The Experts below are selected from a list of 207345 Experts worldwide ranked by ideXlab platform
Sergei Y Sokol - One of the best experts on this subject based on the ideXlab platform.
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interaction of dishevelled and xenopus axin related protein is required for wnt Signal Transduction
Molecular and Cellular Biology, 2000Co-Authors: Keiji Itoh, Alena Antipova, Marianne J Ratcliffe, Sergei Y SokolAbstract:Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt Signal Transduction is controlled by the rate of degradation of b-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt Signal Transduction, and its activation results in stabilization of b-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show that Xenopus Dishevelled (Xdsh) interacts with a Xenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for Signal Transduction through Xdsh. Finally, our data point to a possible mechanism for Signal Transduction, in which Xdsh prevents b-catenin degradation by displacing GSK3 from its complex with XARP.
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interaction of dishevelled and xenopus axin related protein is required for wnt Signal Transduction
Molecular and Cellular Biology, 2000Co-Authors: Keiji Itoh, Alena Antipova, Marianne J Ratcliffe, Sergei Y SokolAbstract:Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt Signal Transduction is controlled by the rate of degradation of beta-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt Signal Transduction, and its activation results in stabilization of beta-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show that Xenopus Dishevelled (Xdsh) interacts with a Xenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for Signal Transduction through Xdsh. Finally, our data point to a possible mechanism for Signal Transduction, in which Xdsh prevents beta-catenin degradation by displacing GSK3 from its complex with XARP.
Keiji Itoh - One of the best experts on this subject based on the ideXlab platform.
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interaction of dishevelled and xenopus axin related protein is required for wnt Signal Transduction
Molecular and Cellular Biology, 2000Co-Authors: Keiji Itoh, Alena Antipova, Marianne J Ratcliffe, Sergei Y SokolAbstract:Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt Signal Transduction is controlled by the rate of degradation of b-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt Signal Transduction, and its activation results in stabilization of b-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show that Xenopus Dishevelled (Xdsh) interacts with a Xenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for Signal Transduction through Xdsh. Finally, our data point to a possible mechanism for Signal Transduction, in which Xdsh prevents b-catenin degradation by displacing GSK3 from its complex with XARP.
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interaction of dishevelled and xenopus axin related protein is required for wnt Signal Transduction
Molecular and Cellular Biology, 2000Co-Authors: Keiji Itoh, Alena Antipova, Marianne J Ratcliffe, Sergei Y SokolAbstract:Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt Signal Transduction is controlled by the rate of degradation of beta-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt Signal Transduction, and its activation results in stabilization of beta-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show that Xenopus Dishevelled (Xdsh) interacts with a Xenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for Signal Transduction through Xdsh. Finally, our data point to a possible mechanism for Signal Transduction, in which Xdsh prevents beta-catenin degradation by displacing GSK3 from its complex with XARP.
Alena Antipova - One of the best experts on this subject based on the ideXlab platform.
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interaction of dishevelled and xenopus axin related protein is required for wnt Signal Transduction
Molecular and Cellular Biology, 2000Co-Authors: Keiji Itoh, Alena Antipova, Marianne J Ratcliffe, Sergei Y SokolAbstract:Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt Signal Transduction is controlled by the rate of degradation of b-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt Signal Transduction, and its activation results in stabilization of b-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show that Xenopus Dishevelled (Xdsh) interacts with a Xenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for Signal Transduction through Xdsh. Finally, our data point to a possible mechanism for Signal Transduction, in which Xdsh prevents b-catenin degradation by displacing GSK3 from its complex with XARP.
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interaction of dishevelled and xenopus axin related protein is required for wnt Signal Transduction
Molecular and Cellular Biology, 2000Co-Authors: Keiji Itoh, Alena Antipova, Marianne J Ratcliffe, Sergei Y SokolAbstract:Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt Signal Transduction is controlled by the rate of degradation of beta-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt Signal Transduction, and its activation results in stabilization of beta-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show that Xenopus Dishevelled (Xdsh) interacts with a Xenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for Signal Transduction through Xdsh. Finally, our data point to a possible mechanism for Signal Transduction, in which Xdsh prevents beta-catenin degradation by displacing GSK3 from its complex with XARP.
Marianne J Ratcliffe - One of the best experts on this subject based on the ideXlab platform.
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interaction of dishevelled and xenopus axin related protein is required for wnt Signal Transduction
Molecular and Cellular Biology, 2000Co-Authors: Keiji Itoh, Alena Antipova, Marianne J Ratcliffe, Sergei Y SokolAbstract:Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt Signal Transduction is controlled by the rate of degradation of b-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt Signal Transduction, and its activation results in stabilization of b-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show that Xenopus Dishevelled (Xdsh) interacts with a Xenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for Signal Transduction through Xdsh. Finally, our data point to a possible mechanism for Signal Transduction, in which Xdsh prevents b-catenin degradation by displacing GSK3 from its complex with XARP.
