The Experts below are selected from a list of 237 Experts worldwide ranked by ideXlab platform

Mark C Taylor - One of the best experts on this subject based on the ideXlab platform.

  • enterohaemorrhagic escherichia coli and Shigella dysenteriae type 1 induced haemolytic uraemic syndrome
    Pediatric Nephrology, 2008
    Co-Authors: Mark C Taylor
    Abstract:

    Haemolytic uraemic syndrome (HUS) can be classified according to the aetiology of the different disorders from which it is composed. The most prevalent form is that induced by shigatoxin producing Escherichia coli (STEC) and, in some tropical regions, by Shigella dysenteriae type 1. STEC cause a zoonosis, are widely distributed in nature, enter the food chain in different ways, and show regional differences. Not all STEC are human pathogens. Enterohaemorrhagic E. coli usually cause attachment and effacing lesions in the intestine. This is not essential, but production of a shigatoxin (Stx) is. Because Stx are encoded by a bacteriophage, this property is transferable to naive strains. Laboratory methods have improved by identifying STEC either via the toxin or its bacteriophage. Shigella dysenteriae type 1 produces shigatoxin, identical to Stx-1, but also has entero-invasive properties that enterohaemorrhagic Escherichia coli (EHEC) do not. Shigella patients risk bacteremia and benefit from early antibiotic treatment, unlike those with EHEC.

C. Mark Taylor - One of the best experts on this subject based on the ideXlab platform.

  • Enterohaemorrhagic Escherichia coli and Shigella dysenteriae type 1-induced haemolytic uraemic syndrome
    Pediatric Nephrology, 2008
    Co-Authors: C. Mark Taylor
    Abstract:

    Haemolytic uraemic syndrome (HUS) can be classified according to the aetiology of the different disorders from which it is composed. The most prevalent form is that induced by shigatoxin producing Escherichia coli (STEC) and, in some tropical regions, by Shigella dysenteriae type 1. STEC cause a zoonosis, are widely distributed in nature, enter the food chain in different ways, and show regional differences. Not all STEC are human pathogens. Enterohaemorrhagic E. coli usually cause attachment and effacing lesions in the intestine. This is not essential, but production of a shigatoxin (Stx) is. Because Stx are encoded by a bacteriophage, this property is transferable to naïve strains. Laboratory methods have improved by identifying STEC either via the toxin or its bacteriophage. Shigella dysenteriae type 1 produces shigatoxin, identical to Stx-1, but also has entero-invasive properties that enterohaemorrhagic Escherichia coli (EHEC) do not. Shigella patients risk bacteremia and benefit from early antibiotic treatment, unlike those with EHEC.

Eric D Mintz - One of the best experts on this subject based on the ideXlab platform.

Sundeep Gupta - One of the best experts on this subject based on the ideXlab platform.

Anup Kumar Misra - One of the best experts on this subject based on the ideXlab platform.

  • Synthesis of Di- and Trisaccharides Related to the O-Polysaccharide of Shigella dysenteriae Type 8
    Journal of Carbohydrate Chemistry, 2015
    Co-Authors: Abhishek Santra, Tamashree Ghosh, Anup Kumar Misra
    Abstract:

    GRAPHICAL ABSTRACTA disaccharide and a trisaccharide fragment related to the cell wall O-polysaccharide of Shigella dysenteriae type 8 have been synthesized in a minimum number of steps using recently reported reaction conditions. Stereoselective 1,2-cis glycosylation and late-stage selective oxidation of the primary hydroxyl group to the carboxylic group are key features of the synthetic strategy. The yields of the glycosylation reactions are excellent with high stereoselectivity.

  • Convergent synthesis of a common pentasaccharide corresponding to the O-antigen of Escherichia coli O168 and Shigella dysenteriae type 4
    Glycoconjugate Journal, 2011
    Co-Authors: Goutam Guchhait, Anup Kumar Misra
    Abstract:

    A convenient synthetic strategy of the common acidic pentasaccharide repeating unit corresponding to the O -antigen of enterotoxigenic E. coli O168 and Shigella dysenteriae type 4 has been successfully developed. A stereoselective [2 + 3] block glycosylation method has been exploited to get the target pentasaccharide derivative. Most of the synthetic intermediates were solid and prepared in high yields from commercially available reducing sugars following a series of protection-deprotection reactions. A α-D-mannose moiety has been used as the source of α-D-glucosamine moiety. A late-stage TEMPO mediated selective oxidation reaction finally resulted in the pentasaccharide containing a glucuronic acid unit. A convenient synthetic strategy of the common acidic pentasaccharide repeating unit corresponding to the O -antigen of enterotoxigenic E. coli O168 and Shigella dysenteriae type 4 has been successfully developed using stereoselective [2+3] block glycosylation technique.