The Experts below are selected from a list of 15993 Experts worldwide ranked by ideXlab platform

Peng Cong - One of the best experts on this subject based on the ideXlab platform.

  • Wireless batteryless implantable blood pressure monitoring microsystem for small laboratory animals
    2010
    Co-Authors: Peng Cong
    Abstract:

    A novel, wireless, batteryless, implantable blood pressure monitoring microsystem for small laboratory animals is developed for advanced biological and system biology research. The system employs an instrumented elastic circular cuff, wrapped around a blood vessel, for real-time blood pressure monitoring. The elastic circular cuff is made of soft bio-compatible Silicone Material, which is filled with bio-compatible insulating fluid with an immersed microelectromechanical systems (MEMS) pressure sensor and integrated electronic system to detect a down-scaled vessel blood pressure waveform. This technique avoids vessel penetration and substantially minimizes vessel restriction due to the soft cuff elasticity, thus attractive for long-term monitoring. A large-model engineering experiment is first developed to verify and demonstrate the concept. A miniature prototype monitoring cuff is then fabricated and implanted in two laboratory rats to evaluate its functionality. A wireless and batteryless monitoring microsystem is then implanted and characterized in a laboratory rat. The measured in vivo blood pressure waveform by the microsystem and a reference waveform recorded by a commercial catheter-tip transducer are closely matched in shape with a constant scaling factor, demonstrating a blood pressure signal with high fidelity can be wirelessly obtained by the implantable monitoring microsystem. The overall implant dissipates 300 ¿W, which is powered by an external adaptive RF powering source.

  • Novel long-term implantable blood pressure monitoring system with reduced baseline drift
    2006
    Co-Authors: Peng Cong, Brian Hoit
    Abstract:

    A novel long-term less-invasive blood pressure monitoring system with fluid-filled cuff is proposed for advanced biological research. The system employs an instrumented elastic cuff attached with a rigid isolation ring on the outside wall of the cuff. The cuff is wrapped around a blood vessel for real-time blood pressure monitoring. The elastic cuff is made of bio-compatible soft Silicone Material and is filled with bio-compatible insulating Silicone oil with an immersed MEMS pressure sensor. This technique avoids vessel penetration and substantially minimizes vessel restriction due to the soft cuff elasticity, thus attractive for long-term monitoring. A rigid isolation ring is used to isolate the cuff from environmental variations to suppress baseline drift in the measured waveform inside the monitoring cuff. The prototype monitoring cuff is wrapped around the right carotid artery of a laboratory rat to measure real-time blood pressure waveform. The measured in vivo blood waveform is compared with a reference waveform recorded simultaneously by using a commercial catheter-tip transducer inserted into the left carotid artery, showing matched waveforms with a scaling factor about 0.03 and a baseline drift of 0.6 mm Hg. The measured baseline drift is three times smaller compared to using a cuff without a rigid isolation ring.

Brian Hoit - One of the best experts on this subject based on the ideXlab platform.

  • Novel long-term implantable blood pressure monitoring system with reduced baseline drift
    2006
    Co-Authors: Peng Cong, Brian Hoit
    Abstract:

    A novel long-term less-invasive blood pressure monitoring system with fluid-filled cuff is proposed for advanced biological research. The system employs an instrumented elastic cuff attached with a rigid isolation ring on the outside wall of the cuff. The cuff is wrapped around a blood vessel for real-time blood pressure monitoring. The elastic cuff is made of bio-compatible soft Silicone Material and is filled with bio-compatible insulating Silicone oil with an immersed MEMS pressure sensor. This technique avoids vessel penetration and substantially minimizes vessel restriction due to the soft cuff elasticity, thus attractive for long-term monitoring. A rigid isolation ring is used to isolate the cuff from environmental variations to suppress baseline drift in the measured waveform inside the monitoring cuff. The prototype monitoring cuff is wrapped around the right carotid artery of a laboratory rat to measure real-time blood pressure waveform. The measured in vivo blood waveform is compared with a reference waveform recorded simultaneously by using a commercial catheter-tip transducer inserted into the left carotid artery, showing matched waveforms with a scaling factor about 0.03 and a baseline drift of 0.6 mm Hg. The measured baseline drift is three times smaller compared to using a cuff without a rigid isolation ring.

