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Pabla Noblia - One of the best experts on this subject based on the ideXlab platform.
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vanadium v complexes with salicylaldehyde Semicarbazone derivatives bearing in vitro anti tumor activity toward kidney tumor cells tk 10 crystal structure of vvo2 5 bromosalicylaldehyde Semicarbazone
Journal of Inorganic Biochemistry, 2005Co-Authors: Pabla Noblia, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Marisol Vieites, Beatriz S Parajoncosta, Enrique J Baran, Patricia Draper, Amaia AzquetaAbstract:As a contribution to the development of novel vanadium complexes with pharmacologically interesting moieties, new dioxovanadium(V) Semicarbazone complexes with the formula cis-VO2L, where L = 5-bromosalicylaldehyde Semicarbazone and 2-hydroxynaphtalen-1-carboxaldehyde Semicarbazone have been synthesized and characterized by 1H and 13C NMR, Raman and FTIR spectroscopies. Results were compared with those previously reported for other three analogous complexes of this series. The five complexes were tested in three different human tumor cell lines for bioactivity as potential anti-tumor agents, showing selective cytotoxicity on TK-10 cell line. Results showed that structural modifications on the Semicarbazone moiety could have a significant effect on the anti-tumor activity of the vanadium complexes. In addition, the electrochemical behavior of all the complexes was studied. No apparent correlation could be demonstrated between reduction potentials of the complexes and their anti-tumor activities. The molecular structure of the novel [VVO2(5-bromosalicylaldehyde Semicarbazone)] complex was solved by X-ray diffraction methods. The vanadium atom shows a distorted square pyramidal coordination sphere. The (VO2)+ cation is coordinated to a nearly planar (L)− anion acting as a tridentate ligand through both oxygen and one nitrogen atoms.
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new vanadium v complexes with salicylaldehyde Semicarbazone derivatives synthesis characterization and in vitro insulin mimetic activity crystal structure of vvo2 salicylaldehyde Semicarbazone
European Journal of Inorganic Chemistry, 2004Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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New Vanadium(V) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin‐Mimetic Activity − Crystal Structure of [VvO2(salicylaldehyde Semicarbazone)]
European Journal of Inorganic Chemistry, 2003Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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new rhenium v nitrofuryl Semicarbazone complexes crystal structure of reocl2 pph3 3 5 nitrofuryl acroleine Semicarbazone
Zeitschrift für anorganische und allgemeine Chemie, 2003Co-Authors: Lucia Otero, Pabla Noblia, Dinorah Gambino, Hugo Cerecetto, Mercedes Gonzalez, Roberto A Sanchezdelgado, Eduardo E Castellano, Oscar E PiroAbstract:The synthesis and characterization of the first two Re complexes with Semicarbazone ligands is presented. Selected ligands are 5-Nitro-2-furaldehyde Semicarbazone (Nitrofurazone) (L1) and its derivative 3-(5-Nitrofuryl)acroleine Semicarbazone (L2). Complexes of general formula [ReVOCl2(PPh3)L], where L = L1 and L2, were prepared in good yields and high purity by reaction of [ReVOCl3(PPh3)2] with L in ethanol or methanol solutions. The complexes formula and molecular structures were supported by elemental analyses and electronic, FTIR, 1H, 13C and 31P NMR spectroscopies. In addition, the crystal and molecular structure of [ReVOCl2(PPh3)L2] was determined by X-ray diffraction methods. [ReOCl2(PPh3)(3-(5-Nitrofuryl)acroleine Semicarbazone)] crystallizes in the space group P-1 with a = 11.2334(2), b = 11.3040(2), c = 12.5040(2) A, α = 81.861(1), β = 63.555(1), γ = 83.626(1)°, and Z = 2. The Re(V) ion is in a distorted octahedral environment, equatorially coordinated to a deprotonated Semicarbazone molecule acting as a bidentate ligand through its carbonylic oxygen and azomethynic nitrogen atoms, to an oxo ligand and a chlorine atom. The six-fold coordination is completed by