The Experts below are selected from a list of 222 Experts worldwide ranked by ideXlab platform
Eckart Altenmüller - One of the best experts on this subject based on the ideXlab platform.
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Sensory Trick phenomenon improves motor control in pianists with dystonia: prognostic value of glove-effect.
Frontiers in Psychology, 2014Co-Authors: Jakobine Paulig, Michael Großbach, Hans-christian Jabusch, Laurent Boullet, Eckart AltenmüllerAbstract:Musician’s dystonia (MD) is a task-specific movement disorder that causes loss of voluntary motor control while playing the instrument. A subgroup of patients displays the so-called Sensory Trick: alteration of somatoSensory input, e.g., by wearing a latex glove, may result in short-term improvement of motor control. In this study, the glove-effect in pianists with MD was quantified and its potential association with MD-severity and outcome after treatment was investigated. Thirty affected pianists were included in the study. Music instrument digital interface-based scale analysis was used for assessment of fine motor control. Therapeutic options included botulinum toxin, pedagogical retraining and anticholinergic medication (trihexyphenidyl). 19% of patients showed significant improvement of fine motor control through wearing a glove. After treatment, outcome was significantly better in patients with a significant pre-treatment Sensory Trick. We conclude that the Sensory Trick may have a prognostic value for the outcome after treatment in pianists with MD.
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Edited by:
2014Co-Authors: Jakobine Paulig, Michael Großbach, Eckart Altenmüller, Hans-christian Jabusch, Laurent Boullet, Matthew A. WyonAbstract:Sensory Trick phenomenon improves motor control i
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Altered Sensory feedbacks in pianist's dystonia: the altered auditory feedback paradigm and the glove effect
Frontiers in Human Neuroscience, 2013Co-Authors: Felicia P.-h. Cheng, Michael Großbach, Eckart AltenmüllerAbstract:Background: This study investigates the effect of altered auditory feedback (AAF) in musician's dystonia (MD) and discusses whether altered auditory feedback can be considered as a Sensory Trick in MD. Furthermore, the effect of AAF is compared with altered tactile feedback, which can serve as a Sensory Trick in several other forms of focal dystonia. Methods: The method is based on scale analysis (Jabusch et al. 2004). Experiment 1 employs synchronization paradigm: 12 MD patients and 25 healthy pianists had to repeatedly play C-major scales in synchrony with a metronome on a MIDI-piano with 3 auditory feedback conditions: 1. normal feedback; 2. no feedback; 3. constant delayed feedback. Experiment 2 employs synchronization-continuation paradigm: 12 MD patients and 12 healthy pianists had to repeatedly play C-major scales in two phases: first in synchrony with a metronome, secondly continue the established tempo without the metronome. There are 4 experimental conditions, among them 3 are the same altered auditory feedback as in Experiment 1 and 1 is related to altered tactile Sensory input. The coefficient of variation of inter-onset intervals of the key depressions was calculated to evaluate fine motor control. Results: In both experiments, the healthy controls and the patients behaved very similarly. There is no difference in the regularity of playing between the two groups under any condition, and neither did AAF nor did altered tactile feedback have a beneficial effect on patients’ fine motor control. Conclusions: The results of the two experiments suggest that in the context of our experimental designs, AAF and altered tactile feedback play a minor role in motor coordination in patients with musicians' dystonia. We propose that altered auditory and tactile feedback do not serve as effective Sensory Tricks and may not temporarily reduce the symptoms of patients suffering from MD in this experimental context.
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a model of task specific focal dystonia
Neural Networks, 2013Co-Authors: Eckart Altenmüller, Dieter MullerAbstract:Task-specific focal dystonia is a task-specific movement disorder which manifests itself as a loss of voluntary motor control in extensively trained movements. The condition is most frequent in musicians. Until today, the aetiology of focal hand dystonia is not completely understood, but there is growing evidence for an abnormal cortical processing of Sensory information, as well as degraded representation of motor functions. It was demonstrated that in the somatoSensory cortex the topographical location of Sensory inputs from individual fingers is corrupted. Occasionally, a change in Sensory information of the hand may at least temporarily improve the condition. This phenomenon is called Sensory Trick. In this paper, we propose a model of encoding of Sensory stimuli which could explain the task specificity of cortical representations of the fingers or other effectors in the context of dystonia. In the framework of this model a Sensory stimulus is encoded as a signal vector of higher dimension. A part of its components directly represents the Sensory stimulus, while the remaining components describe the context. This model does not only account for the task specificity, but may also explain some characteristics of the retraining process in this disorder.
