The Experts below are selected from a list of 48783 Experts worldwide ranked by ideXlab platform
Karl Deisseroth - One of the best experts on this subject based on the ideXlab platform.
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developmental dysfunction of vip interneurons impairs cortical circuits
Neuron, 2017Co-Authors: Renata Batistabrito, Martin Vinck, Katie A Ferguson, Jeremy T Chang, David Laubender, Gyorgy Lur, James M Mossner, Victoria G Hernandez, Charu Ramakrishnan, Karl DeisserothAbstract:Summary GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 ( NRG1 ) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo . ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state dependence. These alterations emerge during adolescence, and mature animals in which VIP interneurons lack ErbB4 exhibit reduced cortical responses to Sensory stimuli and impaired Sensory Learning. Our data support a key role for VIP interneurons in cortical circuit development and suggest a possible contribution to pathophysiology in neurodevelopmental disorders. These findings provide a new perspective on the role of GABAergic interneuron diversity in cortical development. Video Abstract
Renata Batistabrito - One of the best experts on this subject based on the ideXlab platform.
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developmental dysfunction of vip interneurons impairs cortical circuits
Neuron, 2017Co-Authors: Renata Batistabrito, Martin Vinck, Katie A Ferguson, Jeremy T Chang, David Laubender, Gyorgy Lur, James M Mossner, Victoria G Hernandez, Charu Ramakrishnan, Karl DeisserothAbstract:Summary GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 ( NRG1 ) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo . ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state dependence. These alterations emerge during adolescence, and mature animals in which VIP interneurons lack ErbB4 exhibit reduced cortical responses to Sensory stimuli and impaired Sensory Learning. Our data support a key role for VIP interneurons in cortical circuit development and suggest a possible contribution to pathophysiology in neurodevelopmental disorders. These findings provide a new perspective on the role of GABAergic interneuron diversity in cortical development. Video Abstract
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developmental dysfunction of vip interneurons impairs cortical circuits
bioRxiv, 2016Co-Authors: Renata Batistabrito, Martin Vinck, Katie A Ferguson, David Laubender, Gyorgy Lur, Michael J Higley, Jessica A CardinAbstract:Current evidence suggests that dysregulation of GABAergic interneurons contributes to neural and behavioral deficits in several neurodevelopmental disorders, including schizophrenia. However, there are multiple populations of interneurons and their respective roles in psychiatric disease remain poorly explored. Neuregulin 1 (NRG1) and its interneuron-specific tyrosine kinase receptor ERBB4 are risk genes for schizophrenia, and the Nrg1/ErbB4 pathway is important for normal cortical development. Using a conditional ErbB4 deletion model, we directly tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in schizophrenia-related deficits in vivo. ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of the temporal organization and state-dependence of cortical activity. As a result of these neural circuit alterations, animals in which VIP interneurons lack ErbB4 exhibit behavioral abnormalities, reduced cortical responses to Sensory stimuli, and impaired Sensory Learning. Our data support a key role for VIP interneurons in normal cortical circuit development and suggest that their disruption contributes to pathophysiology in the ErbB4 model of schizophrenia. These findings provide a new perspective on the role of GABAergic interneuron diversity in the disruption of cortical function in complex psychiatric diseases.
Robert C Liu - One of the best experts on this subject based on the ideXlab platform.
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becoming a better parent mice learn sounds that improve a stereotyped maternal behavior
Hormones and Behavior, 2020Co-Authors: Alexander G Dunlap, Cristina Besosa, Leila M Pascual, Kelly K Chong, Hasse Walum, Dorottya B Kacsoh, Brenda B Tankeu, Robert C LiuAbstract:Abstract While mothering is often instinctive and stereotyped in species-specific ways, evolution can favor genetically “open” behavior programs that allow experience to shape infant care. Among experience-dependent maternal behavioral mechanisms, Sensory Learning about infants has been hard to separate from motivational changes arising from sensitization with infants. We developed a paradigm in which Sensory Learning of an infant-associated cue improves a stereotypical maternal behavior in female mice. Mice instinctively employed a spatial memory-based strategy when engaged repetitively in a pup search and retrieval task. However, by playing a sound from a T-maze arm to signal where a pup will be delivered for retrieval, mice learned within 7 days and retained for at least 2 weeks the ability to use this specific cue to guide a more efficient search strategy. The motivation to retrieve pups also increased with Learning on average, but their correlation did not explain performance at the trial level. Bilaterally silencing auditory cortical activity significantly impaired the utilization of new strategy without changing the motivation to retrieve pups. Finally, motherhood as compared to infant-care experience alone accelerated how quickly the new Sensory-based strategy was acquired, suggesting a role for the maternal hormonal state. By rigorously establishing that newly formed Sensory associations can improve the performance of a natural maternal behavior, this work facilitates future studies into the neurochemical and circuit mechanisms that mediate novel Sensory Learning in the maternal context, as well as more Learning-based mechanisms of parental behavior in rodents.
