The Experts below are selected from a list of 3675 Experts worldwide ranked by ideXlab platform
A J P M Smout - One of the best experts on this subject based on the ideXlab platform.
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role of chemical stimulation of the duodenum in dyspeptic symptom generation
The American Journal of Gastroenterology, 2010Co-Authors: O S Van Boxel, J J M Ter Linde, Peter D Siersema, A J P M SmoutAbstract:The response to chemical stimuli such as acid, nutrients, and capsaicin at the level of the duodenum is increasingly recognized as important in the etiology of dyspeptic symptoms. Increased duodenal acid exposure has been reported for patients with dyspeptic symptoms. Duodenal hypersensitivity to acid and the enhancing effect of duodenal acid on gastroduodenal mechanosensitivity may also contribute to dyspeptic symptom generation. Serotonergic signaling pathways may be involved in acid-induced dyspeptic symptoms. As for nutrients, lipid has been unequivocally shown to have a function in the pathogenesis of dyspeptic symptoms. Cholecystokinin (CCK) is an important mediator of the effects of duodenal lipid on gastroduodenal Sensorimotor Activities. It is unclear whether CCK hypersecretion or hypersensitivity to CCK is responsible for symptoms in dyspeptic patients. The presence of capsaicin in the duodenum evokes symptoms and affects gastric Sensorimotor function. In patients with dyspepsia, capsaicin-induced symptoms appeared to occur earlier and to be more severe, however the effects of duodenal infusion and putative consequent gastric Sensorimotor abnormalities have not been examined. Capsaicin activates transient receptor potential ion channel of the vanilloid type I, which can also be activated and sensitized by acid. The interaction between the different chemical stimuli is complex and has not yet been studied in patients with dyspeptic symptoms. In conclusion, the mechanisms underlying an enhanced response to duodenal chemical stimulation in patients with dyspeptic symptoms are partially understood. At the level of the duodenum, abnormalities may exist in stimulus intensity, mucosal mRNA expression, biosynthesis, release, or inactivation of mucosal mediators, or receptor expression on afferent nerve endings. Elucidation of the abnormalities involved will provide a basis for rational treatment of dyspeptic symptoms.
Junichi Ushiba - One of the best experts on this subject based on the ideXlab platform.
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neurofeedback of scalp bi hemispheric eeg Sensorimotor rhythm guides hemispheric activation of Sensorimotor cortex in the targeted hemisphere
NeuroImage, 2020Co-Authors: Masaaki Hayashi, Shohei Tsuchimoto, Nobuaki Mizuguchi, Junichi UshibaAbstract:Oscillatory electroencephalographic (EEG) activity is associated with excitability of cortical regions. Visual feedback of EEG-oscillations may promote increased excitability in targeted cortical regions, but is not truly guaranteed due to its limited spatial specificity and signal interaction among interhemispheric brain regions. Guiding spatially specific Sensorimotor cortical activation is important for facilitating neural rehabilitation processes. Here, we developed a spatially bivariate EEG-based neurofeedback approach that monitors bi-hemispheric Sensorimotor Activities during unilateral upper-limb motor imagery (MI), and tested whether users could volitionally lateralize Sensorimotor activity to the contralateral or ipsilateral hemisphere using right shoulder MI-associated neurofeedback. Then, hand MI-associated BCI-neurofeedback was tested as a negative control via the same procedure. Lateralized EEG activity was compared between shoulder and hand MIs to see how differences in intrinsic corticomuscular projection patterns might influence activity lateralization. In right shoulder MI, ipsilaterally and contralaterally dominant Sensorimotor activation was guided via EEG-based neurofeedback. Conversely, in right hand MI, only contralaterally (but not ipsilaterally) dominant Sensorimotor activation was guided. These results are compatible with neuroanatomy; shoulder muscles are innervated bihemispherically, whereas hand muscles are mostly innervated contralaterally.
Nobuaki Mizuguchi - One of the best experts on this subject based on the ideXlab platform.