Giovanni Defazio - One of the best experts on this subject based on the ideXlab platform.
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Sensory Trick in upper limb dystonia
Parkinsonism & Related Disorders, 2019Co-Authors: Sabino Dagostino, Tommaso Ercoli, Roberta Pellicciari, Angelo Fabio Gigante, Laura Fadda, Giovanni DefazioAbstract:Abstract Introduction Sensory Trick is a specific maneuver that temporarily improves dystonia that is usually observed in 44%–89% of patients with cranial-cervical dystonia and in 20% of patients with upper limb dystonia. This study aimed to assess the prevalence of Sensory Trick in a cohort of 37 patients with idiopathic adult-onset upper limb dystonia and to determine whether Sensory Trick can be a useful tool to distinguish dystonic and non-dystonic tremor. Methods Thirty-seven right-handed patients with idiopathic upper limb dystonia and disturbed handwriting and 19 patients with non-dystonic action tremor in the upper limb causing writing disturbances participated into the study. Patients were asked to write a standard sentence twice, before and after applying a standardized Sensory Trick (gently grabbing right wrist with his left hand). Readability of the two sentences was assessed by three observers blinded to diagnosis. Results Five/37 patients (13%) self-discovered ST over disease history, while performing the standardized Trick maneuver improved handwriting in 14/37 patients (38%). Interobserver agreement on the effectiveness of Sensory Trick among the three observers yielded a kappa value of 0.86 (p Conclusion The results of applying a standardized non-spontaneous Trick demonstrated that, in upper limb dystonia, ST may be more frequent than usually observed. Effective Sensory Trick, when present, may be a hallmark of idiopathic dystonia. The lack of effective Sensory Trick may help to identify non dystonic upper limb tremor.
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Expert recommendations for diagnosing cervical, oromandibular, and limb dystonia
Neurological Sciences, 2019Co-Authors: Giovanni Defazio, Marcello Esposito, Roberta Pellicciari, Francesco Bono, Alberto Albanese, Cesa L. Scaglione, Francesca Morgante, Giovanni Abbruzzese, Anna R. Bentivoglio, Mario Coletti MojaAbstract:Background Diagnosis of focal dystonia is based on clinical grounds and is therefore open to bias. To date, diagnostic guidelines have been only proposed for blepharospasm and laryngeal dystonia. To provide practical guidance for clinicians with less expertise in dystonia, a group of Italian Movement Disorder experts formulated clinical diagnostic recommendations for cervical, oromandibular, and limb dystonia. Methods A panel of four neurologists generated a list of clinical items related to the motor phenomenology of the examined focal dystonias and a list of clinical features characterizing neurological/non-neurological conditions mimicking dystonia. Thereafter, ten additional expert neurologists assessed the diagnostic relevance of the selected features and the content validity ratio was calculated. The clinical features reaching a content validity ratio > 0.5 contributed to the final recommendations. Results The recommendations retained patterned and repetitive movements/postures as the core feature of dystonia in different body parts. If present, a Sensory Trick confirmed diagnosis of dystonia. In the patients who did not manifest Sensory Trick, active exclusion of clinical features related to conditions mimicking dystonia (features that would be expected to be absent in dystonia) would be necessary for dystonia to be diagnosed. Discussion Although reliability, sensitivity, and specificity of the recommendations are yet to be demonstrated, information from the present study would hopefully facilitate diagnostic approach to focal dystonias in the clinical practice and would be the basis for future validated diagnostic guidelines.
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expert recommendations for diagnosing cervical oromandibular and limb dystonia
Neurological Sciences, 2019Co-Authors: Giovanni Defazio, Marcello Esposito, Roberta Pellicciari, Francesco Bono, Alberto Albanese, Francesca Morgante, Giovanni Abbruzzese, Anna R. Bentivoglio, Cesa Scaglione, Mario Coletti MojaAbstract:Diagnosis of focal dystonia is based on clinical grounds and is therefore open to bias. To date, diagnostic guidelines have been only proposed for blepharospasm and laryngeal dystonia. To provide practical guidance for clinicians with less expertise in dystonia, a group of Italian Movement Disorder experts formulated clinical diagnostic recommendations for cervical, oromandibular, and limb dystonia. A panel of four neurologists generated a list of clinical items related to the motor phenomenology of the examined focal dystonias and a list of clinical features characterizing neurological/non-neurological conditions mimicking dystonia. Thereafter, ten additional expert neurologists assessed the diagnostic relevance of the selected features and the content validity ratio was calculated. The clinical features reaching a content validity ratio > 0.5 contributed to the final recommendations. The recommendations retained patterned and repetitive movements/postures as the core feature of dystonia in different body parts. If present, a Sensory Trick confirmed diagnosis of dystonia. In the patients who did not manifest Sensory Trick, active exclusion of clinical features related to conditions mimicking dystonia (features that would be expected to be absent in dystonia) would be necessary for dystonia to be diagnosed. Although reliability, sensitivity, and specificity of the recommendations are yet to be demonstrated, information from the present study would hopefully facilitate diagnostic approach to focal dystonias in the clinical practice and would be the basis for future validated diagnostic guidelines.
