The Experts below are selected from a list of 10416 Experts worldwide ranked by ideXlab platform
Rodney Sinclair - One of the best experts on this subject based on the ideXlab platform.
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novel Shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine associated receptor
Journal of Cosmetic Dermatology, 2019Co-Authors: Maja Kovacevic, Andy Goren, Jerry Shapiro, John Mccoy, Andrija Stanimirovic, Sergio Vanogalvan, Mirna Šitum, Rodney SinclairAbstract:BACKGROUND: Approximately 40% of women experience excessive hair shedding when washing their hair. Previously, we have demonstrated that a topically applied alpha1 adrenergic receptor agonist can be used to contract the arrector pili muscle of the follicular unit (ie, produce "goose bumps"), increasing the force required to pluck hair by as much as 400%. Subsequently, we reported a topical cosmetic solution containing an alpha1 adrenergic receptor agonist that reduced hair shedding during brushing by a maximum of 77%. AIMS: In this communication, we explore a novel mechanism to contract the arrector pili muscle. Trace amine-associated receptors (TAAR) have been shown to regulate smooth muscle tone in blood vessels, but have not been reported to be present in the skin. Here, we report on the anti-shedding efficacy of a Shampoo containing a selective TAAR agonist, tyramine hydrochloride. METHODS: A single-blinded crossover study was designed to test the efficacy of the novel Shampoo versus placebo in reducing hairs lost during brushing. RESULTS: In this study, the novel TAAR Shampoo reduced hair shedding during brushing by 31% in a cohort of 24 women with a maximum reduction of 77%. CONCLUSIONS: A Shampoo formulated with a selective TAAR agonist was demonstrated to contract the arrector pili muscle and reduce hair shedding subsequent to washing.
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Novel Shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine-associated receptor.
Journal of Cosmetic Dermatology, 2019Co-Authors: Maja Kovacevic, Andy Goren, Jerry Shapiro, John Mccoy, Andrija Stanimirovic, Sergio Vano-galvan, Mirna Šitum, Rodney SinclairAbstract:Approximately 40% of women experience excessive hair shedding when washing their hair. Previously, we have demonstrated that a topically applied α1 adrenergic receptor agonist can be used to contract the arrector pili muscle of the follicular unit (ie, produce "goose bumps"), increasing the force required to pluck hair by as much as 400%. Subsequently, we reported a topical cosmetic solution containing an α1 adrenergic receptor agonist that reduced hair shedding during brushing by a maximum of 77%. In this communication, we explore a novel mechanism to contract the arrector pili muscle. Trace amine-associated receptors (TAAR) have been shown to regulate smooth muscle tone in blood vessels, but have not been reported to be present in the skin. Here, we report on the anti-shedding efficacy of a Shampoo containing a selective TAAR agonist, tyramine hydrochloride. A single-blinded crossover study was designed to test the efficacy of the novel Shampoo versus placebo in reducing hairs lost during brushing. In this study, the novel TAAR Shampoo reduced hair shedding during brushing by 31% in a cohort of 24 women with a maximum reduction of 77%. A Shampoo formulated with a selective TAAR agonist was demonstrated to contract the arrector pili muscle and reduce hair shedding subsequent to washing. © 2019 Wiley Periodicals, Inc.
Yukako Matsue - One of the best experts on this subject based on the ideXlab platform.
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development of an evaluation method of the frictional property of human hair microscopic mechanism of lowering effect of squeaky sensation by Shampoo
Systems Man and Cybernetics, 2011Co-Authors: Yoko Akiyama, Fumihito Mishima, Shigehiro Nishijima, Yukako MatsueAbstract:In the previous study, we proposed a method to evaluate the tactile sensation of human hair during hair washing. By using this method, a sensory score of “squeaky” sensation during hair washing with Shampoo was reproduced by the physical indexes obtained by the integration of the reactive force and the frequency analysis of temporal fluctuation. By clarifying the microscopic mechanism of decrease in “squeaky” sensation by using Shampoo products, it becomes possible to formulate better hair-care products. In this study, the microscopic interaction between human hair and Shampoo components was investigated by using sound analysis and hair surface analysis. It was shown that the “squeaky” sensation can be evaluated by the sound parameters. Furthermore, based on the microscopic observation and identification, the model of microscopic interaction by hydrophilic interaction between hair surface and coacervate was suggested.
