healing can be studied and to compare this model with a human adult and Scar Tissue model. A burn wound (10 × 2 mm) was made in human ex vivo fetal, adult, and Scar Tissue under controlled and standardized conditions. Subsequently, the skin samples were cultured for 7, 14, and 21 days. Cells in the skin samples maintained their viability during the 21-day culture period. Already after 7 days, a significantly higher median percentage of wound closure was achieved in the fetal skin model vs. the adult and Scar Tissue model (74% vs. 28 and 29%, respectively, p
Esther Middelkoop - One of the best experts on this subject based on the ideXlab platform.
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wound healing in a fetal adult and Scar Tissue model a comparative study
Wound Repair and Regeneration, 2010Co-Authors: Neeltje A. Coolen, Kelly C. W. M. Schouten, Bouke K. H. L. Boekema, Esther Middelkoop, Magda M. W. UlrichAbstract:Early gestation fetal wounds heal without Scar formation. Understanding the mechanism of this Scarless healing may lead to new therapeutic strategies for improving adult wound healing. The aims of this study were to develop a human fetal wound model in which fetal healing can be studied and to compare this model with a human adult and Scar Tissue model. A burn wound (10 × 2 mm) was made in human ex vivo fetal, adult, and Scar Tissue under controlled and standardized conditions. Subsequently, the skin samples were cultured for 7, 14, and 21 days. Cells in the skin samples maintained their viability during the 21-day culture period. Already after 7 days, a significantly higher median percentage of wound closure was achieved in the fetal skin model vs. the adult and Scar Tissue model (74% vs. 28 and 29%, respectively, p<0.05). After 21 days of culture, only fetal wounds were completely reepithelialized. Fibroblasts migrated into the wounded dermis of all three wound models during culture, but more fibroblasts were present earlier in the wound area of the fetal skin model. The fast reepithelialization and prompt presence of many fibroblasts in the fetal model suggest that rapid healing might play a role in Scarless healing.
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Wound healing in a fetal, adult, and Scar Tissue model: A comparative study
Wound Repair and Regeneration, 2010Co-Authors: Neeltje A. Coolen, Kelly C. W. M. Schouten, Bouke K. H. L. Boekema, Esther Middelkoop, Magda M. W. UlrichAbstract:Early gestation fetal wounds heal without Scar formation. Understanding the mechanism of this Scarless healing may lead to new therapeutic strategies for improving adult wound healing. The aims of this study were to develop a human fetal wound model in which fetal healing can be studied and to compare this model with a human adult and Scar Tissue model. A burn wound (10 × 2 mm) was made in human ex vivo fetal, adult, and Scar Tissue under controlled and standardized conditions. Subsequently, the skin samples were cultured for 7, 14, and 21 days. Cells in the skin samples maintained their viability during the 21-day culture period. Already after 7 days, a significantly higher median percentage of wound closure was achieved in the fetal skin model vs. the adult and Scar Tissue model (74% vs. 28 and 29%, respectively, p
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collagen morphology in human skin and Scar Tissue no adaptations in response to mechanical loading at joints
Burns, 2003Co-Authors: Paul P M Van Zuijlen, Joris J B Ruurda, Henk A Van Veen, Jan Van Marle, Antoine J M Van Trier, F Groenevelt, Robert W Kreis, Esther MiddelkoopAbstract:Abstract Dermal collagen displays a random-like structure that has a major role in strength and function of the human integument. It is hypothesised that collagen bundles align in a parallel fashion in the direction of mechanical tension during Scarring, which may explain the problematic Scar formation that occurs specifically at joints. Scar Tissue and normal skin were biopsied from joints and control areas and evaluated by the Fourier analysis. Collagen orientation was represented by an index ranging from 0 (perfectly random) to 1 (perfectly parallel). Collagen bundle packing signifies the average distance between the centres of collagen bundles. No differences were shown in collagen morphology of Scar Tissue and normal skin between joints and control areas. Normal skin had a significantly lower collagen orientation index than Scar Tissue (0.26 versus 0.44, P P P =0.06). Normal skin had a less parallel organisation in sections that were cut parallel compared to those that were cut perpendicular to the epidermis (0.24 versus 0.30, P =0.02). Collagen orientation of Scar Tissue is more parallel compared to normal skin. Morphology differs with respect to superficial and deep dermal layers and parallel and perpendicular planes, but appears not to respond to mechanical tension.
C Joseph Y Chang - One of the best experts on this subject based on the ideXlab platform.
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pressed Scar Tissue for tympanic membrane grafting in revision tympanoplasty
Otolaryngology-Head and Neck Surgery, 2005Co-Authors: C Joseph Y Chang, Lincoln C GrayAbstract:OBJECTIVECompare the efficacy of pressed Scar Tissue grafts to standard fascia and areolar Tissue grafts for use in tympanoplasty.STUDY DESIGNA retrospective review of a prospective computerized database of tympanoplasty and mastoid surgeries at an academic, tertiary care practice was performed. Search parameters were set to find all patients who underwent tympanoplasty with or without mastoidectomy with use of various grafting materials for repair of tympanic membrane perforation from 1996 to 2002. All ages were included. Patients with cholesteatoma at the time of surgery were excluded. The short-term graft take rate was evaluated at 30 to 90 days to identify any differences in results using the standard fascia and areolar grafts vs. pressed Scar Tissue grafts. Other parameters that may have an influence on outcome were analyzed including mastoidectomy, infection, perforation size, perforation location, age of patient, primary vs. revision surgery, number of previous surgeries, postauricular vs. transcan...
Kees Vuik - One of the best experts on this subject based on the ideXlab platform.
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a mathematical model for the simulation of the formation and the subsequent regression of hypertrophic Scar Tissue after dermal wounding
Biomechanics and Modeling in Mechanobiology, 2017Co-Authors: Daniel C Koppenol, Paul P M Van Zuijlen, F J Vermolen, Frank B Niessen, Kees VuikAbstract:A continuum hypothesis-based model is presented for the simulation of the formation and the subsequent regression of hypertrophic Scar Tissue after dermal wounding. Solely the dermal layer of the skin is modeled explicitly and it is modeled as a heterogeneous, isotropic and compressible neo-Hookean solid. With respect to the constituents of the dermal layer, the following components are selected as primary model components: fibroblasts, myofibroblasts, a generic signaling molecule and collagen molecules. A good match with respect to the evolution of the thickness of the dermal layer of Scars between the outcomes of simulations and clinical measurements on hypertrophic Scars at different time points after injury in human subjects is demonstrated. Interestingly, the comparison between the outcomes of the simulations and the clinical measurements demonstrates that a relatively high apoptosis rate of myofibroblasts results in Scar Tissue that behaves more like normal Scar Tissue with respect to the evolution of the thickness of the Tissue over time, while a relatively low apoptosis rate results in Scar Tissue that behaves like hypertrophic Scar Tissue with respect to the evolution of the thickness of the Tissue over time. Our ultimate goal is to construct models with which the properties of newly generated Tissues that form during wound healing can be predicted with a high degree of certainty. The development of the presented model is considered by us as a step toward their construction.
