The Experts below are selected from a list of 294 Experts worldwide ranked by ideXlab platform
Andrea Du Toit - One of the best experts on this subject based on the ideXlab platform.
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A 'Pain-relieving' toxin
Nature Reviews Microbiology, 2014Co-Authors: Andrea Du ToitAbstract:The Mycobacterium ulcerans toxin mycolactone induces the angiotensin signalling pathway to decrease the Sensation of Pain from the inflicted lesions.
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Bacterial toxins: A 'Pain-relieving' toxin.
Nature reviews. Microbiology, 2014Co-Authors: Andrea Du ToitAbstract:The Mycobacterium ulcerans toxin mycolactone induces the angiotensin signalling pathway to decrease the Sensation of Pain from the inflicted lesions.
Young Ho Jang - One of the best experts on this subject based on the ideXlab platform.
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The Treatment of Referred Otalgia in a Laryngeal Cancer Patient -A case report-
The Korean Journal of Pain, 2004Co-Authors: Ji Hee Hong, Young Ho JangAbstract:Otalgia is a Sensation of Pain in the ear, while referred otalgia is Pain felt in the ear, but which originates from a nonotologic source. Ear Pain is a diagnostic problem when there is no pathology under examination for the ear. Also, it is very important to find the primary site provoking the ear Pain. Nonotogenic otalgia may be due to referred otalgia, reflex Pain and neuralgia, or to a psychogenic problem. Otalgia may be also be referred from a primary carcinoma of the head, neck and fifth, ninth or tenth cranial nerves when the spinal nerves C2 and C3 are involved. For the otalgia in a patient with laryngeal cancer and cervical metastasis he was referred from the otorhinolaryngology department. On physical examination, he had no problem around his ear. For his Pain relief, cervical epidural block and opioid medication were planned. As a result, his otalgia dramatically improved.
Ji Hee Hong - One of the best experts on this subject based on the ideXlab platform.
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The Treatment of Referred Otalgia in a Laryngeal Cancer Patient -A case report-
The Korean Journal of Pain, 2004Co-Authors: Ji Hee Hong, Young Ho JangAbstract:Otalgia is a Sensation of Pain in the ear, while referred otalgia is Pain felt in the ear, but which originates from a nonotologic source. Ear Pain is a diagnostic problem when there is no pathology under examination for the ear. Also, it is very important to find the primary site provoking the ear Pain. Nonotogenic otalgia may be due to referred otalgia, reflex Pain and neuralgia, or to a psychogenic problem. Otalgia may be also be referred from a primary carcinoma of the head, neck and fifth, ninth or tenth cranial nerves when the spinal nerves C2 and C3 are involved. For the otalgia in a patient with laryngeal cancer and cervical metastasis he was referred from the otorhinolaryngology department. On physical examination, he had no problem around his ear. For his Pain relief, cervical epidural block and opioid medication were planned. As a result, his otalgia dramatically improved.
H Sugiyama - One of the best experts on this subject based on the ideXlab platform.
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brown sequard syndrome produced by cervical disc herniation report of two cases and review of the literature
The Spine Journal, 2003Co-Authors: Nobusuke Kobayashi, Syunji Asamoto, H SugiyamaAbstract:Abstract Background context Brown-Sequard syndrome is most commonly seen with spinal trauma and extramedullary spinal neoplasm. A herniated cervical disc has rarely been considered to be a cause of Brown-Sequard syndrome. Purpose To report and discuss two cases of Brown-Sequard syndrome produced by herniated cervical disc. Study design/setting Case studies in Japan. Patient sample The first patient was a 64-year-old man who presented with right leg weakness and diminished Sensation to Pain and temperature in the left side below the T4 dermatome. The second patient was a 39-year-old man who presented with right-sided weakness and diminished Sensation to Pain and temperature in the left side below the T6 dermatome. Outcome measures American Spinal Cord Injury Association (ASIA) impairment scale (only our cases). Methods These patients were diagnosed to have Brown-Sequard syndrome produced by herniated cervical disc. Anterior cervical discectomy with fusion was performed for these patients. Results These cases revealed contralateral deficit in Sensation of Pain and temperature of more than a few levels below the cord compression, and showed paracentral protruded disc in magnetic resonance images and cervical spinal stenosis in cervical spine X-rays. Postoperatively, motor and sensory function of these patients returned to normal. Conclusions Characteristic finding in discogenic Brown-Sequard syndrome are contralateral deficit in Sensation of Pain and temperature of more below than a few levels below the cord compression and paracentral protruded disc with cervical spinal stenosis. Outcomes are favorable in rapid diagnosis by magnetic resonance images and performance of anterior approach.
Félix Viana - One of the best experts on this subject based on the ideXlab platform.
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Nociceptors: thermal allodynia and thermal Pain
Handbook of Clinical Neurology, 2018Co-Authors: Félix VianaAbstract:Abstract The Sensation of Pain plays a vital protecting role, alerting organisms about potentially damaging stimuli. Tissue injury is detected by nerve endings of specialized peripheral sensory neurons called nociceptors that are equipped with different ion channels activated by thermal, mechanic, and chemical stimuli. Several transient receptor potential channels have been identified as molecular transducers of thermal stimuli in Pain-sensing neurons. Skin injury or inflammation leads to increased sensitivity to thermal and mechanic stimuli, clinically defined as allodynia or hyperalgesia. This hypersensitivity is also characteristic of systemic inflammatory disorders and neuropathic Pain conditions. Mechanisms of thermal hyperalgesia include peripheral sensitization of nociceptor afferents and maladaptive changes in Pain-encoding neurons within the central nervous system. An important aspect of Pain management involves attempts to minimize the development of nociceptor hypersensitivity. However, knowledge about the cellular and molecular mechanisms causing thermal hyperalgesia and allodynia in human subjects is still limited, and such knowledge would be an essential step for the development of more effective therapies.
