The Experts below are selected from a list of 13632 Experts worldwide ranked by ideXlab platform
Johannes A Lenstra - One of the best experts on this subject based on the ideXlab platform.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset. Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild Sheep, mouflon, primitive North European Breeds and modern Sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic Breeds, with subclusters of Merino and Merino-derived Breeds, other Spanish Breeds and other Italian Breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish Breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices. Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived Breeds. To explain how the current Merino and Merino-derived Breeds were obtained, we propose a scenario that includes several consecutive migrations of Sheep populations that may serve as working hypotheses for subsequent studies.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Background Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset.
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genome wide analysis of the world s Sheep Breeds reveals high levels of historic mixture and strong recent selection
PLOS Biology, 2012Co-Authors: James W. Kijas, Johannes A Lenstra, Ben J Hayes, Simon Boitard, Laercio Porto R Neto, Magali San Cristobal, Bertrand Servin, Russell Mcculloch, Vicki Whan, Kimberly GietzenAbstract:Through their domestication and subsequent selection, Sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 Sheep Breeds. We find the majority of Sheep populations contain high SNP diversity and have retained an effective population size much higher than most cattle or dog Breeds, suggesting domestication occurred from a broad genetic base. Extensive haplotype sharing and generally low divergence time between Breeds reveal frequent genetic exchange has occurred during the development of modern Breeds. A scan of the genome for selection signals revealed 31 regions containing genes for coat pigmentation, skeletal morphology, body size, growth, and reproduction. We demonstrate the strongest selection signal has occurred in response to breeding for the absence of horns. The high density map of genetic variability provides an in-depth view of the genetic history for this important livestock species.
Emiliano Lasagna - One of the best experts on this subject based on the ideXlab platform.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Background Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset. Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild Sheep, mouflon, primitive North European Breeds and modern Sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic Breeds, with subclusters of Merino and Merino-derived Breeds, other Spanish Breeds and other Italian Breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish Breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices. Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived Breeds. To explain how the current Merino and Merino-derived Breeds were obtained, we propose a scenario that includes several consecutive migrations of Sheep populations that may serve as working hypotheses for subsequent studies.
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phylogenetic relationships of three italian merino derived Sheep Breeds evaluated through a complete mitogenome analysis
PLOS ONE, 2013Co-Authors: Hovirag Lancioni, Piera Di Lorenzo, Simone Ceccobelli, Ugo A Perego, Arianna Miglio, Vincenzo Landi, Maria Teresa Antognoni, Francesca Maria Sarti, Emiliano LasagnaAbstract:In Italy, the crisis of the wool industry triggered the necessity to reconvert the two traditional Merino-derived Breeds, Gentile di Puglia and Sopravissana, to meat production, by creating the Merinizzata Italiana. The aim of the present study was to assess the genetic diversity of these three Italian Merino-derived (IMd) Breeds by examining the molecular information encoded in the maternally-inherited mitochondrial DNA (mtDNA). A parallel molecular investigation was performed on the putative paternal and maternal Breeds, the Merino from Spain and the Appenninica from Italy, respectively, as well as on three unrelated dairy Breeds (Sarda and Comisana from Italy, and Lacaune from France). Firstly, the mtDNA control region of 291 samples was analyzed. When comparing the overall genetic distances among the eight stocks, the three IMd Breeds clustered together close to the Appenninica, thus confirming its parental role. Among the 90 IMd samples, 82 different haplotypes were observed, almost all belonging to haplogroup B, and only one to A. For 23 mtDNAs, including nine IMd, the analysis was then brought to the level of entire mitogenomes. Three distinct sub-haplogroups within B were found to encompass the IMd samples, with one clade (B1a2a1) apparently restricted to those Sheep. Thus, despite experiencing a drastic reduction in number (mainly due to changes in breeding practices driven by the economy), the IMd Breeds still represent a reservoir of distinctive mitochondrial variants, which could potentially contribute to the development of conservation and management programs of Italian Sheep Breeds.