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neurofeedback of scalp bi hemispheric eeg Sensorimotor rhythm guides hemispheric activation of Sensorimotor cortex in the targeted hemisphere
NeuroImage, 2020Co-Authors: Masaaki Hayashi, Shohei Tsuchimoto, Nobuaki Mizuguchi, Junichi UshibaAbstract:Oscillatory electroencephalographic (EEG) activity is associated with excitability of cortical regions. Visual feedback of EEG-oscillations may promote increased excitability in targeted cortical regions, but is not truly guaranteed due to its limited spatial specificity and signal interaction among interhemispheric brain regions. Guiding spatially specific Sensorimotor cortical activation is important for facilitating neural rehabilitation processes. Here, we developed a spatially bivariate EEG-based neurofeedback approach that monitors bi-hemispheric Sensorimotor Activities during unilateral upper-limb motor imagery (MI), and tested whether users could volitionally lateralize Sensorimotor activity to the contralateral or ipsilateral hemisphere using right shoulder MI-associated neurofeedback. Then, hand MI-associated BCI-neurofeedback was tested as a negative control via the same procedure. Lateralized EEG activity was compared between shoulder and hand MIs to see how differences in intrinsic corticomuscular projection patterns might influence activity lateralization. In right shoulder MI, ipsilaterally and contralaterally dominant Sensorimotor activation was guided via EEG-based neurofeedback. Conversely, in right hand MI, only contralaterally (but not ipsilaterally) dominant Sensorimotor activation was guided. These results are compatible with neuroanatomy; shoulder muscles are innervated bihemispherically, whereas hand muscles are mostly innervated contralaterally.
O S Van Boxel - One of the best experts on this subject based on the ideXlab platform.
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role of chemical stimulation of the duodenum in dyspeptic symptom generation
The American Journal of Gastroenterology, 2010Co-Authors: O S Van Boxel, J J M Ter Linde, Peter D Siersema, A J P M SmoutAbstract:The response to chemical stimuli such as acid, nutrients, and capsaicin at the level of the duodenum is increasingly recognized as important in the etiology of dyspeptic symptoms. Increased duodenal acid exposure has been reported for patients with dyspeptic symptoms. Duodenal hypersensitivity to acid and the enhancing effect of duodenal acid on gastroduodenal mechanosensitivity may also contribute to dyspeptic symptom generation. Serotonergic signaling pathways may be involved in acid-induced dyspeptic symptoms. As for nutrients, lipid has been unequivocally shown to have a function in the pathogenesis of dyspeptic symptoms. Cholecystokinin (CCK) is an important mediator of the effects of duodenal lipid on gastroduodenal Sensorimotor Activities. It is unclear whether CCK hypersecretion or hypersensitivity to CCK is responsible for symptoms in dyspeptic patients. The presence of capsaicin in the duodenum evokes symptoms and affects gastric Sensorimotor function. In patients with dyspepsia, capsaicin-induced symptoms appeared to occur earlier and to be more severe, however the effects of duodenal infusion and putative consequent gastric Sensorimotor abnormalities have not been examined. Capsaicin activates transient receptor potential ion channel of the vanilloid type I, which can also be activated and sensitized by acid. The interaction between the different chemical stimuli is complex and has not yet been studied in patients with dyspeptic symptoms. In conclusion, the mechanisms underlying an enhanced response to duodenal chemical stimulation in patients with dyspeptic symptoms are partially understood. At the level of the duodenum, abnormalities may exist in stimulus intensity, mucosal mRNA expression, biosynthesis, release, or inactivation of mucosal mediators, or receptor expression on afferent nerve endings. Elucidation of the abnormalities involved will provide a basis for rational treatment of dyspeptic symptoms.
Masaaki Hayashi - One of the best experts on this subject based on the ideXlab platform.
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neurofeedback of scalp bi hemispheric eeg Sensorimotor rhythm guides hemispheric activation of Sensorimotor cortex in the targeted hemisphere
NeuroImage, 2020Co-Authors: Masaaki Hayashi, Shohei Tsuchimoto, Nobuaki Mizuguchi, Junichi UshibaAbstract:Oscillatory electroencephalographic (EEG) activity is associated with excitability of cortical regions. Visual feedback of EEG-oscillations may promote increased excitability in targeted cortical regions, but is not truly guaranteed due to its limited spatial specificity and signal interaction among interhemispheric brain regions. Guiding spatially specific Sensorimotor cortical activation is important for facilitating neural rehabilitation processes. Here, we developed a spatially bivariate EEG-based neurofeedback approach that monitors bi-hemispheric Sensorimotor Activities during unilateral upper-limb motor imagery (MI), and tested whether users could volitionally lateralize Sensorimotor activity to the contralateral or ipsilateral hemisphere using right shoulder MI-associated neurofeedback. Then, hand MI-associated BCI-neurofeedback was tested as a negative control via the same procedure. Lateralized EEG activity was compared between shoulder and hand MIs to see how differences in intrinsic corticomuscular projection patterns might influence activity lateralization. In right shoulder MI, ipsilaterally and contralaterally dominant Sensorimotor activation was guided via EEG-based neurofeedback. Conversely, in right hand MI, only contralaterally (but not ipsilaterally) dominant Sensorimotor activation was guided. These results are compatible with neuroanatomy; shoulder muscles are innervated bihemispherically, whereas hand muscles are mostly innervated contralaterally.
