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Thomas A Mustoe - One of the best experts on this subject based on the ideXlab platform.

  • the effects of topically applied silicone gel and its Silver Derivative on the prevention of hypertrophic scarring in two rabbit ear scarring models
    Journal of Plastic Reconstructive and Aesthetic Surgery, 2011
    Co-Authors: Shengxian Jia, Yanan Zhao, Thomas A Mustoe
    Abstract:

    Summary Topically applied silicone gel is an effective treatment in the management of hypertrophic scars. This early study of silicone gel predates other well-controlled scientific studies that demonstrate these findings. Our well-established rabbit ear scarring model creates 7 mm punch wounds down to the bare cartilage, including the removal of the perichondrium. In this study, we employ a new model that creates 10 mm punch wounds that leaves the perichondrium intact. Both the 7 mm and new 10 mm scar models were used to study the effectiveness of silicone gel and silicone gel Silver respectively on hypertrophy and the inhibition of scar formation. All samples were harvested at post-wounding day 35 for histological analysis. Silicone gel significantly reduced scar area ( p = 0.005), scar elevation index ( p = 0.03), and epidermal area ( p = 0.016). Silicone gel Silver significantly reduced scar elevation index ( p  = 0.004). The new 10 mm scar model resulted in more hypertrophic scarring than the typical, 7 mm wound scar model ( p = 0.0001). In conclusion, silicone gel and its Silver Derivative are effective in preventing hypertrophic scarring and scar models that leave the perichondrium intact causes scars with more hypertrophy.

Shengxian Jia - One of the best experts on this subject based on the ideXlab platform.

  • the effects of topically applied silicone gel and its Silver Derivative on the prevention of hypertrophic scarring in two rabbit ear scarring models
    Journal of Plastic Reconstructive and Aesthetic Surgery, 2011
    Co-Authors: Shengxian Jia, Yanan Zhao, Thomas A Mustoe
    Abstract:

    Summary Topically applied silicone gel is an effective treatment in the management of hypertrophic scars. This early study of silicone gel predates other well-controlled scientific studies that demonstrate these findings. Our well-established rabbit ear scarring model creates 7 mm punch wounds down to the bare cartilage, including the removal of the perichondrium. In this study, we employ a new model that creates 10 mm punch wounds that leaves the perichondrium intact. Both the 7 mm and new 10 mm scar models were used to study the effectiveness of silicone gel and silicone gel Silver respectively on hypertrophy and the inhibition of scar formation. All samples were harvested at post-wounding day 35 for histological analysis. Silicone gel significantly reduced scar area ( p = 0.005), scar elevation index ( p = 0.03), and epidermal area ( p = 0.016). Silicone gel Silver significantly reduced scar elevation index ( p  = 0.004). The new 10 mm scar model resulted in more hypertrophic scarring than the typical, 7 mm wound scar model ( p = 0.0001). In conclusion, silicone gel and its Silver Derivative are effective in preventing hypertrophic scarring and scar models that leave the perichondrium intact causes scars with more hypertrophy.

Yanan Zhao - One of the best experts on this subject based on the ideXlab platform.

  • the effects of topically applied silicone gel and its Silver Derivative on the prevention of hypertrophic scarring in two rabbit ear scarring models
    Journal of Plastic Reconstructive and Aesthetic Surgery, 2011
    Co-Authors: Shengxian Jia, Yanan Zhao, Thomas A Mustoe
    Abstract:

    Summary Topically applied silicone gel is an effective treatment in the management of hypertrophic scars. This early study of silicone gel predates other well-controlled scientific studies that demonstrate these findings. Our well-established rabbit ear scarring model creates 7 mm punch wounds down to the bare cartilage, including the removal of the perichondrium. In this study, we employ a new model that creates 10 mm punch wounds that leaves the perichondrium intact. Both the 7 mm and new 10 mm scar models were used to study the effectiveness of silicone gel and silicone gel Silver respectively on hypertrophy and the inhibition of scar formation. All samples were harvested at post-wounding day 35 for histological analysis. Silicone gel significantly reduced scar area ( p = 0.005), scar elevation index ( p = 0.03), and epidermal area ( p = 0.016). Silicone gel Silver significantly reduced scar elevation index ( p  = 0.004). The new 10 mm scar model resulted in more hypertrophic scarring than the typical, 7 mm wound scar model ( p = 0.0001). In conclusion, silicone gel and its Silver Derivative are effective in preventing hypertrophic scarring and scar models that leave the perichondrium intact causes scars with more hypertrophy.

Truscott, Byron John - One of the best experts on this subject based on the ideXlab platform.

  • Design and synthesis of multidentate NHC as metathesis catalyst ligands
    Faculty of Science Chemistry, 2011
    Co-Authors: Truscott, Byron John
    Abstract:

    This study has focused on the design and preparation of bi– and tridentate N–Heterocyclic Carbene (NHC) ligands in order to investigate the effect of a multidentate approach to the formation, stability and catalytic activity of coordination complexes. Chapters 1 – 3 provide background information of relevant catalysis, carbene and coordination chemistry, followed by previous work performed within our research group. In Chapter 4 attention is given to the synthetic aspects of the research conducted, comprising two distinct approaches to the preparation of unsymmetrical saturated and unsaturated NHCs. Firstly, an investigation of the saturated NHC ligands yielded three novel, unsymmetrical pro–ligands, viz., two halopropyl imidazolinium salts and a bidentate hydroxypropyl imidazolinium salt. Secondly, eight imidazolium salts have been generated, including a hydroxypropyl analogue and novel decyl and tridentate malonyl Derivatives. These compounds were prepared using microwave–assisted methodology for the alkylation of N– mesitylimidazole – an approach that drastically reduced reaction times (from 8 hours – 7 days to ca. 0.5 – 2 hours) and facilitated isolation of the imidazolium salts. Many of the compounds prepared in this study are novel and were fully characterized using HRMS and 1– and 2–D NMR analysis. Coordination studies using a selection of the prepared pro–ligands afforded an alkoxy–NHC Silver Derivative and four novel Ru–complexes, viz., Grubbs II–type Ru–complexes containing:– chloropropyl imidazolinylidene; propenyl imidazolylidene; and bidentate alkoxypropyl imidazolylidene ligands. Furthermore, a well–defined benzyl mesitylimidazolylidene Ru–complex has been isolated, which exhibited good stability in air. DFT–level geometry–optimization studies, using the Accelrys DMol3 package have given valuable insights into the likely geometries of the prepared and putative catalysts