The Experts below are selected from a list of 192 Experts worldwide ranked by ideXlab platform
Matti Ilmavirta - One of the best experts on this subject based on the ideXlab platform.
-
A visual migraine aura locus maps to 9q21-q22
Neurology, 2010Co-Authors: P. Tikka-kleemola, Ville Artto, Salli Vepsäläinen, Eric M. Sobel, S. Räty, Mari A. Kaunisto, Verneri Anttila, Eija Hämäläinen, Marja-liisa Sumelahti, Matti IlmavirtaAbstract:To identify susceptibility loci for visual migraine aura in migraine families primarily affected with Scintillating Scotoma type of aura. We included Finnish migraine families with at least 2 affected family members with Scintillating Scotoma as defined by the International Criteria for Headache Disorders-II. A total of 36 multigenerational families containing 351 individuals were included, 185 of whom have visual aura and 159 have Scintillating Scotoma. Parametric and nonparametric linkage analyses were performed with 378 microsatellite markers. The most promising linkage loci found were fine-mapped with additional microsatellite markers. A novel locus on chromosome 9q22-q31 for migraine aura was identified (HLOD = 4.7 at 104 cM). Fine-mapping identified a shared haplotype segment of 12 cM (9.8 Mb) on 9q21-q22 among the aura affected. Four other loci showed linkage to aura: a locus on 12p13 showed significant evidence of linkage, and suggestive evidence of linkage was detected to loci on chromosomes 5q13, 6q25, and 13q14. A novel visual migraine aura locus has been mapped to chromosome 9q21-q22. Interestingly, this region has previously been linked to occipitotemporal lobe epilepsy with prominent visual symptoms. Our finding further supports a shared genetic background in migraine and epilepsy and suggests that susceptibility variant(s) to visual aura for both of these traits are located in the 9q21-q22 locus.
-
A visual migraine aura locus maps to 9q21-q22
Neurology, 2010Co-Authors: P. Tikka-kleemola, Ville Artto, Salli Vepsäläinen, Eric M. Sobel, S. Räty, Mari A. Kaunisto, Verneri Anttila, Eija Hämäläinen, Marja-liisa Sumelahti, Matti IlmavirtaAbstract:Objective: To identify susceptibility loci for visual migraine aura in migraine families primarily affected with Scintillating Scotoma type of aura. Methods: We included Finnish migraine families with at least 2 affected family members with Scintillating Scotoma as defined by the International Criteria for Headache Disorders–II. A total of 36 multigenerational families containing 351 individuals were included, 185 of whom have visual aura and 159 have Scintillating Scotoma. Parametric and nonparametric linkage analyses were performed with 378 microsatellite markers. The most promising linkage loci found were fine-mapped with additional microsatellite markers. Results: A novel locus on chromosome 9q22-q31 for migraine aura was identified (HLOD = 4.7 at 104 cM). Fine-mapping identified a shared haplotype segment of 12 cM (9.8 Mb) on 9q21-q22 among the aura affecteds. Four other loci showed linkage to aura: a locus on 12p13 showed significant evidence of linkage, and suggestive evidence of linkage was detected to loci on chromosomes 5q13, 6q25, and 13q14. Conclusions: A novel visual migraine aura locus has been mapped to chromosome 9q21-q22. Interestingly, this region has previously been linked to occipitotemporal lobe epilepsy with prominent visual symptoms. Our finding further supports a shared genetic background in migraine and epilepsy and suggests that susceptibility variant(s) to visual aura for both of these traits are located in the 9q21-q22 locus.
P. Tikka-kleemola - One of the best experts on this subject based on the ideXlab platform.
-
A visual migraine aura locus maps to 9q21-q22
Neurology, 2010Co-Authors: P. Tikka-kleemola, Ville Artto, Salli Vepsäläinen, Eric M. Sobel, S. Räty, Mari A. Kaunisto, Verneri Anttila, Eija Hämäläinen, Marja-liisa Sumelahti, Matti IlmavirtaAbstract:To identify susceptibility loci for visual migraine aura in migraine families primarily affected with Scintillating Scotoma type of aura. We included Finnish migraine families with at least 2 affected family members with Scintillating Scotoma as defined by the International Criteria for Headache Disorders-II. A total of 36 multigenerational families containing 351 individuals were included, 185 of whom have visual aura and 159 have Scintillating Scotoma. Parametric and nonparametric linkage analyses were performed with 378 microsatellite markers. The most promising linkage loci found were fine-mapped with additional microsatellite markers. A novel locus on chromosome 9q22-q31 for migraine aura was identified (HLOD = 4.7 at 104 cM). Fine-mapping identified a shared haplotype segment of 12 cM (9.8 Mb) on 9q21-q22 among the aura affected. Four other loci showed linkage to aura: a locus on 12p13 showed significant evidence of linkage, and suggestive evidence of linkage was detected to loci on chromosomes 5q13, 6q25, and 13q14. A novel visual migraine aura locus has been mapped to chromosome 9q21-q22. Interestingly, this region has previously been linked to occipitotemporal lobe epilepsy with prominent visual symptoms. Our finding further supports a shared genetic background in migraine and epilepsy and suggests that susceptibility variant(s) to visual aura for both of these traits are located in the 9q21-q22 locus.
