The Experts below are selected from a list of 1236 Experts worldwide ranked by ideXlab platform
Mimi Yow - One of the best experts on this subject based on the ideXlab platform.
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Secondary Dentition characteristics in an ethnic chinese orthodontic population a retrospective cross sectional study
Journal of Investigative and Clinical Dentistry, 2019Co-Authors: Grace X. L. Chan, Elaine L. Y. Tan, Ming T. Chew, Hung C. Wong, Kelvin Weng Chiong Foong, Mimi YowAbstract:AIM To determine the prevalence of dental anomalies and its association with gender. METHODS This retrospective cross-sectional study was conducted using radiographs, photographs and clinical records of patients who attended the Department of Orthodontics at the National Dental Centre Singapore. Records of 2508 ethnic Chinese orthodontic patients aged 14-25 years were examined for the prevalence of dental anomalies in the permanent Dentition, excluding third molars. Statistical analyses were performed using SAS version 9.4 (SAS Institute Inc.). Logistic regression was used to determine the association between gender and the occurrence of various dental anomalies. Kappa coefficients were calculated to test for intra-examiner reproducibility. Statistical significance was set at P < 0.05. RESULTS Prevalence of dental anomalies was 5.7% hyperdontia, 11.1% hypodontia, 5.5% peg-shaped upper lateral incisors, 21.9% impacted teeth, 1.3% transposition and 0.4% double teeth. There was no significant gender difference in the occurrence of the anomalies except hyperdontia, with males having significantly higher odds of hyperdontia compared with females (odds ratio, 1.488; 95% confidence interval, 1.062-2.085; P = 0.021). CONCLUSION Occurrence of hyperdontia is greater in males than females, while no significant gender differences were noted for hypodontia, peg-shaped upper lateral incisors, impacted teeth, transposition and double teeth.
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Secondary Dentition characteristics in an ethnic Chinese orthodontic population: A retrospective cross-sectional study.
Journal of Investigative and Clinical Dentistry, 2019Co-Authors: Grace X. L. Chan, Elaine L. Y. Tan, Ming T. Chew, Hung C. Wong, Kelvin Weng Chiong Foong, Mimi YowAbstract:AIM To determine the prevalence of dental anomalies and its association with gender. METHODS This retrospective cross-sectional study was conducted using radiographs, photographs and clinical records of patients who attended the Department of Orthodontics at the National Dental Centre Singapore. Records of 2508 ethnic Chinese orthodontic patients aged 14-25 years were examined for the prevalence of dental anomalies in the permanent Dentition, excluding third molars. Statistical analyses were performed using SAS version 9.4 (SAS Institute Inc.). Logistic regression was used to determine the association between gender and the occurrence of various dental anomalies. Kappa coefficients were calculated to test for intra-examiner reproducibility. Statistical significance was set at P
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Secondary Dentition characteristics in children with nonsyndromic unilateral cleft lip and palate a retrospective study
The Cleft Palate-Craniofacial Journal, 2018Co-Authors: Elaine Li Yen Tan, Meaw Charm Kuek, Hung Chew Wong, Serene Ai Kiang Ong, Mimi YowAbstract:Objective:Children with cleft lip and palate are reported to be commonly associated with higher prevalence of dental anomalies such as hypodontia, supernumeraries, and abnormalities in tooth size, shape, and position. This study investigated the prevalence of dental anomalies in a longitudinal cohort of children with unilateral cleft lip and palate (UCLP).Design:The study was a retrospective analysis of radiographs, study models, and treatment notes.Patients:Sixty patients with repaired UCLP aged 13 years old with complete dental records dating from 5 years of age were included.Methods:Study casts, dental panoramic, anterior maxillary occlusal, and periapical radiographs of the patients were examined for cleft-sidedness, congenitally missing permanent teeth, supernumerary teeth, microdontic, and macrodontic teeth in the anterior maxillary region, presence of malformed permanent cleft-sided lateral incisor and its morphology (peg-shaped, conical shaped, canine-formed), positions of the permanent lateral in...
Stefan Mundlos - One of the best experts on this subject based on the ideXlab platform.
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mutations in the runx2 gene in patients with cleidocranial dysplasia
Human Mutation, 2002Co-Authors: Florian Otto, Hirokazu Kanegane, Stefan MundlosAbstract:Cleidocranial dysplasia (CCD) is a autosomal dominant disorder characterized by skeletal anomalies such as patent fontanels, late closure of cranial sutures with Wormian bones, late erupting Secondary Dentition, rudimentary clavicles, and short stature. The locus for this disease was mapped to chromosome 6p21. RUNX2 is a member of the runt family of transcription factors and its expression is restricted to developing osteoblasts and a subset of chondrocytes. Mutations in the RUNX2 gene have been shown to cause CCD. Chromosomal translocations, deletions, insertions, nonsense and splice-site mutations, as well as missense mutations of the RUNX2 gene have been described in CCD patients. Although there is a wide spectrum in phenotypic variability ranging from primary dental anomalies to all CCD features plus osteoporosis, no clear phenotype–genotype correlation has been established. However analysis of the three-dimensional structure of the DNA binding runt domain of the RUNX proteins and its interaction with DNA, as well as the cofactor CBFB, start to provide an insight into how missense mutations affect RUNX2 function. Hum Mutat 19:209–216, 2002. © 2002 Wiley-Liss, Inc.
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Mutations in the RUNX2 gene in patients with cleidocranial dysplasia.
Human Mutation, 2002Co-Authors: Florian Otto, Hirokazu Kanegane, Stefan MundlosAbstract:Cleidocranial dysplasia (CCD) is a autosomal dominant disorder characterized by skeletal anomalies such as patent fontanels, late closure of cranial sutures with Wormian bones, late erupting Secondary Dentition, rudimentary clavicles, and short stature. The locus for this disease was mapped to chromosome 6p21. RUNX2 is a member of the runt family of transcription factors and its expression is restricted to developing osteoblasts and a subset of chondrocytes. Mutations in the RUNX2 gene have been shown to cause CCD. Chromosomal translocations, deletions, insertions, nonsense and splice-site mutations, as well as missense mutations of the RUNX2 gene have been described in CCD patients. Although there is a wide spectrum in phenotypic variability ranging from primary dental anomalies to all CCD features plus osteoporosis, no clear phenotype-genotype correlation has been established. However analysis of the three-dimensional structure of the DNA binding runt domain of the RUNX proteins and its interaction with DNA, as well as the cofactor CBFB, start to provide an insight into how missense mutations affect RUNX2 function.
M C Downer - One of the best experts on this subject based on the ideXlab platform.
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community dental health: Clear Criteria for referral of children following school dental inspection can be established
British Dental Journal, 1999Co-Authors: M C DownerAbstract:Aim To clarify the function of the school based dental inspection Objective For representatives of the Community Dental Service, General Dental Service and Hospital Dental Service to identify an agreed set of criteria for the referral of children following school dental inspection. Design Qualitative research methodology used to establish a consensus for the inclusion of referral criteria following dental screening. Setting Ellesmere Port, Cheshire, England Materials A Delphi technique was used to establish a consensus among the study participants on the inclusion of nine possible criteria for referral following dental screening. All participants scored each criterion in the range 1-9, with a score of 1 indicating that referral of individuals with the condition should definitely not take place, and a score of 9 indicating referral should definitely take place. Referral criteria were accepted only if they achieved a group median score of 7 or more, with an interquartile range of three scale points, with the lower value being no less than 7. Results Four of the nine possible criteria met the agreed group standard for inclusion: 'Sepsis', 'Caries in the Secondary Dentition', 'Overjet > 10 mm', and 'Registered & caries in the permanent Dentition'. Conclusion It is possible to agree clear criteria for the referral of children following the school dental inspection.
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Clear Criteria for referral of children following school dental inspection can be established
British Dental Journal, 1999Co-Authors: M C DownerAbstract:Local agreement was obtained on four clinical criteria to trigger referral following school dental inspection. This methodology is widely applicable with different criteria addressing local needs. The process leads to greater standardisation. This approach permits the effectiveness of the school dental inspection to be evaluated. Aim To clarify the function of the school based dental inspection Objective For representatives of the Community Dental Service, General Dental Service and Hospital Dental Service to identify an agreed set of criteria for the referral of children following school dental inspection. Design Qualitative research methodology used to establish a consensus for the inclusion of referral criteria following dental screening. Setting Ellesmere Port, Cheshire, England Materials A Delphi technique was used to establish a consensus among the study participants on the inclusion of nine possible criteria for referral following dental screening. All participants scored each criterion in the range 1-9, with a score of 1 indicating that referral of individuals with the condition should definitely not take place, and a score of 9 indicating referral should definitely take place. Referral criteria were accepted only if they achieved a group median score of 7 or more, with an interquartile range of three scale points, with the lower value being no less than 7. Results Four of the nine possible criteria met the agreed group standard for inclusion: 'Sepsis', 'Caries in the Secondary Dentition', 'Overjet > 10 mm', and 'Registered & caries in the permanent Dentition'. Conclusion It is possible to agree clear criteria for the referral of children following the school dental inspection.
John Pearn - One of the best experts on this subject based on the ideXlab platform.
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Baden-Powell on teeth: a centenary perspective of a pioneer of preventive dental health
British Dental Journal, 2008Co-Authors: John PearnAbstract:In the era when dental care, particularly preventive dental health, did not enjoy a high public profile, Lieut-General (later Lord) Robert Baden-Powell (1857-1941) was an influential advocate for the care of the teeth. He was a pioneer in a targeted outreach to youth, specifically boys and young men, emphasising the importance of dental health as an essential part of total body health and fitness. In his book, Scouting for boys, first published on 1 May 1908, he described personal accounts of the consequences of the neglect of oral hygiene and presented advice on how to make an effective 'camp tooth-brush' in order that dental hygiene would not be compromised even under the exigencies of conditions away from home. Baden-Powell wrote explicitly that daily dental hygiene was the single most important 'one civilised thing [teenage youths] could do', irrespective of one's physical circumstances. Scouting for boys was for more than five decades the world's best seller in English, after the Bible. It has run to, and now surpasses, 60 million copies in 30 languages and has been published in 35 editions. It is believed that Baden-Powell's frank and direct exhortations to preserve the teeth, with simple and direct advice on food and what today would be called oral hygiene, have been read by 350 million people throughout the world. His advocacy reached out to boys and young men as it does today to youths of both sexes in that 'window of opportunity' when life-long habits of healthcare are being inculcated and when important components of Secondary Dentition are forming. This paper is a centenary perspective of Baden-Powell's pioneering advocacy of modern preventive dental health.
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Baden-Powell on teeth: a centenary perspective of a pioneer of preventive dental health
British Dental Journal, 2008Co-Authors: John PearnAbstract:Lord Baden-Powell showed that: Dental hygiene was the most fundamental indicator of the 'civilised life'. Care of the teeth is practical even in the most difficult of physical circumstances. Simple messages of preventive health and dental hygiene can reach the widest audience if such are made relevant to the target population 'at risk'. In the era when dental care, particularly preventive dental health, did not enjoy a high public profile, Lieut-General (later Lord) Robert Baden-Powell (1857–1941) was an influential advocate for the care of the teeth. He was a pioneer in a targeted outreach to youth, specifically boys and young men, emphasising the importance of dental health as an essential part of total body health and fitness. In his book, Scouting for boys , first published on 1 May 1908, he described personal accounts of the consequences of the neglect of oral hygiene and presented advice on how to make an effective 'camp tooth-brush' in order that dental hygiene would not be compromised even under the exigencies of conditions away from home. Baden-Powell wrote explicitly that daily dental hygiene was the single most important 'one civilised thing [teenage youths] could do', irrespective of one's physical circumstances. Scouting for boys was for more than five decades the world's best seller in English, after the Bible . It has run to, and now surpasses, 60 million copies in 30 languages and has been published in 35 editions. It is believed that Baden-Powell's frank and direct exhortations to preserve the teeth, with simple and direct advice on food and what today would be called oral hygiene, have been read by 350 million people throughout the world. His advocacy reached out to boys and young men as it does today to youths of both sexes in that 'window of opportunity' when life-long habits of healthcare are being inculcated and when important components of Secondary Dentition are forming. This paper is a centenary perspective of Baden-Powell's pioneering advocacy of modern preventive dental health.
Florian Otto - One of the best experts on this subject based on the ideXlab platform.
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mutations in the runx2 gene in patients with cleidocranial dysplasia
Human Mutation, 2002Co-Authors: Florian Otto, Hirokazu Kanegane, Stefan MundlosAbstract:Cleidocranial dysplasia (CCD) is a autosomal dominant disorder characterized by skeletal anomalies such as patent fontanels, late closure of cranial sutures with Wormian bones, late erupting Secondary Dentition, rudimentary clavicles, and short stature. The locus for this disease was mapped to chromosome 6p21. RUNX2 is a member of the runt family of transcription factors and its expression is restricted to developing osteoblasts and a subset of chondrocytes. Mutations in the RUNX2 gene have been shown to cause CCD. Chromosomal translocations, deletions, insertions, nonsense and splice-site mutations, as well as missense mutations of the RUNX2 gene have been described in CCD patients. Although there is a wide spectrum in phenotypic variability ranging from primary dental anomalies to all CCD features plus osteoporosis, no clear phenotype–genotype correlation has been established. However analysis of the three-dimensional structure of the DNA binding runt domain of the RUNX proteins and its interaction with DNA, as well as the cofactor CBFB, start to provide an insight into how missense mutations affect RUNX2 function. Hum Mutat 19:209–216, 2002. © 2002 Wiley-Liss, Inc.
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Mutations in the RUNX2 gene in patients with cleidocranial dysplasia.
Human Mutation, 2002Co-Authors: Florian Otto, Hirokazu Kanegane, Stefan MundlosAbstract:Cleidocranial dysplasia (CCD) is a autosomal dominant disorder characterized by skeletal anomalies such as patent fontanels, late closure of cranial sutures with Wormian bones, late erupting Secondary Dentition, rudimentary clavicles, and short stature. The locus for this disease was mapped to chromosome 6p21. RUNX2 is a member of the runt family of transcription factors and its expression is restricted to developing osteoblasts and a subset of chondrocytes. Mutations in the RUNX2 gene have been shown to cause CCD. Chromosomal translocations, deletions, insertions, nonsense and splice-site mutations, as well as missense mutations of the RUNX2 gene have been described in CCD patients. Although there is a wide spectrum in phenotypic variability ranging from primary dental anomalies to all CCD features plus osteoporosis, no clear phenotype-genotype correlation has been established. However analysis of the three-dimensional structure of the DNA binding runt domain of the RUNX proteins and its interaction with DNA, as well as the cofactor CBFB, start to provide an insight into how missense mutations affect RUNX2 function.