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Jan Tack - One of the best experts on this subject based on the ideXlab platform.
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the effect of prucalopride on gastric Sensorimotor Function and satiation in healthy volunteers
Neurogastroenterology and Motility, 2021Co-Authors: Florencia Carbone, Tim Vanuytsel, Jan TackAbstract:BACKGROUND Gastric motor Function alterations have been implicated in the pathogenesis of Functional dyspepsia with postprandial distress syndrome (PDS). Prucalopride, a 5-TH4 agonist, is known to stimulate gastrointestinal motility. We aimed to evaluate the effect of prucalopride on gastric Sensorimotor Function in healthy subjects (HV). METHODS Barostat and intragastric pressure (IGP) measurements were performed in 17 HV (59% females, age 29.4 ± 2.7 y) after treatment with placebo or prucalopride (2 mg) (single-blind cross-over). Isobaric stepwise distensions and gastric sensations were assessed to determine gastric compliance and sensitivity. Gastric accommodation (GA) with the barostat was quantified before and after ingestion of 200 ml of a nutrient drink (ND). GA measured by IGP was quantified as the drop of IGP from baseline during the intragastric infusion of ND until maximal satiation (60 ml/min). KEY RESULTS Prucalopride did not affect barostat assessed gastric compliance or sensitivity. No differences were observed in GA after prucalopride. During the barostat study, 10 min after the meal, 7 HVs reported significantly higher ratings for nausea after prucalopride (p < 0.001), and vomiting was induced in 4 of the HVs. A positive correlation was observed between the delta mean perception of nausea with the delta mean increase of intra-balloon volume before and after meal ingestion (r = 0.37, p = 0.03). During IGP measurements, no effect on nutrient tolerance was observed and increased cramp severity scores were observed which were associated with a significant increase of distal IGP (r = 0.78, p < 0.0001). CONCLUSIONS & INFERENCES Prucalopride does not enhances gastric accommodation but it might increase sensitivity to gastric distention. Furthermore, the increase in sensitivity seems to be related to an increase in nausea with distension. Clinicaltrials.gov: NCT04429802.
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The effect of prucalopride on gastric Sensorimotor Function and satiation in healthy volunteers.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2021Co-Authors: Florencia Carbone, Tim Vanuytsel, Jan TackAbstract:BACKGROUND Gastric motor Function alterations have been implicated in the pathogenesis of Functional dyspepsia with postprandial distress syndrome (PDS). Prucalopride, a 5-TH4 agonist, is known to stimulate gastrointestinal motility. We aimed to evaluate the effect of prucalopride on gastric Sensorimotor Function in healthy subjects (HV). METHODS Barostat and intragastric pressure (IGP) measurements were performed in 17 HV (59% females, age 29.4 ± 2.7 y) after treatment with placebo or prucalopride (2 mg) (single-blind cross-over). Isobaric stepwise distensions and gastric sensations were assessed to determine gastric compliance and sensitivity. Gastric accommodation (GA) with the barostat was quantified before and after ingestion of 200 ml of a nutrient drink (ND). GA measured by IGP was quantified as the drop of IGP from baseline during the intragastric infusion of ND until maximal satiation (60 ml/min). KEY RESULTS Prucalopride did not affect barostat assessed gastric compliance or sensitivity. No differences were observed in GA after prucalopride. During the barostat study, 10 min after the meal, 7 HVs reported significantly higher ratings for nausea after prucalopride (p
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Esophageal Sensorimotor Function and Psychological Factors Each Contribute to Symptom Severity in Globus Patients.
The American journal of gastroenterology, 2016Co-Authors: Nathalie Rommel, Jan Tack, Lukas Van Oudenhove, Joris Arts, Philip Caenepeel, Ans PauwelsAbstract:Esophageal Sensorimotor Function and Psychological Factors Each Contribute to Symptom Severity in Globus Patients
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Influence of a neurokinin-1 receptor antagonist (aprepitant) on gastric Sensorimotor Function in healthy volunteers.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2013Co-Authors: Daphne Ang, Robin Vos, Ans Pauwels, F Akyuz, Jan TackAbstract:Background Substance P (SP) is a member of the neurokinin (NK) family and is one of the established neurotransmitters in the mammalian central and enteric nervous system. It is unclear whether NK1 receptors are involved in the control of gastric Sensorimotor Function in man. Methods We studied the effects of aprepitant, an NK1 receptor antagonist used in the treatment of chemotherapy-induced emesis, on gastric Sensorimotor Function in healthy volunteers. Sixteen healthy volunteers (six males, 32.4 ± 2.7 years) were studied on three separate occasions after placebo, aprepitant 80 or 125 mg in randomized double-blind study to assess gastric compliance, perception to isobaric distensions, and gastric accommodation with a gastric barostat. Key Results Compared to placebo, both doses of aprepitant did not influence gastric compliance or sensitivity to gastric distension. Aprepitant 80 and 125 mg did not have any significant effects on gastric accommodation compared with placebo (mean postprandial gastric volume increase, respectively, 83.4 ± 28.4 vs 35.3 ± 16.2 vs 83.9 ± 30.4 mL, NS). Postprandial gastric compliance and sensitivity to distention were also not altered. Conclusions & Inferences In health, NK1 receptors do not appear to be involved in the control of gastric compliance, accommodation or sensitivity to distention in man.
