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Michael Schlosser - One of the best experts on this subject based on the ideXlab platform.
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autoantibodies against zinc transporter 8 further stratify the autoantibody defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes results fro
Diabetic Medicine, 2021Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
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Autoantibodies against zinc transporter 8 further stratify the autoantibody‐defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes: results fr
Diabetic medicine : a journal of the British Diabetic Association, 2020Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
K Baumann - One of the best experts on this subject based on the ideXlab platform.
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autoantibodies against zinc transporter 8 further stratify the autoantibody defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes results fro
Diabetic Medicine, 2021Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
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Autoantibodies against zinc transporter 8 further stratify the autoantibody‐defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes: results fr
Diabetic medicine : a journal of the British Diabetic Association, 2020Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
Ralf Wassmuth - One of the best experts on this subject based on the ideXlab platform.
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autoantibodies against zinc transporter 8 further stratify the autoantibody defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes results fro
Diabetic Medicine, 2021Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
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Autoantibodies against zinc transporter 8 further stratify the autoantibody‐defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes: results fr
Diabetic medicine : a journal of the British Diabetic Association, 2020Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
Vito Lampasona - One of the best experts on this subject based on the ideXlab platform.
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autoantibodies against zinc transporter 8 further stratify the autoantibody defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes results fro
Diabetic Medicine, 2021Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
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Autoantibodies against zinc transporter 8 further stratify the autoantibody‐defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes: results fr
Diabetic medicine : a journal of the British Diabetic Association, 2020Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
U. Walschus - One of the best experts on this subject based on the ideXlab platform.
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autoantibodies against zinc transporter 8 further stratify the autoantibody defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes results fro
Diabetic Medicine, 2021Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
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Autoantibodies against zinc transporter 8 further stratify the autoantibody‐defined risk for type 1 diabetes in a general population of Schoolchildren and have distinctive isoform binding patterns in different forms of autoimmune diabetes: results fr
Diabetic medicine : a journal of the British Diabetic Association, 2020Co-Authors: K Baumann, Vito Lampasona, K Kesselring, U. Walschus, Wolfgang Kerner, Ralf Wassmuth, Michael SchlosserAbstract:Aims To evaluate the diagnostic relevance of autoantibodies against zinc transporter 8 (ZnT8) in Schoolchildren from the general population as well as in people with autoimmune diabetes. Methods A total of 137 Schoolchildren positive for at least one of the three major diabetes-associated autoantibodies, without diabetes heredity or preselection on HLA typing, from the Karlsburg Type 1 Diabetes Risk Study, as well as 102 people at type 1 diabetes onset, 88 people with latent autoimmune diabetes in adults and 119 people with type 2 diabetes, were analysed for different ZnT8 autoantibody variants. Results Zinc transporter 8 autoantibody positivity was found in 18% of autoantibody-positive Schoolchildren, with a noticeable association with other autoantibodies associated with type 1 diabetes and disease progression. Furthermore, ZnT8 autoantibody positivity was associated with diabetes progression in Schoolchildren positive for autoantibodies against insulinoma-associated antigen-2 (IA-2) and, importantly, in seven IA-2 autoantibody-negative Schoolchildren. Additionally, ZnT8 autoantibodies were found in 56% of people with type 1 diabetes, predominantly directed against all three ZnT8 variants and comparable to Schoolchildren with multiple autoantibodies. In contrast, ZnT8 autoantibodies were detected in 10% of people with latent autoimmune diabetes in adults, none of them with reactivity to all three isoforms. Conclusion Zinc transporter 8 autoantibodies are useful markers for prediction of type 1 diabetes in a general population, further stratifying the risk of progression in autoantibody-positive children. ZnT8 autoantibodies are also important markers in adult-onset diabetes, with a completely different reaction pattern in type 1 diabetes in comparison to latent autoimmune diabetes in adults, and may therefore help to differentiate between the two forms.
