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Tamer Baysal - One of the best experts on this subject based on the ideXlab platform.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n = 3) or III (n = 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 × 2 × 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n 3) or III (n 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 2 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P < .01). In patients with SSPE, NAA/Cr ratios in POWM were significantly less than those in FSWM (P < .01). NAA/Cr ratios in patients with stage II SSPE and those in the control group were not significantly different; this may reflect the absence of neuronal loss. Decreased NAA/Cr, increased Cho/Cr and Ins/Cr ratios, and increased lactate and lipid peaks were found in patients with stage III SSPE. CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

Alpay Alkan - One of the best experts on this subject based on the ideXlab platform.

  • neuroimaging findings in hyperargininemia
    Journal of Neuroimaging, 2008
    Co-Authors: Serdal Gungor, Aysehan Akinci, Ahmet Firat, Yilmaz Tabel, Alpay Alkan
    Abstract:

    In hyperarginenemia, there is a defect in argininase enzyme, which is a catalyzer of urea cycle. Though the pathogenesis of neuronal damage in hyperargininemia is not clear, high serum and cerebrospinal fluid arginine levels can be directly related with neuronal damage. In this study, our aim was to assess brain magnetic resonance images and magnetic resonance spectroscopy (MRS) patterns of two siblings with hyperarginenemia. We acquired Single Voxel MRS from the white matter to show the myelination pattern and to figure out any abnormal peak of metabolite stored due to enzymatic defect. We observed mild cerebral and cerebellar atrophy and infarct at bilateral posterior putamen and insular cortex localization on conventional images and elevated choline/creatine ratios and abnormal peak at 3.8 ppm, most likely representing arginine deposition. To the best of our knowledge, this is the first article revealing the brain MRS pattern of hyperargininemia. We reported the clinical and imaging findings of patients and discuss the correlation.

  • MultiVoxel magnetic resonance spectroscopy in a rhizomelic chondrodysplasia punctata case.
    Journal of child neurology, 2005
    Co-Authors: Ahmet Sigirci, Alpay Alkan, Ramazan Kutlu, Hande Gülcan
    Abstract:

    A case of a 5-day-old newborn with rhizomelic chondrodysplasia punctata was investigated with multiVoxel magnetic resonance spectroscopy, including chemical shift imaging maps, which disclosed a decrease in the choline peak and the choline signal intensity, respectively, in the right cerebral hemisphere. This is the second report of multiVoxel magnetic resonance spectroscopy examination of the brain associated with rhizomelic chondrodysplasia punctata in the literature. MultiVoxel magnetic resonance spectroscopy with chemical shift imaging maps has the advantage of obtaining more information in a short period of time, which shortens the duration of anesthesia and its associated risks and complications. We suggest that future efforts be directed to evaluating such patients with multiVoxel magnetic resonance spectroscopy instead of Single-Voxel magnetic resonance spectroscopy.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n = 3) or III (n = 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 × 2 × 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n 3) or III (n 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 2 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P < .01). In patients with SSPE, NAA/Cr ratios in POWM were significantly less than those in FSWM (P < .01). NAA/Cr ratios in patients with stage II SSPE and those in the control group were not significantly different; this may reflect the absence of neuronal loss. Decreased NAA/Cr, increased Cho/Cr and Ins/Cr ratios, and increased lactate and lipid peaks were found in patients with stage III SSPE. CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

Ahmet Sigirci - One of the best experts on this subject based on the ideXlab platform.

  • MultiVoxel magnetic resonance spectroscopy in a rhizomelic chondrodysplasia punctata case.
    Journal of child neurology, 2005
    Co-Authors: Ahmet Sigirci, Alpay Alkan, Ramazan Kutlu, Hande Gülcan
    Abstract:

    A case of a 5-day-old newborn with rhizomelic chondrodysplasia punctata was investigated with multiVoxel magnetic resonance spectroscopy, including chemical shift imaging maps, which disclosed a decrease in the choline peak and the choline signal intensity, respectively, in the right cerebral hemisphere. This is the second report of multiVoxel magnetic resonance spectroscopy examination of the brain associated with rhizomelic chondrodysplasia punctata in the literature. MultiVoxel magnetic resonance spectroscopy with chemical shift imaging maps has the advantage of obtaining more information in a short period of time, which shortens the duration of anesthesia and its associated risks and complications. We suggest that future efforts be directed to evaluating such patients with multiVoxel magnetic resonance spectroscopy instead of Single-Voxel magnetic resonance spectroscopy.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n = 3) or III (n = 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 × 2 × 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n 3) or III (n 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 2 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P < .01). In patients with SSPE, NAA/Cr ratios in POWM were significantly less than those in FSWM (P < .01). NAA/Cr ratios in patients with stage II SSPE and those in the control group were not significantly different; this may reflect the absence of neuronal loss. Decreased NAA/Cr, increased Cho/Cr and Ins/Cr ratios, and increased lactate and lipid peaks were found in patients with stage III SSPE. CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