Simone Ceccobelli - One of the best experts on this subject based on the ideXlab platform.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Background Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset. Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild Sheep, mouflon, primitive North European Breeds and modern Sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic Breeds, with subclusters of Merino and Merino-derived Breeds, other Spanish Breeds and other Italian Breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish Breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices. Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived Breeds. To explain how the current Merino and Merino-derived Breeds were obtained, we propose a scenario that includes several consecutive migrations of Sheep populations that may serve as working hypotheses for subsequent studies.
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phylogenetic relationships of three italian merino derived Sheep Breeds evaluated through a complete mitogenome analysis
PLOS ONE, 2013Co-Authors: Hovirag Lancioni, Piera Di Lorenzo, Simone Ceccobelli, Ugo A Perego, Arianna Miglio, Vincenzo Landi, Maria Teresa Antognoni, Francesca Maria Sarti, Emiliano LasagnaAbstract:In Italy, the crisis of the wool industry triggered the necessity to reconvert the two traditional Merino-derived Breeds, Gentile di Puglia and Sopravissana, to meat production, by creating the Merinizzata Italiana. The aim of the present study was to assess the genetic diversity of these three Italian Merino-derived (IMd) Breeds by examining the molecular information encoded in the maternally-inherited mitochondrial DNA (mtDNA). A parallel molecular investigation was performed on the putative paternal and maternal Breeds, the Merino from Spain and the Appenninica from Italy, respectively, as well as on three unrelated dairy Breeds (Sarda and Comisana from Italy, and Lacaune from France). Firstly, the mtDNA control region of 291 samples was analyzed. When comparing the overall genetic distances among the eight stocks, the three IMd Breeds clustered together close to the Appenninica, thus confirming its parental role. Among the 90 IMd samples, 82 different haplotypes were observed, almost all belonging to haplogroup B, and only one to A. For 23 mtDNAs, including nine IMd, the analysis was then brought to the level of entire mitogenomes. Three distinct sub-haplogroups within B were found to encompass the IMd samples, with one clade (B1a2a1) apparently restricted to those Sheep. Thus, despite experiencing a drastic reduction in number (mainly due to changes in breeding practices driven by the economy), the IMd Breeds still represent a reservoir of distinctive mitochondrial variants, which could potentially contribute to the development of conservation and management programs of Italian Sheep Breeds.
James W. Kijas - One of the best experts on this subject based on the ideXlab platform.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset. Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild Sheep, mouflon, primitive North European Breeds and modern Sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic Breeds, with subclusters of Merino and Merino-derived Breeds, other Spanish Breeds and other Italian Breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish Breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices. Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived Breeds. To explain how the current Merino and Merino-derived Breeds were obtained, we propose a scenario that includes several consecutive migrations of Sheep populations that may serve as working hypotheses for subsequent studies.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Background Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset.
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genome wide analysis of the world s Sheep Breeds reveals high levels of historic mixture and strong recent selection
PLOS Biology, 2012Co-Authors: James W. Kijas, Johannes A Lenstra, Ben J Hayes, Simon Boitard, Laercio Porto R Neto, Magali San Cristobal, Bertrand Servin, Russell Mcculloch, Vicki Whan, Kimberly GietzenAbstract:Through their domestication and subsequent selection, Sheep have been adapted to thrive in a diverse range of environments. To characterise the genetic consequence of both domestication and selection, we genotyped 49,034 SNP in 2,819 animals from a diverse collection of 74 Sheep Breeds. We find the majority of Sheep populations contain high SNP diversity and have retained an effective population size much higher than most cattle or dog Breeds, suggesting domestication occurred from a broad genetic base. Extensive haplotype sharing and generally low divergence time between Breeds reveal frequent genetic exchange has occurred during the development of modern Breeds. A scan of the genome for selection signals revealed 31 regions containing genes for coat pigmentation, skeletal morphology, body size, growth, and reproduction. We demonstrate the strongest selection signal has occurred in response to breeding for the absence of horns. The high density map of genetic variability provides an in-depth view of the genetic history for this important livestock species.
