The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
Raja Azadar Hussain - One of the best experts on this subject based on the ideXlab platform.
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Comparative DNA binding and antioxidant studies of acetyl and benzoyl substituted ferrocene incorporated Selenoureas
Russian Journal of Electrochemistry, 2015Co-Authors: Raja Azadar Hussain, Amin Badshah, Kamran AkbarAbstract:In this article we have reported synthesis, chemical characterization (^1H and ^13C NMR, FTIR, CHNS, AAS), DNA binding (with cyclic voltammetry, UV-vis spectroscopy, viscometry and molecular docking) and antioxidant (1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging) activities of two ferrocene incorporated Selenoureas namely 1-benzoyl-3-(4-ferrocenylphenyl)Selenourea (PB) and 1-acetyl-3-(4-ferrocenylphenyl)Selenourea (PA). PA has a DNA binding constant value of 4.510 × 10^4 M^−1 which is lower than DNA binding constant of PB (7.691 × 10^4 M^−1). DNA binding constant was calculated by a decrease in the peak current of compound-DNA adduct relative to the free compound in cyclic voltammetry. Diffusion coefficient of free PA is 1.14 × 10^−5 cm^2 s^−1 which is greater than diffusion coefficient of PA-DNA adduct (2.1 × 10^−6 cm^2 s^−1) and same is the case with free PB (5.41 × 10^−5 cm^2 s^−1) and PB-DNA adduct (4.57 × 10^−5 cm^2 s^−1). IC_50 value of PA (50 μM) was found lower than PB (130 μM) for DPPH scavenging.
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Effect of surfactants on the morphology of FeSe films fabricated from a single source precursor by aerosol assisted chemical vapour deposition
Journal of Chemical Sciences, 2015Co-Authors: Raja Azadar Hussain, Amin Badshah, Naghma Haider, Malik Dilshad KhanAbstract:This article presents the fabrication of FeSe thin films from a single source precursor namely (1-(2-fluorobenzoyl)-3-(4-ferrocenyl-3-methylphenyl)Selenourea (MeP2F)) by aerosol assisted chemical vapour deposition (AACVD). All the films were prepared via similar experimental conditions (temperature, flow rate, concentration, solvent system and reactor type) except the use of three different concentrations of two different surfactants i.e., triton and span. Seven thin films were characterized with PXRD, SEM, AFM, EDS and EDS mapping. The mechanism of the interaction of surfactant with MeP2F was determined with cyclic voltammetry (CV) and UV-Vis spectroscopy. Graphical Abstract Morphological studies of FeSe thin films fabricated from a single source ferrocene-incorporated Selenourea precursor under the influence of two surfactants viz., triton and span are presented.
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iron selenide nanoparticles coated on carbon nanotubes from single source ferrocene incorporated Selenourea precursor for fuel cell and photocatalytic applications
Journal of Organometallic Chemistry, 2014Co-Authors: Raja Azadar Hussain, Amin Badshah, Shafiqullah Marwat, Farida Yasmin, Muhammad Nawaz TahirAbstract:Abstract This article presents the synthesis and characterization (multinuclear NMR, FTIR, CHNS, AAS and single crystal XRD) of a single source organometallic precursor namely 1-(4-methylbenzoyl)-3-(3-ferrocenylphenyl)Selenourea for the fabrication of iron selenide (FeSe) nanoparticles (NPs) supported on multi walled carbon nanotubes (MWCNTs) which were characterized with XRD, SEM and TEM with fuel cell and photocatalytic applications.
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Synthesis and biological applications of Selenoureas
Applied Organometallic Chemistry, 2014Co-Authors: Raja Azadar Hussain, Amin Badshah, Afzal ShahAbstract:In this review article we have discussed synthesis, free radical scavenging, enzyme inhibition, anticancer activity, DNA binding of Selenoureas and detection of selenium species. We have given the structure and activity relationships of different Selenoureas with each other and with their sulfur homologues (thioureas). Copyright © 2014 John Wiley & Sons, Ltd.
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Synthesis, chemical characterization, DNA binding, antioxidant, antibacterial, and antifungal activities of ferrocence incorporated Selenoureas.
