The Experts below are selected from a list of 210 Experts worldwide ranked by ideXlab platform
Beyene Petros - One of the best experts on this subject based on the ideXlab platform.
-
Epidemiological study on Schistosoma Mansoni infection in Sanja area, Amhara region, Ethiopia
Parasites & Vectors, 2014Co-Authors: Getachew Alebie, Berhanu Erko, Mulugeta Aemero, Beyene PetrosAbstract:Background The epidemiology of schistosomiasis is well documented and its geographic distribution has been mapped and there is an ongoing mapping in Ethiopia. Nevertheless, new transmission foci have been discovered in different parts of the country. The objective of this study was to assess the establishment of transmission and determine the prevalence of Schistosoma Mansoni infection in school children from Sanja Town, northwest Ethiopia. Methods A cross-sectional parasitological survey involving 384 school children in two primary schools of Sanja Town was conducted between February and April 2013. Stool specimens were collected and microscopically examined using Kato-Katz and Sodium acetate-acetic acid-formalin (SAF) concentration methods. Malacological survey was also carried out to identify snail intermediate hosts and larval infection rate in the snail. The snails collected were checked for trematode infection by shedding. Observation was also made on water contact habits of the study population. Results The prevalence of Schistosoma Mansoni infection using Kato-Katz method was high among male (79.5%) children in Sanja Primary school while it was high among female (75%) children in Ewket Amba Primary school. The prevalence of Schistosoma Mansoni infection among Sanja Primary school children in the age groups 5–9 and 10–14 years were 84.6% and 75.2%, respectively while in Ewket Amba Primary school, the prevalence was 66% and 77.9% in the age groups 5–9 and 10–14 years respectively. The prevalence of schistosome infection in Biomphalaria pfeifferi was 16.9% and 0.027% during February and April, respectively. S. Mansoni infection was successfully established in laboratory mice and adult worms were harvested after six weeks of laboratory maintenance. Observations made on water contact activities showed swimming, bathing and washing in the river and the stream as the high risk activities for Schistosoma Mansoni infection. Conclusion The study has shown establishment of transmission of schistosomiasis Mansoni in Sanja Town. Therefore, appropriate integrated control measures need to be introduced to reduce morbidity in the population and also to control the transmission of schistosomiasis in the study area.
Arício Xavier Linhares - One of the best experts on this subject based on the ideXlab platform.
-
Seleção genética de Biomphalaria glabrata e Biomphalaria tenagophila visando a alteração da suscetibilidade e resistência ao Schistosoma Mansoni Genetic selection of Biomphalaria glabrata and Biomphalaria tenagophila seeking the alteration of the sus
2020Co-Authors: Nádia Regina Borim Zuim, Eliana Maria Zanotti-magalhães, Luiz Augusto Magalhães, Arício Xavier LinharesAbstract:ABSTRACT Generations of Biomphalaria glabrata and Biomphalaria tenagophila selected genetically for resistance and susceptibilityto Schistosoma Mansoni of strains BH and SJ were used in a study of the trematode adaptation to the intermediate host.Descendants of the planorbids were obtained by self-fertilization of the mollusks that became susceptible or resistantafter exposure to the miracidia of Schistosoma Mansoni. For Biomphalaria glabrata they were obtained from the followinggenerations: Parental, F 1 S (Susceptible), F 1 R (Resistant), F 2 S and F 2 R. For Biomphalaria tenagophila the studied generationswere: Parental, F 1 S, F 1 R and F 50 S. The comparison of the infection rates presented by the different generations showedthat the increase in susceptibility was more easily obtained in both species. The difficulty in increasing the resistance ofthe mollusks to Schistosoma Mansoni has important epidemiologic implications. Key-words: Biomphalaria glabrata. Biomphalaria tenagophila. Schistosoma Mansoni.
Ana Afonso - One of the best experts on this subject based on the ideXlab platform.
-
anti inflammatory properties of menthol and menthone in Schistosoma Mansoni infection
Frontiers in Pharmacology, 2016Co-Authors: Mauricio Grecco Zaia, Tulio Di Orlando Cagnazzo, Karina Alves Feitosa, Edson Garcia Soares, Lucia Helena Faccioli, Silmara Marques Allegretti, Ana Afonso, Fernanda De Freitas AnibalAbstract:Schistosomiasis is a parasitic disease caused by several species of trematode worms and it is believed that more than 261 million people are affected worldwide. The development of new drugs has become essential due to the risk of the parasite to become resistant to Praziquantel, the only drug available for this infection. This study evaluated parasitological, immunological and histological parameters in Schistosoma Mansoni infected mice treated with an herbal commercial medicine. This drug consists of menthol (30-55%) and menthone (14-32%). A 60 day treatment regimen with the herbal medicine decreased the number of S. Mansoni eggs in the faeces, liver and intestine and reduced the number of hepatic granulomas. In addition, a reduction of 84% in blood eosinophilia and a decrease in the IL-4 and IL-10 blood levels after treatment, was observed. Therefore, we propose that schistosomiasis treatment with this herbal medicine, consisting of menthol and menthone, for 60 days has an immunomodulatory and anti-inflammatory action in this animal model of schistosomiasis thus contributing to the decrease in physio pathological effects caused by Schistosoma Mansoni infection.
