Seizure

14,000,000 Leading Edge Experts on the ideXlab platform

Scan Science and Technology

Contact Leading Edge Experts & Companies

Scan Science and Technology

Contact Leading Edge Experts & Companies

The Experts below are selected from a list of 517254 Experts worldwide ranked by ideXlab platform

Fabrice Bartolomei - One of the best experts on this subject based on the ideXlab platform.

  • Self-control of epileptic Seizures by nonpharmacological strategies
    Epilepsy & Behavior, 2016
    Co-Authors: Iliana Kotwas, Fabrice Bartolomei, Aileen Mcgonigal, Agnses Trebuchon, Mireille Bastien-toniazzo, Yoko Nagai, Jean-arthur Micoulaud-franchi
    Abstract:

    Despite the unpredictability of epileptic Seizures, many patients report that they can anticipate Seizure occurrence. Using certain alert symptoms (i.e., auras, prodromes, precipitant factors), patients can adopt behaviors to avoid injury during and after the Seizure or may implement spontaneous cognitive and emotional strategies to try to control the Seizure itself. From the patient's view point, potential means of enhancing Seizure prediction and developing Seizure control supports are seen as very important issues, especially when the epilepsy is drug-resistant. In this review, we first describe how some patients anticipate their Seizures and whether this is effective in terms of Seizure prediction. Secondly, we examine how these anticipatory elements might help patients to prevent or control their Seizures and how the patient's neuropsychological profile, specifically parameters of perceived self-control (PSC) and locus of control (LOC), might impact these strategies and quality of life (QOL). Thirdly, we review the external supports that can help patients to better predict Seizures. Finally, we look at nonpharmacological means of increasing perceived self-control and achieving potential reduction of Seizure frequency (i.e., stress-based and arousal-based strategies). In the past few years, various approaches for detection and control of Seizures have gained greater interest, but more research is needed to confirm a positive effect on Seizure frequency as well as on QOL. (C) 2015 Elsevier Inc. All rights reserved.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure termination. Twenty-two Seizures from ten patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings (stereoelectroencephalography, SEEG). We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then we derived synchronization indices, namely global, thalamic, mesio-temporal and thalamo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p= 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike and wave pattern (SWP) at the end. They were associated to higher values of all synchronization indices and outputs from thalamus ( p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure termination via modulation of cortical synchronization. In the subgroup of SWP Seizures thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure termination.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in Neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure termination. Twenty-two Seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thala-mo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic " outputs and inputs " connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure termination via modulation of cortical synchronization. In the subgroup of SWP Seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure termination.

  • Semiologic and electrophysiologic correlations in temporal lobe Seizure subtypes.
    Epilepsia, 2004
    Co-Authors: Louis Maillard, Jean-pierre Vignal, Martine Gavaret, Maxime Guye, Arnaud Biraben, Aileen Mcgonigal, Patrick Chauvel, Fabrice Bartolomei
    Abstract:

    Summary: Purpose: The International League Against Epilepsy (ILAE) classification distinguishes medial and neocortical temporal lobe epilepsies. Among other criteria, this classification relies on the identification of two different electroclinical patterns, those of medial (limbic) and lateral (neocortical) temporal lobe Seizures, depending on the structure initially involved in the Seizure activity. Recent electrophysiologic studies have now identified Seizures in which medial and neocortical structures are both involved at Seizure onset. The purpose of the study was therefore to study the correlations of ictal semiology with the spatiotemporal pattern of discharge in temporal lobe Seizures. Methods: The 187 stereoelectroencephalography-recorded Seizures from 55 patients were analyzed. Patients were classified into three groups according to electrophysiologic findings: medial (M; Seizure onset limited to medial structures, n = 24), lateral (L; Seizure onset limited to lateral structures, n = 13), and medial-lateral (ML; Seizure onset involving both medial and lateral structures, n = 18). Clinical findings were compared between groups. Results: Initial epigastric sensation, initial fear, delayed oroalimentary and elementary upper limb automatisms, delayed loss of contact, long Seizure duration, and absent or rare secondary generalizations were associated with M Seizures. Initial auditory illusion or hallucination, initial loss of contact, shorter duration of Seizures, and more frequent generalizations were associated with L Seizures. Initial epigastric sensation, initial loss of contact, early oroalimentary and verbal automatisms, and long duration of Seizures were associated with ML Seizures. Conclusions: Although the syndrome of mesial temporal epilepsy is now relatively well defined, our findings support the idea that the organization of temporal lobe Seizures may be complex and that different patterns exist. We demonstrate three distinct patterns, characterized by both semiologic and electrophysiologic features. This distinction may help to define better the epileptogenic zone and the subsequent surgical procedure.