Roberta Pellicciari - One of the best experts on this subject based on the ideXlab platform.
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Demographic and clinical determinants of neck pain in idiopathic cervical dystonia
Journal of Neural Transmission, 2020Co-Authors: Michele Tinazzi, Gina Ferrazzano, Roberto Erro, Marcello Mario Mascia, Marcello Esposito, Tommaso Ercoli, Francesca Biasio, Roberta Pellicciari, Roberto Eleopra, Francesco BonoAbstract:Cervical dystonia is associated with neck pain in a significant proportion of cases, but the mechanisms underlying pain are largely unknown. In this exploratory study, we compared demographic and clinical variables in cervical dystonia patients with and without neck pain from the Italian Dystonia Registry. Univariable and multivariable logistic regression analysis indicated a higher frequency of Sensory Trick and a lower educational level among patients with pain.
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Sensory Trick in upper limb dystonia
Parkinsonism & Related Disorders, 2019Co-Authors: Sabino Dagostino, Tommaso Ercoli, Roberta Pellicciari, Angelo Fabio Gigante, Laura Fadda, Giovanni DefazioAbstract:Abstract Introduction Sensory Trick is a specific maneuver that temporarily improves dystonia that is usually observed in 44%–89% of patients with cranial-cervical dystonia and in 20% of patients with upper limb dystonia. This study aimed to assess the prevalence of Sensory Trick in a cohort of 37 patients with idiopathic adult-onset upper limb dystonia and to determine whether Sensory Trick can be a useful tool to distinguish dystonic and non-dystonic tremor. Methods Thirty-seven right-handed patients with idiopathic upper limb dystonia and disturbed handwriting and 19 patients with non-dystonic action tremor in the upper limb causing writing disturbances participated into the study. Patients were asked to write a standard sentence twice, before and after applying a standardized Sensory Trick (gently grabbing right wrist with his left hand). Readability of the two sentences was assessed by three observers blinded to diagnosis. Results Five/37 patients (13%) self-discovered ST over disease history, while performing the standardized Trick maneuver improved handwriting in 14/37 patients (38%). Interobserver agreement on the effectiveness of Sensory Trick among the three observers yielded a kappa value of 0.86 (p Conclusion The results of applying a standardized non-spontaneous Trick demonstrated that, in upper limb dystonia, ST may be more frequent than usually observed. Effective Sensory Trick, when present, may be a hallmark of idiopathic dystonia. The lack of effective Sensory Trick may help to identify non dystonic upper limb tremor.
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Expert recommendations for diagnosing cervical, oromandibular, and limb dystonia
Neurological Sciences, 2019Co-Authors: Giovanni Defazio, Marcello Esposito, Roberta Pellicciari, Francesco Bono, Alberto Albanese, Cesa L. Scaglione, Francesca Morgante, Giovanni Abbruzzese, Anna R. Bentivoglio, Mario Coletti MojaAbstract:Background Diagnosis of focal dystonia is based on clinical grounds and is therefore open to bias. To date, diagnostic guidelines have been only proposed for blepharospasm and laryngeal dystonia. To provide practical guidance for clinicians with less expertise in dystonia, a group of Italian Movement Disorder experts formulated clinical diagnostic recommendations for cervical, oromandibular, and limb dystonia. Methods A panel of four neurologists generated a list of clinical items related to the motor phenomenology of the examined focal dystonias and a list of clinical features characterizing neurological/non-neurological conditions mimicking dystonia. Thereafter, ten additional expert neurologists assessed the diagnostic relevance of the selected features and the content validity ratio was calculated. The clinical features reaching a content validity ratio > 0.5 contributed to the final recommendations. Results The recommendations retained patterned and repetitive movements/postures as the core feature of dystonia in different body parts. If present, a Sensory Trick confirmed diagnosis of dystonia. In the patients who did not manifest Sensory Trick, active exclusion of clinical features related to conditions mimicking dystonia (features that would be expected to be absent in dystonia) would be necessary for dystonia to be diagnosed. Discussion Although reliability, sensitivity, and specificity of the recommendations are yet to be demonstrated, information from the present study would hopefully facilitate diagnostic approach to focal dystonias in the clinical practice and would be the basis for future validated diagnostic guidelines.