Elena Ciani - One of the best experts on this subject based on the ideXlab platform.
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Lamb Meat Quality and Carcass Evaluation of Five Autochthonous Sheep Breeds: Towards Biodiversity Protection
'MDPI AG', 2021Co-Authors: Maria Giovanna Ciliberti, Elena Ciani, Antonella Santillo, Rosaria Marino, Mariangela Caroprese, Luigina Rillo, Donato Matassino, Agostino Sevi, Marzia AlbenzioAbstract:In the present study, the evaluation of the carcasses and meat quality, in terms of chemical composition and fatty acid profile, of lambs from five autochthonous Sheep Breeds (Altamurana, Bagnolese, Gentile di Puglia, Laticauda, and Leccese) reared in continental Southern Italy, were studied. All the carcasses were evaluated according to the EU Mediterranean classification system for carcasses weighing less than 13 kg. Meat chemical composition and fatty acids profile were assessed on both loin and leg commercial cuts. Fatty acid composition of loin resulted in differences among Breeds, displaying lower values of saturated fatty acid in Altamurana, Bagnolese, and Leccese Breeds and the highest content of polyunsaturated fatty acid in the Altamurana breed. Principal component analysis grouped lamb according to fatty acid content and to conjugated linoleic acid (CLA), omega n-3 and n-6 fatty acids; thus, Altamurana, Bagnolese, and Leccese Breeds are characterized by the highest values of CLA content. Our data demonstrated that lamb meat from autochthonous breed has good carcass quality and the content of CLA, n-3, and n-6 was valuable for human consumption; therefore, the valorisation of local meat quality can help to avoid the extinction of the autochthonous breed offering to the market and consumer’s high nutritive products
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset. Based on a multi-dimensional scaling analysis, we highlighted four main clusters in this dataset, which corresponded to wild Sheep, mouflon, primitive North European Breeds and modern Sheep (including Merino), respectively. The neighbor-network analysis further differentiated North-European and Mediterranean domestic Breeds, with subclusters of Merino and Merino-derived Breeds, other Spanish Breeds and other Italian Breeds. Model-based clustering, migration analysis and haplotype sharing indicated that genetic exchange occurred between archaic populations and also that a more recent Merino-mediated gene flow to several Merino-derived populations around the world took place. The close relationship between Spanish Merino and other Spanish Breeds was consistent with an Iberian origin for the Merino breed, with possible earlier contributions from other Mediterranean stocks. The Merino populations from Australia, New Zealand and China were clearly separated from their European ancestors. We observed a genetic substructuring in the Spanish Merino population, which reflects recent herd management practices. Our data suggest that intensive gene flow, founder effects and geographic isolation are the main factors that determined the genetic makeup of current Merino and Merino-derived Breeds. To explain how the current Merino and Merino-derived Breeds were obtained, we propose a scenario that includes several consecutive migrations of Sheep populations that may serve as working hypotheses for subsequent studies.
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merino and merino derived Sheep Breeds a genome wide intercontinental study
Genetics Selection Evolution, 2015Co-Authors: Elena Ciani, James W. Kijas, Simone Ceccobelli, Francesca Maria Sarti, Emiliano Lasagna, Mariasilvia Dandrea, Ingrid Alloggio, Fabio Marroni, Juan Vicente Delgado Bermejo, Johannes A LenstraAbstract:Background Merino and Merino-derived Sheep Breeds have been widely distributed across the world, both as purebred and admixed populations. They represent an economically and historically important genetic resource which over time has been used as the basis for the development of new Breeds. In order to examine the genetic influence of Merino in the context of a global collection of domestic Sheep Breeds, we analyzed genotype data that were obtained with the OvineSNP50 BeadChip (Illumina) for 671 individuals from 37 populations, including a subset of Breeds from the Sheep HapMap dataset.