Ramazan Kutlu - One of the best experts on this subject based on the ideXlab platform.

  • MultiVoxel magnetic resonance spectroscopy in a rhizomelic chondrodysplasia punctata case.
    Journal of child neurology, 2005
    Co-Authors: Ahmet Sigirci, Alpay Alkan, Ramazan Kutlu, Hande Gülcan
    Abstract:

    A case of a 5-day-old newborn with rhizomelic chondrodysplasia punctata was investigated with multiVoxel magnetic resonance spectroscopy, including chemical shift imaging maps, which disclosed a decrease in the choline peak and the choline signal intensity, respectively, in the right cerebral hemisphere. This is the second report of multiVoxel magnetic resonance spectroscopy examination of the brain associated with rhizomelic chondrodysplasia punctata in the literature. MultiVoxel magnetic resonance spectroscopy with chemical shift imaging maps has the advantage of obtaining more information in a short period of time, which shortens the duration of anesthesia and its associated risks and complications. We suggest that future efforts be directed to evaluating such patients with multiVoxel magnetic resonance spectroscopy instead of Single-Voxel magnetic resonance spectroscopy.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n = 3) or III (n = 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 × 2 × 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n 3) or III (n 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 2 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P < .01). In patients with SSPE, NAA/Cr ratios in POWM were significantly less than those in FSWM (P < .01). NAA/Cr ratios in patients with stage II SSPE and those in the control group were not significantly different; this may reflect the absence of neuronal loss. Decreased NAA/Cr, increased Cho/Cr and Ins/Cr ratios, and increased lactate and lipid peaks were found in patients with stage III SSPE. CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

Kaya Sarac - One of the best experts on this subject based on the ideXlab platform.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n = 3) or III (n = 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 × 2 × 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.

  • early and late state subacute sclerosing panencephalitis chemical shift imaging and Single Voxel mr spectroscopy
    American Journal of Neuroradiology, 2003
    Co-Authors: Alpay Alkan, Ramazan Kutlu, Ahmet Sigirci, Kaya Sarac, Cengiz Yakinci, Mehmet Aslan, Tamer Baysal
    Abstract:

    BACKGROUND AND PURPOSE: Subacute sclerosing panencephalitis (SSPE) is a rare, progressive, inflammatory neurodegenerative disease. Our aim was to determine the metabolic abnormalities of brain in early- and late-stage SSPE by using MR spectroscopy and to assess areas of involvement in the early stages when MR imaging findings were normal. METHODS: Children with stage II (n 3) or III (n 3) SSPE and 10 healthy, age-matched children underwent MR imaging, multiVoxel MR spectroscopy, and short-echo Single-Voxel MR spectroscopy (SVS). Areas of involvement in the brain were determined with chemical shift imaging. For SVS, 2 2 2-cm Voxels were placed in the frontal subcortical white matter (FSWM) and parieto-occipital white matter (POWM). N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (Ins)/Cr, and NAA/Cho ratios were calculated. RESULTS: Comparisons of NAA/Cr, Cho/Cr, Ins/Cr and NAA/Cho ratios between patients and control subjects showed significant differences in FSWM and POWM (P < .01). In patients with SSPE, NAA/Cr ratios in POWM were significantly less than those in FSWM (P < .01). NAA/Cr ratios in patients with stage II SSPE and those in the control group were not significantly different; this may reflect the absence of neuronal loss. Decreased NAA/Cr, increased Cho/Cr and Ins/Cr ratios, and increased lactate and lipid peaks were found in patients with stage III SSPE. CONCLUSION: MR spectroscopy showed findings suggestive of inflammation in stage II and findings of demyelination, gliosis, cellular necrosis, and anaerobic metabolism in stage III. MR spectroscopy could be a promising technique for early diagnosis and treatment planning in cases of SSPE.