Susan Gibbs - One of the best experts on this subject based on the ideXlab platform.

  • label free stimulated raman scattering imaging reveals Silicone breast implant Material in tissue
    2020
    Co-Authors: Ludo Van Haasterecht, Liron Zada, Robert W Schmidt, Erik De Bakker, Ellis Barbe, H A Leslie, Dick A Vethaak, Susan Gibbs
    Abstract:

    Millions of women worldwide have Silicone breast implants. It has been reported that implant failure occurs in approximately a tenth of patients within 10 years, and the consequences of dissemination of Silicone debris are poorly understood. Currently, Silicone detection in histopathological slides is based on morphological features as no specific immunohistochemical technique is available. Here, we show the feasibility and sensitivity of stimulated Raman scattering (SRS) imaging to specifically detect Silicone Material in stained histopathological slides, without additional sample treatment. Histology slides of four periprosthetic capsules from different implant types were obtained after explantation, as well as an enlarged axillary lymph node from a patient with a ruptured implant. SRS images coregistered with bright-field images revealed the distribution and quantity of Silicone Material in the tissue. Fast and high-resolution imaging of histology slides with molecular specificity using SRS provides an opportunity to investigate the role of Silicone debris in the pathophysiology of implant-linked diseases.

Mool C Gupta - One of the best experts on this subject based on the ideXlab platform.

  • Oil-infused superhydrophobic Silicone Material for low ice adhesion with long-term infusion stability
    2016
    Co-Authors: Yong Han Yeong, Kenneth J. Wynne, Mool C Gupta
    Abstract:

    A new approach for anti-icing Materials was created to combat the effects of ice accretion and adhesion. The concept combines the strengths of individual characteristics for low ice adhesion based on elasticity, superhydrophobicity, and slippery liquid infused porous surfaces (SLIPS) for an optimal combination of high water repellency and ice-phobicity. This was achieved by replicating microtextures from a laser-irradiated aluminum substrate to an oil-infused polydimethylsiloxane (PDMS) elastomer, the result of which is a flexible, superhydrophobic, and lubricated Material. This design provides multiple strategies of icing protection through high water repellency to retard ice accretion and with elasticity and oil infusion for low ice adhesion in a single Material. Studies showed that an infusion of Silicone oils with viscosity at 100 cSt and below 8 wt % in PDMS solution is sufficient to reduce the ice shear strength to an average of 38 kPa while maintaining contact angles and roll-off angles of above 15...

Ludo Van Haasterecht - One of the best experts on this subject based on the ideXlab platform.

  • label free stimulated raman scattering imaging reveals Silicone breast implant Material in tissue
    2020
    Co-Authors: Ludo Van Haasterecht, Liron Zada, Robert W Schmidt, Erik De Bakker, Ellis Barbe, H A Leslie, Dick A Vethaak, Susan Gibbs
    Abstract:

    Millions of women worldwide have Silicone breast implants. It has been reported that implant failure occurs in approximately a tenth of patients within 10 years, and the consequences of dissemination of Silicone debris are poorly understood. Currently, Silicone detection in histopathological slides is based on morphological features as no specific immunohistochemical technique is available. Here, we show the feasibility and sensitivity of stimulated Raman scattering (SRS) imaging to specifically detect Silicone Material in stained histopathological slides, without additional sample treatment. Histology slides of four periprosthetic capsules from different implant types were obtained after explantation, as well as an enlarged axillary lymph node from a patient with a ruptured implant. SRS images coregistered with bright-field images revealed the distribution and quantity of Silicone Material in the tissue. Fast and high-resolution imaging of histology slides with molecular specificity using SRS provides an opportunity to investigate the role of Silicone debris in the pathophysiology of implant-linked diseases.