another chlorine atom and a triphenylphosphine ligand at the axial positions. Neue Rhenium(V)-Nitrofuryl-semicarbazon-Komplexe. Kristallstruktur von [ReOCl2(PPh3){3-(5-Nitrofuryl)acrolein-semibarbazon}] Die Synthese und die Charakterisierung der ersten beiden Re-Komplexe mit Semicarbazon-Liganden wird beschrieben. Die ausgewahlten Liganden sind 5-Nitro-2-furaldehyd-semicarbazon (Nitrofurazon) (L1) und sein Derivat 3-(5-Nitrofuryl)acrolein-semicarbazon (L2). Die Komplexe der allgemeinen Formel [ReVOCl2(PPh3)L] mit L = L1 und L2 wurden in guten Ausbeuten und hoher Reinheit durch Reaktion von [ReVOCl3(PPh3)2] mit L in Ethanol- oder Methanollosungen hergestellt. Die Komplexformeln und die Molekulstrukturen werden durch Elementaranalysen und Elektronen-FTIR-, 1H-, 13C- und 31P-NMR-Spektroskopie gestutzt. Zusatzlich wird die Kristall- und Molekulstruktur von [ReVOCl2(PPh3)L2] durch Rontgenmethoden ermittelt. [ReOCl2(PPh3){3-(5-Nitrofuryl)acrolein-semicarbazon}] kristallisiert in der Raumgruppe P1¯ mit a = 11, 2334(2); b = 11, 3040(2); c = 12.5040(2) A; α = 81, 861(1); β = 63, 555(1); γ = 83, 626(1)° und Z = 2. Das Rheniumatom befindet sich in verzerrt oktaedrischer Umgebung, es ist aquatorial durch den deprotonierten, als zweizahnig fungierenden Semicarbazon-Liganden mittels des Carbonylsauerstoffatoms und des Azomethin-Stickstoffatoms koordiniert sowie durch den Oxo- und einen Chloroliganden. Die Sechsfachkoordination wird durch ein weiteres Chloratom und durch den Triphenylphosphin-Liganden in den Axialpositionen erganzt.
Yusuke Adachi - One of the best experts on this subject based on the ideXlab platform.
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new vanadium v complexes with salicylaldehyde Semicarbazone derivatives synthesis characterization and in vitro insulin mimetic activity crystal structure of vvo2 salicylaldehyde Semicarbazone
European Journal of Inorganic Chemistry, 2004Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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New Vanadium(V) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin‐Mimetic Activity − Crystal Structure of [VvO2(salicylaldehyde Semicarbazone)]
European Journal of Inorganic Chemistry, 2003Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
Eduardo E Castellano - One of the best experts on this subject based on the ideXlab platform.
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vanadium v complexes with salicylaldehyde Semicarbazone derivatives bearing in vitro anti tumor activity toward kidney tumor cells tk 10 crystal structure of vvo2 5 bromosalicylaldehyde Semicarbazone
Journal of Inorganic Biochemistry, 2005Co-Authors: Pabla Noblia, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Marisol Vieites, Beatriz S Parajoncosta, Enrique J Baran, Patricia Draper, Amaia AzquetaAbstract:As a contribution to the development of novel vanadium complexes with pharmacologically interesting moieties, new dioxovanadium(V) Semicarbazone complexes with the formula cis-VO2L, where L = 5-bromosalicylaldehyde Semicarbazone and 2-hydroxynaphtalen-1-carboxaldehyde Semicarbazone have been synthesized and characterized by 1H and 13C NMR, Raman and FTIR spectroscopies. Results were compared with those previously reported for other three analogous complexes of this series. The five complexes were tested in three different human tumor cell lines for bioactivity as potential anti-tumor agents, showing selective cytotoxicity on TK-10 cell line. Results showed that structural modifications on the Semicarbazone moiety could have a significant effect on the anti-tumor activity of the vanadium complexes. In addition, the electrochemical behavior of all the complexes was studied. No apparent correlation could be demonstrated between reduction potentials of the complexes and their anti-tumor activities. The molecular structure of the novel [VVO2(5-bromosalicylaldehyde Semicarbazone)] complex was solved by X-ray diffraction methods. The vanadium atom shows a distorted square pyramidal coordination sphere. The (VO2)+ cation is coordinated to a nearly planar (L)− anion acting as a tridentate ligand through both oxygen and one nitrogen atoms.
