The Experts below are selected from a list of 1470 Experts worldwide ranked by ideXlab platform
Makoto Kashiwayanagi - One of the best experts on this subject based on the ideXlab platform.
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Hard-Diet Feeding Recovers Neurogenesis in the Subventricular Zone and Olfactory Functions of Mice Impaired by Soft-Diet Feeding
2016Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The presen
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hard diet feeding recovers neurogenesis in the subventricular zone and olfactory functions of mice impaired by soft diet feeding
PLOS ONE, 2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The present results suggest that feeding with a hard diet improves neurogenesis in the SVZ, which in turn enhances olfactory function at the OB.
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Effects of a hard or soft diet on the expression of Fos-ir cells in Pr5, PTg and SNc.
2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:A: A schematic transmission pathway of oral sensation from the mouth to the SVZ. The principal Sensory Trigeminal Nucleus (Pr5), which receive intraoral touch information via the Trigeminal nerve, transmits to the pedunculopontine tegmental Nucleus (PTg) via the thalamus [24], somatoSensory cortex [25], and motor cortex [26]. Neurons of the PTg innervate to the substantia nigra pars compacta (SNc) [27], [28], [47], in which dopaminergic neurons innervate to the SVZ [29], [30]. The number of Fos-ir cells in 100 µm thickness in Figure 115 of the mouse atlas (lateral 1.68 mm) of the Pr5 (B), 100 µm thickness in Figure 111 of the mouse atlas (lateral 1.20 mm) of PTg (C), and 200 µm thickness from Figure 106 of the mouse atlas (lateral 0.60 mm) of SNc (D) to the lateral side of mice after the ingestion of a hard diet (black column), soft diet fed (white column) or no diet (gray column). n = 4 (white and gray column in B). n = 5 (C). n = 10 (black and gray column in D). n = 11 (white column in D). *: p
Chizuru Utsugi - One of the best experts on this subject based on the ideXlab platform.
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Hard-Diet Feeding Recovers Neurogenesis in the Subventricular Zone and Olfactory Functions of Mice Impaired by Soft-Diet Feeding
2016Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The presen
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hard diet feeding recovers neurogenesis in the subventricular zone and olfactory functions of mice impaired by soft diet feeding
PLOS ONE, 2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The present results suggest that feeding with a hard diet improves neurogenesis in the SVZ, which in turn enhances olfactory function at the OB.
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Effects of a hard or soft diet on the expression of Fos-ir cells in Pr5, PTg and SNc.
2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:A: A schematic transmission pathway of oral sensation from the mouth to the SVZ. The principal Sensory Trigeminal Nucleus (Pr5), which receive intraoral touch information via the Trigeminal nerve, transmits to the pedunculopontine tegmental Nucleus (PTg) via the thalamus [24], somatoSensory cortex [25], and motor cortex [26]. Neurons of the PTg innervate to the substantia nigra pars compacta (SNc) [27], [28], [47], in which dopaminergic neurons innervate to the SVZ [29], [30]. The number of Fos-ir cells in 100 µm thickness in Figure 115 of the mouse atlas (lateral 1.68 mm) of the Pr5 (B), 100 µm thickness in Figure 111 of the mouse atlas (lateral 1.20 mm) of PTg (C), and 200 µm thickness from Figure 106 of the mouse atlas (lateral 0.60 mm) of SNc (D) to the lateral side of mice after the ingestion of a hard diet (black column), soft diet fed (white column) or no diet (gray column). n = 4 (white and gray column in B). n = 5 (C). n = 10 (black and gray column in D). n = 11 (white column in D). *: p
Sadaharu Miyazono - One of the best experts on this subject based on the ideXlab platform.
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Hard-Diet Feeding Recovers Neurogenesis in the Subventricular Zone and Olfactory Functions of Mice Impaired by Soft-Diet Feeding
2016Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The presen
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hard diet feeding recovers neurogenesis in the subventricular zone and olfactory functions of mice impaired by soft diet feeding
PLOS ONE, 2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The present results suggest that feeding with a hard diet improves neurogenesis in the SVZ, which in turn enhances olfactory function at the OB.
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Effects of a hard or soft diet on the expression of Fos-ir cells in Pr5, PTg and SNc.
2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:A: A schematic transmission pathway of oral sensation from the mouth to the SVZ. The principal Sensory Trigeminal Nucleus (Pr5), which receive intraoral touch information via the Trigeminal nerve, transmits to the pedunculopontine tegmental Nucleus (PTg) via the thalamus [24], somatoSensory cortex [25], and motor cortex [26]. Neurons of the PTg innervate to the substantia nigra pars compacta (SNc) [27], [28], [47], in which dopaminergic neurons innervate to the SVZ [29], [30]. The number of Fos-ir cells in 100 µm thickness in Figure 115 of the mouse atlas (lateral 1.68 mm) of the Pr5 (B), 100 µm thickness in Figure 111 of the mouse atlas (lateral 1.20 mm) of PTg (C), and 200 µm thickness from Figure 106 of the mouse atlas (lateral 0.60 mm) of SNc (D) to the lateral side of mice after the ingestion of a hard diet (black column), soft diet fed (white column) or no diet (gray column). n = 4 (white and gray column in B). n = 5 (C). n = 10 (black and gray column in D). n = 11 (white column in D). *: p
Kazumi Osada - One of the best experts on this subject based on the ideXlab platform.