-
A visual migraine aura locus maps to 9q21-q22
Neurology, 2010Co-Authors: P. Tikka-kleemola, Ville Artto, Salli Vepsäläinen, Eric M. Sobel, S. Räty, Mari A. Kaunisto, Verneri Anttila, Eija Hämäläinen, Marja-liisa Sumelahti, Matti IlmavirtaAbstract:Objective: To identify susceptibility loci for visual migraine aura in migraine families primarily affected with Scintillating Scotoma type of aura. Methods: We included Finnish migraine families with at least 2 affected family members with Scintillating Scotoma as defined by the International Criteria for Headache Disorders–II. A total of 36 multigenerational families containing 351 individuals were included, 185 of whom have visual aura and 159 have Scintillating Scotoma. Parametric and nonparametric linkage analyses were performed with 378 microsatellite markers. The most promising linkage loci found were fine-mapped with additional microsatellite markers. Results: A novel locus on chromosome 9q22-q31 for migraine aura was identified (HLOD = 4.7 at 104 cM). Fine-mapping identified a shared haplotype segment of 12 cM (9.8 Mb) on 9q21-q22 among the aura affecteds. Four other loci showed linkage to aura: a locus on 12p13 showed significant evidence of linkage, and suggestive evidence of linkage was detected to loci on chromosomes 5q13, 6q25, and 13q14. Conclusions: A novel visual migraine aura locus has been mapped to chromosome 9q21-q22. Interestingly, this region has previously been linked to occipitotemporal lobe epilepsy with prominent visual symptoms. Our finding further supports a shared genetic background in migraine and epilepsy and suggests that susceptibility variant(s) to visual aura for both of these traits are located in the 9q21-q22 locus.
Charles A. Henrikson - One of the best experts on this subject based on the ideXlab platform.
-
Association of transseptal punctures with isolated migraine aura in patients undergoing catheter ablation of cardiac arrhythmias
Journal of cardiovascular electrophysiology, 2009Co-Authors: Karuna Chilukuri, Sunil Sinha, Ronald D. Berger, Joseph E. Marine, Alan Cheng, Saman Nazarian, Daniel Scherr, David Spragg, Hugh Calkins, Charles A. HenriksonAbstract:Transseptal catheterization (TSC) is performed during catheter ablation involving the lefthand side of the heart. TSC causes a transient iatrogenic atrial septal defect that can predispose patients to migraine episodes. However, isolated migraine aura episodes in patients undergoing TSC have not been described. Five hundred seventy-one procedures involving TSC were performed over a 3-year duration. Of these, 3 patients presented with visual symptoms in the first month after the procedure. One patient underwent a TSC during catheter ablation of left-sided accessory pathway and 2 patients underwent TSC during catheter ablation of atrial fibrillation. The incidence of migraine aura in this patient population was 0.5%. In the first week after the procedure, all 3 patients experienced transient reversible visual symptoms of Scintillating Scotoma consistent with migraine aura. None of the patients had an associated headache. The workup for stroke or transient ischemic attack was negative. All the patients recovered completely within 1 hour of symptom onset and did not have any sequelae. This study reports for the first time the incidence and outcomes of isolated migraine aura in patients undergoing electrophysiology procedures involving TSC. For post-TSC patients who present with atypical neurologic symptoms, especially "Scintillating Scotoma," once transient ischemic attack or other neurologic event has been ruled out, an aura associated with the TSC should be entertained as a possible diagnosis. Electrophysiologists who perform TSC, need to be aware of this phenomenon and can reassure the patients of the transient and benign nature.
M Hugh D Calkins - One of the best experts on this subject based on the ideXlab platform.
