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Jerry A. Shields - One of the best experts on this subject based on the ideXlab platform.

  • eyelid Sebaceous Carcinoma associated with muir torre syndrome in two cases
    Ophthalmic Plastic and Reconstructive Surgery, 2007
    Co-Authors: Hakan Demirci, Ralph C. Eagle, Carol L. Shields, Christine C Nelson, Jerry A. Shields
    Abstract:

    Abstract: We report the rare but serious association between Sebaceous Carcinoma of eyelid and Muir-Torre syndrome in two cases, a 79-year-old woman and 54-year-old man. The presenting sign was a yellow-pink nodule with telangiectatic vessels on the left lower eyelid in one patient and a yellowish-red, pedunculated lesion with intrinsic vascularization on the right superior tarsal conjunctiva in the other. A history of multiple primary colon cancers was present in both patients, associated transitional cell Carcinoma of bladder and renal cancer in one patient and prostate cancer in the other. Both patients underwent excisional biopsy and cryotherapy of the eyelid tumors. Histopathology revealed Sebaceous Carcinoma of eyelid and conjunctiva. Immunohistochemical staining for MSH2 DNA mismatch repair gene performed in one patient showed lack of expression. Muir-Torre syndrome was diagnosed on the basis of Sebaceous Carcinoma, associated with multiple visceral malignancies in both patients. We conclude that patients with Sebaceous Carcinoma should have evaluation for visceral malignancies, mainly colon cancer.

  • Sebaceous Carcinoma of the caruncle
    Cornea, 2006
    Co-Authors: Jerry A. Shields, Carol L. Shields, Brian P. Marr, Ralph C. Eagle
    Abstract:

    Purpose: To report a case of Sebaceous Carcinoma of the caruncle. Methods: A 68-year-old woman developed a slowly enlarging mass of her left caruncle. Incisional biopsy elsewhere was interpreted histopathologically as invasive squamous cell Carcinoma. On the basis of the clinical findings, however, we suspected Sebaceous Carcinoma. Excisional biopsy with frozen section control was undertaken and the lesion was studied histopathologically. Results: Histopathological examination disclosed infiltration of the caruncular stroma by lobules of a malignant neoplasm that had prominent cytoplasmic vacuoles, typical of Sebaceous Carcinoma. Conclusion: Although it is best known to arise in the meibomian glands of the tarsus, Sebaceous Carcinoma can rarely arise in the caruncle and can be misinterpreted histopathologically as squamous cell Carcinoma.

  • Sebaceous Carcinoma of the eyelids personal experience with 60 cases
    Ophthalmology, 2004
    Co-Authors: Jerry A. Shields, Brian P. Marr, Ralph C. Eagle, Hakan Demirci, Carol L. Shields
    Abstract:

    Objective To describe clinical features, management, and prognosis of Sebaceous Carcinoma of the eyelid and adjacent structures. Design Single-center retrospective interventional case series. Participants Sixty consecutive patients with Sebaceous Carcinoma of the eyelid and adjacent structures. Methods Retrospective chart review and literature review. Main outcome measures Presenting features, sites of origin, location, growth patterns, management, histopathologic findings, incidence of recurrence, metastasis, and mortality. Results The median age at referral was 72 years, with 73% female. Four patients had prior irradiation to the area where the Sebaceous Carcinoma developed. Initial clinical diagnoses elsewhere were Sebaceous Carcinoma (32%), blepharoconjunctivitis (25%), chalazion (20%), basal cell Carcinoma (13%), and squamous cell Carcinoma (10%). Initial histopathologic diagnoses elsewhere were Sebaceous Carcinoma (50%), squamous cell Carcinoma (18%), basal cell Carcinoma (8%), and others or not available (24%). Initial anatomic sites were upper eyelid (75%), lower eyelid (22%), caruncle (2%), and bulbar conjunctiva (2% [1 case]). Orbital exenteration was necessary in 13%. Recently introduced techniques of posterior lamellar resection of the eyelids with reconstruction (7%) hopefully will decrease this incidence in the future. Pathologically, 47% showed intraepithelial (pagetoid) involvement, 27% of Sebaceous Carcinomas arose from the meibomian glands, and 18% arose from both meibomian and Zeis glands. Local recurrence developed in 18%, metastasis in 8%, and death from metastasis in 6%. Conclusions Despite the fact that the clinical features of Sebaceous Carcinoma have been widely reported, the diagnosis was suspected initially in only 32% of patients at first examination elsewhere and in only 50% at histopathologic examination elsewhere. Orbital exenteration was necessary in 13%, mostly patients seen in the earlier years of the study. With more recently employed treatment methods, there is a tendency to avoid exenteration and to use more conservative methods of treatment. It is hoped that these modern therapeutic approaches will result in fewer cases of recurrence and metastasis.

Joseph F Sobanko - One of the best experts on this subject based on the ideXlab platform.

