The Experts below are selected from a list of 291 Experts worldwide ranked by ideXlab platform
Xiao-nong Zhou - One of the best experts on this subject based on the ideXlab platform.
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Schistosomiasis Japonica: Modelling as a tool to explore transmission patterns
Acta tropica, 2014Co-Authors: Qing-yun Wang, Robert Bergquist, Men-bao Qian, Qin Liu, Xiao-nong ZhouAbstract:Modelling is an important tool for the exploration of Schistosoma japonicum transmission patterns. It provides a general theoretical framework for decision-makers and lends itself specifically to assessing the progress of the national control programme by following the outcome of surveys. The challenge of keeping up with the many changes of social, ecological and environmental factors involved in control activities is greatly facilitated by modelling that can also indicate which activities are critical and which are less important. This review examines the application of modelling tools in the epidemiological study of Schistosomiasis Japonica during the last 20 years and explores the application of enhanced models for surveillance and response. Updated and timely information for decision-makers in the national elimination programme is provided but, in spite of the new modelling techniques introduced, many questions remain. Issues on application of modelling are discussed with the view to improve the current situation with respect to Schistosomiasis Japonica.
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The dynamics of growing islets and transmission of Schistosomiasis Japonica in the Yangtze River.
Bulletin of mathematical biology, 2014Co-Authors: Chunhua Shan, Xiao-nong Zhou, Huaiping ZhuAbstract:We formulate and analyze a system of ordinary differential equations for the transmission of Schistosomiasis Japonica on the islets in the Yangtze River, China. The impact of growing islets on the spread of Schistosomiasis is investigated by the bifurcation analysis. Using the projection technique developed by Hassard, Kazarinoff and Wan, the normal form of the cusp bifurcation of codimension 2 is derived to overcome the technical difficulties in studying the existence, stability, and bifurcation of the multiple endemic equilibria in high-dimensional phase space. We show that the model can also undergo transcritical bifurcations, saddle-node bifurcations, a pitchfork bifurcation, and Hopf bifurcations. The bifurcation diagrams and epidemiological interpretations are given. We conclude that when the islet reaches a critical size, the transmission cycle of the Schistosomiasis Japonica between wild rats Rattus norvegicus and snails Oncomelania hupensis could be established, which serves as a possible source of Schistosomiasis transmission along the Yangtze River.
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Quantifying quality of life and disability of patients with advanced Schistosomiasis Japonica
PLoS neglected tropical diseases, 2011Co-Authors: Tie Wu Jia, Kun Yang, Jürg Utzinger, Yao Deng, Jin Huan Zhu, Charles H. King, Xiao-nong ZhouAbstract:BACKGROUND: The Chinese government lists advanced Schistosomiasis as a leading healthcare priority due to its serious health and economic impacts, yet it has not been included in the estimates of Schistosomiasis burden in the Global Burden of Disease (GBD) study. Therefore, the quality of life and disability weight (DW) for the advanced cases of Schistosomiasis Japonica have to be taken into account in the re-estimation of burden of disease due to Schistosomiasis. METHODOLOGY/PRINCIPAL FINDINGS: A patient-based quality-of-life evaluation was performed for advanced Schistosomiasis Japonica. Suspected or officially registered advanced cases in a Schistosoma japonicum-hyperendemic county of the People's Republic of China (P.R. China) were screened using a short questionnaire and physical examination. Disability and morbidity were assessed in confirmed cases, using the European quality of life questionnaire with an additional cognitive dimension (known as the 'EQ-5D plus'), ultrasonography, and laboratory testing. The age-specific DW of advanced Schistosomiasis Japonica was estimated based on patients' self-rated health scores on the visual analogue scale of the questionnaire. The relationships between health status, morbidity and DW were explored using multivariate regression models. Of 506 candidates, 215 cases were confirmed as advanced Schistosomiasis Japonica and evaluated. Most of the patients reported impairments in at least one health dimension, such as pain or discomfort (90.7%), usual activities (87.9%), and anxiety or depression (80.9%). The overall DW was 0.447, and age-specific DWs ranged from 0.378 among individuals aged 30-44 years to 0.510 among the elderly aged
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quantifying quality of life and disability of patients with advanced Schistosomiasis Japonica
