The Experts below are selected from a list of 168 Experts worldwide ranked by ideXlab platform
Tracy Butler - One of the best experts on this subject based on the ideXlab platform.
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Basal forebrain Septal Nuclei are enlarged in healthy subjects prior to the development of Alzheimer's disease.
Neurobiology of aging, 2018Co-Authors: Tracy Butler, Xiuyuan Wang, Patrick Harvey, Anup Deshpande, Emily Tanzi, Wai Tsui, Caroline Silver, Esther Fischer, Jingyun ChenAbstract:Abstract Alzheimer's disease (AD) is known to be associated with loss of cholinergic neurons in the nucleus basalis of Meynert, located in the posterior basal forebrain. Structural changes of Septal Nuclei, located in the anterior basal forebrain, have not been well studied in AD. Using a validated algorithm, we manually traced Septal Nuclei on high-resolution coronal magnetic resonance imaging (MRI) in 40 subjects with mild cognitive impairment (MCI) or AD, 89 healthy controls, and 18 subjects who were cognitively normal at the time of MRI but went on to develop AD an average of 2.8 years later. We found that cognitively normal subjects destined to develop AD in the future had enlarged Septal Nuclei as compared to both healthy controls and patients with current MCI or AD. To our knowledge, this is the first time a brain structure has been found to be enlarged in association with risk of AD. Further research is needed to determine if Septal enlargement reflects neuroplastic compensation, amyloid deposition, inflammation, or another process and to determine whether it can serve as an early MRI biomarker of AD.
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comparison of human Septal Nuclei mri measurements using automated segmentation and a new manual protocol based on histology
NeuroImage, 2014Co-Authors: Tracy Butler, Laszlo Zaborszky, Wai Tsui, Elizabeth Pirraglia, Xiuyuan Hugh Wang, Delia M Talos, Orrin Devinsky, Izabela Kuchna, Krzysztof Nowicki, Jacqueline A. FrenchAbstract:Septal Nuclei, located in basal forebrain, are strongly connected with hippocampi and important in learning and memory, but have received limited research attention in human MRI studies. While probabilistic maps for estimating Septal volume on MRI are now available, they have not been independently validated against manual tracing of MRI, typically considered the gold standard for delineating brain structures. We developed a protocol for manual tracing of the human Septal region on MRI based on examination of neuroanatomical specimens. We applied this tracing protocol to T1 MRI scans (n=86) from subjects with temporal epilepsy and healthy controls to measure Septal volume. To assess the inter-rater reliability of the protocol, a second tracer used the same protocol on 20 scans that were randomly selected from the 72 healthy controls. In addition to measuring Septal volume, maximum Septal thickness between the ventricles was measured and recorded. The same scans (n=86) were also analyzed using Septal probabilistic maps and DARTEL toolbox in SPM. Results show that our manual tracing algorithm is reliable, and that Septal volume measurements obtained via manual and automated methods correlate significantly with each other (p<.001). Both manual and automated methods detected significantly enlarged Septal Nuclei in patients with temporal lobe epilepsy in accord with a proposed compensatory neuroplastic process related to the strong connections between Septal Nuclei and hippocampi. Septal thickness, which was simple to measure with excellent inter-rater reliability, correlated well with both manual and automated Septal volume, suggesting it could serve as an easy-to-measure surrogate for Septal volume in future studies. Our results call attention to the important though understudied human Septal region, confirm its enlargement in temporal lobe epilepsy, and provide a reliable new manual delineation protocol that will facilitate continued study of this critical region.
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Comparison of human Septal Nuclei MRI measurements using automated segmentation and a new manual protocol based on histology.
