The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
Pichuan Fan - One of the best experts on this subject based on the ideXlab platform.
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long term outcome of Schilder Disease treated with interferon β
Pediatrics, 2019Co-Authors: Weisheng Lin, Mengfai Kuo, Steven Shinnforng Peng, Pichuan FanAbstract:Schilder Disease, also termed diffuse myelinoclastic sclerosis, is characterized by a large demyelinating lesion involving 1 or both sides of the centrum semiovale of the cerebral hemispheres. It often presents with tumorlike features and poses a diagnostic challenge. Schilder Disease can be monophasic or relapsing, and Disease-modifying therapy for the latter scenario is largely empirical. Here, we report a 14-year-old girl with relapsing Schilder Disease within 1 year after Disease onset. She has been followed-up for nearly 10 years and remains in sustained remission ever since interferon-β therapy was prescribed after the second attack. In this case study, it is suggested that interferon-β may induce long-term remission in relapsing Schilder Disease and is therefore worth considering in this regard.
Weisheng Lin - One of the best experts on this subject based on the ideXlab platform.
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long term outcome of Schilder Disease treated with interferon β
Pediatrics, 2019Co-Authors: Weisheng Lin, Mengfai Kuo, Steven Shinnforng Peng, Pichuan FanAbstract:Schilder Disease, also termed diffuse myelinoclastic sclerosis, is characterized by a large demyelinating lesion involving 1 or both sides of the centrum semiovale of the cerebral hemispheres. It often presents with tumorlike features and poses a diagnostic challenge. Schilder Disease can be monophasic or relapsing, and Disease-modifying therapy for the latter scenario is largely empirical. Here, we report a 14-year-old girl with relapsing Schilder Disease within 1 year after Disease onset. She has been followed-up for nearly 10 years and remains in sustained remission ever since interferon-β therapy was prescribed after the second attack. In this case study, it is suggested that interferon-β may induce long-term remission in relapsing Schilder Disease and is therefore worth considering in this regard.
Steven Shinnforng Peng - One of the best experts on this subject based on the ideXlab platform.
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long term outcome of Schilder Disease treated with interferon β
Pediatrics, 2019Co-Authors: Weisheng Lin, Mengfai Kuo, Steven Shinnforng Peng, Pichuan FanAbstract:Schilder Disease, also termed diffuse myelinoclastic sclerosis, is characterized by a large demyelinating lesion involving 1 or both sides of the centrum semiovale of the cerebral hemispheres. It often presents with tumorlike features and poses a diagnostic challenge. Schilder Disease can be monophasic or relapsing, and Disease-modifying therapy for the latter scenario is largely empirical. Here, we report a 14-year-old girl with relapsing Schilder Disease within 1 year after Disease onset. She has been followed-up for nearly 10 years and remains in sustained remission ever since interferon-β therapy was prescribed after the second attack. In this case study, it is suggested that interferon-β may induce long-term remission in relapsing Schilder Disease and is therefore worth considering in this regard.
Mengfai Kuo - One of the best experts on this subject based on the ideXlab platform.
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long term outcome of Schilder Disease treated with interferon β
Pediatrics, 2019Co-Authors: Weisheng Lin, Mengfai Kuo, Steven Shinnforng Peng, Pichuan FanAbstract:Schilder Disease, also termed diffuse myelinoclastic sclerosis, is characterized by a large demyelinating lesion involving 1 or both sides of the centrum semiovale of the cerebral hemispheres. It often presents with tumorlike features and poses a diagnostic challenge. Schilder Disease can be monophasic or relapsing, and Disease-modifying therapy for the latter scenario is largely empirical. Here, we report a 14-year-old girl with relapsing Schilder Disease within 1 year after Disease onset. She has been followed-up for nearly 10 years and remains in sustained remission ever since interferon-β therapy was prescribed after the second attack. In this case study, it is suggested that interferon-β may induce long-term remission in relapsing Schilder Disease and is therefore worth considering in this regard.
R Sauter - One of the best experts on this subject based on the ideXlab platform.
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metabolic and destructive brain disorders in children findings with localized proton mr spectroscopy
Radiology, 1991Co-Authors: Wolfgang Grodd, Ingeborg Kragelohmann, Uwe Klose, R SauterAbstract:The diagnostic potential of volume-selective proton magnetic resonance (MR) spectroscopy in vivo was evaluated in 20 children and young adults with various neurodegenerative brain disorders. All patients were examined with MR spectroscopy in conjunction with MR imaging of the brain on a whole-body imager at 1.5 T. Comparison of spectra in our patients with those of children with normal myelination (prominent signals from N-acetylaspartate [NAA], creatine/phosphocreatine, and choline) revealed a marked decrease of NAA in 12 of 17 patients with focal or generalized demyelination. In patients with Canavan Disease, NAA signal intensity was markedly increased, but no choline signal was found. Increased signal intensity from lactate occurred in patients with Leigh Disease, neuroaxonal dystrophy, Schilder Disease, and Cockayne Disease, which indicated a disturbed energy metabolism in the examined region. These results demonstrate that proton MR spectroscopy can be applied in a clinical environment to facilitate ...