Martin Vinck - One of the best experts on this subject based on the ideXlab platform.
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developmental dysfunction of vip interneurons impairs cortical circuits
Neuron, 2017Co-Authors: Renata Batistabrito, Martin Vinck, Katie A Ferguson, Jeremy T Chang, David Laubender, Gyorgy Lur, James M Mossner, Victoria G Hernandez, Charu Ramakrishnan, Karl DeisserothAbstract:Summary GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 ( NRG1 ) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo . ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state dependence. These alterations emerge during adolescence, and mature animals in which VIP interneurons lack ErbB4 exhibit reduced cortical responses to Sensory stimuli and impaired Sensory Learning. Our data support a key role for VIP interneurons in cortical circuit development and suggest a possible contribution to pathophysiology in neurodevelopmental disorders. These findings provide a new perspective on the role of GABAergic interneuron diversity in cortical development. Video Abstract
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developmental dysfunction of vip interneurons impairs cortical circuits
bioRxiv, 2016Co-Authors: Renata Batistabrito, Martin Vinck, Katie A Ferguson, David Laubender, Gyorgy Lur, Michael J Higley, Jessica A CardinAbstract:Current evidence suggests that dysregulation of GABAergic interneurons contributes to neural and behavioral deficits in several neurodevelopmental disorders, including schizophrenia. However, there are multiple populations of interneurons and their respective roles in psychiatric disease remain poorly explored. Neuregulin 1 (NRG1) and its interneuron-specific tyrosine kinase receptor ERBB4 are risk genes for schizophrenia, and the Nrg1/ErbB4 pathway is important for normal cortical development. Using a conditional ErbB4 deletion model, we directly tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in schizophrenia-related deficits in vivo. ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of the temporal organization and state-dependence of cortical activity. As a result of these neural circuit alterations, animals in which VIP interneurons lack ErbB4 exhibit behavioral abnormalities, reduced cortical responses to Sensory stimuli, and impaired Sensory Learning. Our data support a key role for VIP interneurons in normal cortical circuit development and suggest that their disruption contributes to pathophysiology in the ErbB4 model of schizophrenia. These findings provide a new perspective on the role of GABAergic interneuron diversity in the disruption of cortical function in complex psychiatric diseases.
Gyorgy Lur - One of the best experts on this subject based on the ideXlab platform.
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developmental dysfunction of vip interneurons impairs cortical circuits
Neuron, 2017Co-Authors: Renata Batistabrito, Martin Vinck, Katie A Ferguson, Jeremy T Chang, David Laubender, Gyorgy Lur, James M Mossner, Victoria G Hernandez, Charu Ramakrishnan, Karl DeisserothAbstract:Summary GABAergic interneurons play important roles in cortical circuit development. However, there are multiple populations of interneurons and their respective developmental contributions remain poorly explored. Neuregulin 1 ( NRG1 ) and its interneuron-specific receptor ERBB4 are critical genes for interneuron maturation. Using a conditional ErbB4 deletion, we tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in the postnatal maturation of cortical circuits in vivo . ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of cortical temporal organization and state dependence. These alterations emerge during adolescence, and mature animals in which VIP interneurons lack ErbB4 exhibit reduced cortical responses to Sensory stimuli and impaired Sensory Learning. Our data support a key role for VIP interneurons in cortical circuit development and suggest a possible contribution to pathophysiology in neurodevelopmental disorders. These findings provide a new perspective on the role of GABAergic interneuron diversity in cortical development. Video Abstract
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developmental dysfunction of vip interneurons impairs cortical circuits
bioRxiv, 2016Co-Authors: Renata Batistabrito, Martin Vinck, Katie A Ferguson, David Laubender, Gyorgy Lur, Michael J Higley, Jessica A CardinAbstract:Current evidence suggests that dysregulation of GABAergic interneurons contributes to neural and behavioral deficits in several neurodevelopmental disorders, including schizophrenia. However, there are multiple populations of interneurons and their respective roles in psychiatric disease remain poorly explored. Neuregulin 1 (NRG1) and its interneuron-specific tyrosine kinase receptor ERBB4 are risk genes for schizophrenia, and the Nrg1/ErbB4 pathway is important for normal cortical development. Using a conditional ErbB4 deletion model, we directly tested the role of vasoactive intestinal peptide (VIP)-expressing interneurons in schizophrenia-related deficits in vivo. ErbB4 removal from VIP interneurons during development leads to changes in their activity, along with severe dysregulation of the temporal organization and state-dependence of cortical activity. As a result of these neural circuit alterations, animals in which VIP interneurons lack ErbB4 exhibit behavioral abnormalities, reduced cortical responses to Sensory stimuli, and impaired Sensory Learning. Our data support a key role for VIP interneurons in normal cortical circuit development and suggest that their disruption contributes to pathophysiology in the ErbB4 model of schizophrenia. These findings provide a new perspective on the role of GABAergic interneuron diversity in the disruption of cortical function in complex psychiatric diseases.