-
association of transseptal punctures with isolated migraine aura in patients undergoing catheter ablation of cardiac arrhythmias
Journal of Cardiovascular Electrophysiology, 2009Co-Authors: M Karuna D Chilukuri, Ronald D. Berger, M Sunil D Sinha, E Joseph M D Marine, M Alan D Cheng, M Saman D Nazarian, M Daniel D Scherr, M David D Spragg, M Hugh D CalkinsAbstract:Background: Transseptal catheterization (TSC) is performed during catheter ablation involving the lefthand side of the heart. TSC causes a transient iatrogenic atrial septal defect that can predispose patients to migraine episodes. However, isolated migraine aura episodes in patients undergoing TSC have not been described. Methods: Five hundred seventy-one procedures involving TSC were performed over a 3-year duration. Of these, 3 patients presented with visual symptoms in the first month after the procedure. One patient underwent a TSC during catheter ablation of left-sided accessory pathway and 2 patients underwent TSC during catheter ablation of atrial fibrillation. Results: The incidence of migraine aura in this patient population was 0.5%. In the first week after the procedure, all 3 patients experienced transient reversible visual symptoms of Scintillating Scotoma consistent with migraine aura. None of the patients had an associated headache. The workup for stroke or transient ischemic attack was negative. All the patients recovered completely within 1 hour of symptom onset and did not have any sequelae. Conclusion: This study reports for the first time the incidence and outcomes of isolated migraine aura in patients undergoing electrophysiology procedures involving TSC. For post-TSC patients who present with atypical neurologic symptoms, especially “Scintillating Scotoma,” once transient ischemic attack or other neurologic event has been ruled out, an aura associated with the TSC should be entertained as a possible diagnosis. Electrophysiologists who perform TSC, need to be aware of this phenomenon and can reassure the patients of the transient and benign nature.
Ronald D. Berger - One of the best experts on this subject based on the ideXlab platform.
-
association of transseptal punctures with isolated migraine aura in patients undergoing catheter ablation of cardiac arrhythmias
Journal of Cardiovascular Electrophysiology, 2009Co-Authors: M Karuna D Chilukuri, Ronald D. Berger, M Sunil D Sinha, E Joseph M D Marine, M Alan D Cheng, M Saman D Nazarian, M Daniel D Scherr, M David D Spragg, M Hugh D CalkinsAbstract:Background: Transseptal catheterization (TSC) is performed during catheter ablation involving the lefthand side of the heart. TSC causes a transient iatrogenic atrial septal defect that can predispose patients to migraine episodes. However, isolated migraine aura episodes in patients undergoing TSC have not been described. Methods: Five hundred seventy-one procedures involving TSC were performed over a 3-year duration. Of these, 3 patients presented with visual symptoms in the first month after the procedure. One patient underwent a TSC during catheter ablation of left-sided accessory pathway and 2 patients underwent TSC during catheter ablation of atrial fibrillation. Results: The incidence of migraine aura in this patient population was 0.5%. In the first week after the procedure, all 3 patients experienced transient reversible visual symptoms of Scintillating Scotoma consistent with migraine aura. None of the patients had an associated headache. The workup for stroke or transient ischemic attack was negative. All the patients recovered completely within 1 hour of symptom onset and did not have any sequelae. Conclusion: This study reports for the first time the incidence and outcomes of isolated migraine aura in patients undergoing electrophysiology procedures involving TSC. For post-TSC patients who present with atypical neurologic symptoms, especially “Scintillating Scotoma,” once transient ischemic attack or other neurologic event has been ruled out, an aura associated with the TSC should be entertained as a possible diagnosis. Electrophysiologists who perform TSC, need to be aware of this phenomenon and can reassure the patients of the transient and benign nature.
-
Association of transseptal punctures with isolated migraine aura in patients undergoing catheter ablation of cardiac arrhythmias
Journal of cardiovascular electrophysiology, 2009Co-Authors: Karuna Chilukuri, Sunil Sinha, Ronald D. Berger, Joseph E. Marine, Alan Cheng, Saman Nazarian, Daniel Scherr, David Spragg, Hugh Calkins, Charles A. HenriksonAbstract:Transseptal catheterization (TSC) is performed during catheter ablation involving the lefthand side of the heart. TSC causes a transient iatrogenic atrial septal defect that can predispose patients to migraine episodes. However, isolated migraine aura episodes in patients undergoing TSC have not been described. Five hundred seventy-one procedures involving TSC were performed over a 3-year duration. Of these, 3 patients presented with visual symptoms in the first month after the procedure. One patient underwent a TSC during catheter ablation of left-sided accessory pathway and 2 patients underwent TSC during catheter ablation of atrial fibrillation. The incidence of migraine aura in this patient population was 0.5%. In the first week after the procedure, all 3 patients experienced transient reversible visual symptoms of Scintillating Scotoma consistent with migraine aura. None of the patients had an associated headache. The workup for stroke or transient ischemic attack was negative. All the patients recovered completely within 1 hour of symptom onset and did not have any sequelae. This study reports for the first time the incidence and outcomes of isolated migraine aura in patients undergoing electrophysiology procedures involving TSC. For post-TSC patients who present with atypical neurologic symptoms, especially "Scintillating Scotoma," once transient ischemic attack or other neurologic event has been ruled out, an aura associated with the TSC should be entertained as a possible diagnosis. Electrophysiologists who perform TSC, need to be aware of this phenomenon and can reassure the patients of the transient and benign nature.