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Effect of the GLP-1 analog liraglutide on satiation and gastric Sensorimotor Function during nutrient-drink ingestion.
International journal of obesity (2005), 2012Co-Authors: Alessandra Rotondo, Pieter Janssen, Flavia Mulè, Jan TackAbstract:Effect of the GLP-1 analog liraglutide on satiation and gastric Sensorimotor Function during nutrient-drink ingestion
Won-young Lee - One of the best experts on this subject based on the ideXlab platform.
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Accelerated recovery of Sensorimotor Function in a dog submitted to quasi-total transection of the cervical spinal cord and treated with PEG.
Surgical neurology international, 2016Co-Authors: C-yoon Kim, In-kyu Hwang, Hana Kim, Se-woong Jang, Hong Seog Kim, Won-young LeeAbstract:A case report on observing the recovery of sensory-motor Function after cervical spinal cord transection. Laminectomy and transection of cervical spinal cord (C5) was performed on a male beagle weighing 3.5 kg. After applying polyethylene glycol (PEG) on the severed part, reconstruction of cervical spinal cord was confirmed by the restoration of Sensorimotor Function. Tetraplegia was observed immediately after operation, however, the dog showed stable respiration and survival without any complication. The dog showed fast recovery after 1 week, and recovered approximately 90% of normal Sensorimotor Function 3 weeks after the operation, although urinary disorder was still present. All recovery stages were recorded by video camera twice a week for behavioral analysis. While current belief holds that Functional recovery is impossible after a section greater than 50% at C5-6 in the canine model, this case study shows the possibility of cervical spinal cord reconstruction after near-total transection. Furthermore, this case study also confirms that PEG can truly expedite the recovery of Sensorimotor Function after cervical spinal cord sections in dogs.
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Accelerated recovery of Sensorimotor Function in a dog submitted to quasi-total transection of the cervical spinal cord and treated with PEG.
Surgical Neurology International, 2016Co-Authors: C-yoon Kim, In-kyu Hwang, Hana Kim, Se-woong Jang, Hong Seog Kim, Won-young LeeAbstract:BACKGROUND A case report on observing the recovery of sensory-motor Function after cervical spinal cord transection. CASE DESCRIPTION Laminectomy and transection of cervical spinal cord (C5) was performed on a male beagle weighing 3.5 kg. After applying polyethylene glycol (PEG) on the severed part, reconstruction of cervical spinal cord was confirmed by the restoration of Sensorimotor Function. Tetraplegia was observed immediately after operation, however, the dog showed stable respiration and survival without any complication. The dog showed fast recovery after 1 week, and recovered approximately 90% of normal Sensorimotor Function 3 weeks after the operation, although urinary disorder was still present. All recovery stages were recorded by video camera twice a week for behavioral analysis. CONCLUSION While current belief holds that Functional recovery is impossible after a section greater than 50% at C5-6 in the canine model, this case study shows the possibility of cervical spinal cord reconstruction after near-total transection. Furthermore, this case study also confirms that PEG can truly expedite the recovery of Sensorimotor Function after cervical spinal cord sections in dogs.
C-yoon Kim - One of the best experts on this subject based on the ideXlab platform.
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Accelerated recovery of Sensorimotor Function in a dog submitted to quasi-total transection of the cervical spinal cord and treated with PEG.
Surgical neurology international, 2016Co-Authors: C-yoon Kim, In-kyu Hwang, Hana Kim, Se-woong Jang, Hong Seog Kim, Won-young LeeAbstract:A case report on observing the recovery of sensory-motor Function after cervical spinal cord transection. Laminectomy and transection of cervical spinal cord (C5) was performed on a male beagle weighing 3.5 kg. After applying polyethylene glycol (PEG) on the severed part, reconstruction of cervical spinal cord was confirmed by the restoration of Sensorimotor Function. Tetraplegia was observed immediately after operation, however, the dog showed stable respiration and survival without any complication. The dog showed fast recovery after 1 week, and recovered approximately 90% of normal Sensorimotor Function 3 weeks after the operation, although urinary disorder was still present. All recovery stages were recorded by video camera twice a week for behavioral analysis. While current belief holds that Functional recovery is impossible after a section greater than 50% at C5-6 in the canine model, this case study shows the possibility of cervical spinal cord reconstruction after near-total transection. Furthermore, this case study also confirms that PEG can truly expedite the recovery of Sensorimotor Function after cervical spinal cord sections in dogs.
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Accelerated recovery of Sensorimotor Function in a dog submitted to quasi-total transection of the cervical spinal cord and treated with PEG.
