The Experts below are selected from a list of 1746 Experts worldwide ranked by ideXlab platform
Michael M Kaplan - One of the best experts on this subject based on the ideXlab platform.
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radioiodine uptake and thyroid Scintiscanning
Endocrinology and Metabolism Clinics of North America, 2001Co-Authors: Donald A Meier, Michael M KaplanAbstract:Decades ago, the measurement of thyroidal radioactive iodine uptake and thyroid scintigraphy were routinely used to assess thyroid function. This application has largely been replaced by sensitive in vitro tests of thyroid function. Radioactive iodine uptake remains an important technique in evaluating the hyperthyroid patient, and thyroid imaging is valuable in the work-up of hyperthyroidism, thyroid nodules, differentiated thyroid cancer, and ectopic thyroid tissue. This article reviews current uses of radioactive iodine uptake testing and radionuclide thyroid scanning in thyroid conditions other than established thyroid cancer. Other thyroid imaging modalities and the role of nuclear medicine in thyroid cancer are discussed elsewhere.
Donald A Meier - One of the best experts on this subject based on the ideXlab platform.
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radioiodine uptake and thyroid Scintiscanning
Endocrinology and Metabolism Clinics of North America, 2001Co-Authors: Donald A Meier, Michael M KaplanAbstract:Decades ago, the measurement of thyroidal radioactive iodine uptake and thyroid scintigraphy were routinely used to assess thyroid function. This application has largely been replaced by sensitive in vitro tests of thyroid function. Radioactive iodine uptake remains an important technique in evaluating the hyperthyroid patient, and thyroid imaging is valuable in the work-up of hyperthyroidism, thyroid nodules, differentiated thyroid cancer, and ectopic thyroid tissue. This article reviews current uses of radioactive iodine uptake testing and radionuclide thyroid scanning in thyroid conditions other than established thyroid cancer. Other thyroid imaging modalities and the role of nuclear medicine in thyroid cancer are discussed elsewhere.
G. Riccabona - One of the best experts on this subject based on the ideXlab platform.
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Surgical therapy for primary hyperparathyroidism in patients with previous thyroid surgery.
American journal of surgery, 1999Co-Authors: Christoph Profanter, Rupert Prommegger, Gerold J. Wetscher, Anton Klingler, S Strolz, E. Bodner, G. RiccabonaAbstract:Abstract Background: In patients with primary hyperparathyroidism (HPTH) and previous thyroid operations, complications of parathyroidectomy are more frequent than in patients undergoing initial neck surgery. The aim of this study was to investigate the value of preoperative imaging with regard to its influence on the surgical strategy. Methods: We retrospectively analyzed 17 patients with primary HPTH and previous thyroid surgery. Preoperatively 16 patients underwent sonography and/or scintigraphy. Results: Sonography had an overall accuracy to correctly localize enlarged parathyroid glands of 80%, and Scintiscanning had overall accuracy of 78.6%. The accuracy of localization was increased up to 84.6% if both diagnostic procedures were applied. In patients with normal thyroid residues the accuracy of sonography was 85.7%, and it was 100% if Scintiscanning was used. Conclusions: Preoperative localization techniques in patients with primary HPTH and previous thyroid surgery have high accuracy. This allows for an imaging-directed operative strategy, thus preventing unnecessary bilateral neck explorations, which carry a high risk of recurrent laryngeal nerve injury.
Christoph Profanter - One of the best experts on this subject based on the ideXlab platform.
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Comparison of Planar Scintiscanning and Pinhole Subtraction Spect in Preoperative Imaging of Primary Hyperparathyroidism in an Endemic Goiter Area
The Endocrinologist, 2003Co-Authors: Christoph Profanter, Rupert Prommegger, Michael Gabriel, Paolo Lucciarini, Roy Moncayo, Gerold J. WetscherAbstract:A unilateral surgical approach in patients with primary hyperparathyroidism (HPTH) requires a reliable preoperative parathyroid localization procedure. The aim of this study was to compare the approved planar Scintiscanning by means of 99mTcO4−201Tl subtraction or 99mTc-sestamibi with 99mTcO4−201Tl pinhole subtraction SPECT. Fifty patients with primary HPTH and preoperative localization diagnosis were retrospectively analyzed. Thirty-three of them underwent preoperative planar Scintiscanning with 99mTcO4−201Tl subtraction or 99mTc-sestamibi, 17 had 99mTcO4−201Tl pinhole subtraction SPECT. Planar Scintiscanning had an overall accuracy of 81.8%, 99mTcO4−201Tl pinhole subtraction SPECT of 81.3%. In patients with solitary parathyroid adenomas the planar Scintiscanning provided correct results in 86.7%, whereas 99mTcO4−201Tl pinhole subtraction SPECT had an accuracy of 93.3% in these patients. Concomitant thyroid nodules diminished the accuracy of planar scanning to 78.6%. The accuracy of 99mTcO4−201Tl pinhole subtraction SPECT was not diminished by multinodular goiter, all patients with solitary parathyroid adenomas and multinodular thyroid disease were accurately localized. The sensitivity of 99mTcO4−201Tl pinhole subtraction SPECT is statistically not significantly different compared with planar 99mTcO4−201Tl subtraction or 99mTc-sestamibi Scintiscanning in patients with HPTH and solitary adenomas. Therefore, it is concluded that both imaging procedures are comparable in their diagnostic value for preoperative localization for successful unilateral parathyroidectomy. Although the results are not significantly different because of the number of patients, it is concluded 99mTcO4−201Tl pinhole subtraction SPECT to be superior to planar Scintiscanning in patients with underlying multinodular thyroid pathology.