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Hard-Diet Feeding Recovers Neurogenesis in the Subventricular Zone and Olfactory Functions of Mice Impaired by Soft-Diet Feeding
2016Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The presen
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hard diet feeding recovers neurogenesis in the subventricular zone and olfactory functions of mice impaired by soft diet feeding
PLOS ONE, 2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The present results suggest that feeding with a hard diet improves neurogenesis in the SVZ, which in turn enhances olfactory function at the OB.
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Effects of a hard or soft diet on the expression of Fos-ir cells in Pr5, PTg and SNc.
2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:A: A schematic transmission pathway of oral sensation from the mouth to the SVZ. The principal Sensory Trigeminal Nucleus (Pr5), which receive intraoral touch information via the Trigeminal nerve, transmits to the pedunculopontine tegmental Nucleus (PTg) via the thalamus [24], somatoSensory cortex [25], and motor cortex [26]. Neurons of the PTg innervate to the substantia nigra pars compacta (SNc) [27], [28], [47], in which dopaminergic neurons innervate to the SVZ [29], [30]. The number of Fos-ir cells in 100 µm thickness in Figure 115 of the mouse atlas (lateral 1.68 mm) of the Pr5 (B), 100 µm thickness in Figure 111 of the mouse atlas (lateral 1.20 mm) of PTg (C), and 200 µm thickness from Figure 106 of the mouse atlas (lateral 0.60 mm) of SNc (D) to the lateral side of mice after the ingestion of a hard diet (black column), soft diet fed (white column) or no diet (gray column). n = 4 (white and gray column in B). n = 5 (C). n = 10 (black and gray column in D). n = 11 (white column in D). *: p
Tomohiro Noguchi - One of the best experts on this subject based on the ideXlab platform.
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Hard-Diet Feeding Recovers Neurogenesis in the Subventricular Zone and Olfactory Functions of Mice Impaired by Soft-Diet Feeding
2016Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The presen
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hard diet feeding recovers neurogenesis in the subventricular zone and olfactory functions of mice impaired by soft diet feeding
PLOS ONE, 2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:The subventricular zone (SVZ) generates an immense number of neurons even during adulthood. These neurons migrate to the olfactory bulb (OB) and differentiate into granule cells and periglomerular cells. The information broadcast by general odorants is received by the olfactory Sensory neurons and transmitted to the OB. Recent studies have shown that a reduction of mastication impairs both neurogenesis in the hippocampus and brain functions. To examine these effects, we first measured the difference in Fos-immunoreactivity (Fos-ir) at the principal Sensory Trigeminal Nucleus (Pr5), which receives intraoral touch information via the Trigeminal nerve, when female adult mice ingested a hard or soft diet to explore whether soft-diet feeding could mimic impaired mastication. Ingestion of a hard diet induced greater expression of Fos-ir cells at the Pr5 than did a soft diet or no diet. Bromodeoxyuridine-immunoreactive (BrdU-ir) structures in sagittal sections of the SVZ and in the OB of mice fed a soft or hard diet were studied to explore the effects of changes in mastication on newly generated neurons. After 1 month, the density of BrdU-ir cells in the SVZ and OB was lower in the soft-diet-fed mice than in the hard-diet-fed mice. The odor preferences of individual female mice to butyric acid were tested in a Y-maze apparatus. Avoidance of butyric acid was reduced by the soft-diet feeding. We then explored the effects of the hard-diet feeding on olfactory functions and neurogenesis in the SVZ of mice impaired by soft-diet feeding. At 3 months of hard-diet feeding, avoidance of butyric acid was reversed and responses to odors and neurogenesis were recovered in the SVZ. The present results suggest that feeding with a hard diet improves neurogenesis in the SVZ, which in turn enhances olfactory function at the OB.
-
Effects of a hard or soft diet on the expression of Fos-ir cells in Pr5, PTg and SNc.
2014Co-Authors: Chizuru Utsugi, Tomohiro Noguchi, Sadaharu Miyazono, Kazumi Osada, Hitoshi Sasajima, Mitsuyoshi Matsuda, Makoto KashiwayanagiAbstract:A: A schematic transmission pathway of oral sensation from the mouth to the SVZ. The principal Sensory Trigeminal Nucleus (Pr5), which receive intraoral touch information via the Trigeminal nerve, transmits to the pedunculopontine tegmental Nucleus (PTg) via the thalamus [24], somatoSensory cortex [25], and motor cortex [26]. Neurons of the PTg innervate to the substantia nigra pars compacta (SNc) [27], [28], [47], in which dopaminergic neurons innervate to the SVZ [29], [30]. The number of Fos-ir cells in 100 µm thickness in Figure 115 of the mouse atlas (lateral 1.68 mm) of the Pr5 (B), 100 µm thickness in Figure 111 of the mouse atlas (lateral 1.20 mm) of PTg (C), and 200 µm thickness from Figure 106 of the mouse atlas (lateral 0.60 mm) of SNc (D) to the lateral side of mice after the ingestion of a hard diet (black column), soft diet fed (white column) or no diet (gray column). n = 4 (white and gray column in B). n = 5 (C). n = 10 (black and gray column in D). n = 11 (white column in D). *: p