NeuroImage, 2014Co-Authors: Tracy Butler, Laszlo Zaborszky, Wai Tsui, Elizabeth Pirraglia, Xiuyuan Hugh Wang, Delia M Talos, Orrin Devinsky, Izabela KuchnaAbstract:Septal Nuclei, located in basal forebrain, are strongly connected with hippocampi and important in learning and memory, but have received limited research attention in human MRI studies. While probabilistic maps for estimating Septal volume on MRI are now available, they have not been independently validated against manual tracing of MRI, typically considered the gold standard for delineating brain structures. We developed a protocol for manual tracing of the human Septal region on MRI based on examination of neuroanatomical specimens. We applied this tracing protocol to T1 MRI scans (n=86) from subjects with temporal epilepsy and healthy controls to measure Septal volume. To assess the inter-rater reliability of the protocol, a second tracer used the same protocol on 20 scans that were randomly selected from the 72 healthy controls. In addition to measuring Septal volume, maximum Septal thickness between the ventricles was measured and recorded. The same scans (n=86) were also analyzed using Septal probabilistic maps and DARTEL toolbox in SPM. Results show that our manual tracing algorithm is reliable, and that Septal volume measurements obtained via manual and automated methods correlate significantly with each other (p
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Septal Nuclei enlargement in human temporal lobe epilepsy without mesial temporal sclerosis.
Neurology, 2013Co-Authors: Tracy Butler, Laszlo Zaborszky, Xiuyuan Wang, Carrie R. Mcdonald, Karen Blackmon, Brian T. Quinn, Jonathan Dubois, Chad Carlson, William B. Barr, Jacqueline A. FrenchAbstract:Objective: To measure the volume of basal forebrain Septal Nuclei in patients with temporal lobe epilepsy (TLE) as compared to patients with extratemporal epilepsy and controls. In animal models of TLE, Septal lesions facilitate epileptogenesis, while Septal stimulation is antiepileptic. Method: Subjects were recruited from 2 sites and consisted of patients with pharmacoresistant focal epilepsy (20 with TLE and mesial temporal sclerosis [MTS], 24 with TLE without MTS, 23 with extratemporal epilepsy) and 114 controls. Septal volume was measured using high-resolution MRI in association with newly developed probabilistic Septal Nuclei maps. Septal volume was compared between subject groups while controlling for relevant factors. Results: Patients with TLE without MTS had significantly larger Septal Nuclei than patients with extratemporal epilepsy and controls. This was not true for patients with MTS. These results are interpreted with reference to prior studies demonstrating expansion of the septo-hippocampal cholinergic system in animal models of TLE and human TLE surgical specimens. Conclusion: Septal Nuclei are enlarged in patients with TLE without MTS. Further investigation of Septal Nuclei and antiepileptic septo-hippocampal neurocircuitry could be relevant to development of new therapeutic interventions such as Septal stimulation for refractory TLE.
Jacqueline A. French - One of the best experts on this subject based on the ideXlab platform.
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comparison of human Septal Nuclei mri measurements using automated segmentation and a new manual protocol based on histology
NeuroImage, 2014Co-Authors: Tracy Butler, Laszlo Zaborszky, Wai Tsui, Elizabeth Pirraglia, Xiuyuan Hugh Wang, Delia M Talos, Orrin Devinsky, Izabela Kuchna, Krzysztof Nowicki, Jacqueline A. FrenchAbstract:Septal Nuclei, located in basal forebrain, are strongly connected with hippocampi and important in learning and memory, but have received limited research attention in human MRI studies. While probabilistic maps for estimating Septal volume on MRI are now available, they have not been independently validated against manual tracing of MRI, typically considered the gold standard for delineating brain structures. We developed a protocol for manual tracing of the human Septal region on MRI based on examination of neuroanatomical specimens. We applied this tracing protocol to T1 MRI scans (n=86) from subjects with temporal epilepsy and healthy controls to measure Septal volume. To assess the inter-rater reliability of the protocol, a second tracer used the same protocol on 20 scans that were randomly selected from the 72 healthy controls. In addition to measuring Septal volume, maximum Septal thickness between the ventricles was measured and recorded. The same scans (n=86) were also analyzed using Septal probabilistic maps and DARTEL toolbox in SPM. Results show that our manual tracing algorithm is reliable, and that Septal volume measurements obtained via manual and automated methods correlate significantly with each other (p<.001). Both manual and automated methods detected significantly enlarged Septal Nuclei in patients with temporal lobe epilepsy in accord with a proposed compensatory neuroplastic process related to the strong connections between Septal Nuclei and hippocampi. Septal thickness, which was simple to measure with excellent inter-rater reliability, correlated well with both manual and automated Septal volume, suggesting it could serve as an easy-to-measure surrogate for Septal volume in future studies. Our results call attention to the important though understudied human Septal region, confirm its enlargement in temporal lobe epilepsy, and provide a reliable new manual delineation protocol that will facilitate continued study of this critical region.