Journal of Biochemical and Molecular Toxicology, 2013Co-Authors: Raja Azadar Hussain, Tamoor-ul Hassan, Muhammad Nawaz Tahir, Amin Badshah, Asghari BanoAbstract:Ferrocene-incorporated Selenoureas 1-(4-methoxybenzoyl)-3-(4-ferrocenylphenyl)Selenourea (P4Me), 1-(3-methoxybenzoyl)-3-(4-ferrocenylphenyl)Selenourea (P3Me), and 1-(2-methoxybenzoyl)-3-(4-ferrocenylphenyl)Selenourea (P2Me) were synthesized and characterized by nuclear magnetic resonance, Fourier transform infrared spectroscopy, atomic absorption spectroscopy, CHNS, and single-crystal X-ray diffraction. DNA interaction of the compounds was investigated with cyclic voltammetry, UV–visible spectroscopy, and viscometry, which is a prerequisite for anticancer agents. Drug-DNA binding constant was found to vary in the sequence: KP4Me (4.9000 × 104 M−1) > KP2Me (2.318 × 104 M−1) > KP3Me (1.296 × 104 M−1). Antioxidant (1,1-diphenyl-2-picrylhydrazyl), antifungal (against Faussarium solani and Helmentosporium sativum), and antibacterial (against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Bacillus subtilis) activities have also been reported in addition.
Marta Diaz - One of the best experts on this subject based on the ideXlab platform.
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synthesis and leishmanicidal activity of novel urea thiourea and Selenourea derivatives of diselenides
Antimicrobial Agents and Chemotherapy, 2019Co-Authors: Marta Diaz, Hector De Lucio, Esther Moreno, Socorro Espuelas, Carlos Aydillo, Antonio Jimenezruiz, Miguel A Toro, Killian Jesus Gutierrez, Victor Martinezmerino, Alfonso CornejoAbstract:: A novel series of thirty-one N-substituted urea, thiourea, and Selenourea derivatives containing diphenyldiselenide entities were synthesized, fully characterized by spectroscopic and analytical methods, and screened for their in vitro leishmanicidal activities. The cytotoxic activity of these derivatives was tested against Leishmania infantum axenic amastigotes, and selectivity was assessed in human THP-1 cells. Thirteen of the synthesized compounds showed a significant antileishmanial activity, with 50% effective concentration (EC50) values lower than that for the reference drug miltefosine (EC50, 2.84 μM). In addition, the derivatives 9, 11, 42, and 47, with EC50 between 1.1 and 1.95 μM, also displayed excellent selectivity (selectivity index ranged from 12.4 to 22.7) and were tested against infected macrophages. Compound 11, a derivative with a cyclohexyl chain, exhibited the highest activity against intracellular amastigotes, with EC50 values similar to those observed for the standard drug edelfosine. Structure-activity relationship analyses revealed that N-aliphatic substitution in urea and Selenourea is recommended for the leishmanicidal activity of these analogs. Preliminary studies of the mechanism of action for the hit compounds was carried out by measuring their ability to inhibit trypanothione reductase. Even though the obtained results suggest that this enzyme is not the target for most of these derivatives, their activity comparable to that of the standards and lack of toxicity in THP-1 cells highlight the potential of these compounds to be optimized for leishmaniasis treatment.
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thermal stability and decomposition of urea thiourea and Selenourea analogous diselenide derivatives
Journal of Thermal Analysis and Calorimetry, 2017Co-Authors: Marta Diaz, Juan Antonio Palop, Carmen Sanmartin, Elena LizarragaAbstract:The fusion and thermal decomposition of thirty-three diselenide compounds with a urea, thiourea or Selenourea group linked with different aliphatic or aromatic substituents have been studied by thermogravimetry, differential scanning calorimetry and mass spectrometry in order to perform comparative thermal stability studies among analogs. A relationship has been found between stability and a series of effects which occur in the compound structures. Analysis of the thermal data indicated that: (a) in general, compounds with a urea or Selenourea group are more stable than those with a thiourea group; (b) no difference in stability exists when an aromatic or aliphatic group is linked to the thiourea group but when linked to the urea or Selenourea groups, stability does differ; (c) Selenourea compounds with aliphatic chain are the most unstable; and (d) the nature of the substituent located on the benzyl ring has no effects on thermal stability. Therefore, criteria for the selection of substituents can be established in order to improve the stability of these drugs. In addition, the mass spectral fragmentation in comparison with thermal analytical data helps in confirming the thermal behavior of the compounds.
Hideharu Ishihara - One of the best experts on this subject based on the ideXlab platform.