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expert recommendations for diagnosing cervical oromandibular and limb dystonia
Neurological Sciences, 2019Co-Authors: Giovanni Defazio, Marcello Esposito, Roberta Pellicciari, Francesco Bono, Alberto Albanese, Francesca Morgante, Giovanni Abbruzzese, Anna R. Bentivoglio, Cesa Scaglione, Mario Coletti MojaAbstract:Diagnosis of focal dystonia is based on clinical grounds and is therefore open to bias. To date, diagnostic guidelines have been only proposed for blepharospasm and laryngeal dystonia. To provide practical guidance for clinicians with less expertise in dystonia, a group of Italian Movement Disorder experts formulated clinical diagnostic recommendations for cervical, oromandibular, and limb dystonia. A panel of four neurologists generated a list of clinical items related to the motor phenomenology of the examined focal dystonias and a list of clinical features characterizing neurological/non-neurological conditions mimicking dystonia. Thereafter, ten additional expert neurologists assessed the diagnostic relevance of the selected features and the content validity ratio was calculated. The clinical features reaching a content validity ratio > 0.5 contributed to the final recommendations. The recommendations retained patterned and repetitive movements/postures as the core feature of dystonia in different body parts. If present, a Sensory Trick confirmed diagnosis of dystonia. In the patients who did not manifest Sensory Trick, active exclusion of clinical features related to conditions mimicking dystonia (features that would be expected to be absent in dystonia) would be necessary for dystonia to be diagnosed. Although reliability, sensitivity, and specificity of the recommendations are yet to be demonstrated, information from the present study would hopefully facilitate diagnostic approach to focal dystonias in the clinical practice and would be the basis for future validated diagnostic guidelines.
Michael Großbach - One of the best experts on this subject based on the ideXlab platform.
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Sensory Trick phenomenon improves motor control in pianists with dystonia: prognostic value of glove-effect.
Frontiers in Psychology, 2014Co-Authors: Jakobine Paulig, Michael Großbach, Hans-christian Jabusch, Laurent Boullet, Eckart AltenmüllerAbstract:Musician’s dystonia (MD) is a task-specific movement disorder that causes loss of voluntary motor control while playing the instrument. A subgroup of patients displays the so-called Sensory Trick: alteration of somatoSensory input, e.g., by wearing a latex glove, may result in short-term improvement of motor control. In this study, the glove-effect in pianists with MD was quantified and its potential association with MD-severity and outcome after treatment was investigated. Thirty affected pianists were included in the study. Music instrument digital interface-based scale analysis was used for assessment of fine motor control. Therapeutic options included botulinum toxin, pedagogical retraining and anticholinergic medication (trihexyphenidyl). 19% of patients showed significant improvement of fine motor control through wearing a glove. After treatment, outcome was significantly better in patients with a significant pre-treatment Sensory Trick. We conclude that the Sensory Trick may have a prognostic value for the outcome after treatment in pianists with MD.
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Edited by:
2014Co-Authors: Jakobine Paulig, Michael Großbach, Eckart Altenmüller, Hans-christian Jabusch, Laurent Boullet, Matthew A. WyonAbstract:Sensory Trick phenomenon improves motor control i
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Altered Sensory feedbacks in pianist's dystonia: the altered auditory feedback paradigm and the glove effect
Frontiers in Human Neuroscience, 2013Co-Authors: Felicia P.-h. Cheng, Michael Großbach, Eckart AltenmüllerAbstract:Background: This study investigates the effect of altered auditory feedback (AAF) in musician's dystonia (MD) and discusses whether altered auditory feedback can be considered as a Sensory Trick in MD. Furthermore, the effect of AAF is compared with altered tactile feedback, which can serve as a Sensory Trick in several other forms of focal dystonia. Methods: The method is based on scale analysis (Jabusch et al. 2004). Experiment 1 employs synchronization paradigm: 12 MD patients and 25 healthy pianists had to repeatedly play C-major scales in synchrony with a metronome on a MIDI-piano with 3 auditory feedback conditions: 1. normal feedback; 2. no feedback; 3. constant delayed feedback. Experiment 2 employs synchronization-continuation paradigm: 12 MD patients and 12 healthy pianists had to repeatedly play C-major scales in two phases: first in synchrony with a metronome, secondly continue the established tempo without the metronome. There are 4 experimental conditions, among them 3 are the same altered auditory feedback as in Experiment 1 and 1 is related to altered tactile Sensory input. The coefficient of variation of inter-onset intervals of the key depressions was calculated to evaluate fine motor control. Results: In both experiments, the healthy controls and the patients behaved very similarly. There is no difference in the regularity of playing between the two groups under any condition, and neither did AAF nor did altered tactile feedback have a beneficial effect on patients’ fine motor control. Conclusions: The results of the two experiments suggest that in the context of our experimental designs, AAF and altered tactile feedback play a minor role in motor coordination in patients with musicians' dystonia. We propose that altered auditory and tactile feedback do not serve as effective Sensory Tricks and may not temporarily reduce the symptoms of patients suffering from MD in this experimental context.
