The Experts below are selected from a list of 27 Experts worldwide ranked by ideXlab platform

Takashi Kanbayashi - One of the best experts on this subject based on the ideXlab platform.

  • A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting Secondary Hypersomnia
    Neurological Sciences, 2012
    Co-Authors: Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki
    Abstract:

    Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasma-associated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with Hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient’s daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barré syndrome mediated by anti-glycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

  • a case with anti galactocerebroside antibody positive mycoplasma pneumoniae meningoencephalitis presenting Secondary Hypersomnia
    Neurological Sciences, 2012
    Co-Authors: Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki
    Abstract:

    Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasma-associated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with Hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient’s daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barre syndrome mediated by anti-glycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

  • CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration
    Journal of the Neurological Sciences, 2006
    Co-Authors: Kenichi Yasui, Takashi Kanbayashi, Yuichi Inoue, Takashi Nomura, Masayoshi Kusumi, Kenji Nakashima
    Abstract:

    Abstract Excessive daytime sleepiness has been widely accepted as a common problem not only in Parkinson's disease (PD) but also in other related disorders. Lowered excretion of orexin A (hypocretin 1) into the cerebrospinal fluid (CSF) is known to play a pathological role in narcolepsy and Secondary Hypersomnia due to hypothalamic dysfunction. Although the levels of CSF orexin in PD have been previously examined, the results have been controversial, and no systematic investigation of CSF orexin excretion has been conducted on PD related disorders. In this study, orexin was measured in CSF collected by lumbar puncture in 62 patients with PD, 13 patients with dementia with Lewy bodies (DLB), 16 patients with progressive supranuclear palsy (PSP), and 7 patients with corticobasal degeneration (CBD). Levels of CSF orexin (mean ± SD pg/ml) were 302 ± 38 in PD, 297 ± 48 in DLB, 258 ± 37 in PSP, 246 ± 90 in CBD. The occurrence of low orexin levels (≤110pg/ml) was rare in both PD and DLB, and orexin levels were significantly lower in the PSP and CBD groups compared to PD (PSP: p

  • CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration.
    Journal of the neurological sciences, 2006
    Co-Authors: Kenichi Yasui, Takashi Kanbayashi, Yuichi Inoue, Takashi Nomura, Masayoshi Kusumi, Kenji Nakashima
    Abstract:

    Excessive daytime sleepiness has been widely accepted as a common problem not only in Parkinson's disease (PD) but also in other related disorders. Lowered excretion of orexin A (hypocretin 1) into the cerebrospinal fluid (CSF) is known to play a pathological role in narcolepsy and Secondary Hypersomnia due to hypothalamic dysfunction. Although the levels of CSF orexin in PD have been previously examined, the results have been controversial, and no systematic investigation of CSF orexin excretion has been conducted on PD related disorders. In this study, orexin was measured in CSF collected by lumbar puncture in 62 patients with PD, 13 patients with dementia with Lewy bodies (DLB), 16 patients with progressive supranuclear palsy (PSP), and 7 patients with corticobasal degeneration (CBD). Levels of CSF orexin (mean+/-SD pg/ml) were 302+/-38 in PD, 297+/-48 in DLB, 258+/-37 in PSP, 246+/-90 in CBD. The occurrence of low orexin levels (

Masashi Aoki - One of the best experts on this subject based on the ideXlab platform.

  • A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting Secondary Hypersomnia
    Neurological Sciences, 2012
    Co-Authors: Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki
    Abstract:

    Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasma-associated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with Hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient’s daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barré syndrome mediated by anti-glycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

  • a case with anti galactocerebroside antibody positive mycoplasma pneumoniae meningoencephalitis presenting Secondary Hypersomnia
    Neurological Sciences, 2012
    Co-Authors: Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki
    Abstract:

    Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasma-associated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with Hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient’s daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barre syndrome mediated by anti-glycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

Naoto Sugeno - One of the best experts on this subject based on the ideXlab platform.

  • A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting Secondary Hypersomnia
    Neurological Sciences, 2012
    Co-Authors: Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki
    Abstract:

    Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasma-associated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with Hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient’s daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barré syndrome mediated by anti-glycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

  • a case with anti galactocerebroside antibody positive mycoplasma pneumoniae meningoencephalitis presenting Secondary Hypersomnia
    Neurological Sciences, 2012
    Co-Authors: Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki
    Abstract:

    Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasma-associated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with Hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient’s daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barre syndrome mediated by anti-glycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

Kenji Nakashima - One of the best experts on this subject based on the ideXlab platform.

  • CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration
    Journal of the Neurological Sciences, 2006
    Co-Authors: Kenichi Yasui, Takashi Kanbayashi, Yuichi Inoue, Takashi Nomura, Masayoshi Kusumi, Kenji Nakashima
    Abstract:

    Abstract Excessive daytime sleepiness has been widely accepted as a common problem not only in Parkinson's disease (PD) but also in other related disorders. Lowered excretion of orexin A (hypocretin 1) into the cerebrospinal fluid (CSF) is known to play a pathological role in narcolepsy and Secondary Hypersomnia due to hypothalamic dysfunction. Although the levels of CSF orexin in PD have been previously examined, the results have been controversial, and no systematic investigation of CSF orexin excretion has been conducted on PD related disorders. In this study, orexin was measured in CSF collected by lumbar puncture in 62 patients with PD, 13 patients with dementia with Lewy bodies (DLB), 16 patients with progressive supranuclear palsy (PSP), and 7 patients with corticobasal degeneration (CBD). Levels of CSF orexin (mean ± SD pg/ml) were 302 ± 38 in PD, 297 ± 48 in DLB, 258 ± 37 in PSP, 246 ± 90 in CBD. The occurrence of low orexin levels (≤110pg/ml) was rare in both PD and DLB, and orexin levels were significantly lower in the PSP and CBD groups compared to PD (PSP: p

  • CSF orexin levels of Parkinson's disease, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal degeneration.
    Journal of the neurological sciences, 2006
    Co-Authors: Kenichi Yasui, Takashi Kanbayashi, Yuichi Inoue, Takashi Nomura, Masayoshi Kusumi, Kenji Nakashima
    Abstract:

    Excessive daytime sleepiness has been widely accepted as a common problem not only in Parkinson's disease (PD) but also in other related disorders. Lowered excretion of orexin A (hypocretin 1) into the cerebrospinal fluid (CSF) is known to play a pathological role in narcolepsy and Secondary Hypersomnia due to hypothalamic dysfunction. Although the levels of CSF orexin in PD have been previously examined, the results have been controversial, and no systematic investigation of CSF orexin excretion has been conducted on PD related disorders. In this study, orexin was measured in CSF collected by lumbar puncture in 62 patients with PD, 13 patients with dementia with Lewy bodies (DLB), 16 patients with progressive supranuclear palsy (PSP), and 7 patients with corticobasal degeneration (CBD). Levels of CSF orexin (mean+/-SD pg/ml) were 302+/-38 in PD, 297+/-48 in DLB, 258+/-37 in PSP, 246+/-90 in CBD. The occurrence of low orexin levels (

Takashi Kuroda - One of the best experts on this subject based on the ideXlab platform.

  • A case with anti-galactocerebroside antibody-positive Mycoplasma pneumoniae meningoencephalitis presenting Secondary Hypersomnia
    Neurological Sciences, 2012
    Co-Authors: Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki
    Abstract:

    Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasma-associated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with Hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient’s daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barré syndrome mediated by anti-glycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.

  • a case with anti galactocerebroside antibody positive mycoplasma pneumoniae meningoencephalitis presenting Secondary Hypersomnia
    Neurological Sciences, 2012
    Co-Authors: Naoto Sugeno, Norihiko Kawaguchi, Takafumi Hasegawa, Takashi Kuroda, Ichiro Nakashima, Takashi Kanbayashi, Susumu Kusunoki, Masashi Aoki
    Abstract:

    Galactocerebroside (Gal-C) is a major myelin component in the central nervous system. The anti-Gal-C antibody induced by mycoplasma infection may therefore be involved in the pathogenic mechanisms of mycoplasma-associated encephalitis. Here we report an adult case of mycoplasma encephalitis developing excessive daytime sleepiness. Brain MRI suggested that hypothalamic involvement was compatible with Hypersomnia. This finding was corroborated by decreased hypocretin-1 in cerebrospinal fluid (CSF) and the manifestation of diabetes insipidus. Screening for anti-glycolipid antibody profiles showed the selective increase of serum anti-Gal-C antibody. After treatment with minocyclin, the patient’s daytime sleepiness was markedly improved and the CSF hypocretin-1 level became almost normal, as well. It is known that CSF hypocretin-1 is decreased in Guillain-Barre syndrome mediated by anti-glycolipid antibody, suggesting a possible mechanistic link between anti-glycolipid antibodies and hypothalamic involvement. The present case further emphasizes the broad spectrum of neurological complications after mycoplasma infection.