The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Dan J Stein - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence
BMC Psychiatry, 2005Co-Authors: Bavanisha Vythilingum, Charmaine J Hugo, J Stefan Maritz, Willie Pienaar, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink. Methods Fifteen patients with alcohol dependence who had undergone detoxification were recruited. Sumatriptan (100 mg) and placebo was administered in cross-over fashion on 2 separate days 72 hours apart. Both patients and raters were blind to all treatments. Patients were assessed on the following scales at -30, 0, 30, 90, 150 and 210 minutes: A 6-item scale designed to rate the patient's intention to drink; The Sensation Scale; a 13-item affect analog scale designed to rate the pattern and extent of emotional changes; and an 8-item scale designed to rate the patient's craving for alcohol Results No significant differences were found between the placebo and sumatriptan groups and no significant cross over effects were found. Conclusion The general lack of efficacy of sumatriptan in producing alcohol-like symptoms or a desire to drink alcohol may suggest that the 5HT1D receptor plays little role in the pathophysiology of alcoholism.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence.
BMC psychiatry, 2005Co-Authors: Bavanisha Vythilingum, J Stefan Maritz, Willie Pienaar, Charmaine Hugo, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink.
Bavanisha Vythilingum - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence
BMC Psychiatry, 2005Co-Authors: Bavanisha Vythilingum, Charmaine J Hugo, J Stefan Maritz, Willie Pienaar, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink. Methods Fifteen patients with alcohol dependence who had undergone detoxification were recruited. Sumatriptan (100 mg) and placebo was administered in cross-over fashion on 2 separate days 72 hours apart. Both patients and raters were blind to all treatments. Patients were assessed on the following scales at -30, 0, 30, 90, 150 and 210 minutes: A 6-item scale designed to rate the patient's intention to drink; The Sensation Scale; a 13-item affect analog scale designed to rate the pattern and extent of emotional changes; and an 8-item scale designed to rate the patient's craving for alcohol Results No significant differences were found between the placebo and sumatriptan groups and no significant cross over effects were found. Conclusion The general lack of efficacy of sumatriptan in producing alcohol-like symptoms or a desire to drink alcohol may suggest that the 5HT1D receptor plays little role in the pathophysiology of alcoholism.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence.
BMC psychiatry, 2005Co-Authors: Bavanisha Vythilingum, J Stefan Maritz, Willie Pienaar, Charmaine Hugo, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink.
J Stefan Maritz - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence
BMC Psychiatry, 2005Co-Authors: Bavanisha Vythilingum, Charmaine J Hugo, J Stefan Maritz, Willie Pienaar, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink. Methods Fifteen patients with alcohol dependence who had undergone detoxification were recruited. Sumatriptan (100 mg) and placebo was administered in cross-over fashion on 2 separate days 72 hours apart. Both patients and raters were blind to all treatments. Patients were assessed on the following scales at -30, 0, 30, 90, 150 and 210 minutes: A 6-item scale designed to rate the patient's intention to drink; The Sensation Scale; a 13-item affect analog scale designed to rate the pattern and extent of emotional changes; and an 8-item scale designed to rate the patient's craving for alcohol Results No significant differences were found between the placebo and sumatriptan groups and no significant cross over effects were found. Conclusion The general lack of efficacy of sumatriptan in producing alcohol-like symptoms or a desire to drink alcohol may suggest that the 5HT1D receptor plays little role in the pathophysiology of alcoholism.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence.
BMC psychiatry, 2005Co-Authors: Bavanisha Vythilingum, J Stefan Maritz, Willie Pienaar, Charmaine Hugo, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink.
Willie Pienaar - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence
BMC Psychiatry, 2005Co-Authors: Bavanisha Vythilingum, Charmaine J Hugo, J Stefan Maritz, Willie Pienaar, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink. Methods Fifteen patients with alcohol dependence who had undergone detoxification were recruited. Sumatriptan (100 mg) and placebo was administered in cross-over fashion on 2 separate days 72 hours apart. Both patients and raters were blind to all treatments. Patients were assessed on the following scales at -30, 0, 30, 90, 150 and 210 minutes: A 6-item scale designed to rate the patient's intention to drink; The Sensation Scale; a 13-item affect analog scale designed to rate the pattern and extent of emotional changes; and an 8-item scale designed to rate the patient's craving for alcohol Results No significant differences were found between the placebo and sumatriptan groups and no significant cross over effects were found. Conclusion The general lack of efficacy of sumatriptan in producing alcohol-like symptoms or a desire to drink alcohol may suggest that the 5HT1D receptor plays little role in the pathophysiology of alcoholism.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence.
BMC psychiatry, 2005Co-Authors: Bavanisha Vythilingum, J Stefan Maritz, Willie Pienaar, Charmaine Hugo, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink.
Charmaine J Hugo - One of the best experts on this subject based on the ideXlab platform.
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Pharmacological challenge with a Serotonin 1D Agonist in alcohol dependence
BMC Psychiatry, 2005Co-Authors: Bavanisha Vythilingum, Charmaine J Hugo, J Stefan Maritz, Willie Pienaar, Dan J SteinAbstract:Background Both animal and clinical studies have implicated serotonergic dysfunction in the pathogenesis of alcohol abuse and dependence. However the exact mechanisms involved remain unknown. Theoretically, low Serotonin promotes alcohol seeking behavior. Sumatriptan is a Serotonin1D Agonist. It is postulated that sumatriptan's agonism at this terminal autoreceptor increases negative feedback, creating a net effect of decreased serotonergic neurotransmission. Administration of sumatriptan should therefore produce a craving for alcohol and the desire to drink. Methods Fifteen patients with alcohol dependence who had undergone detoxification were recruited. Sumatriptan (100 mg) and placebo was administered in cross-over fashion on 2 separate days 72 hours apart. Both patients and raters were blind to all treatments. Patients were assessed on the following scales at -30, 0, 30, 90, 150 and 210 minutes: A 6-item scale designed to rate the patient's intention to drink; The Sensation Scale; a 13-item affect analog scale designed to rate the pattern and extent of emotional changes; and an 8-item scale designed to rate the patient's craving for alcohol Results No significant differences were found between the placebo and sumatriptan groups and no significant cross over effects were found. Conclusion The general lack of efficacy of sumatriptan in producing alcohol-like symptoms or a desire to drink alcohol may suggest that the 5HT1D receptor plays little role in the pathophysiology of alcoholism.
