The Experts below are selected from a list of 795 Experts worldwide ranked by ideXlab platform
Andreas F. Widmer - One of the best experts on this subject based on the ideXlab platform.
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lymphocytic choriomeningitis virus meningitis after needlestick injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel. In laboratories working with the lymphocytic choriomeningitis virus (LCMV), the virus can be transmitted to humans through needlestick injury and lead to serious acute illness up to meningitis. We report of a case of LCMV meningitis in a laboratory worker who sustained a penetrating needlestick injury with a LCMV-contaminated hollow needle whilst disposing of a used syringe into the Sharps Waste bin. Four days after needlestick injury the laboratory worker developed a systemic disease: 11 days after exposure, she was diagnosed with meningitis with clinical signs and symptoms of meningismus, photophobia, nausea and vomiting, requiring hospitalisation. The PCR was positive for LCMV from the blood sample. 18 days after exposure, seroconversion confirmed the diagnosis of LCMV-induced meningitis with an increase in specific LCMV-IgM antibodies to 1:10′240 (day 42: 1:20′480). Ten weeks after exposure, a follow-up titre for IgM returned negative, whereas IgG titre increased to 1:20′480. This is the first case report of a PCR-documented LCMV meningitis, coupled with seroconversion, following needlestick injury. It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection.
Mentore Vaccari - One of the best experts on this subject based on the ideXlab platform.
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Healthcare Waste Management: A Case Study from Sudan
'MDPI AG', 2018Co-Authors: Ahmed Ali Hassan, Terry Tudor, Mentore VaccariAbstract:Healthcare Waste (HCW) represents a major public health issue, especially in developing countries. Among HCW categories, Sharps Waste is one of the most hazardous. Exposure to needle-stick injuries can lead to blood-borne pathogens, therefore HCW should be managed in an effective manner. The main aims of this study were to assess the current management of used needles and to suggest suitable recommendations for an improved and safer system for needle management in Khartoum, Sudan. The study showed that the management of both healthcare and home-generated HCW in Sudan is inefficient, as all Wastes are mixed together and disposed of improperly, especially used needles. The study attributes this to many reasons, including lack of Waste segregation at the source, lack of policies, failure of planning, inadequate training, lack of awareness of the hazardous nature of such kinds of Waste, weak infrastructure, and a lack of suitable treatment technologies. The estimated average generated rate of HCW ranged from 0.38 to 0.87 kg/bed/day in 2009 and 2012, respectively. Such ineffective healthcare Waste management HCWM, especially used needles, can put public health as well as the environment at risk, particularly Waste workers, thus urgent action needs to be taken by all involved parties and at all levels
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international governance structures for health care Waste management a systematic review of scientific literature
Journal of Environmental Management, 2015Co-Authors: Marco Caniato, Terry L Tudor, Mentore VaccariAbstract:Significant differences exist in the management of health-care Waste management, globally. This is particularly so between low, middle and high-income countries. A systematic review of scientific literature on global healthcare Waste management spanning the period 2000 – current was undertaken, in order to identify key policies, practices, challenges and best practice. The findings were analysed considering the Gross National Income and the Human Development Index of each country. Effective regulation and operative definitions of Waste categories are key-factors requiring improvement at the national level. The economic conditions in the country are an important factor, especially regarding treatment and disposal. Areas for improvement (e.g. the need for improved governance structures, the development of regional clusters, as well as Sharps Waste segregation) are suggested.
Sarah Drager - One of the best experts on this subject based on the ideXlab platform.
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lymphocytic choriomeningitis virus meningitis after needlestick injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel. In laboratories working with the lymphocytic choriomeningitis virus (LCMV), the virus can be transmitted to humans through needlestick injury and lead to serious acute illness up to meningitis. We report of a case of LCMV meningitis in a laboratory worker who sustained a penetrating needlestick injury with a LCMV-contaminated hollow needle whilst disposing of a used syringe into the Sharps Waste bin. Four days after needlestick injury the laboratory worker developed a systemic disease: 11 days after exposure, she was diagnosed with meningitis with clinical signs and symptoms of meningismus, photophobia, nausea and vomiting, requiring hospitalisation. The PCR was positive for LCMV from the blood sample. 18 days after exposure, seroconversion confirmed the diagnosis of LCMV-induced meningitis with an increase in specific LCMV-IgM antibodies to 1:10′240 (day 42: 1:20′480). Ten weeks after exposure, a follow-up titre for IgM returned negative, whereas IgG titre increased to 1:20′480. This is the first case report of a PCR-documented LCMV meningitis, coupled with seroconversion, following needlestick injury. It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection.
Fiona Pigny - One of the best experts on this subject based on the ideXlab platform.
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lymphocytic choriomeningitis virus meningitis after needlestick injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel. In laboratories working with the lymphocytic choriomeningitis virus (LCMV), the virus can be transmitted to humans through needlestick injury and lead to serious acute illness up to meningitis. We report of a case of LCMV meningitis in a laboratory worker who sustained a penetrating needlestick injury with a LCMV-contaminated hollow needle whilst disposing of a used syringe into the Sharps Waste bin. Four days after needlestick injury the laboratory worker developed a systemic disease: 11 days after exposure, she was diagnosed with meningitis with clinical signs and symptoms of meningismus, photophobia, nausea and vomiting, requiring hospitalisation. The PCR was positive for LCMV from the blood sample. 18 days after exposure, seroconversion confirmed the diagnosis of LCMV-induced meningitis with an increase in specific LCMV-IgM antibodies to 1:10′240 (day 42: 1:20′480). Ten weeks after exposure, a follow-up titre for IgM returned negative, whereas IgG titre increased to 1:20′480. This is the first case report of a PCR-documented LCMV meningitis, coupled with seroconversion, following needlestick injury. It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection.
Philip Eisermann - One of the best experts on this subject based on the ideXlab platform.
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lymphocytic choriomeningitis virus meningitis after needlestick injury a case report
Antimicrobial Resistance and Infection Control, 2019Co-Authors: Sarah Drager, Annafriederike Marx, Fiona Pigny, Philip Eisermann, Pascal Cherpillod, Parham Sendi, Andreas F. WidmerAbstract:Needlestick accidents while handling of infectious material in research laboratories can lead to life-threatening infections in laboratory personnel. In laboratories working with the lymphocytic choriomeningitis virus (LCMV), the virus can be transmitted to humans through needlestick injury and lead to serious acute illness up to meningitis. We report of a case of LCMV meningitis in a laboratory worker who sustained a penetrating needlestick injury with a LCMV-contaminated hollow needle whilst disposing of a used syringe into the Sharps Waste bin. Four days after needlestick injury the laboratory worker developed a systemic disease: 11 days after exposure, she was diagnosed with meningitis with clinical signs and symptoms of meningismus, photophobia, nausea and vomiting, requiring hospitalisation. The PCR was positive for LCMV from the blood sample. 18 days after exposure, seroconversion confirmed the diagnosis of LCMV-induced meningitis with an increase in specific LCMV-IgM antibodies to 1:10′240 (day 42: 1:20′480). Ten weeks after exposure, a follow-up titre for IgM returned negative, whereas IgG titre increased to 1:20′480. This is the first case report of a PCR-documented LCMV meningitis, coupled with seroconversion, following needlestick injury. It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection.