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Makoto Aihara - One of the best experts on this subject based on the ideXlab platform.
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comparison of visual field defect progression in Secondary Glaucoma due to anterior uveitis caused by three types of herpes viruses
Graefes Archive for Clinical and Experimental Ophthalmology, 2020Co-Authors: Shintaro Shirahama, Keiko Komae, Rie Tanaka, Hisae Nakahara, Yujiro Fujino, Toshikatsu Kaburaki, Sachiko Takada, Hidetoshi Kawashima, Makoto AiharaAbstract:To clarify the prevalence of Secondary Glaucoma (SG) and its speed of progression in patients with herpes simplex virus (HSV)-anterior uveitis (AU), varicella zoster virus (VZV)-AU, and cytomegalovirus (CMV)-AU. In total, 170 patients with herpetic AU were enrolled in this retrospective observational case series. Patients with visual field (VF) defects and Glaucomatous disc abnormalities were diagnosed with SG. Moreover, the speed of SG progression was defined as decreasing mean deviation (MD) values per year. SG prevalence and annual MD-value decrease were compared among the three types of herpetic AU. SG prevalence was 16%, 9%, and 72% in patients with HSV-AU, VZV-AU, and CMV-AU, respectively. Patients with CMV-AU had the highest SG prevalence (odds ratio = 3.15; 95% confidence interval = 1.15–8.65; P < 0.05). Furthermore, the annual MD-value change was significantly higher in SG caused by CMV-AU than in that caused by HSV/VZV-AU (−2.6 ± 2.4 dB/year and −0.45 ± 0.54 dB/year, respectively; P < 0.05). Our results demonstrated that patients with CMV-AU may have a higher risk and faster speed of progression of SG than patients with HSV/VZV-AU. Therefore, clinicians should monitor Glaucoma onset and VF-defect progression in patients with CMV-AU.
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comparison of visual field defect progression in Secondary Glaucoma due to anterior uveitis caused by three types of herpes viruses
Graefes Archive for Clinical and Experimental Ophthalmology, 2020Co-Authors: Shintaro Shirahama, Keiko Komae, Rie Tanaka, Hisae Nakahara, Yujiro Fujino, Toshikatsu Kaburaki, Sachiko Takada, Hidetoshi Kawashima, Makoto AiharaAbstract:PURPOSE To clarify the prevalence of Secondary Glaucoma (SG) and its speed of progression in patients with herpes simplex virus (HSV)-anterior uveitis (AU), varicella zoster virus (VZV)-AU, and cytomegalovirus (CMV)-AU. METHODS In total, 170 patients with herpetic AU were enrolled in this retrospective observational case series. Patients with visual field (VF) defects and Glaucomatous disc abnormalities were diagnosed with SG. Moreover, the speed of SG progression was defined as decreasing mean deviation (MD) values per year. SG prevalence and annual MD-value decrease were compared among the three types of herpetic AU. RESULTS SG prevalence was 16%, 9%, and 72% in patients with HSV-AU, VZV-AU, and CMV-AU, respectively. Patients with CMV-AU had the highest SG prevalence (odds ratio = 3.15; 95% confidence interval = 1.15-8.65; P < 0.05). Furthermore, the annual MD-value change was significantly higher in SG caused by CMV-AU than in that caused by HSV/VZV-AU (-2.6 ± 2.4 dB/year and -0.45 ± 0.54 dB/year, respectively; P < 0.05). CONCLUSIONS Our results demonstrated that patients with CMV-AU may have a higher risk and faster speed of progression of SG than patients with HSV/VZV-AU. Therefore, clinicians should monitor Glaucoma onset and VF-defect progression in patients with CMV-AU.
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initial trabeculectomy with mitomycin c for Secondary Glaucoma associated with uveitis in behcet disease patients
Journal of Glaucoma, 2017Co-Authors: Keiko Komae, Mitsuko Takamoto, Rie Tanaka, Makoto Aihara, Kazuyoshi Ohtomo, Kimiko Okinaga, Junko Matsuda, Hisae Nakahara, Yujiro Fujino, Toshikatsu KaburakiAbstract:Purpose:To examine clinical outcomes following an initial trabeculectomy with mitomycin-C for Secondary Glaucoma associated with uveitis in Behcet disease (BD) patients.Design:Retrospective interventional case series.Patients and Methods:Twenty-two eyes in 18 patients with uveitic Glaucoma (UG) asso
Xiaobo Xia - One of the best experts on this subject based on the ideXlab platform.
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the role of primary intraocular lens implantation in the risk of Secondary Glaucoma following congenital cataract surgery a systematic review and meta analysis
PLOS ONE, 2019Co-Authors: Shuo Zhang, Jiaxing Wang, Ye Liu, Xiaobo XiaAbstract:Objective This meta-analysis aims to evaluate the incidence of Secondary Glaucoma in patients under the age of 2 years who underwent congenital cataract surgery with or without primary intraocular lens (IOL) implantation. Methods An electronic literature search was performed in Medline, EMBASE, and Web of Science databases to retrieve studies between January 2011 and November 2018. Patients with congenital cataract who did primary IOL implantation, aphakia, or Secondary IOL implantation followed by receiving extraction surgery were included in this study. Relevant studies meeting defined eligibility criteria were selected and reviewed systematically by meta-analysis. Long-term incidences of Secondary Glaucoma, which developed at least one year after cataract surgery, were considered and discussed as clinical outcomes in each cohort. The pooled data were analyzed according to a random effects model. Results Eight publications involving 892 eyes were included in the current meta-analysis. In the general population of eyes with congenital cataract, the long-term incidence of Secondary Glaucoma was lower (P = 0.06) in eyes with primary IOL (9.5%) than in eyes without primary IOL (15.1%), including aphakia and Secondary IOL. The pooled risk ratio (RR) favors primary IOL implantation in all patients (RR = 0.63). For bilateral congenital cataract, the incidence was 6.7% in eyes with primary IOL implantation, which is significantly lower than the 16.7% in eyes with aphakia and Secondary IOL implantation (P<0.05, RR = 0.44). However, for unilateral congenital cataract surgery, the incidence was very similar in eyes with and without primary IOL (12.4% vs 12.0%, P = 0.61, RR = 0.87). Conclusions In patients under 2 years of age, primary IOL implantation for bilateral congenital cataract surgery is associated with a lower risk of Secondary Glaucoma.
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Forest plots describing the treatment effects in all congenital cataract cases.
2019Co-Authors: Shuo Zhang, Jiaxing Wang, Ye Liu, Xiaobo XiaAbstract:A. Development of Secondary Glaucoma after primary IOL implantation versus aphakia. B. Primary IOL implantation versus aphakia and Secondary IOL implantation regarding the development of Secondary Glaucoma.
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Forest plots describing the treatment effects in subpopulations with unilateral congenital cataract.
2019Co-Authors: Shuo Zhang, Jiaxing Wang, Ye Liu, Xiaobo XiaAbstract:A. Development of Secondary Glaucoma in primary IOL implantation versus aphakia alone. B. Primary IOL implantation versus aphakia and Secondary IOL implantation regarding the development of Secondary Glaucoma.
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Forest plots describing the effects of treatments in patients with bilateral congenital cataract.
2019Co-Authors: Shuo Zhang, Jiaxing Wang, Ye Liu, Xiaobo XiaAbstract:A. Primary IOL implantation versus aphakia alone regarding the development of Secondary Glaucoma. B. Development of Secondary Glaucoma in primary IOL implantation versus aphakia and Secondary IOL implantation.
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The role of primary intraocular lens implantation in the risk of Secondary Glaucoma following congenital cataract surgery: A systematic review and meta-analysis
2019Co-Authors: Shuo Zhang, Jiaxing Wang, Ye Liu, Xiaobo XiaAbstract:ObjectiveThis meta-analysis aims to evaluate the incidence of Secondary Glaucoma in patients under the age of 2 years who underwent congenital cataract surgery with or without primary intraocular lens (IOL) implantation.MethodsAn electronic literature search was performed in Medline, EMBASE, and Web of Science databases to retrieve studies between January 2011 and November 2018. Patients with congenital cataract who did primary IOL implantation, aphakia, or Secondary IOL implantation followed by receiving extraction surgery were included in this study. Relevant studies meeting defined eligibility criteria were selected and reviewed systematically by meta-analysis. Long-term incidences of Secondary Glaucoma, which developed at least one year after cataract surgery, were considered and discussed as clinical outcomes in each cohort. The pooled data were analyzed according to a random effects model.ResultsEight publications involving 892 eyes were included in the current meta-analysis. In the general population of eyes with congenital cataract, the long-term incidence of Secondary Glaucoma was lower (P = 0.06) in eyes with primary IOL (9.5%) than in eyes without primary IOL (15.1%), including aphakia and Secondary IOL. The pooled risk ratio (RR) favors primary IOL implantation in all patients (RR = 0.63). For bilateral congenital cataract, the incidence was 6.7% in eyes with primary IOL implantation, which is significantly lower than the 16.7% in eyes with aphakia and Secondary IOL implantation (P
Carsten Heinz - One of the best experts on this subject based on the ideXlab platform.
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multiplex cytokine analysis of aqueous humor in juvenile idiopathic arthritis associated anterior uveitis with or without Secondary Glaucoma
Frontiers in Immunology, 2018Co-Authors: Dirk Bauer, Maren Kasper, Karoline Walscheid, J M Koch, Philipp S Muther, Bernd Kirchhof, Arnd Heiligenhaus, Carsten HeinzAbstract:Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing Secondary Glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without Secondary Glaucoma (JIAUwoG), or from patients with senile cataract as controls. Laser-flare photometry analysis prior to surgery showed no significant differences between JIAUwG or JIAUwoG. Compared with the control group, levels of interleukin-8, matrix metalloproteinase-2, -3, -9, serum amyloid A (SAA), transforming growth factor beta-1, -2, -3 (TGFβ-1, -2, -3), and tumor necrosis factor-alpha in the AH were significantly higher in patients with clinically inactive JIAUwG or JIAUwoG. Samples from JIAwoG patients displayed significantly higher levels of SAA (P < 0.0116) than JIAUwG patients. JIAUwG patients showed an increased level of TGFβ-2 in AH samples compared with JIAUwoG (P < 0.0009). These molecules may contribute to the clinical development of Glaucoma in patients with JIAU.
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prevalence of uveitic Secondary Glaucoma and success of nonsurgical treatment in adults and children in a tertiary referral center
Ocular Immunology and Inflammation, 2009Co-Authors: Carsten Heinz, Jorg M Koch, Beatrix Zurekimhoff, Arnd HeiligenhausAbstract:Purpose: The aim of this study is to compare treatment strategies, the success of topical and systemic therapy, and the need for Glaucoma surgery in children and adults with Secondary uveitic Glaucoma. Methods: Retrospective observational case series with 1997 consecutive new uveitis patients. Results: Overall, 176 patients (8.8%) suffered from Secondary Glaucoma (n = 126) or ocular hypertension (n = 50). All patients received topical therapy, and 107 (62%) patients also received systemic Glaucoma therapy. Topical therapy was successful (IOP ≤ 21 mmHg) in 24% of adults and 26% of children. Surgery was required in 59% of children and in 35% of adults (p =.02). The number of surgical interventions differed per patient with 2.6 procedures in children compared to 1.6 procedures in adults (p <.001). Conclusions: Only a limited number of patients with Secondary uveitic Glaucoma can be sufficiently controlled with topical and systemic antiGlaucomatous therapy alone. There is a significantly higher need for glauc...