Kailash P. Bhatia - One of the best experts on this subject based on the ideXlab platform.
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Sensory Trick efficacy in cervical dystonia is linked to processing of neck proprioception
Parkinsonism & Related Disorders, 2019Co-Authors: Kailash P. Bhatia, Florian Brugger, Amy Peters, Dejan Georgiev, Georg Kagi, Bettina Balint, B L DayAbstract:Abstract Background Muscle vibration activates muscle spindles and when applied over posterior neck muscles during stance modulates global body orientation. This is characterised by a tonic forward sway response that is reportedly diminished or absent in patients with idiopathic cervical dystonia. Objective To investigating the impact of the Sensory Trick on vibration-induced postural responses. Methods 20 patients with idiopathic cervical dystonia and a Sensory Trick, 15 patients without a Trick, and 16 healthy controls were recruited. Neck muscle vibration was applied bilaterally over the upper trapezius under three different conditions: 1) Quiet standing; 2) standing while performing the Trick (or Trick-like movement in non-responders); 3) standing while elevating the flexed arm without touching any part of the body. Centre of pressure position and whole-body orientation in the sagittal plane were analysed. Results Patients with a Sensory Trick responded similarly to healthy controls: neck muscle vibration led to an initial forward sway of the body that slowly increased during the prolonged vibration for all three conditions. This response was mainly mediated by ankle flexion. In patients without a Trick, the initial sagittal sway was significantly reduced in all three conditions and the later slow increase was absent. Performance of the Trick did not have an effect on any aspect of the response in either cervical dystonia group. Conclusions The whole-body response to neck vibration in cervical dystonia differs depending on the effectiveness of the Sensory Trick to alleviate the dystonic neck posture. Variable pathophysiology of proprioceptive processing may be the common factor.
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Pathogenesis of dystonia: is it of cerebellar or basal ganglia origin?
Journal of Neurology Neurosurgery & Psychiatry, 2017Co-Authors: Ryuji Kaji, Kailash P. Bhatia, Ann M. GraybielAbstract:Dystonia is a disorder of motor programmes controlling semiautomatic movements or postures, with clinical features such as Sensory Trick , which suggests sensorimotor mismatch as the basis. Dystonia was originally classified as a basal ganglia disease. It is now regarded as a ‘ network’ disorder including the cerebellum, but the exact pathogenesis being unknown. Rare autopsy studies have found pathology both in the striatum and the cerebellum, and functional disorganisation was reported in the somatoSensory cortex in patients. Recent animal studies showed physiologically tight di synaptic connections between the cerebellum and the striatum. We review clinical evidence in light of this new functional interaction between the cerebellum and basal ganglia, and put forward a hypothesis that dystonia is a basal ganglia disorder that can be induced by aberrant afferent inputs from the cerebellum.
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Sensory Tricks in primary cervical dystonia depend on visuotactile temporal discrimination. Mov. Disord. 28, 356–361. doi: 10.1002/mds.25305
2013Co-Authors: Petra Katschnig, Michele Tinazzi, Mirta Fiorio, Diane Ruge, John Rothwell, Kailash P. BhatiaAbstract:ABSTRACT: A characteristic feature of primary cervical dystonia is the presence of ‘‘Sensory Tricks’’ as well as the impairment of temporal and spatial sen-sory discrimination on formal testing. The aim of the present study was to test whether the amount of improvement of abnormal head deviation due to a Sensory Trick is associated with different performance of temporal Sensory discrimination in patients with cer-vical dystonia. We recruited 32 patients with cervical dystonia. Dystonia severity was assessed using the To-ronto Western Spasmodic Torticollis Rating Scale. Patients were rated according to clinical improvement to a Sensory Trick and assigned to 1 of the following groups: (1) no improvement (n 5 6), (2) partial improvement (n 5 17), (3) complete improvement (n