Elisa Evangelista - One of the best experts on this subject based on the ideXlab platform.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure termination. Twenty-two Seizures from ten patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings (stereoelectroencephalography, SEEG). We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then we derived synchronization indices, namely global, thalamic, mesio-temporal and thalamo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p= 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike and wave pattern (SWP) at the end. They were associated to higher values of all synchronization indices and outputs from thalamus ( p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure termination via modulation of cortical synchronization. In the subgroup of SWP Seizures thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure termination.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in Neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure termination. Twenty-two Seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thala-mo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic " outputs and inputs " connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure termination via modulation of cortical synchronization. In the subgroup of SWP Seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure termination.

Shlomo Shinnar - One of the best experts on this subject based on the ideXlab platform.

  • the association between Seizure clustering and convulsive status epilepticus in patients with intractable complex partial Seizures
    Epilepsia, 1999
    Co-Authors: Sheryl R Haut, Shlomo Shinnar, Solomon L Moshe, Christine Odell, Alan D Legatt
    Abstract:

    Summary: Purpose: We examined the association between Seizure clustering and convulsive status epilepticus (SE) in patients with intractable complex partial Seizures, to identify whether patients whose Seizures typically cluster are at high risk for convulsive SE (CSE). Methods: Seventy-six patients with intractable complex partial epilepsy who underwent presurgical evaluation in the Montefiore Epilepsy Management Unit from 1993 to 1997 were contacted and interviewed about typical Seizure frequency and distribution and history of CSE. Seizure clustering was defined as three or more complex partial Seizures within a 24-h period, with return to baseline between Seizures. Results: Of the 76 patients contacted, 21 (28%) had experienced at least one episode of CSE, and 36 (47%) typically experienced clustered Seizures. SE occurred in 16 (44%) of 36 patients with clustered Seizures, and in five (12.5%) of 40 patients with nonclustered Seizures (p < 0.002). Of 53 patients with temporal lobe epilepsy, CSE occurred in 13 (50%) of 26 patients with clustered Seizures, and four (14.8%) of 27 patients with nonclustered Seizures (p < 0.006). Conclusions: Patients with intractable complex partial or localization-related epilepsy who typically experience Seizure clustering are at a significantly higher risk for CSE than are patients with nonclustered Seizures.

  • brief communication the association between Seizure clustering and convulsive status epilepticus in patients with intractable complex partial Seizures
    1999
    Co-Authors: R Haut, Shlomo Shinnar, Solomon L Mosh, Alan D Legatt
    Abstract:

    Summary: Purpose: We examined the association between Seizure clustering and convulsive status epilepticus (SE) in patients with intractable complex partial Seizures, to identify whether patients whose Seizures typically cluster are at high risk for convulsive SE (CSE). Methods: Seventy-six patients with intractable complex partial epilepsy who underwent presurgical evaluation in the Montefiore Epilepsy Management Unit from 1993 to 1997 were contacted and interviewed about typical Seizure frequency and distribution and history of CSE. Seizure clustering was defined as three or more complex partial Seizures within a 24-h period, with return to baseline between Seizures. Results: Of the 76 patients contacted, 21 (28%) had experienced at least one episode of CSE, and 36 (47%) typically experienced clustered Seizures. SE occurred in 16 (44%) of 36 patients with clustered Seizures, and in five (12.5%) of 40 patients with nonclustered Seizures (p < 0.002). Of 53 patients with temporal lobe epilepsy, CSE occurred in 13 (50%) of 26 patients with clustered Seizures, and four (14.8%) of 27 patients with nonclustered Seizures (p < 0.006). Conclusions: Patients with intractable complex partial or localization-related epilepsy who typically experience Seizure clustering are at a significantly higher risk for CSE than are patients with nonclustered Seizures. Key Words: Clustered Seizures-Status epilepticus-Intractable epilepsy-Partial Seizures-Temporal lobe epilepsy.

  • Seizures with fever after unprovoked Seizures: an analysis in children followed from the time of a first febrile Seizure.
    Epilepsia, 1998
    Co-Authors: Anne T. Berg, Amy S. Darefsky, Theodore R. Holford, Shlomo Shinnar
    Abstract:

    Summary: Purpose: To determine how the onset of unprovoked Seizures influences recurrence of Seizures with fever in children followed from the time of a first febrile Seizure. Methods: In a prospective cohort of children (n = 428) identified at the time of a first febrile Seizure, predictors of a second Seizure with fever were identified. The occurrence of a first unprovoked Seizure was treated as a time-dependent covariate in a Cox regression model rather than as a censoring point as it traditionally has been in the past. Results: One hundred forty-three (33.4%) children had further Seizures. Seven had further Seizures with fever only after onset of unprovoked Seizures. After adjustment was made for the four previously described predictors of recurrent febrile Seizures (age at onset, family history, height of fever, and duration of fever), the onset of unprovoked Seizures was associated with a rate ratio of 3.47 (p = 0.0015), indicating a large increase in the risk of further Seizures with fever after onset of unprovoked Seizures. Conclusions: Young children who develop unprovoked Seizures after a febrile Seizure are at substantial risk for further Seizures with fever. This may represent part of the spectrum of benign febrile Seizures or it may represent the so-called “epilepsy triggered by fever” spectrum. It affects only a small proportion of children with febrile Seizures; however, in some children, it may be useful information to consider when making treatment decisions.