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transscleral diode laser cyclophotocoagulation as primary surgical treatment for Secondary Glaucoma in juvenile idiopathic arthritis high failure rate after short term follow up
British Journal of Ophthalmology, 2006Co-Authors: Carsten Heinz, J M Koch, Arnd HeiligenhausAbstract:Aim: To evaluate the success rates of transscleral diode cyclophotocoagulation (TD-CPC) for Secondary Glaucoma in patients with juvenile idiopathic arthritis (JIA) as primary surgical treatment. Methods: Retrospective chart review of 12 paediatric patients with JIA associated uveitis and Secondary open angle Glaucoma. Results: 21 eyes of the 12 patients had chronic anterior uveitis, 21 eyes had Secondary open angle Glaucoma, and 19 eyes were treated 41 times with TD-CPC. Patients underwent a mean of 2.15 treatment sessions per eye. Pretreatment intraocular pressure (IOP) was 30.2 (5.5) mm Hg before the first treatment, 30.5 (5.7) mm Hg before the second treatment, and 28.7 (6.3) mm Hg before the third treatment. Reduction of IOP 6 weeks after treatment was highest after the second and third treatments with 9.4 (8.8) and 8.7 (5.8) mm Hg, respectively and 5.2 (10.7) mm Hg after the first treatment. Qualified success (IOP ⩽21 mm Hg with Glaucoma medication) was achieved at the end of follow up in six of 19 eyes (32%, follow up time 10.1 (9.3) months). Conclusion: TD-CPC as a primary surgical treatment in JIA patients, is often unsatisfactory in eyes with uveitic Glaucoma.
Arnd Heiligenhaus - One of the best experts on this subject based on the ideXlab platform.
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multiplex cytokine analysis of aqueous humor in juvenile idiopathic arthritis associated anterior uveitis with or without Secondary Glaucoma
Frontiers in Immunology, 2018Co-Authors: Dirk Bauer, Maren Kasper, Karoline Walscheid, J M Koch, Philipp S Muther, Bernd Kirchhof, Arnd Heiligenhaus, Carsten HeinzAbstract:Patients with juvenile idiopathic arthritis often develop chronic anterior uveitis (JIAU). JIAU patients possess a particularly high risk for developing Secondary Glaucoma when inflammatory inactivity has been achieved. By using multiplex bead assay analysis, we assessed levels of pro- and anti-inflammatory cytokines, chemokines, or metalloproteinases in the aqueous humor (AH) of patients with clinically inactive JIAU with (JIAUwG) or without Secondary Glaucoma (JIAUwoG), or from patients with senile cataract as controls. Laser-flare photometry analysis prior to surgery showed no significant differences between JIAUwG or JIAUwoG. Compared with the control group, levels of interleukin-8, matrix metalloproteinase-2, -3, -9, serum amyloid A (SAA), transforming growth factor beta-1, -2, -3 (TGFβ-1, -2, -3), and tumor necrosis factor-alpha in the AH were significantly higher in patients with clinically inactive JIAUwG or JIAUwoG. Samples from JIAwoG patients displayed significantly higher levels of SAA (P < 0.0116) than JIAUwG patients. JIAUwG patients showed an increased level of TGFβ-2 in AH samples compared with JIAUwoG (P < 0.0009). These molecules may contribute to the clinical development of Glaucoma in patients with JIAU.