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new vanadium v complexes with salicylaldehyde Semicarbazone derivatives synthesis characterization and in vitro insulin mimetic activity crystal structure of vvo2 salicylaldehyde Semicarbazone
European Journal of Inorganic Chemistry, 2004Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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New Vanadium(V) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin‐Mimetic Activity − Crystal Structure of [VvO2(salicylaldehyde Semicarbazone)]
European Journal of Inorganic Chemistry, 2003Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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new rhenium v nitrofuryl Semicarbazone complexes crystal structure of reocl2 pph3 3 5 nitrofuryl acroleine Semicarbazone
Zeitschrift für anorganische und allgemeine Chemie, 2003Co-Authors: Lucia Otero, Pabla Noblia, Dinorah Gambino, Hugo Cerecetto, Mercedes Gonzalez, Roberto A Sanchezdelgado, Eduardo E Castellano, Oscar E PiroAbstract:The synthesis and characterization of the first two Re complexes with Semicarbazone ligands is presented. Selected ligands are 5-Nitro-2-furaldehyde Semicarbazone (Nitrofurazone) (L1) and its derivative 3-(5-Nitrofuryl)acroleine Semicarbazone (L2). Complexes of general formula [ReVOCl2(PPh3)L], where L = L1 and L2, were prepared in good yields and high purity by reaction of [ReVOCl3(PPh3)2] with L in ethanol or methanol solutions. The complexes formula and molecular structures were supported by elemental analyses and electronic, FTIR, 1H, 13C and 31P NMR spectroscopies. In addition, the crystal and molecular structure of [ReVOCl2(PPh3)L2] was determined by X-ray diffraction methods. [ReOCl2(PPh3)(3-(5-Nitrofuryl)acroleine Semicarbazone)] crystallizes in the space group P-1 with a = 11.2334(2), b = 11.3040(2), c = 12.5040(2) A, α = 81.861(1), β = 63.555(1), γ = 83.626(1)°, and Z = 2. The Re(V) ion is in a distorted octahedral environment, equatorially coordinated to a deprotonated Semicarbazone molecule acting as a bidentate ligand through its carbonylic oxygen and azomethynic nitrogen atoms, to an oxo ligand and a chlorine atom. The six-fold coordination is completed by another chlorine atom and a triphenylphosphine ligand at the axial positions. Neue Rhenium(V)-Nitrofuryl-semicarbazon-Komplexe. Kristallstruktur von [ReOCl2(PPh3){3-(5-Nitrofuryl)acrolein-semibarbazon}] Die Synthese und die Charakterisierung der ersten beiden Re-Komplexe mit Semicarbazon-Liganden wird beschrieben. Die ausgewahlten Liganden sind 5-Nitro-2-furaldehyd-semicarbazon (Nitrofurazon) (L1) und sein Derivat 3-(5-Nitrofuryl)acrolein-semicarbazon (L2). Die Komplexe der allgemeinen Formel [ReVOCl2(PPh3)L] mit L = L1 und L2 wurden in guten Ausbeuten und hoher Reinheit durch Reaktion von [ReVOCl3(PPh3)2] mit L in Ethanol- oder Methanollosungen hergestellt. Die Komplexformeln und die Molekulstrukturen werden durch Elementaranalysen und Elektronen-FTIR-, 1H-, 13C- und 31P-NMR-Spektroskopie gestutzt. Zusatzlich wird die Kristall- und Molekulstruktur von [ReVOCl2(PPh3)L2] durch Rontgenmethoden ermittelt. [ReOCl2(PPh3){3-(5-Nitrofuryl)acrolein-semicarbazon}] kristallisiert in der Raumgruppe P1¯ mit a = 11, 2334(2); b = 11, 3040(2); c = 12.5040(2) A; α = 81, 861(1); β = 63, 555(1); γ = 83, 626(1)° und Z = 2. Das Rheniumatom befindet sich in verzerrt oktaedrischer Umgebung, es ist aquatorial durch den deprotonierten, als zweizahnig fungierenden Semicarbazon-Liganden mittels des Carbonylsauerstoffatoms und des Azomethin-Stickstoffatoms koordiniert sowie durch den Oxo- und einen Chloroliganden. Die Sechsfachkoordination wird durch ein weiteres Chloratom und durch den Triphenylphosphin-Liganden in den Axialpositionen erganzt.
