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Jan Faergemann - One of the best experts on this subject based on the ideXlab platform.
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efficacious and safe management of moderate to severe scalp Seborrhoeic Dermatitis using clobetasol propionate shampoo 0 05 combined with ketoconazole shampoo 2 a randomized controlled study
British Journal of Dermatology, 2011Co-Authors: J P Ortonne, Arjen Nikkels, K Reich, R Ponce M Olivera, N Kerrouche, F Sidou, Jan FaergemannAbstract:Summary Background Topical antifungals and corticosteroids are the mainstay of treatment for Seborrhoeic Dermatitis. The short-contact clobetasol propionate 0·05% shampoo (CP) is an efficacious and safe once-daily treatment for scalp psoriasis. Objectives To evaluate the efficacy and safety of CP alone and combined with ketoconazole shampoo 2% (KC) in the treatment of moderate to severe scalp Seborrhoeic Dermatitis. Methods This randomized and investigator-blinded study consisted of three phases, each lasting 4 weeks. During the treatment phase, subjects were randomized to receive KC twice weekly (K2), CP twice weekly (C2), CP twice weekly alternating with KC twice weekly (C2 + K2) or CP four times weekly alternating with KC twice weekly (C4 + K2). All subjects received KC once weekly during the maintenance phase and were untreated during the follow-up phase. Results At the end of the treatment phase, all three CP-containing regimens were significantly more efficacious than K2 in decreasing the overall disease severity (P < 0·05). Both combination regimens were also significantly more efficacious than K2 in decreasing each individual sign of the disease (P < 0·05). While the C2 and C4 + K2 groups experienced slight worsening during the maintenance phase, the efficacy of C2 + K2 was sustained and remained the highest among all groups. All regimens were well tolerated without inducing any skin atrophy. Similarly low incidences of telangiectasia, burning and adverse events were observed among the four groups. Conclusions The combination therapy of twice-weekly CP alternating with twice-weekly KC provided significantly greater efficacy than KC alone and a sustained effect in the treatment of moderate to severe scalp Seborrhoeic Dermatitis.
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the prevalence of malassezia yeasts in patients with atopic Dermatitis Seborrhoeic Dermatitis and healthy controls
Acta Dermato-venereologica, 2005Co-Authors: Mari Helen Sandstrom Falk, Maria Tengvall Linder, Catharina Johansson, Jacek Bartosik, Ove Back, Tore Sarnhult, Carlfredrik Wahlgren, Annika Scheynius, Jan FaergemannAbstract:Cultures for Malassezia yeasts were taken from both normal-looking skin and lesional skin in 124 patients with atopic Dermatitis, 16 patients with Seborrhoeic Dermatitis and from normal skin of 31 healthy controls. Positive Malassezia growth was found in fewer patients with atopic Dermatitis (56%) than in patients with Seborrhoeic Dermatitis (88%) or in healthy controls (84%, p<0.01). In the patients with atopic Dermatitis, fewer positive cultures were found in lesional (28%) than in non-lesional skin (44%, p<0.05), while positive cultures were found in 75% of both lesional and non-lesional skin of patients with Seborrhoeic Dermatitis (not significant). M. sympodialis dominated in patients with atopic Dermatitis (46%) and in healthy controls (69%). In patients with Seborrhoeic Dermatitis both M. sympodialis and M. obtusa were cultured in 43%. A Malassezia species extract mixture would increase the possibility of detecting IgE sensitization to Malassezia in patients with atopic Dermatitis.