PLOS Neglected Tropical Diseases, 2011Co-Authors: Tie Wu Jia, Kun Yang, Jürg Utzinger, Yao Deng, Jin Huan Zhu, Charles H. King, Xiao-nong ZhouAbstract:BACKGROUND: The Chinese government lists advanced Schistosomiasis as a leading healthcare priority due to its serious health and economic impacts, yet it has not been included in the estimates of Schistosomiasis burden in the Global Burden of Disease (GBD) study. Therefore, the quality of life and disability weight (DW) for the advanced cases of Schistosomiasis Japonica have to be taken into account in the re-estimation of burden of disease due to Schistosomiasis. METHODOLOGY/PRINCIPAL FINDINGS: A patient-based quality-of-life evaluation was performed for advanced Schistosomiasis Japonica. Suspected or officially registered advanced cases in a Schistosoma japonicum-hyperendemic county of the People's Republic of China (P.R. China) were screened using a short questionnaire and physical examination. Disability and morbidity were assessed in confirmed cases, using the European quality of life questionnaire with an additional cognitive dimension (known as the 'EQ-5D plus'), ultrasonography, and laboratory testing. The age-specific DW of advanced Schistosomiasis Japonica was estimated based on patients' self-rated health scores on the visual analogue scale of the questionnaire. The relationships between health status, morbidity and DW were explored using multivariate regression models. Of 506 candidates, 215 cases were confirmed as advanced Schistosomiasis Japonica and evaluated. Most of the patients reported impairments in at least one health dimension, such as pain or discomfort (90.7%), usual activities (87.9%), and anxiety or depression (80.9%). The overall DW was 0.447, and age-specific DWs ranged from 0.378 among individuals aged 30-44 years to 0.510 among the elderly aged work capacity, psychological abnormality, ascites, and active hepatitis B virus, while splenectomy and high albumin were protective factors for quality of life. CONCLUSIONS/SIGNIFICANCE: These patient-preference disability estimates could provide updated data for a revision of the GBD, as well as for evidence-based decision-making in P.R. China's national Schistosomiasis control program
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Schistosomiasis Japonica control and research needs.
Advances in parasitology, 2010Co-Authors: Xiao-nong Zhou, Robert Bergquist, Lydia Leonardo, Guo-jing Yang, Kun Yang, Mohammad Sudomo, Remigio M. OlvedaAbstract:Schistosomiasis Japonica, a chronic and debilitating disease caused by the blood fluke Schistosoma japonicum, is still of considerable economic and public health concern in the People's Republic of China, the Philippines, and Indonesia. Despite major progress made over the past several decades with the control of Schistosomiasis Japonica in the aforementioned countries, the disease is emerging in some areas. We review the epidemiological status and transmission patterns of Schistosomiasis Japonica, placing it into a historical context, and discuss experiences and lessons with national control efforts. Our analyses reveal that an integrated control approach, implemented through intersectoral collaboration, is essential to bring down the prevalence and intensity of Schistosoma japonicum infections and disease-related morbidity, and to sustain these parameters at low levels. The need for innovation and a sufficiently flexible control approach to adapt interventions in response to the changing nature and challenges of Schistosomiasis control from the initial phase of morbidity control to the final state of elimination is emphasised. The aim of the presentation and the analyses is to inspire researchers and disease control managers elsewhere in Asia, Africa, and the Americas to harness the experiences gained and the lessons presented here to improve the control and eventual elimination of Schistosomiasis and parasitic diseases.
Cai Shifei - One of the best experts on this subject based on the ideXlab platform.
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Diagnosis of acute Schistosomiasis Japonica by amplifying Sj26,Sj32 and Sj14-3-3 encoding gene using RT-PCR
Chinese journal of zoonoses, 2011Co-Authors: Cai ShifeiAbstract:In order to investigate the value of amplifying Sj26,Sj32 and Sj14-3-3 encoding gene by RT-PCR for diagnosis patients with acute Schistosomiasis Japonica,the total RNA was extracted from the sera of patients with acute Schistosomiasis Japonica.The antigen encoding gene of Sj26,Sj32 and Sj14-3-3 were amplified by RT-PCR from the total RNA and identified by 1.2% AgaroseⅡ.At the same time,the total RNA were obtained from the sera of patients with paragonimiasis westermani,clonorchiasis sinensis and the normal subjects as the control groups.A 400bp Sj14-3-3 encoding gene was obtained by RT-PCR from the 50 Schistosomiasis Japonica patients,but the encoding gene of Sj26 and Sj32 weren't obtained,and the control groups were negative.The sensitivity and specialty were both 100% by RT-PCR with Sj14-3-3.There was no cross reaction between clonorchiasis sinensis and paragonimiasis westermani.It's indicated that the amplification of Sj14-3-3 encoding gene might be used for the gene diagnosis of patients with acute Schistosomiasis Japonica.
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The study on diagnostic value of the Immunogold-Dipstick reagent developed with Sj26-Sj32 recombinant protein for chronic Schistosomiasis Japonica.