Hugo Cerecetto - One of the best experts on this subject based on the ideXlab platform.
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vanadium v complexes with salicylaldehyde Semicarbazone derivatives bearing in vitro anti tumor activity toward kidney tumor cells tk 10 crystal structure of vvo2 5 bromosalicylaldehyde Semicarbazone
Journal of Inorganic Biochemistry, 2005Co-Authors: Pabla Noblia, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Marisol Vieites, Beatriz S Parajoncosta, Enrique J Baran, Patricia Draper, Amaia AzquetaAbstract:As a contribution to the development of novel vanadium complexes with pharmacologically interesting moieties, new dioxovanadium(V) Semicarbazone complexes with the formula cis-VO2L, where L = 5-bromosalicylaldehyde Semicarbazone and 2-hydroxynaphtalen-1-carboxaldehyde Semicarbazone have been synthesized and characterized by 1H and 13C NMR, Raman and FTIR spectroscopies. Results were compared with those previously reported for other three analogous complexes of this series. The five complexes were tested in three different human tumor cell lines for bioactivity as potential anti-tumor agents, showing selective cytotoxicity on TK-10 cell line. Results showed that structural modifications on the Semicarbazone moiety could have a significant effect on the anti-tumor activity of the vanadium complexes. In addition, the electrochemical behavior of all the complexes was studied. No apparent correlation could be demonstrated between reduction potentials of the complexes and their anti-tumor activities. The molecular structure of the novel [VVO2(5-bromosalicylaldehyde Semicarbazone)] complex was solved by X-ray diffraction methods. The vanadium atom shows a distorted square pyramidal coordination sphere. The (VO2)+ cation is coordinated to a nearly planar (L)− anion acting as a tridentate ligand through both oxygen and one nitrogen atoms.
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new vanadium v complexes with salicylaldehyde Semicarbazone derivatives synthesis characterization and in vitro insulin mimetic activity crystal structure of vvo2 salicylaldehyde Semicarbazone
European Journal of Inorganic Chemistry, 2004Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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New Vanadium(V) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin‐Mimetic Activity − Crystal Structure of [VvO2(salicylaldehyde Semicarbazone)]
European Journal of Inorganic Chemistry, 2003Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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new rhenium v nitrofuryl Semicarbazone complexes crystal structure of reocl2 pph3 3 5 nitrofuryl acroleine Semicarbazone
Zeitschrift für anorganische und allgemeine Chemie, 2003Co-Authors: Lucia Otero, Pabla Noblia, Dinorah Gambino, Hugo Cerecetto, Mercedes Gonzalez, Roberto A Sanchezdelgado, Eduardo E Castellano, Oscar E PiroAbstract:The synthesis and characterization of the first two Re complexes with Semicarbazone ligands is presented. Selected ligands are 5-Nitro-2-furaldehyde Semicarbazone (Nitrofurazone) (L1) and its derivative 3-(5-Nitrofuryl)acroleine Semicarbazone (L2). Complexes of general formula [ReVOCl2(PPh3)L], where L = L1 and L2, were prepared in good yields and high purity by reaction of [ReVOCl3(PPh3)2] with L in ethanol or methanol solutions. The complexes formula and molecular structures were supported by elemental analyses and electronic, FTIR, 1H, 13C and 31P NMR spectroscopies. In addition, the crystal and molecular structure of [ReVOCl2(PPh3)L2] was determined by X-ray diffraction methods. [ReOCl2(PPh3)(3-(5-Nitrofuryl)acroleine Semicarbazone)] crystallizes in the space group P-1 with a = 11.2334(2), b = 11.3040(2), c = 12.5040(2) A, α = 81.861(1), β = 63.555(1), γ = 83.626(1)°, and Z = 2. The Re(V) ion is in a distorted octahedral environment, equatorially coordinated to a deprotonated Semicarbazone molecule acting as a bidentate ligand through its carbonylic oxygen and azomethynic nitrogen atoms, to an oxo ligand and a chlorine atom. The six-fold coordination is completed by another chlorine atom and a triphenylphosphine ligand at the axial positions. Neue Rhenium(V)-Nitrofuryl-semicarbazon-Komplexe. Kristallstruktur von [ReOCl2(PPh3){3-(5-Nitrofuryl)acrolein-semibarbazon}] Die Synthese und die Charakterisierung der ersten beiden Re-Komplexe mit Semicarbazon-Liganden wird beschrieben. Die ausgewahlten Liganden sind 5-Nitro-2-furaldehyd-semicarbazon (Nitrofurazon) (L1) und sein Derivat 3-(5-Nitrofuryl)acrolein-semicarbazon (L2). Die Komplexe der allgemeinen Formel [ReVOCl2(PPh3)L] mit L = L1 und L2 wurden in guten Ausbeuten und hoher Reinheit durch Reaktion von [ReVOCl3(PPh3)2] mit L in Ethanol- oder Methanollosungen hergestellt. Die Komplexformeln und die Molekulstrukturen werden durch Elementaranalysen und Elektronen-FTIR-, 1H-, 13C- und 31P-NMR-Spektroskopie gestutzt. Zusatzlich wird die Kristall- und Molekulstruktur von [ReVOCl2(PPh3)L2] durch Rontgenmethoden ermittelt. [ReOCl2(PPh3){3-(5-Nitrofuryl)acrolein-semicarbazon}] kristallisiert in der Raumgruppe P1¯ mit a = 11, 2334(2); b = 11, 3040(2); c = 12.5040(2) A; α = 81, 861(1); β = 63, 555(1); γ = 83, 626(1)° und Z = 2. Das Rheniumatom befindet sich in verzerrt oktaedrischer Umgebung, es ist aquatorial durch den deprotonierten, als zweizahnig fungierenden Semicarbazon-Liganden mittels des Carbonylsauerstoffatoms und des Azomethin-Stickstoffatoms koordiniert sowie durch den Oxo- und einen Chloroliganden. Die Sechsfachkoordination wird durch ein weiteres Chloratom und durch den Triphenylphosphin-Liganden in den Axialpositionen erganzt.
Mercedes Gonzalez - One of the best experts on this subject based on the ideXlab platform.
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vanadium v complexes with salicylaldehyde Semicarbazone derivatives bearing in vitro anti tumor activity toward kidney tumor cells tk 10 crystal structure of vvo2 5 bromosalicylaldehyde Semicarbazone
Journal of Inorganic Biochemistry, 2005Co-Authors: Pabla Noblia, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Marisol Vieites, Beatriz S Parajoncosta, Enrique J Baran, Patricia Draper, Amaia AzquetaAbstract:As a contribution to the development of novel vanadium complexes with pharmacologically interesting moieties, new dioxovanadium(V) Semicarbazone complexes with the formula cis-VO2L, where L = 5-bromosalicylaldehyde Semicarbazone and 2-hydroxynaphtalen-1-carboxaldehyde Semicarbazone have been synthesized and characterized by 1H and 13C NMR, Raman and FTIR spectroscopies. Results were compared with those previously reported for other three analogous complexes of this series. The five complexes were tested in three different human tumor cell lines for bioactivity as potential anti-tumor agents, showing selective cytotoxicity on TK-10 cell line. Results showed that structural modifications on the Semicarbazone moiety could have a significant effect on the anti-tumor activity of the vanadium complexes. In addition, the electrochemical behavior of all the complexes was studied. No apparent correlation could be demonstrated between reduction potentials of the complexes and their anti-tumor activities. The molecular structure of the novel [VVO2(5-bromosalicylaldehyde Semicarbazone)] complex was solved by X-ray diffraction methods. The vanadium atom shows a distorted square pyramidal coordination sphere. The (VO2)+ cation is coordinated to a nearly planar (L)− anion acting as a tridentate ligand through both oxygen and one nitrogen atoms.