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the prevalence of malassezia yeasts in patients with atopic Dermatitis Seborrhoeic Dermatitis and healthy controls
Acta Dermato-venereologica, 2005Co-Authors: Mari Helen Sandstrom Falk, Maria Tengvall Linder, Catharina Johansson, Jacek Bartosik, Ove Back, Tore Sarnhult, Carlfredrik Wahlgren, Annika Scheynius, Jan FaergemannAbstract:Cultures for Malassezia yeasts were taken from both normal-looking skin and lesional skin in 124 patients with atopic Dermatitis, 16 patients with Seborrhoeic Dermatitis and from normal skin of 31 healthy controls. Positive Malassezia growth was found in fewer patients with atopic Dermatitis (56%) than in patients with Seborrhoeic Dermatitis (88%) or in healthy controls (84%, pv0.01). In the patients with atopic Dermatitis, fewer positive cultures were found in lesional (28%) than in non-lesional skin (44%, pv0.05), while positive cultures were found in 75% of both lesional and non-lesional skin of patients with Seborrhoeic Dermatitis (not significant). M. sympodialis dominated in patients with atopic Dermatitis (46%) and in healthy controls (69%). In patients with Seborrhoeic Dermatitis both M. sympodialis and M. obtusa were cultured in 43%. A Malassezia species extract mixture would increase the possibility of detecting IgE sensiti
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Seborrhoeic Dermatitis and pityrosporum malassezia folliculitis characterization of inflammatory cells and mediators in the skin by immunohistochemistry
British Journal of Dermatology, 2001Co-Authors: Jan Faergemann, Im Bergbrant, M Dohse, A Scott, G WestgateAbstract:Background The fact that Pityrosporum ovale plays a part in Seborrhoeic Dermatitis is well established but the mechanism of this relationship has not been established. Objectives To compare the number and type of inflammatory cells and mediators in skin biopsies from normal and lesional skin from the trunk and scalp in patients with Seborrhoeic Dermatitis, Pityrosporum (Malassezia) folliculitis and in normal skin from healthy controls. Methods The skin biopsies were stained using the labelled Streptavidin-biotin method. The following markers were studied: CD4, CD8, CD68, HLA-DR, NK1, CD16, Clq, C3c, IgG, CD54 (ICAM-1), interleukin (IL) -1α, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-12, tumour necrosis factor-a and interferon-γ. Results HLA-DR+ cells were seen in the highest number, and were higher in lesional skin compared with normal skin from both patients and healthy volunteers, ICAM-1 expression was also increased in lesional skin. Clq and the interleukins showed an increased cellular and intercellular staining in patients compared with healthy controls and the intercellular staining was often more intense in lesions compared with non-lesional skin. Staining was often more intense when Malassezia (Pityrosporum ovale) yeast cells were present. Conclusions An increase in NK1+ and CD16+ cells in combination with complement activation indicates that an irritant non-immunogenic stimulation of the immune system is important. The result with the interleukins showed both an increase in the production of inflammatory interleukins as well as in the regulatory interleukins for both T H 1 and T H 2 cells. Similarities to the immune response described for Candida albicans infections indicate the role of Malassezia in the skin response in Seborrhoeic Dermatitis and Pityrosporum folliculitis.
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pityrosporum ovale malassezia furfur as the causative agent of Seborrhoeic Dermatitis new treatment options
British Journal of Dermatology, 1996Co-Authors: Jan Faergemann, T C Jones, O Hettler, Y LoriaAbstract:Summary Several studies indicate that Pityrosporum ovale plays an important role in Seborrhoeic Dermatitis. Many of these are treatment studies which describe the effectiveness of antimycotics, paralleled by a reduction in the number of P. ovale colonies and then recolonization, leading to a recurrence of Seborrhoeic Dermatitis. In this study 20 patients with Seborrhoeic Dermatitis of the scalp were treated with terbinafine (Lamisil®) 1% solution once daily for 4 weeks. Eleven of 18 patients (61%) were cured and they were still free of lesions 2 weeks after stopping treatment. No side-effects related to treatment were seen. There was also a significant reduction in the number of P. ovale colonies. This may explain both the good clinical effect and the observation that all patients who were cleared of P. ovale were still free of lesions 2 weeks after stopping treatment.
Jacques Guillot - One of the best experts on this subject based on the ideXlab platform.
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identification of malassezia species isolated from patients with Seborrhoeic Dermatitis atopic Dermatitis pityriasis versicolor and normal subjects
Medical Mycology, 2000Co-Authors: A Nakabayashi, Yoshihiro Sei, Jacques GuillotAbstract:We identified Malassezia species isolated from 42 patients with Seborrhoeic Dermatitis, 17 patients with atopic Dermatitis, 22 patients with pityriasis versicolor, 35 normal subjects and 73 healthy medical students. Regarding the prevalence of Malassezia species in the 35 normal subjects, the frequency of isolation of Malassezia globosa was 22%, M. sympodialis 10% and M. furfur 3%. M. slooffiae, M. pachydermatis, M. restricta and M. obtusa were infrequently isolated from normal skin. Two different species were isolated coincidentally from seven samples. In the patients with atopic Dermatitis, M. furfur was isolated more frequently from lesional skin (21%) than non-lesional skin (11%). However, there was no statistical significance. Therefore, this result, by itself, is insufficient to prove that M. furfur should be considered to be an exacerbating factor of atopic Dermatitis. In Seborrhoeic Dermatitis, M. furfur (35%) and M. globosa (22%) were isolated from lesional skin on the face at significantly high rates in comparison with the normal subjects. Therefore, M. furfur and/or M. globosa may be pathogens of Seborrhoeic Dermatitis. M. globosa was isolated at a frequency of 55% from lesional skin of pityriasis versicolor, while all other species were below 10%. These data suggest that the pathogenic species of pityriasis versicolor is M. globosa.