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Septal Nuclei enlargement in human temporal lobe epilepsy without mesial temporal sclerosis.
Neurology, 2013Co-Authors: Tracy Butler, Laszlo Zaborszky, Xiuyuan Wang, Carrie R. Mcdonald, Karen Blackmon, Brian T. Quinn, Jonathan Dubois, Chad Carlson, William B. Barr, Jacqueline A. FrenchAbstract:Objective: To measure the volume of basal forebrain Septal Nuclei in patients with temporal lobe epilepsy (TLE) as compared to patients with extratemporal epilepsy and controls. In animal models of TLE, Septal lesions facilitate epileptogenesis, while Septal stimulation is antiepileptic. Method: Subjects were recruited from 2 sites and consisted of patients with pharmacoresistant focal epilepsy (20 with TLE and mesial temporal sclerosis [MTS], 24 with TLE without MTS, 23 with extratemporal epilepsy) and 114 controls. Septal volume was measured using high-resolution MRI in association with newly developed probabilistic Septal Nuclei maps. Septal volume was compared between subject groups while controlling for relevant factors. Results: Patients with TLE without MTS had significantly larger Septal Nuclei than patients with extratemporal epilepsy and controls. This was not true for patients with MTS. These results are interpreted with reference to prior studies demonstrating expansion of the septo-hippocampal cholinergic system in animal models of TLE and human TLE surgical specimens. Conclusion: Septal Nuclei are enlarged in patients with TLE without MTS. Further investigation of Septal Nuclei and antiepileptic septo-hippocampal neurocircuitry could be relevant to development of new therapeutic interventions such as Septal stimulation for refractory TLE.
Laszlo Zaborszky - One of the best experts on this subject based on the ideXlab platform.
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comparison of human Septal Nuclei mri measurements using automated segmentation and a new manual protocol based on histology
NeuroImage, 2014Co-Authors: Tracy Butler, Laszlo Zaborszky, Wai Tsui, Elizabeth Pirraglia, Xiuyuan Hugh Wang, Delia M Talos, Orrin Devinsky, Izabela Kuchna, Krzysztof Nowicki, Jacqueline A. FrenchAbstract:Septal Nuclei, located in basal forebrain, are strongly connected with hippocampi and important in learning and memory, but have received limited research attention in human MRI studies. While probabilistic maps for estimating Septal volume on MRI are now available, they have not been independently validated against manual tracing of MRI, typically considered the gold standard for delineating brain structures. We developed a protocol for manual tracing of the human Septal region on MRI based on examination of neuroanatomical specimens. We applied this tracing protocol to T1 MRI scans (n=86) from subjects with temporal epilepsy and healthy controls to measure Septal volume. To assess the inter-rater reliability of the protocol, a second tracer used the same protocol on 20 scans that were randomly selected from the 72 healthy controls. In addition to measuring Septal volume, maximum Septal thickness between the ventricles was measured and recorded. The same scans (n=86) were also analyzed using Septal probabilistic maps and DARTEL toolbox in SPM. Results show that our manual tracing algorithm is reliable, and that Septal volume measurements obtained via manual and automated methods correlate significantly with each other (p<.001). Both manual and automated methods detected significantly enlarged Septal Nuclei in patients with temporal lobe epilepsy in accord with a proposed compensatory neuroplastic process related to the strong connections between Septal Nuclei and hippocampi. Septal thickness, which was simple to measure with excellent inter-rater reliability, correlated well with both manual and automated Septal volume, suggesting it could serve as an easy-to-measure surrogate for Septal volume in future studies. Our results call attention to the important though understudied human Septal region, confirm its enlargement in temporal lobe epilepsy, and provide a reliable new manual delineation protocol that will facilitate continued study of this critical region.
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Comparison of human Septal Nuclei MRI measurements using automated segmentation and a new manual protocol based on histology.
