The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Jeffrey Aube - One of the best experts on this subject based on the ideXlab platform.
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a tandem prins Schmidt reaction approach to marine alkaloids formal and total syntheses of lepadiformines a and c
Organic Letters, 2010Co-Authors: Angelica M Meyer, Christopher E Katz, David Vander Velde, Jeffrey AubeAbstract:The tricyclic core of the cylindricine or lepadiformine families of alkaloid natural products was assembled via a Prins addition/intramolecular Schmidt Rearrangement under Lewis acid conditions. Both single-pot and two-stage variations of this process were examined, with particular attention to the stereochemical outcome of the processes. This technology has been applied to a formal total synthesis of lepadiformine A and a total synthesis of lepadiformine C.
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A tandem Prins/Schmidt reaction approach to marine alkaloids: formal and total syntheses of lepadiformines A and C.
Organic letters, 2010Co-Authors: Angelica M Meyer, Christopher E Katz, David G. Vander Velde, Jeffrey AubeAbstract:The tricyclic core of the cylindricine or lepadiformine families of alkaloid natural products was assembled via a Prins addition/intramolecular Schmidt Rearrangement under Lewis acid conditions. Both single-pot and two-stage variations of this process were examined, with particular attention to the stereochemical outcome of the processes. This technology has been applied to a formal total synthesis of lepadiformine A and a total synthesis of lepadiformine C.
Angelica M Meyer - One of the best experts on this subject based on the ideXlab platform.
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a tandem prins Schmidt reaction approach to marine alkaloids formal and total syntheses of lepadiformines a and c
Organic Letters, 2010Co-Authors: Angelica M Meyer, Christopher E Katz, David Vander Velde, Jeffrey AubeAbstract:The tricyclic core of the cylindricine or lepadiformine families of alkaloid natural products was assembled via a Prins addition/intramolecular Schmidt Rearrangement under Lewis acid conditions. Both single-pot and two-stage variations of this process were examined, with particular attention to the stereochemical outcome of the processes. This technology has been applied to a formal total synthesis of lepadiformine A and a total synthesis of lepadiformine C.
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A tandem Prins/Schmidt reaction approach to marine alkaloids: formal and total syntheses of lepadiformines A and C.
Organic letters, 2010Co-Authors: Angelica M Meyer, Christopher E Katz, David G. Vander Velde, Jeffrey AubeAbstract:The tricyclic core of the cylindricine or lepadiformine families of alkaloid natural products was assembled via a Prins addition/intramolecular Schmidt Rearrangement under Lewis acid conditions. Both single-pot and two-stage variations of this process were examined, with particular attention to the stereochemical outcome of the processes. This technology has been applied to a formal total synthesis of lepadiformine A and a total synthesis of lepadiformine C.
Jingping Zhang - One of the best experts on this subject based on the ideXlab platform.
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interruption of formal Schmidt Rearrangement hosomi sakurai reaction of vinyl azides with allyl propargylsilanes
Organic Letters, 2018Co-Authors: Guichun Fang, Haiyan Yuan, Jingping ZhangAbstract:An interrupted Schmidt Rearrangement/Hosomi–Sakurai reaction of N-tosyl and S-substituted vinyl azides is reported. With BF3·Et2O as a Lewis acid promoter, the denitrogenative fragmentation of vinyl azides facilitates the generation of the N/S-stabilized carbocations, which further undergo nucleophilic addition by allyl/propargylsilanes for C–C bond formation. As a result, a variety of homoallylic/allenylic amines can be afforded in good yields under mild reaction conditions with well-defined functional-group tolerance.
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Interruption of Formal Schmidt Rearrangement/Hosomi-Sakurai Reaction of Vinyl Azides with Allyl/Propargylsilanes.
Organic Letters, 2018Co-Authors: Guichun Fang, Haiyan Yuan, Jingping ZhangAbstract:An interrupted Schmidt Rearrangement/Hosomi–Sakurai reaction of N-tosyl and S-substituted vinyl azides is reported. With BF3·Et2O as a Lewis acid promoter, the denitrogenative fragmentation of vinyl azides facilitates the generation of the N/S-stabilized carbocations, which further undergo nucleophilic addition by allyl/propargylsilanes for C–C bond formation. As a result, a variety of homoallylic/allenylic amines can be afforded in good yields under mild reaction conditions with well-defined functional-group tolerance.