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new vanadium v complexes with salicylaldehyde Semicarbazone derivatives synthesis characterization and in vitro insulin mimetic activity crystal structure of vvo2 salicylaldehyde Semicarbazone
European Journal of Inorganic Chemistry, 2004Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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New Vanadium(V) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin‐Mimetic Activity − Crystal Structure of [VvO2(salicylaldehyde Semicarbazone)]
European Journal of Inorganic Chemistry, 2003Co-Authors: Pabla Noblia, Lucia Otero, Hugo Cerecetto, Mercedes Gonzalez, Eduardo E Castellano, Oscar E Piro, Enrique J Baran, Patricia Draper, Toshifumi Inohara, Yusuke AdachiAbstract:The new dioxo(Semicarbazone)vanadium(V) complexes cis-VO2L, where L = salicylaldehyde Semicarbazone (L1), salicylaldehyde 4-n-butylSemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)Semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(V) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P42/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
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new rhenium v nitrofuryl Semicarbazone complexes crystal structure of reocl2 pph3 3 5 nitrofuryl acroleine Semicarbazone
Zeitschrift für anorganische und allgemeine Chemie, 2003Co-Authors: Lucia Otero, Pabla Noblia, Dinorah Gambino, Hugo Cerecetto, Mercedes Gonzalez, Roberto A Sanchezdelgado, Eduardo E Castellano, Oscar E PiroAbstract:The synthesis and characterization of the first two Re complexes with Semicarbazone ligands is presented. Selected ligands are 5-Nitro-2-furaldehyde Semicarbazone (Nitrofurazone) (L1) and its derivative 3-(5-Nitrofuryl)acroleine Semicarbazone (L2). Complexes of general formula [ReVOCl2(PPh3)L], where L = L1 and L2, were prepared in good yields and high purity by reaction of [ReVOCl3(PPh3)2] with L in ethanol or methanol solutions. The complexes formula and molecular structures were supported by elemental analyses and electronic, FTIR, 1H, 13C and 31P NMR spectroscopies. In addition, the crystal and molecular structure of [ReVOCl2(PPh3)L2] was determined by X-ray diffraction methods. [ReOCl2(PPh3)(3-(5-Nitrofuryl)acroleine Semicarbazone)] crystallizes in the space group P-1 with a = 11.2334(2), b = 11.3040(2), c = 12.5040(2) A, α = 81.861(1), β = 63.555(1), γ = 83.626(1)°, and Z = 2. The Re(V) ion is in a distorted octahedral environment, equatorially coordinated to a deprotonated Semicarbazone molecule acting as a bidentate ligand through its carbonylic oxygen and azomethynic nitrogen atoms, to an oxo ligand and a chlorine atom. The six-fold coordination is completed by another chlorine atom and a triphenylphosphine ligand at the axial positions. Neue Rhenium(V)-Nitrofuryl-semicarbazon-Komplexe. Kristallstruktur von [ReOCl2(PPh3){3-(5-Nitrofuryl)acrolein-semibarbazon}] Die Synthese und die Charakterisierung der ersten beiden Re-Komplexe mit Semicarbazon-Liganden wird beschrieben. Die ausgewahlten Liganden sind 5-Nitro-2-furaldehyd-semicarbazon (Nitrofurazon) (L1) und sein Derivat 3-(5-Nitrofuryl)acrolein-semicarbazon (L2). Die Komplexe der allgemeinen Formel [ReVOCl2(PPh3)L] mit L = L1 und L2 wurden in guten Ausbeuten und hoher Reinheit durch Reaktion von [ReVOCl3(PPh3)2] mit L in Ethanol- oder Methanollosungen hergestellt. Die Komplexformeln und die Molekulstrukturen werden durch Elementaranalysen und Elektronen-FTIR-, 1H-, 13C- und 31P-NMR-Spektroskopie gestutzt. Zusatzlich wird die Kristall- und Molekulstruktur von [ReVOCl2(PPh3)L2] durch Rontgenmethoden ermittelt. [ReOCl2(PPh3){3-(5-Nitrofuryl)acrolein-semicarbazon}] kristallisiert in der Raumgruppe P1¯ mit a = 11, 2334(2); b = 11, 3040(2); c = 12.5040(2) A; α = 81, 861(1); β = 63, 555(1); γ = 83, 626(1)° und Z = 2. Das Rheniumatom befindet sich in verzerrt oktaedrischer Umgebung, es ist aquatorial durch den deprotonierten, als zweizahnig fungierenden Semicarbazon-Liganden mittels des Carbonylsauerstoffatoms und des Azomethin-Stickstoffatoms koordiniert sowie durch den Oxo- und einen Chloroliganden. Die Sechsfachkoordination wird durch ein weiteres Chloratom und durch den Triphenylphosphin-Liganden in den Axialpositionen erganzt.