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interaction of dishevelled and xenopus axin related protein is required for wnt Signal Transduction
Molecular and Cellular Biology, 2000Co-Authors: Keiji Itoh, Alena Antipova, Marianne J Ratcliffe, Sergei Y SokolAbstract:Signaling by the Wnt family of secreted proteins plays an important role in animal development and is often misregulated in carcinogenesis. Wnt Signal Transduction is controlled by the rate of degradation of beta-catenin by a complex of proteins including glycogen synthase kinase 3 (GSK3), adenomatous polyposis coli, and Axin. Dishevelled is required for Wnt Signal Transduction, and its activation results in stabilization of beta-catenin. However, the biochemical events underlying this process remain largely unclear. Here we show that Xenopus Dishevelled (Xdsh) interacts with a Xenopus Axin-related protein (XARP). This interaction depends on the presence of the Dishevelled-Axin (DIX) domains in both XARP and Xdsh. Moreover, the same domains are essential for Signal Transduction through Xdsh. Finally, our data point to a possible mechanism for Signal Transduction, in which Xdsh prevents beta-catenin degradation by displacing GSK3 from its complex with XARP.
Arnoud Van Der Laarse - One of the best experts on this subject based on the ideXlab platform.
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mechanical stress induced cardiac hypertrophy mechanisms and Signal Transduction pathways
Cardiovascular Research, 2000Co-Authors: C Ruwhof, Arnoud Van Der LaarseAbstract:Cardiac hypertrophy is a well known response to increased hemodynamic load. Mechanical stress is considered to be the trigger inducing a growth response in the overloaded myocardium. Furthermore, mechanical stress induces the release of growth-promoting factors, such as angiotensin II, endothelin-1, and transforming growth factor-β, which provide a second line of growth induction. In this review, we will focus on the primary effects of mechanical stress: how mechanical stress may be sensed, and which Signal Transduction pathways may couple mechanical stress to modulation of gene expression, and to increased protein synthesis. Mechanical stress may be coupled to intracellular Signals that are responsible for the hypertrophic response via integrins and the cytoskeleton or via sarcolemmal proteins, such as phospholipases, ion channels and ion exchangers. The Signal Transduction pathways that may be involved belong to two groups: (1) the mitogen-activated protein kinases (MAPK) pathway; and (2) the janus kinase/Signal transducers and activators of transcription (JAK/STAT) pathway. The MAPK pathway can be subdivided into the extracellular-regulated kinase (ERK), the c-Jun N-terminal kinase (JNK), and the 38-kDa MAPK (p38 MAPK) pathway. Alternatively, the stress Signal may be directly submitted to the nucleus via the cytoskeleton without the involvement of Signal Transduction pathways. Finally, by promoting an increase in intracellular Ca2+ concentration stretch may stimulate the calcium/calmodulin-dependent phosphatase calcineurin, a novel hypertrophic Signalling pathway.
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mechanical stress induced cardiac hypertrophy mechanisms and Signal Transduction pathways
Cardiovascular Research, 2000Co-Authors: C Ruwhof, Arnoud Van Der LaarseAbstract:Cardiac hypertrophy is a well known response to increased hemodynamic load. Mechanical stress is considered to be the trigger inducing a growth response in the overloaded myocardium. Furthermore, mechanical stress induces the release of growth-promoting factors, such as angiotensin II, endothelin-1, and transforming growth factor-beta, which provide a second line of growth induction. In this review, we will focus on the primary effects of mechanical stress: how mechanical stress may be sensed, and which Signal Transduction pathways may couple mechanical stress to modulation of gene expression, and to increased protein synthesis. Mechanical stress may be coupled to intracellular Signals that are responsible for the hypertrophic response via integrins and the cytoskeleton or via sarcolemmal proteins, such as phospholipases, ion channels and ion exchangers. The Signal Transduction pathways that may be involved belong to two groups: (1) the mitogen-activated protein kinases (MAPK) pathway; and (2) the janus kinase/Signal transducers and activators of transcription (JAK/STAT) pathway. The MAPK pathway can be subdivided into the extracellular-regulated kinase (ERK), the c-Jun N-terminal kinase (JNK), and the 38-kDa MAPK (p38 MAPK) pathway. Alternatively, the stress Signal may be directly submitted to the nucleus via the cytoskeleton without the involvement of Signal Transduction pathways. Finally, by promoting an increase in intracellular Ca2+ concentration stretch may stimulate the calcium/calmodulin-dependent phosphatase calcineurin, a novel hypertrophic Signalling pathway.