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identification of malassezia species isolated from patients with Seborrhoeic Dermatitis atopic Dermatitis pityriasis versicolor and normal subjects
Medical Mycology, 2000Co-Authors: A Nakabayashi, Jacques GuillotAbstract:We identified Malassezia species isolated from 42 patients with Seborrhoeic Dermatitis, 17 patients with atopic Dermatitis, 22 patients with pityriasis versicolor, 35 normal subjects and 73 healthy medical students. Regarding the prevalence of Malassezia species in the 35 normal subjects, the frequency of isolation of Malassezia globosa was 22%, M. sympodialis 10% and M. furfur 3%. M. slooffiae, M. pachydermatis, M. restricta and M. obtusa were infrequently isolated from normal skin. Two different species were isolated coincidentally from seven samples. In the patients with atopic Dermatitis, M. furfur was isolated more frequently from lesional skin (21%) than non-lesional skin (11%). However, there was no statistical significance. Therefore, this result, by itself, is insufficient to prove that M. furfur should be considered to be an exacerbating factor of atopic Dermatitis. In Seborrhoeic Dermatitis, M. furfur (35%) and M. globosa (22%) were isolated from lesional skin on the face at significantly high ...
A Nakabayashi - One of the best experts on this subject based on the ideXlab platform.
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identification of malassezia species isolated from patients with Seborrhoeic Dermatitis atopic Dermatitis pityriasis versicolor and normal subjects
Medical Mycology, 2000Co-Authors: A Nakabayashi, Yoshihiro Sei, Jacques GuillotAbstract:We identified Malassezia species isolated from 42 patients with Seborrhoeic Dermatitis, 17 patients with atopic Dermatitis, 22 patients with pityriasis versicolor, 35 normal subjects and 73 healthy medical students. Regarding the prevalence of Malassezia species in the 35 normal subjects, the frequency of isolation of Malassezia globosa was 22%, M. sympodialis 10% and M. furfur 3%. M. slooffiae, M. pachydermatis, M. restricta and M. obtusa were infrequently isolated from normal skin. Two different species were isolated coincidentally from seven samples. In the patients with atopic Dermatitis, M. furfur was isolated more frequently from lesional skin (21%) than non-lesional skin (11%). However, there was no statistical significance. Therefore, this result, by itself, is insufficient to prove that M. furfur should be considered to be an exacerbating factor of atopic Dermatitis. In Seborrhoeic Dermatitis, M. furfur (35%) and M. globosa (22%) were isolated from lesional skin on the face at significantly high rates in comparison with the normal subjects. Therefore, M. furfur and/or M. globosa may be pathogens of Seborrhoeic Dermatitis. M. globosa was isolated at a frequency of 55% from lesional skin of pityriasis versicolor, while all other species were below 10%. These data suggest that the pathogenic species of pityriasis versicolor is M. globosa.
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identification of malassezia species isolated from patients with Seborrhoeic Dermatitis atopic Dermatitis pityriasis versicolor and normal subjects
Medical Mycology, 2000Co-Authors: A Nakabayashi, Jacques GuillotAbstract:We identified Malassezia species isolated from 42 patients with Seborrhoeic Dermatitis, 17 patients with atopic Dermatitis, 22 patients with pityriasis versicolor, 35 normal subjects and 73 healthy medical students. Regarding the prevalence of Malassezia species in the 35 normal subjects, the frequency of isolation of Malassezia globosa was 22%, M. sympodialis 10% and M. furfur 3%. M. slooffiae, M. pachydermatis, M. restricta and M. obtusa were infrequently isolated from normal skin. Two different species were isolated coincidentally from seven samples. In the patients with atopic Dermatitis, M. furfur was isolated more frequently from lesional skin (21%) than non-lesional skin (11%). However, there was no statistical significance. Therefore, this result, by itself, is insufficient to prove that M. furfur should be considered to be an exacerbating factor of atopic Dermatitis. In Seborrhoeic Dermatitis, M. furfur (35%) and M. globosa (22%) were isolated from lesional skin on the face at significantly high ...
Mari Helen Sandstrom Falk - One of the best experts on this subject based on the ideXlab platform.