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Surgical therapy for primary hyperparathyroidism in patients with previous thyroid surgery.
American journal of surgery, 1999Co-Authors: Christoph Profanter, Rupert Prommegger, Gerold J. Wetscher, Anton Klingler, S Strolz, E. Bodner, G. RiccabonaAbstract:Abstract Background: In patients with primary hyperparathyroidism (HPTH) and previous thyroid operations, complications of parathyroidectomy are more frequent than in patients undergoing initial neck surgery. The aim of this study was to investigate the value of preoperative imaging with regard to its influence on the surgical strategy. Methods: We retrospectively analyzed 17 patients with primary HPTH and previous thyroid surgery. Preoperatively 16 patients underwent sonography and/or scintigraphy. Results: Sonography had an overall accuracy to correctly localize enlarged parathyroid glands of 80%, and Scintiscanning had overall accuracy of 78.6%. The accuracy of localization was increased up to 84.6% if both diagnostic procedures were applied. In patients with normal thyroid residues the accuracy of sonography was 85.7%, and it was 100% if Scintiscanning was used. Conclusions: Preoperative localization techniques in patients with primary HPTH and previous thyroid surgery have high accuracy. This allows for an imaging-directed operative strategy, thus preventing unnecessary bilateral neck explorations, which carry a high risk of recurrent laryngeal nerve injury.
Rupert Prommegger - One of the best experts on this subject based on the ideXlab platform.
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Comparison of Planar Scintiscanning and Pinhole Subtraction Spect in Preoperative Imaging of Primary Hyperparathyroidism in an Endemic Goiter Area
The Endocrinologist, 2003Co-Authors: Christoph Profanter, Rupert Prommegger, Michael Gabriel, Paolo Lucciarini, Roy Moncayo, Gerold J. WetscherAbstract:A unilateral surgical approach in patients with primary hyperparathyroidism (HPTH) requires a reliable preoperative parathyroid localization procedure. The aim of this study was to compare the approved planar Scintiscanning by means of 99mTcO4−201Tl subtraction or 99mTc-sestamibi with 99mTcO4−201Tl pinhole subtraction SPECT. Fifty patients with primary HPTH and preoperative localization diagnosis were retrospectively analyzed. Thirty-three of them underwent preoperative planar Scintiscanning with 99mTcO4−201Tl subtraction or 99mTc-sestamibi, 17 had 99mTcO4−201Tl pinhole subtraction SPECT. Planar Scintiscanning had an overall accuracy of 81.8%, 99mTcO4−201Tl pinhole subtraction SPECT of 81.3%. In patients with solitary parathyroid adenomas the planar Scintiscanning provided correct results in 86.7%, whereas 99mTcO4−201Tl pinhole subtraction SPECT had an accuracy of 93.3% in these patients. Concomitant thyroid nodules diminished the accuracy of planar scanning to 78.6%. The accuracy of 99mTcO4−201Tl pinhole subtraction SPECT was not diminished by multinodular goiter, all patients with solitary parathyroid adenomas and multinodular thyroid disease were accurately localized. The sensitivity of 99mTcO4−201Tl pinhole subtraction SPECT is statistically not significantly different compared with planar 99mTcO4−201Tl subtraction or 99mTc-sestamibi Scintiscanning in patients with HPTH and solitary adenomas. Therefore, it is concluded that both imaging procedures are comparable in their diagnostic value for preoperative localization for successful unilateral parathyroidectomy. Although the results are not significantly different because of the number of patients, it is concluded 99mTcO4−201Tl pinhole subtraction SPECT to be superior to planar Scintiscanning in patients with underlying multinodular thyroid pathology.
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Surgical therapy for primary hyperparathyroidism in patients with previous thyroid surgery.
American journal of surgery, 1999Co-Authors: Christoph Profanter, Rupert Prommegger, Gerold J. Wetscher, Anton Klingler, S Strolz, E. Bodner, G. RiccabonaAbstract:Abstract Background: In patients with primary hyperparathyroidism (HPTH) and previous thyroid operations, complications of parathyroidectomy are more frequent than in patients undergoing initial neck surgery. The aim of this study was to investigate the value of preoperative imaging with regard to its influence on the surgical strategy. Methods: We retrospectively analyzed 17 patients with primary HPTH and previous thyroid surgery. Preoperatively 16 patients underwent sonography and/or scintigraphy. Results: Sonography had an overall accuracy to correctly localize enlarged parathyroid glands of 80%, and Scintiscanning had overall accuracy of 78.6%. The accuracy of localization was increased up to 84.6% if both diagnostic procedures were applied. In patients with normal thyroid residues the accuracy of sonography was 85.7%, and it was 100% if Scintiscanning was used. Conclusions: Preoperative localization techniques in patients with primary HPTH and previous thyroid surgery have high accuracy. This allows for an imaging-directed operative strategy, thus preventing unnecessary bilateral neck explorations, which carry a high risk of recurrent laryngeal nerve injury.