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Preparation of 2 -amino -4H-5,6 -dihydro -1,3 -selenazin -4 -ones by reaction of N,N-unsubstituted Selenoureas with α,β-unsaturated acid chlorides
Synthesis, 2007Co-Authors: Koichi Kanoh, Hideharu Ishihara, Mamoru KoketsuAbstract:2-Dialkylamino-4 H-5,6-dihydro-1,3-selenazin-4-ones were obtained by the reaction of N,N-unsubstituted Selenoureas with α,β-unsaturated acid chlorides at room temperature.
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Efficient synthesis of Selenoureas from the corresponding carbodiimides
Synthetic Communications, 2006Co-Authors: Mamoru Koketsu, Naotaka Takakura, Hideharu IshiharaAbstract:Selenoureas were synthesized by the reaction of carbodiimides with LiAlHSeH in the presence of hydrogen chloride.
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A facile synthesis of 2‐amino‐1,3‐selenazole by reaction of N,N‐unsubstituted Selenourea with ketone
Heteroatom Chemistry, 2006Co-Authors: Mamoru Koketsu, Koichi Kanoh, Hiromune Ando, Hideharu IshiharaAbstract:2-Dialkylamino-1,3-selenazoles were yielded by the reaction of N,N-unsubstituted Selenoureas with ketones in the presence of ferric chloride. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:88–92, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20180
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a facile synthesis of 2 amino 1 3 selenazole by reaction of n n unsubstituted Selenourea with ketone
Heteroatom Chemistry, 2006Co-Authors: Mamoru Koketsu, Koichi Kanoh, Hiromune Ando, Hideharu IshiharaAbstract:2-Dialkylamino-1,3-selenazoles were yielded by the reaction of N,N-unsubstituted Selenoureas with ketones in the presence of ferric chloride. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:88–92, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20180
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Selenoureas and thioureas are effective superoxide radical scavengers in vitro
Life Sciences, 2005Co-Authors: Hitoe Takahashi, Atsuyoshi Nishina, Mamoru Koketsu, Hirokazu Kimura, Ryo-hei Fukumoto, Hideharu IshiharaAbstract:Abstract Oxygen radicals, such as superoxide radicals, embellishing DNA, protein, lipids, etc., and carrying out the obstacle of the function of a cell is known. It depends for the oxidant level in the living body on the balance of a generation system and an elimination system of oxygen radicals, and research which controls an oxidant level in the living body is briskly done by taking in the substance which eliminates an oxygen radical. We investigated scavenging effects of superoxide radicals by Selenoureas and thioureas using a highly sensitive and quantitative chemiluminescence method. At 330 nM, five Selenoureas and five thioureas scavenged fractions of superoxide radicals (O 2 − ) ranging from 8.4% to 87.6%. Among five N , N -unsubstituted Selenoureas and N , N -unsubstituted thioureas 1-selenocarbamoylpiperidine and 1-thiocarbamoylpyrrolidine were the most effective scavengers. A possibility that Selenoureas could use it as a new superoxide anion-scavenging substance from the result of this research became clear.
Mamoru Koketsu - One of the best experts on this subject based on the ideXlab platform.