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the prevalence of malassezia yeasts in patients with atopic Dermatitis Seborrhoeic Dermatitis and healthy controls
Acta Dermato-venereologica, 2005Co-Authors: Mari Helen Sandstrom Falk, Maria Tengvall Linder, Catharina Johansson, Jacek Bartosik, Ove Back, Tore Sarnhult, Carlfredrik Wahlgren, Annika Scheynius, Jan FaergemannAbstract:Cultures for Malassezia yeasts were taken from both normal-looking skin and lesional skin in 124 patients with atopic Dermatitis, 16 patients with Seborrhoeic Dermatitis and from normal skin of 31 healthy controls. Positive Malassezia growth was found in fewer patients with atopic Dermatitis (56%) than in patients with Seborrhoeic Dermatitis (88%) or in healthy controls (84%, pv0.01). In the patients with atopic Dermatitis, fewer positive cultures were found in lesional (28%) than in non-lesional skin (44%, pv0.05), while positive cultures were found in 75% of both lesional and non-lesional skin of patients with Seborrhoeic Dermatitis (not significant). M. sympodialis dominated in patients with atopic Dermatitis (46%) and in healthy controls (69%). In patients with Seborrhoeic Dermatitis both M. sympodialis and M. obtusa were cultured in 43%. A Malassezia species extract mixture would increase the possibility of detecting IgE sensiti
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the prevalence of malassezia yeasts in patients with atopic Dermatitis Seborrhoeic Dermatitis and healthy controls
Acta Dermato-venereologica, 2005Co-Authors: Mari Helen Sandstrom Falk, Maria Tengvall Linder, Catharina Johansson, Jacek Bartosik, Ove Back, Tore Sarnhult, Carlfredrik Wahlgren, Annika Scheynius, Jan FaergemannAbstract:Cultures for Malassezia yeasts were taken from both normal-looking skin and lesional skin in 124 patients with atopic Dermatitis, 16 patients with Seborrhoeic Dermatitis and from normal skin of 31 healthy controls. Positive Malassezia growth was found in fewer patients with atopic Dermatitis (56%) than in patients with Seborrhoeic Dermatitis (88%) or in healthy controls (84%, p<0.01). In the patients with atopic Dermatitis, fewer positive cultures were found in lesional (28%) than in non-lesional skin (44%, p<0.05), while positive cultures were found in 75% of both lesional and non-lesional skin of patients with Seborrhoeic Dermatitis (not significant). M. sympodialis dominated in patients with atopic Dermatitis (46%) and in healthy controls (69%). In patients with Seborrhoeic Dermatitis both M. sympodialis and M. obtusa were cultured in 43%. A Malassezia species extract mixture would increase the possibility of detecting IgE sensitization to Malassezia in patients with atopic Dermatitis.
R J Hay - One of the best experts on this subject based on the ideXlab platform.
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hiv disease and malassezia yeasts a quantitative study of patients presenting with Seborrhoeic Dermatitis
British Journal of Dermatology, 2006Co-Authors: R C Schechtman, G Midgley, R J HayAbstract:Seborrhoeic Dermatitis (SD) is a disease that affects 1-3% of the general population, 3-5% of young adults and 20-83% of patients with AIDS. Malassezia yeasts have been associated with the pathogenesis of this condition. The association between the Malassezia yeasts and HIV-related SD is still a controversial subject. The objective of our study was to investigate the role of Malassezia yeasts in the pathogenesis of SD in the HIV population comparing the number of yeasts' cells with the severity of the disease and degree of immunosuppression. We used two quantitative counting methods: direct counting with Sellotape-stripped skin and recovery of the yeasts in culture using contact plates. This investigation has demonstrated that there is a trend between numbers of yeasts present on lesional skin, severity of SD and CD4-positive T lymphocytes count in HIV-positive patients. No quantitative differences were observed between HIV-related and non-HIV related SD.
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adherence of malassezia isolates to human keratinocytes in vitro a study of hiv positive patients with Seborrhoeic Dermatitis
British Journal of Dermatology, 1995Co-Authors: R C Schechtman, G Midgley, J S Bingham, R J HayAbstract:Adherence of Malassezia yeast cells to human keratinocytes was assessed by a novel technique using double-sided Sellotape. Although adherence using double-sided Sellotape is still merely a model for in vivo adherence, it approximates to the conditions found on the skin surface. There were no differences in adhesive properties to human keratinocytes between Malassezia strains originating from HIV-positive and HIV-negative patients with Seborrhoeic Dermatitis, nor was there a relationship between the severity of Seborrhoeic Dermatitis and in vitro adherence to human keratinocytes.