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Development of an evaluation method of the frictional property of human hair - Microscopic mechanism of lowering effect of “squeaky” sensation by Shampoo
2011 IEEE International Conference on Systems Man and Cybernetics, 2011Co-Authors: Yoko Akiyama, Fumihito Mishima, Shigehiro Nishijima, Yukako MatsueAbstract:In the previous study, we proposed a method to evaluate the tactile sensation of human hair during hair washing. By using this method, a sensory score of “squeaky” sensation during hair washing with Shampoo was reproduced by the physical indexes obtained by the integration of the reactive force and the frequency analysis of temporal fluctuation. By clarifying the microscopic mechanism of decrease in “squeaky” sensation by using Shampoo products, it becomes possible to formulate better hair-care products. In this study, the microscopic interaction between human hair and Shampoo components was investigated by using sound analysis and hair surface analysis. It was shown that the “squeaky” sensation can be evaluated by the sound parameters. Furthermore, based on the microscopic observation and identification, the model of microscopic interaction by hydrophilic interaction between hair surface and coacervate was suggested.
Margit Semmler - One of the best experts on this subject based on the ideXlab platform.
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efficacy of neem seed extract Shampoo on head lice of naturally infected humans in egypt
Parasitology Research, 2007Co-Authors: Fathy Abdelghaffar, Margit SemmlerAbstract:Sixty heavily lice-infested male and female children (4–15 years) were selected and subjected to the treatment with a neem seed extract Shampoo. Twenty to thirty milliliter of the Shampoo were thoroughly mixed with completely wet hair and rubbed in to reach the skin of the scalp. After 5, 10, 15 and 30 min, the Shampoo was washed out and the hair basically combed. Head lice were collected and examined. The neem seed extract Shampoo proved to be highly effective against all stages of head lice. No obvious differences regarding the efficacy of the Shampoo were observed between an exposure time of 10, 15 or 30 min. No side effects, such as skin irritation, burning sensations, or red spots on the scalp, forehead or neck, respectively, were observed.
Maja Kovacevic - One of the best experts on this subject based on the ideXlab platform.
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novel Shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine associated receptor
Journal of Cosmetic Dermatology, 2019Co-Authors: Maja Kovacevic, Andy Goren, Jerry Shapiro, John Mccoy, Andrija Stanimirovic, Sergio Vanogalvan, Mirna Šitum, Rodney SinclairAbstract:BACKGROUND: Approximately 40% of women experience excessive hair shedding when washing their hair. Previously, we have demonstrated that a topically applied alpha1 adrenergic receptor agonist can be used to contract the arrector pili muscle of the follicular unit (ie, produce "goose bumps"), increasing the force required to pluck hair by as much as 400%. Subsequently, we reported a topical cosmetic solution containing an alpha1 adrenergic receptor agonist that reduced hair shedding during brushing by a maximum of 77%. AIMS: In this communication, we explore a novel mechanism to contract the arrector pili muscle. Trace amine-associated receptors (TAAR) have been shown to regulate smooth muscle tone in blood vessels, but have not been reported to be present in the skin. Here, we report on the anti-shedding efficacy of a Shampoo containing a selective TAAR agonist, tyramine hydrochloride. METHODS: A single-blinded crossover study was designed to test the efficacy of the novel Shampoo versus placebo in reducing hairs lost during brushing. RESULTS: In this study, the novel TAAR Shampoo reduced hair shedding during brushing by 31% in a cohort of 24 women with a maximum reduction of 77%. CONCLUSIONS: A Shampoo formulated with a selective TAAR agonist was demonstrated to contract the arrector pili muscle and reduce hair shedding subsequent to washing.