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superoxide radical scavenging effects from polymorphonuclear leukocytes and toxicity in human cell lines of newly synthesized organic selenium compounds
FEBS Journal, 2007Co-Authors: Hiroyuki Tsukagoshi, Atsuyoshi Nishina, Masahiko Kato, Mamoru Koketsu, Masahiko Kurabayashi, Hirokazu KimuraAbstract:Synthetic organic selenium compounds such as 2-phenyl-1,2-benzisoselenazol-3(2H)-one may show glutathione peroxidase-like antioxidant activity. Recently, we synthesized new organic selenium compounds that are thought to be effective antioxidants. To study their possible applications as antioxidants, we evaluated two Selenoureas, N,N-dimethylSelenourea and 1-selenocarbamoylpyrrolidine, and two tertiary selenoamides, N-(phenylselenocarbonyl)-piperidine and N,N-diethyl-4-chloroselenobenzamide, for their superoxide radical (O2–)-scavenging effects and toxicity. We measured O2–-scavenging effects in polymorphonuclear leukocytes (PMNs) with a specific, sensitive and real-time kinetic chemiluminescence method. Furthermore, the toxicity of these compounds was measured in some human cell lines and PMNs using the tetrazolium method. Hydrogen peroxide was measured by a scopoletin method. Finally, translocation of an NADPH oxidase component, p47 phagocyte oxidase, to the cell membrane was investigated by confocal laser scanning microscopy. N,N-DimethylSelenourea and 1-selenocarbamoylpyrrolidine effectively scavenged O2– released from 4β-phorbol 12-myristate 13-acetate-stimulated PMNs, and the 50% inhibitory concentrations were 6.8 ± 2.2 and 6.5 ± 2.5 µm, respectively. N-(Phenylselenocarbonyl)-piperidine and N,N-diethyl-4-chloroselenobenzamide also effectively scavenged O2– from PMNs, and the 50% inhibitory concentrations were 11.3 ± 4.8 and 20.3 ± 6.4 µm, respectively. Selenoureas showed very low toxicity in human cell lines and PMNs, even at high concentrations, whereas tertiary selenoamides were cytotoxic. These compounds did not produce significant amounts of hydrogen peroxide from 4β-phorbol 12-myristate 13-acetate-stimulated PMNs. None of the compounds significantly affected the translocation of p47 phagocyte oxidase. Selenoureas acted as effective antioxidants and showed low toxicity in some human cells. Thus, these compounds might be new candidates as antioxidative substances.
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Preparation of 2 -amino -4H-5,6 -dihydro -1,3 -selenazin -4 -ones by reaction of N,N-unsubstituted Selenoureas with α,β-unsaturated acid chlorides
Synthesis, 2007Co-Authors: Koichi Kanoh, Hideharu Ishihara, Mamoru KoketsuAbstract:2-Dialkylamino-4 H-5,6-dihydro-1,3-selenazin-4-ones were obtained by the reaction of N,N-unsubstituted Selenoureas with α,β-unsaturated acid chlorides at room temperature.
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Efficient synthesis of Selenoureas from the corresponding carbodiimides
Synthetic Communications, 2006Co-Authors: Mamoru Koketsu, Naotaka Takakura, Hideharu IshiharaAbstract:Selenoureas were synthesized by the reaction of carbodiimides with LiAlHSeH in the presence of hydrogen chloride.
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A facile synthesis of 2‐amino‐1,3‐selenazole by reaction of N,N‐unsubstituted Selenourea with ketone
Heteroatom Chemistry, 2006Co-Authors: Mamoru Koketsu, Koichi Kanoh, Hiromune Ando, Hideharu IshiharaAbstract:2-Dialkylamino-1,3-selenazoles were yielded by the reaction of N,N-unsubstituted Selenoureas with ketones in the presence of ferric chloride. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:88–92, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20180
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a facile synthesis of 2 amino 1 3 selenazole by reaction of n n unsubstituted Selenourea with ketone
Heteroatom Chemistry, 2006Co-Authors: Mamoru Koketsu, Koichi Kanoh, Hiromune Ando, Hideharu IshiharaAbstract:2-Dialkylamino-1,3-selenazoles were yielded by the reaction of N,N-unsubstituted Selenoureas with ketones in the presence of ferric chloride. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:88–92, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20180
Elena Lizarraga - One of the best experts on this subject based on the ideXlab platform.
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thermal stability and decomposition of urea thiourea and Selenourea analogous diselenide derivatives
Journal of Thermal Analysis and Calorimetry, 2017Co-Authors: Marta Diaz, Juan Antonio Palop, Carmen Sanmartin, Elena LizarragaAbstract:The fusion and thermal decomposition of thirty-three diselenide compounds with a urea, thiourea or Selenourea group linked with different aliphatic or aromatic substituents have been studied by thermogravimetry, differential scanning calorimetry and mass spectrometry in order to perform comparative thermal stability studies among analogs. A relationship has been found between stability and a series of effects which occur in the compound structures. Analysis of the thermal data indicated that: (a) in general, compounds with a urea or Selenourea group are more stable than those with a thiourea group; (b) no difference in stability exists when an aromatic or aliphatic group is linked to the thiourea group but when linked to the urea or Selenourea groups, stability does differ; (c) Selenourea compounds with aliphatic chain are the most unstable; and (d) the nature of the substituent located on the benzyl ring has no effects on thermal stability. Therefore, criteria for the selection of substituents can be established in order to improve the stability of these drugs. In addition, the mass spectral fragmentation in comparison with thermal analytical data helps in confirming the thermal behavior of the compounds.