Journal of Tropical Medicine, 2010Co-Authors: Cai Shifei, Li Wengui, Wang Min, Zhou BiyingAbstract:Objective To evaluate the diagnostic value of the Immunogold-Dipstick reagent developed with Sj26-Sj32 recombinant protein for chronic Schistosomiasis Japonica.Methods The Immunogold-Dipstick method with Sj26-Sj32 recombinant protein and Schistosoma japonicum adult worms antigen(SjAWA) were used for detecting IgG in sera of chronic Schistosomiasis Japonica patients,sera from the patients with clonorchiasis,paragonimiasis westermani,alveolar echinococcosis,cystic echinococcosis,hepatitis B,tuberculosis and healthy people were used as control.Results The sensitivity and specificity of this method were 92.50% and 97.67%,respectively.The positive predictive value,negative predictive value and diagnosis efficiency were 97.37%,93.33% and 95.18%,respectively.There was no cross reaction with sera of the mentioned parasitic diseases.Conclusion The recombinant Sj26-Sj32-Immunogold-Dipstick reagent may be used to immunodiagnosis of chronic Schistosomiasis Japonica.
Li Wengui - One of the best experts on this subject based on the ideXlab platform.
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Advances in the immunodiagnosis of Sj14-3-3 for Schistosomiasis Japonica
Journal of Pathogen Biology, 2013Co-Authors: Li WenguiAbstract:Schistosomiasis Japonica is a type of parasitic zoonosis.Its diagnosis is central to the control of Schistosomiasis.Immunodiagnostic techniques with satisfactory sensitivity,specificity,and practicality are a means of routinely diagnosing Schistosomiasis.This review describes major advances in the immunodiagnosis of Schistosomiasis Japonica utilizing 14-3-3 proteins.
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The diagnostic value of rSj26-Sj32-IgG-ELISA for acute Schistosomiasis Japonica
2011Co-Authors: Min Wang, Li Wengui, Shi-fei CaiAbstract:Objective To study the diagnostic value of rSj26-Sj32-IgG-ELISA for acute Schistosomiasis Japonica. Methods Purified rSj26-Sj32 fusion protein and crude Schistosoma japonicum antigen (SjAWA)were used to establish IgG-ELISA to detect serum of patients with acute Schistosomiasis, and clonorchiasis sinensis,paragonimiasis westermani, alveolar echinococcosis, cystic echinococcosis, type B hepatitis, lung tuberculosis patients and healthy human serum were used as control. Results The sensitivity and specialty were 90.00%(45/50) ,97.67% (42/43) and 92.00% (46/50),97.67% (42/43) in detection of acute Schistosomiasis Japonica with rSj26-Sj32and SjAWA, respectively, and the difference was not statistically significant(x2 were both 0.0, all P ＞0.05). The serum cross-reaction reactivity was 20.00%(2/10) in patients with alveolar echinococcosis with SjAWA,but no cross-reaction with rSj26-Sj32, the difference was not statistically significant(x2 = 0.5, P ＞ 0.05). The serum cross-reactivity were 14.29% (3/21 ), 7.69% (1/13) and 19.05% (4/21 ), 7.69% (1/13) among patients with clonorchiasis sinensis and paragonimiasis westermani by rSj26-Sj32 and SjAWA, but no cross reaction with type B hepatitis and lung tuberculosis patients, the difference was not statistically significant (x2 were both 0.0, all P ＞ 0.05). The positive predictive value, the negative predictive value and the diagnostic efficiency with acute Schistosomiasis japonicum by rSj26-Sj32-IgG-ELISA and SjAWA-IgG-ELISA were 97.83% (45/46),89.36% (42/47),93.55% (87/93)and 97.87% (46/47),91.30% (42/46),94.62% (88/93), respectively, and the difference was not statistically significant (x2 were both 0.0, all P ＞ 0.05). Conclusion rSj26-Sj32 fusion protein can be used for the immune diagnosis of acute Schistosomiasis Japonica. Key words: Schistosomiasis Japonica; Diagnosis; Enzyme-linked immunosorbent assay; Immunologic tests
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The study on diagnostic value of the Immunogold-Dipstick reagent developed with Sj26-Sj32 recombinant protein for chronic Schistosomiasis Japonica.
