The Experts below are selected from a list of 2058 Experts worldwide ranked by ideXlab platform

Yoshihisa Shimada - One of the best experts on this subject based on the ideXlab platform.

  • A Prospective Multicenter Feasibility Study With Short-Time Infusion of Panitumumab (Ship Trial)
    Annals of Oncology, 2012
    Co-Authors: Kohei Akiyoshi, Tetsuya Hamaguchi, Y. Nagai, Hisateru Yasui, G. Sakai, S. Akatsuka, Ayumu Hosokawa, S. Hirai, Kenichi Yoshimura, Yoshihisa Shimada
    Abstract:

    ABSTRACT Background Panitumumab (Pmab) is now considered to be the standard treatment for metastatic colorectal cancer. Pmab infusions are normally administered over 60 minutes. In a previous study, 30-minute infusions of panitumumab showed similar safety, pharmacokinetics, and frequency of infusion reaction to 60-minute infusions. Because Pmab consists of fully human monoclonal antibodies, infusion reactions occur less frequently than with cetuximab, chimeric monoclonal antibodies. Short-time infusion of Pmab has the potential to improve patient convenience and reduce costs. Purpose We evaluated the safety of short-time infusion of panitumumab in a prospective multicenter study. Methods Between January 2011 and December 2011, from 14 centers in Japan, a phase II study of Pmab + irinotecan (CPT-11) or Pmab monotherapy in KRAS wild-type metastatic colorectal cancer refractory to CPT-11, oxaliplatin, and fluoropyrimidines was performed. As an additional study, the initial dose of Pmab was administered over 60 minutes, followed by 30-minute infusion; then, all subsequent doses were to be administered over 15 minutes. Results Forty-eight patients were enrolled. Their characteristics were median age of 62 (32-75); male/female, 27/21; Performance Status 0/1/2, 23/24/1; primary lesion in colon/rectum, 21/27; and treatment regimen of CPT-11 + Pmab/Pmab monotherapy, 43/5. The number of patients and doses with 60-/30-/15-minute administration were 48/45/38 cases and 67/56/206 doses, respectively. In all cases with 60-/30-/15-minute infusion, infusion reaction was not encountered. Grade 3/4 toxicities included anorexia 8%, stomatitis 4%, diarrhea 6%, fatigue 4%, rash acneiform 6%, perionychia 4%, leucopenia 8%, neutropenia 8%, anemia 15%, hyponatremia 4%, and hypomagnesemia 4%. This was similar to the results from previous clinical studies on panitumumab. Conclusion In this study, no infusion reactions with 60-/30-/15-minute administration of panitumumab and no increase of frequency of adverse events were observed. This is the first prospective study describing the feasibility of short-time infusion of panitumumab. This study suggests that 15-minute infusions of panitumumab are feasible in patients who tolerate a 60- and then 30-minute infusion sequence. Disclosure All authors have declared no conflicts of interest.

Yao Tian Fan - One of the best experts on this subject based on the ideXlab platform.

  • Design of Turning Area for LNG Terminal Base on Computer Simulation
    Applied Mechanics and Materials, 2012
    Co-Authors: Yao Tian Fan
    Abstract:

    Design of turning area for sea port is generally done according to the outcome of theoretical calculation or real-Ship Trial. However, these methods only take into account some limited respects for planning a port or are not so cost-effective. In this paper, computer simulator is used for optimizing the size of turning area for Yangshan LNG terminal. The outcome indicates that the major axis and minor axis of the turning area can meet the requirement of Q-Max LNG carrier berthing operation and it is suggested to do such maneuvering in some given conditions related to wind, current, tide, visibility and wave.

  • Study on Planning of Entrance Fairway for Sea Port Based on Maritime Simulator
    Applied Mechanics and Materials, 2012
    Co-Authors: Yao Tian Fan
    Abstract:

    Planning entrance fairway is a key factor for building a sea port. Generally the quantitative and qualitative analysis on planning the entrance fairway is mainly based on the standards and regulations given by the administrations. However, these standards and regulations only deal with the respective factor but cannot cover synthetic respect of considering the project feasibility. Moreover it is very tough to do a real-Ship Trial for a planned entrance fairway. In this paper, maritime simulator is used for optimizing the planning of entrance fairway for Fujian LNG terminal. The outcome indicates that the width of the fairway can meet the requirement of Q-Flex LNG carrier entering the port and it is suggested to do more sweeping survey and set some aids to navigation for the planned waterway.

Martin Sheehan - One of the best experts on this subject based on the ideXlab platform.

