Signaling System

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V. O. Tkachev - One of the best experts on this subject based on the ideXlab platform.

  • keap1 nrf2 are redox sensitive Signaling System as a pharmacological target
    Biochemistry, 2013
    Co-Authors: N. K. Zenkov, E. B. Menshchikova, V. O. Tkachev
    Abstract:

    The redox-sensitive Signaling System Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE System, key targets for pharmacological intervention, and interconnection of this System with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

  • Keap1/Nrf2/ARE redox-sensitive Signaling System as a pharmacological target
    Biochemistry (Moscow), 2013
    Co-Authors: N. K. Zenkov, E. B. Menshchikova, V. O. Tkachev
    Abstract:

    The redox-sensitive Signaling System Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE System, key targets for pharmacological intervention, and interconnection of this System with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

N. K. Zenkov - One of the best experts on this subject based on the ideXlab platform.

  • keap1 nrf2 are redox sensitive Signaling System as a pharmacological target
    Biochemistry, 2013
    Co-Authors: N. K. Zenkov, E. B. Menshchikova, V. O. Tkachev
    Abstract:

    The redox-sensitive Signaling System Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE System, key targets for pharmacological intervention, and interconnection of this System with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

  • Keap1/Nrf2/ARE redox-sensitive Signaling System as a pharmacological target
    Biochemistry (Moscow), 2013
    Co-Authors: N. K. Zenkov, E. B. Menshchikova, V. O. Tkachev
    Abstract:

    The redox-sensitive Signaling System Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE System, key targets for pharmacological intervention, and interconnection of this System with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

  • Mechanism of the Nrf2/Keap1/ARE Signaling System
    Biochemistry, 2011
    Co-Authors: Victor Tkachev, E. B. Menshchikova, N. K. Zenkov
    Abstract:

    Nrf2 regulates expression of genes containing antioxidant-respons(iv)e element (ARE) in their promoters and plays a pivotal role among all redox-sensitive transcription factors. Nrf2 is constitutively controlled by repressor protein Keap1, which acts as a molecular sensor of disturbances in cellular homeostasis. These molecular patterns are in close inter-connection and function as parts of the integrated redox-sensitive Signaling System Nrf2/Keap1/ARE. Depending on cellular redox balance, activity of this Signaling System changes at the levels of transcription, translation, posttranslational modification, nuclear translocation of transcription factor, and its binding to ARE-driven gene promoters. This review summarizes current conceptions of Nrf2/Keap1/ARE induction and inactivation.

E. B. Menshchikova - One of the best experts on this subject based on the ideXlab platform.

  • keap1 nrf2 are redox sensitive Signaling System as a pharmacological target
    Biochemistry, 2013
    Co-Authors: N. K. Zenkov, E. B. Menshchikova, V. O. Tkachev
    Abstract:

    The redox-sensitive Signaling System Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE System, key targets for pharmacological intervention, and interconnection of this System with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

  • Keap1/Nrf2/ARE redox-sensitive Signaling System as a pharmacological target
    Biochemistry (Moscow), 2013
    Co-Authors: N. K. Zenkov, E. B. Menshchikova, V. O. Tkachev
    Abstract:

    The redox-sensitive Signaling System Keap1/Nrf2/ARE plays a key role in maintenance of cellular homeostasis under stress, inflammatory, carcinogenic, and proapoptotic conditions, which allows us to consider it as a pharmacological target. Here we review the basic regulatory mechanisms of the Keap1/Nrf2/ARE System, key targets for pharmacological intervention, and interconnection of this System with other redox-sensitive transcriptional factors. We also discuss the range of currently available pharmaceuticals. Finally, we promote “indirect” antioxidants as a promising strategy for prevention and treatment of wide range of diseases associated with oxidative stress.