Surgical Neurology International, 2016Co-Authors: C-yoon Kim, In-kyu Hwang, Hana Kim, Se-woong Jang, Hong Seog Kim, Won-young LeeAbstract:BACKGROUND A case report on observing the recovery of sensory-motor Function after cervical spinal cord transection. CASE DESCRIPTION Laminectomy and transection of cervical spinal cord (C5) was performed on a male beagle weighing 3.5 kg. After applying polyethylene glycol (PEG) on the severed part, reconstruction of cervical spinal cord was confirmed by the restoration of Sensorimotor Function. Tetraplegia was observed immediately after operation, however, the dog showed stable respiration and survival without any complication. The dog showed fast recovery after 1 week, and recovered approximately 90% of normal Sensorimotor Function 3 weeks after the operation, although urinary disorder was still present. All recovery stages were recorded by video camera twice a week for behavioral analysis. CONCLUSION While current belief holds that Functional recovery is impossible after a section greater than 50% at C5-6 in the canine model, this case study shows the possibility of cervical spinal cord reconstruction after near-total transection. Furthermore, this case study also confirms that PEG can truly expedite the recovery of Sensorimotor Function after cervical spinal cord sections in dogs.
Sobhy M Aly - One of the best experts on this subject based on the ideXlab platform.
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The effect of scapular dyskinesia on the scapular balance angle and upper extremity Sensorimotor Function in stroke patients with spasticity
Bulletin of Faculty of Physical Therapy, 2020Co-Authors: Saad El-din Mahmoud, Sobhy M AlyAbstract:Post-stroke scapular dyskinesia is a predisposing factor for the affection of motor and somatosensory Functions of the hemiparetic upper extremity. The purpose of the study was to investigate the effect of scapular dyskinesia on the scapular balance angle and upper extremity Sensorimotor Function in stroke patients with spasticity. Sixty patients with spasticity post-stroke participated in this study. The patients were assigned to one of the two groups as determined by the lateral scapular slide test (LSST) using the palpation meter (PALM); group A with scapular dyskinesia and group B stroke patients without scapular dyskinesia. The scapular position was determined by a measurement of scapular balance angle (SBA), and the upper extremity Sensorimotor Function was evaluated using Fugl-Meyer Assessment upper extremity (FMAUE) scale. The scapular balance angle and Fugl-Meyer upper extremity scores were compared between groups. There was a significant increase in the scapular balance angle of group A compared with that of group B (p < 0.001). Also, there was a significant decrease in sensory and motor Functions of group A as measured by Fugl-Meyer upper extremity compared with that of group B (p < 0.001). Scapular dyskinesia had a significant effect on the scapular balance angle and upper extremity Sensorimotor Function in stroke patients with spasticity. Management of scapular dyskinesia should be emphasized in the rehabilitation program for stroke patients with spasticity.
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The effect of scapular dyskinesia on the scapular balance angle and upper extremity Sensorimotor Function in stroke patients with spasticity
Bulletin of Faculty of Physical Therapy, 2020Co-Authors: Lama Saad El-din Mahmoud, Sobhy M AlyAbstract:Background Post-stroke scapular dyskinesia is a predisposing factor for the affection of motor and somatosensory Functions of the hemiparetic upper extremity. Objective The purpose of the study was to investigate the effect of scapular dyskinesia on the scapular balance angle and upper extremity Sensorimotor Function in stroke patients with spasticity. Subjects and methods Sixty patients with spasticity post-stroke participated in this study. The patients were assigned to one of the two groups as determined by the lateral scapular slide test (LSST) using the palpation meter (PALM); group A with scapular dyskinesia and group B stroke patients without scapular dyskinesia. The scapular position was determined by a measurement of scapular balance angle (SBA), and the upper extremity Sensorimotor Function was evaluated using Fugl-Meyer Assessment upper extremity (FMAUE) scale. The scapular balance angle and Fugl-Meyer upper extremity scores were compared between groups. Results There was a significant increase in the scapular balance angle of group A compared with that of group B ( p < 0.001). Also, there was a significant decrease in sensory and motor Functions of group A as measured by Fugl-Meyer upper extremity compared with that of group B ( p < 0.001). Conclusion Scapular dyskinesia had a significant effect on the scapular balance angle and upper extremity Sensorimotor Function in stroke patients with spasticity. Management of scapular dyskinesia should be emphasized in the rehabilitation program for stroke patients with spasticity.
Jason R. Potas - One of the best experts on this subject based on the ideXlab platform.
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Red LED photobiomodulation reduces pain hypersensitivity and improves Sensorimotor Function following mild T10 hemicontusion spinal cord injury
Journal of neuroinflammation, 2016Co-Authors: Shuyu Zhu, Jason R. PotasAbstract:Background The development of hypersensitivity following spinal cord injury can result in incurable persistent neuropathic pain. Our objective was to examine the effect of red light therapy on the development of hypersensitivity and Sensorimotor Function, as well as on microglia/macrophage subpopulations following spinal cord injury.