Journal of Tropical Medicine, 2010Co-Authors: Cai Shifei, Li Wengui, Wang Min, Zhou BiyingAbstract:Objective To evaluate the diagnostic value of the Immunogold-Dipstick reagent developed with Sj26-Sj32 recombinant protein for chronic Schistosomiasis Japonica.Methods The Immunogold-Dipstick method with Sj26-Sj32 recombinant protein and Schistosoma japonicum adult worms antigen(SjAWA) were used for detecting IgG in sera of chronic Schistosomiasis Japonica patients,sera from the patients with clonorchiasis,paragonimiasis westermani,alveolar echinococcosis,cystic echinococcosis,hepatitis B,tuberculosis and healthy people were used as control.Results The sensitivity and specificity of this method were 92.50% and 97.67%,respectively.The positive predictive value,negative predictive value and diagnosis efficiency were 97.37%,93.33% and 95.18%,respectively.There was no cross reaction with sera of the mentioned parasitic diseases.Conclusion The recombinant Sj26-Sj32-Immunogold-Dipstick reagent may be used to immunodiagnosis of chronic Schistosomiasis Japonica.
Zhou Biying - One of the best experts on this subject based on the ideXlab platform.
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The study on diagnostic value of the Immunogold-Dipstick reagent developed with Sj26-Sj32 recombinant protein for chronic Schistosomiasis Japonica.
Journal of Tropical Medicine, 2010Co-Authors: Cai Shifei, Li Wengui, Wang Min, Zhou BiyingAbstract:Objective To evaluate the diagnostic value of the Immunogold-Dipstick reagent developed with Sj26-Sj32 recombinant protein for chronic Schistosomiasis Japonica.Methods The Immunogold-Dipstick method with Sj26-Sj32 recombinant protein and Schistosoma japonicum adult worms antigen(SjAWA) were used for detecting IgG in sera of chronic Schistosomiasis Japonica patients,sera from the patients with clonorchiasis,paragonimiasis westermani,alveolar echinococcosis,cystic echinococcosis,hepatitis B,tuberculosis and healthy people were used as control.Results The sensitivity and specificity of this method were 92.50% and 97.67%,respectively.The positive predictive value,negative predictive value and diagnosis efficiency were 97.37%,93.33% and 95.18%,respectively.There was no cross reaction with sera of the mentioned parasitic diseases.Conclusion The recombinant Sj26-Sj32-Immunogold-Dipstick reagent may be used to immunodiagnosis of chronic Schistosomiasis Japonica.
Kun Yang - One of the best experts on this subject based on the ideXlab platform.
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The effects of health education on Schistosomiasis Japonica prevalence and relevant knowledge in the People's Republic of China: A systematic review and meta-analysis
Parasitology international, 2012Co-Authors: Li-ying Zhou, Yao Deng, Peter Steinmann, Kun YangAbstract:Schistosomiasis Japonica continues to be an important zoonotic disease in the People's Republic of China (P.R. China), despite decades of dedicated control efforts. Different interventions for its control including chemotherapy of humans and animals, mollusciciding, environmental modification, and health education have been implemented at various stages of the control efforts and in different combinations, resulting in remarkable achievements. Here, we present a systematic review and meta-analysis of the documented effectiveness of health education to reduce Schistosomiasis Japonica transmission in P.R. China. A total of 10 relevant publications were identified and included in the meta-analysis. The reported results indicate that the prevalence of Schistosoma japonicum infection in humans and Schistosomiasis-related knowledge are significantly influenced by health education. The implementation of health education over more than 2 years was associated with an overall Schistosomiasis Japonica prevalence decrease of 6% (95% CI: 2%, 11%) and an overall increase of 51% (95% CI: 41%, 61%) in Schistosomiasis-related knowledge after controlling for confounding factors. Among control groups, the prevalence of Schistosomiasis Japonica and relevant knowledge levels were not significantly influenced. The relative risk (RR) of an infection with S. japonicum following health education lasting more than 2 years was 0.43 (95% CI: 0.24, 0.78). In summary, a considerable effectiveness of health education with regard to preventing S. japonicum infections in P.R. China and increasing relevant knowledge is documented in the extant literature. This suggests that the effectiveness of health education may be considerable, particularly after its long-term implementation.