NeuroImage, 2014Co-Authors: Tracy Butler, Laszlo Zaborszky, Wai Tsui, Elizabeth Pirraglia, Xiuyuan Hugh Wang, Delia M Talos, Orrin Devinsky, Izabela KuchnaAbstract:Septal Nuclei, located in basal forebrain, are strongly connected with hippocampi and important in learning and memory, but have received limited research attention in human MRI studies. While probabilistic maps for estimating Septal volume on MRI are now available, they have not been independently validated against manual tracing of MRI, typically considered the gold standard for delineating brain structures. We developed a protocol for manual tracing of the human Septal region on MRI based on examination of neuroanatomical specimens. We applied this tracing protocol to T1 MRI scans (n=86) from subjects with temporal epilepsy and healthy controls to measure Septal volume. To assess the inter-rater reliability of the protocol, a second tracer used the same protocol on 20 scans that were randomly selected from the 72 healthy controls. In addition to measuring Septal volume, maximum Septal thickness between the ventricles was measured and recorded. The same scans (n=86) were also analyzed using Septal probabilistic maps and DARTEL toolbox in SPM. Results show that our manual tracing algorithm is reliable, and that Septal volume measurements obtained via manual and automated methods correlate significantly with each other (p
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Septal Nuclei enlargement in human temporal lobe epilepsy without mesial temporal sclerosis.
Neurology, 2013Co-Authors: Tracy Butler, Laszlo Zaborszky, Xiuyuan Wang, Carrie R. Mcdonald, Karen Blackmon, Brian T. Quinn, Jonathan Dubois, Chad Carlson, William B. Barr, Jacqueline A. FrenchAbstract:Objective: To measure the volume of basal forebrain Septal Nuclei in patients with temporal lobe epilepsy (TLE) as compared to patients with extratemporal epilepsy and controls. In animal models of TLE, Septal lesions facilitate epileptogenesis, while Septal stimulation is antiepileptic. Method: Subjects were recruited from 2 sites and consisted of patients with pharmacoresistant focal epilepsy (20 with TLE and mesial temporal sclerosis [MTS], 24 with TLE without MTS, 23 with extratemporal epilepsy) and 114 controls. Septal volume was measured using high-resolution MRI in association with newly developed probabilistic Septal Nuclei maps. Septal volume was compared between subject groups while controlling for relevant factors. Results: Patients with TLE without MTS had significantly larger Septal Nuclei than patients with extratemporal epilepsy and controls. This was not true for patients with MTS. These results are interpreted with reference to prior studies demonstrating expansion of the septo-hippocampal cholinergic system in animal models of TLE and human TLE surgical specimens. Conclusion: Septal Nuclei are enlarged in patients with TLE without MTS. Further investigation of Septal Nuclei and antiepileptic septo-hippocampal neurocircuitry could be relevant to development of new therapeutic interventions such as Septal stimulation for refractory TLE.
Wai Tsui - One of the best experts on this subject based on the ideXlab platform.
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Basal forebrain Septal Nuclei are enlarged in healthy subjects prior to the development of Alzheimer's disease.
Neurobiology of aging, 2018Co-Authors: Tracy Butler, Xiuyuan Wang, Patrick Harvey, Anup Deshpande, Emily Tanzi, Wai Tsui, Caroline Silver, Esther Fischer, Jingyun ChenAbstract:Abstract Alzheimer's disease (AD) is known to be associated with loss of cholinergic neurons in the nucleus basalis of Meynert, located in the posterior basal forebrain. Structural changes of Septal Nuclei, located in the anterior basal forebrain, have not been well studied in AD. Using a validated algorithm, we manually traced Septal Nuclei on high-resolution coronal magnetic resonance imaging (MRI) in 40 subjects with mild cognitive impairment (MCI) or AD, 89 healthy controls, and 18 subjects who were cognitively normal at the time of MRI but went on to develop AD an average of 2.8 years later. We found that cognitively normal subjects destined to develop AD in the future had enlarged Septal Nuclei as compared to both healthy controls and patients with current MCI or AD. To our knowledge, this is the first time a brain structure has been found to be enlarged in association with risk of AD. Further research is needed to determine if Septal enlargement reflects neuroplastic compensation, amyloid deposition, inflammation, or another process and to determine whether it can serve as an early MRI biomarker of AD.