Luigi Aloe - One of the best experts on this subject based on the ideXlab platform.
-
Neuroinflammatory implication of Schistosoma Mansoni infection in the mouse.
Archives of Physiology and Biochemistry, 2020Co-Authors: Marco Fiore, Luigi AloeAbstract:Schistosomiasis is a parasitic disease due to Schistosoma Mansoni. Schistosome infection is known to induce granulomas not only in the spleen, bladder, liver and intestine but also in the brain and spinal cord resulting in severe neuropathological and psychiatric disorders though the interaction between Schistosoma Mansoni infection and the nervous system has received on the whole little attention. In the present review it has been discussed recent findings from experimental Schistosoma Mansoni infection in mouse nervous system. We show that brain granulomas are associated with a significant alteration in the constitutive levels of nerve growth factor (NGF), a trophic factor playing an essential role in nerve growth and differentiation and in preventing neuronal damages. Animals infected with schistosomes suffered also of increased pain sensitivity which was inhibited by TNF-a antibody injections and not by anti-NGF. These findings suggest that the neuropathological dysfunctions in neuroschistosomiasis ma...
-
Neuroinflammatory Implications of Schistosoma Mansoni Infection: New Information from the Mouse Model
Parasitology Today, 1998Co-Authors: Luigi Aloe, Marco FioreAbstract:Abstract Schistosoma Mansoni infection is known to induce granulomas, not only in the liver and intestine, but also in the brain, resulting in neuropathological and psychiatric disorders. In the past, the interaction between Schistosoma Mansoni infection and the nervous system has received little attention. Here, Luigi Aloe and Marco Fiore discuss recent findings from experimental Schistosoma Mansoni infection in the mouse nervous system showing that brain granulomas are associated with a significant alteration in the constitutive expression of nerve growth factor, a neurotrophic factor that plays an essential role in growth and differentiation and in preventing neuronal damage. These findings suggest that the neuropathological dysfunctions in neuroschistosomiasis may be linked to changes in the basal levels and/or activity of neurotrophic factors caused by local formation of granulomas.
-
Schistosoma Mansoni infection enhances the levels of NGF in the liver and hypothalamus of mice.
Neuroreport, 1994Co-Authors: Luigi Aloe, Rolando Moroni, Cristiana Mollinari, Paola TirassaAbstract:Schistosoma Mansoni infection in adult mice is known to cause granulomas in the liver and intestine. Using a specific enzyme-linked immunoassay, it was found that Schistosoma Mansoni infection enhances the level of nerve growth factor in the liver and surprisingly also in the hypothalamus. Exogenous administration of purified NGF antibodies inhibits NGF biological activity both in the hypothalamus and liver and drastically reduces the number of NGF-responsive cells, the mast cells, present in liver granuloma. These findings and those reported by others showing the effect of NGF on cells of the immune system support the hypothesis that this molecule plays a role in neuroendocrine-immune interactions.
Getachew Alebie - One of the best experts on this subject based on the ideXlab platform.
-
Epidemiological study on Schistosoma Mansoni infection in Sanja area, Amhara region, Ethiopia
Parasites & Vectors, 2014Co-Authors: Getachew Alebie, Berhanu Erko, Mulugeta Aemero, Beyene PetrosAbstract:Background The epidemiology of schistosomiasis is well documented and its geographic distribution has been mapped and there is an ongoing mapping in Ethiopia. Nevertheless, new transmission foci have been discovered in different parts of the country. The objective of this study was to assess the establishment of transmission and determine the prevalence of Schistosoma Mansoni infection in school children from Sanja Town, northwest Ethiopia. Methods A cross-sectional parasitological survey involving 384 school children in two primary schools of Sanja Town was conducted between February and April 2013. Stool specimens were collected and microscopically examined using Kato-Katz and Sodium acetate-acetic acid-formalin (SAF) concentration methods. Malacological survey was also carried out to identify snail intermediate hosts and larval infection rate in the snail. The snails collected were checked for trematode infection by shedding. Observation was also made on water contact habits of the study population. Results The prevalence of Schistosoma Mansoni infection using Kato-Katz method was high among male (79.5%) children in Sanja Primary school while it was high among female (75%) children in Ewket Amba Primary school. The prevalence of Schistosoma Mansoni infection among Sanja Primary school children in the age groups 5–9 and 10–14 years were 84.6% and 75.2%, respectively while in Ewket Amba Primary school, the prevalence was 66% and 77.9% in the age groups 5–9 and 10–14 years respectively. The prevalence of schistosome infection in Biomphalaria pfeifferi was 16.9% and 0.027% during February and April, respectively. S. Mansoni infection was successfully established in laboratory mice and adult worms were harvested after six weeks of laboratory maintenance. Observations made on water contact activities showed swimming, bathing and washing in the river and the stream as the high risk activities for Schistosoma Mansoni infection. Conclusion The study has shown establishment of transmission of schistosomiasis Mansoni in Sanja Town. Therefore, appropriate integrated control measures need to be introduced to reduce morbidity in the population and also to control the transmission of schistosomiasis in the study area.