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quantifying quality of life and disability of patients with advanced Schistosomiasis Japonica
PLOS Neglected Tropical Diseases, 2011Co-Authors: Tie Wu Jia, Kun Yang, Jürg Utzinger, Yao Deng, Jin Huan Zhu, Charles H. King, Xiao-nong ZhouAbstract:BACKGROUND: The Chinese government lists advanced Schistosomiasis as a leading healthcare priority due to its serious health and economic impacts, yet it has not been included in the estimates of Schistosomiasis burden in the Global Burden of Disease (GBD) study. Therefore, the quality of life and disability weight (DW) for the advanced cases of Schistosomiasis Japonica have to be taken into account in the re-estimation of burden of disease due to Schistosomiasis. METHODOLOGY/PRINCIPAL FINDINGS: A patient-based quality-of-life evaluation was performed for advanced Schistosomiasis Japonica. Suspected or officially registered advanced cases in a Schistosoma japonicum-hyperendemic county of the People's Republic of China (P.R. China) were screened using a short questionnaire and physical examination. Disability and morbidity were assessed in confirmed cases, using the European quality of life questionnaire with an additional cognitive dimension (known as the 'EQ-5D plus'), ultrasonography, and laboratory testing. The age-specific DW of advanced Schistosomiasis Japonica was estimated based on patients' self-rated health scores on the visual analogue scale of the questionnaire. The relationships between health status, morbidity and DW were explored using multivariate regression models. Of 506 candidates, 215 cases were confirmed as advanced Schistosomiasis Japonica and evaluated. Most of the patients reported impairments in at least one health dimension, such as pain or discomfort (90.7%), usual activities (87.9%), and anxiety or depression (80.9%). The overall DW was 0.447, and age-specific DWs ranged from 0.378 among individuals aged 30-44 years to 0.510 among the elderly aged work capacity, psychological abnormality, ascites, and active hepatitis B virus, while splenectomy and high albumin were protective factors for quality of life. CONCLUSIONS/SIGNIFICANCE: These patient-preference disability estimates could provide updated data for a revision of the GBD, as well as for evidence-based decision-making in P.R. China's national Schistosomiasis control program
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Quantifying quality of life and disability of patients with advanced Schistosomiasis Japonica
PLoS neglected tropical diseases, 2011Co-Authors: Tie Wu Jia, Kun Yang, Jürg Utzinger, Yao Deng, Jin Huan Zhu, Charles H. King, Xiao-nong ZhouAbstract:BACKGROUND: The Chinese government lists advanced Schistosomiasis as a leading healthcare priority due to its serious health and economic impacts, yet it has not been included in the estimates of Schistosomiasis burden in the Global Burden of Disease (GBD) study. Therefore, the quality of life and disability weight (DW) for the advanced cases of Schistosomiasis Japonica have to be taken into account in the re-estimation of burden of disease due to Schistosomiasis. METHODOLOGY/PRINCIPAL FINDINGS: A patient-based quality-of-life evaluation was performed for advanced Schistosomiasis Japonica. Suspected or officially registered advanced cases in a Schistosoma japonicum-hyperendemic county of the People's Republic of China (P.R. China) were screened using a short questionnaire and physical examination. Disability and morbidity were assessed in confirmed cases, using the European quality of life questionnaire with an additional cognitive dimension (known as the 'EQ-5D plus'), ultrasonography, and laboratory testing. The age-specific DW of advanced Schistosomiasis Japonica was estimated based on patients' self-rated health scores on the visual analogue scale of the questionnaire. The relationships between health status, morbidity and DW were explored using multivariate regression models. Of 506 candidates, 215 cases were confirmed as advanced Schistosomiasis Japonica and evaluated. Most of the patients reported impairments in at least one health dimension, such as pain or discomfort (90.7%), usual activities (87.9%), and anxiety or depression (80.9%). The overall DW was 0.447, and age-specific DWs ranged from 0.378 among individuals aged 30-44 years to 0.510 among the elderly aged
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Schistosomiasis Japonica control and research needs.
Advances in parasitology, 2010Co-Authors: Xiao-nong Zhou, Robert Bergquist, Lydia Leonardo, Guo-jing Yang, Kun Yang, Mohammad Sudomo, Remigio M. OlvedaAbstract:Schistosomiasis Japonica, a chronic and debilitating disease caused by the blood fluke Schistosoma japonicum, is still of considerable economic and public health concern in the People's Republic of China, the Philippines, and Indonesia. Despite major progress made over the past several decades with the control of Schistosomiasis Japonica in the aforementioned countries, the disease is emerging in some areas. We review the epidemiological status and transmission patterns of Schistosomiasis Japonica, placing it into a historical context, and discuss experiences and lessons with national control efforts. Our analyses reveal that an integrated control approach, implemented through intersectoral collaboration, is essential to bring down the prevalence and intensity of Schistosoma japonicum infections and disease-related morbidity, and to sustain these parameters at low levels. The need for innovation and a sufficiently flexible control approach to adapt interventions in response to the changing nature and challenges of Schistosomiasis control from the initial phase of morbidity control to the final state of elimination is emphasised. The aim of the presentation and the analyses is to inspire researchers and disease control managers elsewhere in Asia, Africa, and the Americas to harness the experiences gained and the lessons presented here to improve the control and eventual elimination of Schistosomiasis and parasitic diseases.