Carol L. Shields - One of the best experts on this subject based on the ideXlab platform.

  • eyelid Sebaceous Carcinoma associated with muir torre syndrome in two cases
    Ophthalmic Plastic and Reconstructive Surgery, 2007
    Co-Authors: Hakan Demirci, Ralph C. Eagle, Carol L. Shields, Christine C Nelson, Jerry A. Shields
    Abstract:

    Abstract: We report the rare but serious association between Sebaceous Carcinoma of eyelid and Muir-Torre syndrome in two cases, a 79-year-old woman and 54-year-old man. The presenting sign was a yellow-pink nodule with telangiectatic vessels on the left lower eyelid in one patient and a yellowish-red, pedunculated lesion with intrinsic vascularization on the right superior tarsal conjunctiva in the other. A history of multiple primary colon cancers was present in both patients, associated transitional cell Carcinoma of bladder and renal cancer in one patient and prostate cancer in the other. Both patients underwent excisional biopsy and cryotherapy of the eyelid tumors. Histopathology revealed Sebaceous Carcinoma of eyelid and conjunctiva. Immunohistochemical staining for MSH2 DNA mismatch repair gene performed in one patient showed lack of expression. Muir-Torre syndrome was diagnosed on the basis of Sebaceous Carcinoma, associated with multiple visceral malignancies in both patients. We conclude that patients with Sebaceous Carcinoma should have evaluation for visceral malignancies, mainly colon cancer.

  • Sebaceous Carcinoma of the caruncle
    Cornea, 2006
    Co-Authors: Jerry A. Shields, Carol L. Shields, Brian P. Marr, Ralph C. Eagle
    Abstract:

    Purpose: To report a case of Sebaceous Carcinoma of the caruncle. Methods: A 68-year-old woman developed a slowly enlarging mass of her left caruncle. Incisional biopsy elsewhere was interpreted histopathologically as invasive squamous cell Carcinoma. On the basis of the clinical findings, however, we suspected Sebaceous Carcinoma. Excisional biopsy with frozen section control was undertaken and the lesion was studied histopathologically. Results: Histopathological examination disclosed infiltration of the caruncular stroma by lobules of a malignant neoplasm that had prominent cytoplasmic vacuoles, typical of Sebaceous Carcinoma. Conclusion: Although it is best known to arise in the meibomian glands of the tarsus, Sebaceous Carcinoma can rarely arise in the caruncle and can be misinterpreted histopathologically as squamous cell Carcinoma.

  • Sebaceous Carcinoma of the eyelids personal experience with 60 cases
    Ophthalmology, 2004
    Co-Authors: Jerry A. Shields, Brian P. Marr, Ralph C. Eagle, Hakan Demirci, Carol L. Shields
    Abstract:

    Objective To describe clinical features, management, and prognosis of Sebaceous Carcinoma of the eyelid and adjacent structures. Design Single-center retrospective interventional case series. Participants Sixty consecutive patients with Sebaceous Carcinoma of the eyelid and adjacent structures. Methods Retrospective chart review and literature review. Main outcome measures Presenting features, sites of origin, location, growth patterns, management, histopathologic findings, incidence of recurrence, metastasis, and mortality. Results The median age at referral was 72 years, with 73% female. Four patients had prior irradiation to the area where the Sebaceous Carcinoma developed. Initial clinical diagnoses elsewhere were Sebaceous Carcinoma (32%), blepharoconjunctivitis (25%), chalazion (20%), basal cell Carcinoma (13%), and squamous cell Carcinoma (10%). Initial histopathologic diagnoses elsewhere were Sebaceous Carcinoma (50%), squamous cell Carcinoma (18%), basal cell Carcinoma (8%), and others or not available (24%). Initial anatomic sites were upper eyelid (75%), lower eyelid (22%), caruncle (2%), and bulbar conjunctiva (2% [1 case]). Orbital exenteration was necessary in 13%. Recently introduced techniques of posterior lamellar resection of the eyelids with reconstruction (7%) hopefully will decrease this incidence in the future. Pathologically, 47% showed intraepithelial (pagetoid) involvement, 27% of Sebaceous Carcinomas arose from the meibomian glands, and 18% arose from both meibomian and Zeis glands. Local recurrence developed in 18%, metastasis in 8%, and death from metastasis in 6%. Conclusions Despite the fact that the clinical features of Sebaceous Carcinoma have been widely reported, the diagnosis was suspected initially in only 32% of patients at first examination elsewhere and in only 50% at histopathologic examination elsewhere. Orbital exenteration was necessary in 13%, mostly patients seen in the earlier years of the study. With more recently employed treatment methods, there is a tendency to avoid exenteration and to use more conservative methods of treatment. It is hoped that these modern therapeutic approaches will result in fewer cases of recurrence and metastasis.

Hakan Demirci - One of the best experts on this subject based on the ideXlab platform.