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Novel Shampoo reduces hair shedding by contracting the arrector pili muscle via the trace amine-associated receptor.
Journal of Cosmetic Dermatology, 2019Co-Authors: Maja Kovacevic, Andy Goren, Jerry Shapiro, John Mccoy, Andrija Stanimirovic, Sergio Vano-galvan, Mirna Šitum, Rodney SinclairAbstract:Approximately 40% of women experience excessive hair shedding when washing their hair. Previously, we have demonstrated that a topically applied α1 adrenergic receptor agonist can be used to contract the arrector pili muscle of the follicular unit (ie, produce "goose bumps"), increasing the force required to pluck hair by as much as 400%. Subsequently, we reported a topical cosmetic solution containing an α1 adrenergic receptor agonist that reduced hair shedding during brushing by a maximum of 77%. In this communication, we explore a novel mechanism to contract the arrector pili muscle. Trace amine-associated receptors (TAAR) have been shown to regulate smooth muscle tone in blood vessels, but have not been reported to be present in the skin. Here, we report on the anti-shedding efficacy of a Shampoo containing a selective TAAR agonist, tyramine hydrochloride. A single-blinded crossover study was designed to test the efficacy of the novel Shampoo versus placebo in reducing hairs lost during brushing. In this study, the novel TAAR Shampoo reduced hair shedding during brushing by 31% in a cohort of 24 women with a maximum reduction of 77%. A Shampoo formulated with a selective TAAR agonist was demonstrated to contract the arrector pili muscle and reduce hair shedding subsequent to washing. © 2019 Wiley Periodicals, Inc.
Yoko Akiyama - One of the best experts on this subject based on the ideXlab platform.
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development of an evaluation method of the frictional property of human hair microscopic mechanism of lowering effect of squeaky sensation by Shampoo
Systems Man and Cybernetics, 2011Co-Authors: Yoko Akiyama, Fumihito Mishima, Shigehiro Nishijima, Yukako MatsueAbstract:In the previous study, we proposed a method to evaluate the tactile sensation of human hair during hair washing. By using this method, a sensory score of “squeaky” sensation during hair washing with Shampoo was reproduced by the physical indexes obtained by the integration of the reactive force and the frequency analysis of temporal fluctuation. By clarifying the microscopic mechanism of decrease in “squeaky” sensation by using Shampoo products, it becomes possible to formulate better hair-care products. In this study, the microscopic interaction between human hair and Shampoo components was investigated by using sound analysis and hair surface analysis. It was shown that the “squeaky” sensation can be evaluated by the sound parameters. Furthermore, based on the microscopic observation and identification, the model of microscopic interaction by hydrophilic interaction between hair surface and coacervate was suggested.
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Development of an evaluation method of the frictional property of human hair - Microscopic mechanism of lowering effect of “squeaky” sensation by Shampoo
2011 IEEE International Conference on Systems Man and Cybernetics, 2011Co-Authors: Yoko Akiyama, Fumihito Mishima, Shigehiro Nishijima, Yukako MatsueAbstract:In the previous study, we proposed a method to evaluate the tactile sensation of human hair during hair washing. By using this method, a sensory score of “squeaky” sensation during hair washing with Shampoo was reproduced by the physical indexes obtained by the integration of the reactive force and the frequency analysis of temporal fluctuation. By clarifying the microscopic mechanism of decrease in “squeaky” sensation by using Shampoo products, it becomes possible to formulate better hair-care products. In this study, the microscopic interaction between human hair and Shampoo components was investigated by using sound analysis and hair surface analysis. It was shown that the “squeaky” sensation can be evaluated by the sound parameters. Furthermore, based on the microscopic observation and identification, the model of microscopic interaction by hydrophilic interaction between hair surface and coacervate was suggested.