  • Photographic Visualization of the Surface Wave Field and Boundary Layer Surrounding the Research Vessel, R/V REVELLE (CD-ROM)
    2003
    Co-Authors: Toby Ratcliffe, William S. Boston, Martin Sheehan
    Abstract:

    Abstract : ELECTRONIC FILE CHARACTERISTICS: 3 files; MPEG and JPEG videos. PHYSICAL DESCRIPTION: 1 computer laser optical disc (CD-ROM); 4 3/4 in.; 65.8 MB. SYSTEMS DETAIL NOTE: IBM-clone PC-compatible. ABSTRACT: The free surface wave field and boundary layer surrounding the Research Vessel, R/V REVELLE, was documented using a System of nine video cameras positioned in optimum viewing locations around the hull The two week Ship Trial, from Christ Church, New Zealand to Pago-Pago, American Samoa took place in February and March, 2002. Camera mounting arrangements are shown, as are representative photographs from each of the cameras. The viewing system, as documented in this report, resulted in an extensive set of qualitative data of the wave system around the R/V REVELLE in both calm water and in sea states 2 and 3.

Kohei Akiyoshi - One of the best experts on this subject based on the ideXlab platform.

  • A Prospective Multicenter Feasibility Study With Short-Time Infusion of Panitumumab (Ship Trial)
    Annals of Oncology, 2012
    Co-Authors: Kohei Akiyoshi, Tetsuya Hamaguchi, Y. Nagai, Hisateru Yasui, G. Sakai, S. Akatsuka, Ayumu Hosokawa, S. Hirai, Kenichi Yoshimura, Yoshihisa Shimada
    Abstract:

    ABSTRACT Background Panitumumab (Pmab) is now considered to be the standard treatment for metastatic colorectal cancer. Pmab infusions are normally administered over 60 minutes. In a previous study, 30-minute infusions of panitumumab showed similar safety, pharmacokinetics, and frequency of infusion reaction to 60-minute infusions. Because Pmab consists of fully human monoclonal antibodies, infusion reactions occur less frequently than with cetuximab, chimeric monoclonal antibodies. Short-time infusion of Pmab has the potential to improve patient convenience and reduce costs. Purpose We evaluated the safety of short-time infusion of panitumumab in a prospective multicenter study. Methods Between January 2011 and December 2011, from 14 centers in Japan, a phase II study of Pmab + irinotecan (CPT-11) or Pmab monotherapy in KRAS wild-type metastatic colorectal cancer refractory to CPT-11, oxaliplatin, and fluoropyrimidines was performed. As an additional study, the initial dose of Pmab was administered over 60 minutes, followed by 30-minute infusion; then, all subsequent doses were to be administered over 15 minutes. Results Forty-eight patients were enrolled. Their characteristics were median age of 62 (32-75); male/female, 27/21; Performance Status 0/1/2, 23/24/1; primary lesion in colon/rectum, 21/27; and treatment regimen of CPT-11 + Pmab/Pmab monotherapy, 43/5. The number of patients and doses with 60-/30-/15-minute administration were 48/45/38 cases and 67/56/206 doses, respectively. In all cases with 60-/30-/15-minute infusion, infusion reaction was not encountered. Grade 3/4 toxicities included anorexia 8%, stomatitis 4%, diarrhea 6%, fatigue 4%, rash acneiform 6%, perionychia 4%, leucopenia 8%, neutropenia 8%, anemia 15%, hyponatremia 4%, and hypomagnesemia 4%. This was similar to the results from previous clinical studies on panitumumab. Conclusion In this study, no infusion reactions with 60-/30-/15-minute administration of panitumumab and no increase of frequency of adverse events were observed. This is the first prospective study describing the feasibility of short-time infusion of panitumumab. This study suggests that 15-minute infusions of panitumumab are feasible in patients who tolerate a 60- and then 30-minute infusion sequence. Disclosure All authors have declared no conflicts of interest.

E. A. Stevens - One of the best experts on this subject based on the ideXlab platform.

  • THE INCREASE IN FRICTIONAL RESISTANCE DUE TO THE ACTION OF WATER ON BOTTOM PAINT
    Journal of the American Society for Naval Engineers, 2009
    Co-Authors: E. A. Stevens
    Abstract:

    In this brief discussion, Mr. Stevens points out the rather startling effect of the aging of bottom, paints in water on the hull frictional resistance factor of Ships. While the data he offers, and the conclusions he reaches are open to attack not only because of the rarity of opportunity to secure such data but because of the confusing factors which affect the results obtained on any full scale Ship Trial at sea, a brief consideration will convince the most skeptical that some increase from simple roughening of the bottom is to be expected, and Mr. Stevens presents enough points to indicate the trend of the curve. While the curve is presumed to represent naval rather than merchant marine employment, some consideration of the type of employment will indicate how it can be expected to vary.