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prevalence of uveitic Secondary Glaucoma and success of nonsurgical treatment in adults and children in a tertiary referral center
Ocular Immunology and Inflammation, 2009Co-Authors: Carsten Heinz, Jorg M Koch, Beatrix Zurekimhoff, Arnd HeiligenhausAbstract:Purpose: The aim of this study is to compare treatment strategies, the success of topical and systemic therapy, and the need for Glaucoma surgery in children and adults with Secondary uveitic Glaucoma. Methods: Retrospective observational case series with 1997 consecutive new uveitis patients. Results: Overall, 176 patients (8.8%) suffered from Secondary Glaucoma (n = 126) or ocular hypertension (n = 50). All patients received topical therapy, and 107 (62%) patients also received systemic Glaucoma therapy. Topical therapy was successful (IOP ≤ 21 mmHg) in 24% of adults and 26% of children. Surgery was required in 59% of children and in 35% of adults (p =.02). The number of surgical interventions differed per patient with 2.6 procedures in children compared to 1.6 procedures in adults (p <.001). Conclusions: Only a limited number of patients with Secondary uveitic Glaucoma can be sufficiently controlled with topical and systemic antiGlaucomatous therapy alone. There is a significantly higher need for glauc...
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transscleral diode laser cyclophotocoagulation as primary surgical treatment for Secondary Glaucoma in juvenile idiopathic arthritis high failure rate after short term follow up
British Journal of Ophthalmology, 2006Co-Authors: Carsten Heinz, J M Koch, Arnd HeiligenhausAbstract:Aim: To evaluate the success rates of transscleral diode cyclophotocoagulation (TD-CPC) for Secondary Glaucoma in patients with juvenile idiopathic arthritis (JIA) as primary surgical treatment. Methods: Retrospective chart review of 12 paediatric patients with JIA associated uveitis and Secondary open angle Glaucoma. Results: 21 eyes of the 12 patients had chronic anterior uveitis, 21 eyes had Secondary open angle Glaucoma, and 19 eyes were treated 41 times with TD-CPC. Patients underwent a mean of 2.15 treatment sessions per eye. Pretreatment intraocular pressure (IOP) was 30.2 (5.5) mm Hg before the first treatment, 30.5 (5.7) mm Hg before the second treatment, and 28.7 (6.3) mm Hg before the third treatment. Reduction of IOP 6 weeks after treatment was highest after the second and third treatments with 9.4 (8.8) and 8.7 (5.8) mm Hg, respectively and 5.2 (10.7) mm Hg after the first treatment. Qualified success (IOP ⩽21 mm Hg with Glaucoma medication) was achieved at the end of follow up in six of 19 eyes (32%, follow up time 10.1 (9.3) months). Conclusion: TD-CPC as a primary surgical treatment in JIA patients, is often unsatisfactory in eyes with uveitic Glaucoma.
Leonoor I Los - One of the best experts on this subject based on the ideXlab platform.
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risk factors for Secondary Glaucoma in herpetic anterior uveitis
American Journal of Ophthalmology, 2017Co-Authors: Lisette Hoeksema, Nomdo M Jansonius, Leonoor I LosAbstract:Purpose To determine the incidence of elevated intraocular pressure (IOP) and Secondary Glaucoma in herpetic anterior uveitis (AU), owing to either herpes simplex or varicella zoster virus, by using the Standardization of Uveitis Nomenclature (SUN) criteria, and to identify risk factors for the development of Glaucoma. Design Retrospective observational cohort study. Methods Patients with herpetic AU presenting themselves between 2001 and 2013 at the ophthalmology department of the University Medical Center Groningen were included. Main outcome measures were the incidence of elevated IOP and Glaucoma and risk factors for the development of Glaucoma. Results Seventy-three herpetic AU patients were included. Ocular complications most commonly seen during follow-up for uveitis were elevated IOP (75%), keratitis (59%), dry eyes (34%), posterior synechiae (34%), cataract (32%), and Glaucoma (15%). Glaucoma patients, in comparison to non–Glaucoma patients, had a higher number of IOP peaks during their follow-up for uveitis ( P Conclusions Using the SUN criteria, our study confirmed that elevated IOP and Secondary Glaucoma are major complications in herpetic AU. If an elevated IOP occurred, it was usually already present at the start of a uveitis episode. A risk factor for the development of Glaucoma was the number of endured IOP peaks. Future studies are needed to evaluate whether early and prolonged use of antiviral and IOP-lowering medication may prevent Glaucoma.