  • Unprovoked Seizures in children with febrile Seizures : Short-term outcome
    Neurology, 1996
    Co-Authors: Anne T. Berg, Shlomo Shinnar
    Abstract:

    Background: Febrile Seizures affect 2 to 4% of children, and 2 to 10% develop subsequent unprovoked Seizures. Secondary analyses of two large cohorts identified neurodevelopmental abnormalities, complex febrile Seizures, and a family history of epilepsy as predictors of unprovoked Seizures. We present an analysis of children prospectively followed from their first febrile Seizure to reassess these three factors, examine factors of equivocal importance, and assess the importance of some new factors that we identified as predictors of recurrent febrile Seizures. Methods: Children (N = 428) were prospectively identified for a first febrile Seizure through pediatric emergency departments of four hospitals. Information was collected from medical records and interviews with parents. Children were followed for 2 years or more. Results: Unprovoked Seizures occurred in 26 (6%). Neurodevelopmental abnormalities, complex febrile Seizures, and a family history of epilepsy were associated with an increased risk of unprovoked Seizures. Recurrent febrile Seizures and brief duration of fever before the initial febrile Seizure were also risk factors. A family history of febrile Seizures, temperature and age at the initial febrile Seizure, sex, and race were not associated with unprovoked Seizures. Conclusions: We confirmed the increased risk associated with traditionally accepted predictors of epilepsy following febrile Seizures. Also, the risk clearly increased with recurrent febrile Seizures. In general, predictors of subsequent unprovoked Seizures differ from predictors of recurrent febrile Seizures. One notable exception, brief duration of fever before the initial febrile Seizure, predicts both types of outcome and may be a marker for an increased susceptibility to Seizures. NEUROLOGY 1996;47: 562-568

Bruno Colombet - One of the best experts on this subject based on the ideXlab platform.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure termination. Twenty-two Seizures from ten patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings (stereoelectroencephalography, SEEG). We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then we derived synchronization indices, namely global, thalamic, mesio-temporal and thalamo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p= 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike and wave pattern (SWP) at the end. They were associated to higher values of all synchronization indices and outputs from thalamus ( p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure termination via modulation of cortical synchronization. In the subgroup of SWP Seizures thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure termination.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in Neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure termination. Twenty-two Seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thala-mo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic " outputs and inputs " connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure termination via modulation of cortical synchronization. In the subgroup of SWP Seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure termination.

Romain Carron - One of the best experts on this subject based on the ideXlab platform.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure termination. Twenty-two Seizures from ten patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings (stereoelectroencephalography, SEEG). We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then we derived synchronization indices, namely global, thalamic, mesio-temporal and thalamo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic “outputs and inputs” connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p= 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike and wave pattern (SWP) at the end. They were associated to higher values of all synchronization indices and outputs from thalamus ( p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure termination via modulation of cortical synchronization. In the subgroup of SWP Seizures thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure termination.

  • Does the Thalamo-Cortical Synchrony Play a Role in Seizure Termination?
    Frontiers in Neurology, 2015
    Co-Authors: Elisa Evangelista, Christian Bénar, Francesca Bonini, Romain Carron, Bruno Colombet, Jean Régis, Fabrice Bartolomei
    Abstract:

    The mechanisms underlying Seizure termination are still unclear despite their therapeutic importance. We studied thalamo-cortical connectivity and synchrony in human mesial temporal lobe Seizures in order to analyze their role in Seizure termination. Twenty-two Seizures from 10 patients with drug-resistant mesial temporal lobe epilepsy undergoing pre-surgical evaluation were analyzed using intracerebral recordings [stereoelectroencephalography (SEEG)]. We performed a measure of SEEG signal interdependencies (non-linear correlation), to estimate the functional connectivity between thalamus and cortical regions. Then, we derived synchronization indices, namely global, thalamic, mesio-temporal, and thala-mo-mesio temporal index at the onset and the end of Seizures. In addition, an estimation of thalamic " outputs and inputs " connectivity was proposed. Thalamus was consistently involved in the last phase of all analyzed Seizures and thalamic synchronization index was significantly more elevated at the end of Seizure than at the onset. The global synchronization index at the end of Seizure negatively correlated with Seizure duration (p = 0.045) and in the same way the thalamic synchronization index showed an inverse tendency with Seizure duration. Six Seizures out of twenty-two displayed a particular thalamo-cortical spike-and-wave pattern at the end. They were associated to higher values of all synchronization indices and outputs from thalamus (p = 0.0079). SWP Seizures displayed a higher and sustained increase of cortical and thalamo-cortical synchronization with a stronger participation of thalamic outputs. We suggest that thalamo-cortical oscillations might contribute to Seizure termination via modulation of cortical synchronization. In the subgroup of SWP Seizures, thalamus may exert a control on temporal lobe structures by inducing a stable hypersynchronization that ultimately leads to Seizure termination.