  • eyelid Sebaceous Carcinoma associated with muir torre syndrome in two cases
    Ophthalmic Plastic and Reconstructive Surgery, 2007
    Co-Authors: Hakan Demirci, Ralph C. Eagle, Carol L. Shields, Christine C Nelson, Jerry A. Shields
    Abstract:

    Abstract: We report the rare but serious association between Sebaceous Carcinoma of eyelid and Muir-Torre syndrome in two cases, a 79-year-old woman and 54-year-old man. The presenting sign was a yellow-pink nodule with telangiectatic vessels on the left lower eyelid in one patient and a yellowish-red, pedunculated lesion with intrinsic vascularization on the right superior tarsal conjunctiva in the other. A history of multiple primary colon cancers was present in both patients, associated transitional cell Carcinoma of bladder and renal cancer in one patient and prostate cancer in the other. Both patients underwent excisional biopsy and cryotherapy of the eyelid tumors. Histopathology revealed Sebaceous Carcinoma of eyelid and conjunctiva. Immunohistochemical staining for MSH2 DNA mismatch repair gene performed in one patient showed lack of expression. Muir-Torre syndrome was diagnosed on the basis of Sebaceous Carcinoma, associated with multiple visceral malignancies in both patients. We conclude that patients with Sebaceous Carcinoma should have evaluation for visceral malignancies, mainly colon cancer.

  • Sebaceous Carcinoma of the eyelids personal experience with 60 cases
    Ophthalmology, 2004
    Co-Authors: Jerry A. Shields, Brian P. Marr, Ralph C. Eagle, Hakan Demirci, Carol L. Shields
    Abstract:

    Objective To describe clinical features, management, and prognosis of Sebaceous Carcinoma of the eyelid and adjacent structures. Design Single-center retrospective interventional case series. Participants Sixty consecutive patients with Sebaceous Carcinoma of the eyelid and adjacent structures. Methods Retrospective chart review and literature review. Main outcome measures Presenting features, sites of origin, location, growth patterns, management, histopathologic findings, incidence of recurrence, metastasis, and mortality. Results The median age at referral was 72 years, with 73% female. Four patients had prior irradiation to the area where the Sebaceous Carcinoma developed. Initial clinical diagnoses elsewhere were Sebaceous Carcinoma (32%), blepharoconjunctivitis (25%), chalazion (20%), basal cell Carcinoma (13%), and squamous cell Carcinoma (10%). Initial histopathologic diagnoses elsewhere were Sebaceous Carcinoma (50%), squamous cell Carcinoma (18%), basal cell Carcinoma (8%), and others or not available (24%). Initial anatomic sites were upper eyelid (75%), lower eyelid (22%), caruncle (2%), and bulbar conjunctiva (2% [1 case]). Orbital exenteration was necessary in 13%. Recently introduced techniques of posterior lamellar resection of the eyelids with reconstruction (7%) hopefully will decrease this incidence in the future. Pathologically, 47% showed intraepithelial (pagetoid) involvement, 27% of Sebaceous Carcinomas arose from the meibomian glands, and 18% arose from both meibomian and Zeis glands. Local recurrence developed in 18%, metastasis in 8%, and death from metastasis in 6%. Conclusions Despite the fact that the clinical features of Sebaceous Carcinoma have been widely reported, the diagnosis was suspected initially in only 32% of patients at first examination elsewhere and in only 50% at histopathologic examination elsewhere. Orbital exenteration was necessary in 13%, mostly patients seen in the earlier years of the study. With more recently employed treatment methods, there is a tendency to avoid exenteration and to use more conservative methods of treatment. It is hoped that these modern therapeutic approaches will result in fewer cases of recurrence and metastasis.

Faramarz H. Samie - One of the best experts on this subject based on the ideXlab platform.

  • Sebaceous Carcinoma: A Review of the Scientific Literature
    Current Treatment Options in Oncology, 2017
    Co-Authors: Thomas Knackstedt, Faramarz H. Samie
    Abstract:

    Sebaceous Carcinoma is a rare and potentially aggressive cutaneous malignancy. Commonly reported in the periocular area and the head and neck region, Sebaceous Carcinoma can arise from any Sebaceous gland in the skin. The clinical presentation may be nonspecific, and a biopsy is important to establish a diagnosis and to differentiate from mimickers including benign Sebaceous neoplasms, other adnexal tumors, and basal cell Carcinoma. A diagnosis of Muir Torre syndrome should be considered in patients presenting with a Sebaceous neoplasm. Early treatment is important given the potential of Sebaceous Carcinoma to spread to the regional lymph nodes and beyond. Sentinel lymph node biopsy and imaging to complete tumor staging may be indicated for larger or more aggressive tumors. Surgery, including Mohs micrographic surgery, remains the primary treatment modality for Sebaceous Carcinoma. Mohs micrographic surgery has the advantage of complete margin evaluation and low recurrence rates. Advanced cases may be treated with orbital exenteration, radiation therapy, chemotherapy, or combination therapy.