  • Mechanism of the Nrf2/Keap1/ARE Signaling System
    Biochemistry, 2011
    Co-Authors: Victor Tkachev, E. B. Menshchikova, N. K. Zenkov
    Abstract:

    Nrf2 regulates expression of genes containing antioxidant-respons(iv)e element (ARE) in their promoters and plays a pivotal role among all redox-sensitive transcription factors. Nrf2 is constitutively controlled by repressor protein Keap1, which acts as a molecular sensor of disturbances in cellular homeostasis. These molecular patterns are in close inter-connection and function as parts of the integrated redox-sensitive Signaling System Nrf2/Keap1/ARE. Depending on cellular redox balance, activity of this Signaling System changes at the levels of transcription, translation, posttranslational modification, nuclear translocation of transcription factor, and its binding to ARE-driven gene promoters. This review summarizes current conceptions of Nrf2/Keap1/ARE induction and inactivation.

G. K. Cambron - One of the best experts on this subject based on the ideXlab platform.

  • Signaling System No.7 local exchange deployment : Common channel Signaling
    1992
    Co-Authors: G. K. Cambron
    Abstract:

    This paper examines the deployment of Signaling System No. 7 (SS7) from the viewpoint of the local exchange carrier. The three phases of local exchange deployment, service planning and design, local exchange network design, and interconnection design are discussed in sequence. SS7 is a fundamental change to the infrastructure of the local exchange telecommunications network. It advances the efficiency, service the forces driving SS7 deployment, both services infrastructure improvements

  • Signaling System No.7 local exchange deployment
    Proceedings of the IEEE, 1992
    Co-Authors: G. K. Cambron
    Abstract:

    The author examines the deployment of Signaling System No.7 (SS7) from the viewpoint of the local exchange carrier. The three phases of local exchange deployment-service planning and design, local exchange network design, and interconnection design-are discussed in sequence. SS7 is a fundamental change to the infrastructure of the local exchange telecommunications network. The author describes how the backbone network, centered on the Signaling transfer points (STPs), is installed first, followed by the local exchange network, and then interconnection to interchange and other networks. >

T Hattori - One of the best experts on this subject based on the ideXlab platform.

  • development of railway Signaling System based on network technology
    Systems Man and Cybernetics, 2005
    Co-Authors: Y Hirano, T Kato, T Kunifuji, T Hattori
    Abstract:

    Much Signaling equipment (e.g. signals, switching devices) are installed along railway tracks, and these are working in cooperation with each other, referring to other Signaling equipment status. In today's railway Signaling System, this information is transmitted using signal cables. Owing to this installation of Signaling System itself, especially installation of signal cable, we have some problems on our conventional Signaling System. The problems are 1st "high cost for construction", 2nd "many faults from mistakes in cable connection", and 3rd "much time for restoring when it has failed". To solve these problems we have developed a new Signaling System based on network technology, utilizing Ethernet-passive optical network (E-PON). In this paper, we introduce this System, and define the requirements for securing safety, availability and environmental resistance of this System. Then we describe concrete techniques for realizing the requirements

  • SMC - Development of Railway Signaling System based on Network Technology
    2005 IEEE International Conference on Systems Man and Cybernetics, 2005
    Co-Authors: Y Hirano, T Kato, T Kunifuji, T Hattori
    Abstract:

    Much Signaling equipment (e.g. signals, switching devices) are installed along railway tracks, and these are working in cooperation with each other, referring to other Signaling equipment status. In today's railway Signaling System, this information is transmitted using signal cables. Owing to this installation of Signaling System itself, especially installation of signal cable, we have some problems on our conventional Signaling System. The problems are 1st "high cost for construction", 2nd "many faults from mistakes in cable connection", and 3rd "much time for restoring when it has failed". To solve these problems we have developed a new Signaling System based on network technology, utilizing Ethernet-passive optical network (E-PON). In this paper, we introduce this System, and define the requirements for securing safety, availability and environmental resistance of this System. Then we describe concrete techniques for realizing the requirements

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