The Experts below are selected from a list of 12 Experts worldwide ranked by ideXlab platform
David Goldman - One of the best experts on this subject based on the ideXlab platform.
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Identification of a naturally occurring Pro15-Ser15 substitution in the Serotonin5A Receptor gene in alcoholics and healthy volunteers.
Molecular Brain Research, 1998Co-Authors: Nakao Iwata, Matti Virkkunen, Markku Linnoila, David GoldmanAbstract:Abstract We screened the Serotonin 5A Receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the Receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively ( p =n.s.).
Nakao Iwata - One of the best experts on this subject based on the ideXlab platform.
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Identification of a naturally occurring Pro15-Ser15 substitution in the Serotonin5A Receptor gene in alcoholics and healthy volunteers.
Molecular Brain Research, 1998Co-Authors: Nakao Iwata, Matti Virkkunen, Markku Linnoila, David GoldmanAbstract:Abstract We screened the Serotonin 5A Receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the Receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively ( p =n.s.).
Matti Virkkunen - One of the best experts on this subject based on the ideXlab platform.
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Identification of a naturally occurring Pro15-Ser15 substitution in the Serotonin5A Receptor gene in alcoholics and healthy volunteers.
Molecular Brain Research, 1998Co-Authors: Nakao Iwata, Matti Virkkunen, Markku Linnoila, David GoldmanAbstract:Abstract We screened the Serotonin 5A Receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the Receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively ( p =n.s.).
Markku Linnoila - One of the best experts on this subject based on the ideXlab platform.
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Identification of a naturally occurring Pro15-Ser15 substitution in the Serotonin5A Receptor gene in alcoholics and healthy volunteers.
Molecular Brain Research, 1998Co-Authors: Nakao Iwata, Matti Virkkunen, Markku Linnoila, David GoldmanAbstract:Abstract We screened the Serotonin 5A Receptor gene coding region in 186 unrelated alcoholic patients and 187 controls. A relatively abundant amino acid substitution and two synonymous DNA substitutions were detected. Two synonymous variants, A12T and C789T, had rarer-allele frequencies of 23% and 1%, respectively. The Pro15Ser substitution is located in the amino terminal, extracellular domain of the Receptor adjacent to a putative phosphorylation site. Pro15Ser had rarer-allele frequencies of 8.1% and 5.9% in Finnish alcoholic patients and controls, respectively ( p =n.s.).
Hun Soo Chang - One of the best experts on this subject based on the ideXlab platform.
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Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression.
Neuropsychobiology, 2014Co-Authors: Hun Soo ChangAbstract:BACKGROUND/AIMS: The genetic variations in Serotonin-related genes may be associated with antidepressant treatment response in major depressive disorder (MDD). The tryptophan hydroxylase-1 (TPH1) gene and Serotonin 5A Receptor (HTR5A) gene are known to be involved in Serotonin biosynthesis and signal transduction, respectively. The purpose of this study was to investigate a possible interaction between the TPH1 gene and the HTR5A gene in the treatment outcome of escitalopram in MDD. METHODS: In total, 245 patients diagnosed with MDD were recruited, and their symptoms were evaluated using the 17-item Hamilton Depression Rating scale (HAMD-17). The association between the TPH1 218A/C and HTR5A 12A/T polymorphisms and the clinical outcomes (remission, response and changes in HAMD-17 score) was investigated after 2, 4 and 8 weeks of escitalopram treatment using multiple logistic regression or multiple linear regression analysis. RESULTS: No significant associations of TPH1 or HTR5A gene polymorphisms were observed with either response rate or remission rate at 2, 4 and 8 weeks after escitalopram treatment. In addition, the gene-gene interaction between TPH1 and HTR5A genes was not associated with the treatment outcome. CONCLUSIONS: Our results suggest that TPH1 218A/C and HTR5A 12A/T polymorphisms cannot predict treatment response in major depression.