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comparison of human Septal Nuclei mri measurements using automated segmentation and a new manual protocol based on histology
NeuroImage, 2014Co-Authors: Tracy Butler, Laszlo Zaborszky, Wai Tsui, Elizabeth Pirraglia, Xiuyuan Hugh Wang, Delia M Talos, Orrin Devinsky, Izabela Kuchna, Krzysztof Nowicki, Jacqueline A. FrenchAbstract:Septal Nuclei, located in basal forebrain, are strongly connected with hippocampi and important in learning and memory, but have received limited research attention in human MRI studies. While probabilistic maps for estimating Septal volume on MRI are now available, they have not been independently validated against manual tracing of MRI, typically considered the gold standard for delineating brain structures. We developed a protocol for manual tracing of the human Septal region on MRI based on examination of neuroanatomical specimens. We applied this tracing protocol to T1 MRI scans (n=86) from subjects with temporal epilepsy and healthy controls to measure Septal volume. To assess the inter-rater reliability of the protocol, a second tracer used the same protocol on 20 scans that were randomly selected from the 72 healthy controls. In addition to measuring Septal volume, maximum Septal thickness between the ventricles was measured and recorded. The same scans (n=86) were also analyzed using Septal probabilistic maps and DARTEL toolbox in SPM. Results show that our manual tracing algorithm is reliable, and that Septal volume measurements obtained via manual and automated methods correlate significantly with each other (p<.001). Both manual and automated methods detected significantly enlarged Septal Nuclei in patients with temporal lobe epilepsy in accord with a proposed compensatory neuroplastic process related to the strong connections between Septal Nuclei and hippocampi. Septal thickness, which was simple to measure with excellent inter-rater reliability, correlated well with both manual and automated Septal volume, suggesting it could serve as an easy-to-measure surrogate for Septal volume in future studies. Our results call attention to the important though understudied human Septal region, confirm its enlargement in temporal lobe epilepsy, and provide a reliable new manual delineation protocol that will facilitate continued study of this critical region.
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Comparison of human Septal Nuclei MRI measurements using automated segmentation and a new manual protocol based on histology.
NeuroImage, 2014Co-Authors: Tracy Butler, Laszlo Zaborszky, Wai Tsui, Elizabeth Pirraglia, Xiuyuan Hugh Wang, Delia M Talos, Orrin Devinsky, Izabela KuchnaAbstract:Septal Nuclei, located in basal forebrain, are strongly connected with hippocampi and important in learning and memory, but have received limited research attention in human MRI studies. While probabilistic maps for estimating Septal volume on MRI are now available, they have not been independently validated against manual tracing of MRI, typically considered the gold standard for delineating brain structures. We developed a protocol for manual tracing of the human Septal region on MRI based on examination of neuroanatomical specimens. We applied this tracing protocol to T1 MRI scans (n=86) from subjects with temporal epilepsy and healthy controls to measure Septal volume. To assess the inter-rater reliability of the protocol, a second tracer used the same protocol on 20 scans that were randomly selected from the 72 healthy controls. In addition to measuring Septal volume, maximum Septal thickness between the ventricles was measured and recorded. The same scans (n=86) were also analyzed using Septal probabilistic maps and DARTEL toolbox in SPM. Results show that our manual tracing algorithm is reliable, and that Septal volume measurements obtained via manual and automated methods correlate significantly with each other (p
N.m. Kantak - One of the best experts on this subject based on the ideXlab platform.
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Septal regulation of male sexual behavior in rats
Physiology & Behavior, 1995Co-Authors: Gogate Mg, Brid Sv, Wingkar Kc, N.m. KantakAbstract:Abstract Involvement of Septal Nuclei in modulation of male sexual behavior in rats was investigated. Sexually active Wistar male rats were assigned to intact, sham, lateral Septal Nuclei lesioned (LSL), and medial Septal Nuclei lesioned (MSL) groups. All male rats were tested for sexual behavior in an arena in the presence of a sexually receptive female. Intromiss ion and ejaculation latencies were increased, and mount, intrornission, and ejaculation frequencies were decreased in the LSL group compared to the intact group. In contrast, mount and intromission latencies were decreased, and pursuit and mount frequencies were increased in the MSL group compared to the intact group. The results indicate that medial Septal Nuclei may inhibit and lateral Septal Nuclei may facilitate male sexual behavior in rats.