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Interruption of Formal Schmidt Rearrangement/Hosomi–Sakurai Reaction of Vinyl Azides with Allyl/Propargylsilanes
2018Co-Authors: Guichun Fang, Haiyan Yuan, Jingping Zhang, Zhenhua Liu, Shanshan Cao, Ling PanAbstract:An interrupted Schmidt Rearrangement/Hosomi–Sakurai reaction of N-tosyl and S-substituted vinyl azides is reported. With BF3·Et2O as a Lewis acid promoter, the denitrogenative fragmentation of vinyl azides facilitates the generation of the N/S-stabilized carbocations, which further undergo nucleophilic addition by allyl/propargylsilanes for C–C bond formation. As a result, a variety of homoallylic/allenylic amines can be afforded in good yields under mild reaction conditions with well-defined functional-group tolerance
Christopher E Katz - One of the best experts on this subject based on the ideXlab platform.
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a tandem prins Schmidt reaction approach to marine alkaloids formal and total syntheses of lepadiformines a and c
Organic Letters, 2010Co-Authors: Angelica M Meyer, Christopher E Katz, David Vander Velde, Jeffrey AubeAbstract:The tricyclic core of the cylindricine or lepadiformine families of alkaloid natural products was assembled via a Prins addition/intramolecular Schmidt Rearrangement under Lewis acid conditions. Both single-pot and two-stage variations of this process were examined, with particular attention to the stereochemical outcome of the processes. This technology has been applied to a formal total synthesis of lepadiformine A and a total synthesis of lepadiformine C.
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A tandem Prins/Schmidt reaction approach to marine alkaloids: formal and total syntheses of lepadiformines A and C.
Organic letters, 2010Co-Authors: Angelica M Meyer, Christopher E Katz, David G. Vander Velde, Jeffrey AubeAbstract:The tricyclic core of the cylindricine or lepadiformine families of alkaloid natural products was assembled via a Prins addition/intramolecular Schmidt Rearrangement under Lewis acid conditions. Both single-pot and two-stage variations of this process were examined, with particular attention to the stereochemical outcome of the processes. This technology has been applied to a formal total synthesis of lepadiformine A and a total synthesis of lepadiformine C.
Guichun Fang - One of the best experts on this subject based on the ideXlab platform.
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interruption of formal Schmidt Rearrangement hosomi sakurai reaction of vinyl azides with allyl propargylsilanes
Organic Letters, 2018Co-Authors: Guichun Fang, Haiyan Yuan, Jingping ZhangAbstract:An interrupted Schmidt Rearrangement/Hosomi–Sakurai reaction of N-tosyl and S-substituted vinyl azides is reported. With BF3·Et2O as a Lewis acid promoter, the denitrogenative fragmentation of vinyl azides facilitates the generation of the N/S-stabilized carbocations, which further undergo nucleophilic addition by allyl/propargylsilanes for C–C bond formation. As a result, a variety of homoallylic/allenylic amines can be afforded in good yields under mild reaction conditions with well-defined functional-group tolerance.
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Interruption of Formal Schmidt Rearrangement/Hosomi-Sakurai Reaction of Vinyl Azides with Allyl/Propargylsilanes.
Organic Letters, 2018Co-Authors: Guichun Fang, Haiyan Yuan, Jingping ZhangAbstract:An interrupted Schmidt Rearrangement/Hosomi–Sakurai reaction of N-tosyl and S-substituted vinyl azides is reported. With BF3·Et2O as a Lewis acid promoter, the denitrogenative fragmentation of vinyl azides facilitates the generation of the N/S-stabilized carbocations, which further undergo nucleophilic addition by allyl/propargylsilanes for C–C bond formation. As a result, a variety of homoallylic/allenylic amines can be afforded in good yields under mild reaction conditions with well-defined functional-group tolerance.
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Interruption of Formal Schmidt Rearrangement/Hosomi–Sakurai Reaction of Vinyl Azides with Allyl/Propargylsilanes
2018Co-Authors: Guichun Fang, Haiyan Yuan, Jingping Zhang, Zhenhua Liu, Shanshan Cao, Ling PanAbstract:An interrupted Schmidt Rearrangement/Hosomi–Sakurai reaction of N-tosyl and S-substituted vinyl azides is reported. With BF3·Et2O as a Lewis acid promoter, the denitrogenative fragmentation of vinyl azides facilitates the generation of the N/S-stabilized carbocations, which further undergo nucleophilic addition by allyl/propargylsilanes for C–C bond formation. As a result, a variety of homoallylic/allenylic amines can be afforded in good yields under mild reaction conditions with well-defined functional-group tolerance