The Experts below are selected from a list of 747 Experts worldwide ranked by ideXlab platform
Jongki Hong - One of the best experts on this subject based on the ideXlab platform.
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Simultaneous Determination of Structurally Diverse Compounds in Different Fangchi Species by UHPLC-DAD and UHPLC-ESI-MS/MS
Molecules, 2013Co-Authors: Jongki HongAbstract:Abstract: Two bisbenzylisoquinoline alkaloids, two morphine alkaloids, one aporphine alkaloid, syringaresinol and aristolochic acid І were selected as marker compounds and simultaneously analyzed using an ultra-high pressure liquid chromatography-diode array detection (UHPLC-DAD) method. These marker compounds were used for the quality control of Fangchi species of different origins, including Sinomenium acutum , Stephania tetrandra , Cocculus trilobus and Aristolochia fangchi . A reversed-phase UHPLC-DAD method was developed and validated for the simultaneous quantification of structurally diverse markers in different Fangchi species. In addition, an UHPLC-electrospray ionization tandem mass spectrometry (ESI-MS/MS) method was used for marker identification in Fangchi species, which provided diagnostic MS/MS spectral patterns that were dependent upon the marker structures. The UHPLC-MS/MS data were used to confirm and complement the UHPLC-DAD quality evaluation results. Additionally, magnoflorine and syringaresinol were observed for the first time in
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Simultaneous determination of structurally diverse compounds in different fangchi species by UHPLC-DAD and UHPLC-ESI-MS/MS
Molecules, 2013Co-Authors: Hee Jung Sim, Kang Ro Lee, Ji-hee Kim, Jongki HongAbstract:Two bisbenzylisoquinoline alkaloids, two morphine alkaloids, one aporphine alkaloid, syringaresinol and aristolochic acid І were selected as marker compounds and simultaneously analyzed using an ultra-high pressure liquid chromatography-diode array detection (UHPLC-DAD) method. These marker compounds were used for the quality control of Fangchi species of different origins, including Sinomenium acutum, Stephania tetrandra, Cocculus trilobus and Aristolochia fangchi. A reversed-phase UHPLC-DAD method was developed and validated for the simultaneous quantification of structurally diverse markers in different Fangchi species. In addition, an UHPLC-electrospray ionization tandem mass spectrometry (ESI-MS/MS) method was used for marker identification in Fangchi species, which provided diagnostic MS/MS spectral patterns that were dependent upon the marker structures. The UHPLC-MS/MS data were used to confirm and complement the UHPLC-DAD quality evaluation results. Additionally, magnoflorine and syringaresinol were observed for the first time in S. tetrandra and C. trilobus, respectively. Twenty different Fangchi species samples were analyzed for aristolochic acid I, syringaresinol and the alkaloids using the UHPLC-DAD and MS/MS method. Based on the levels of markers and principal component analysis (PCA), this method allowed for the clear classification of the samples into four different groups representing samples originating from the four species.
Frédéric M.b. Jacques - One of the best experts on this subject based on the ideXlab platform.
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Revised taxonomy of selected fossil endocarp species in the Menispermaceae using a morphometric approach
Geodiversitas, 2011Co-Authors: Frédéric M.b. Jacques, Edoardo Martinetto, Zhe-kun ZhouAbstract:Several Cenozoic endocarp remains from the northern hemisphere have been described with strong affinities to either Menispermum L. or Sinomenium Die Is, a monophyletic group of menispermous vines. It has been proposed that all of these fossil species are synonymous and should be included within Sinomenium. In order to evaluate this suggestion, we have studied the morphological variation ranges in the menispermous endocarps with geometric morphometrics, and then the ranges of the selected fossil endocarps is compared to the ranges of modern endocarps. The shape of each endocarp is described using eight landmarks and 17 semilandmarks, accounting for the outline and the positions of lateral ridge and foramen on the endocarps. Endocarp ornamentation is studied by statistical comparisons of the number of transverse ridges. It is concluded that the ranges of variation within the fossil genera, all morphologically related to horseshoe-shaped endocarps in Menispermaceae, are found not to be greater than that in the only extant species of Sinomenium, S. acutum (Thunb.) Rehder & Wilson. Sinomenium macrocarpum Liu & Jacques, 2010 differs from the other fossil species of Sinomenium by its higher number of transverse ridges. All other fossil species of Sinomenium, except S. macrocarpum, and Wardensheppeya Eyde, 1970 are synonymous. Menispermum? taylori Chandler, 1964 is transferred to Sinomenium. The fossil genus PalaeoSinomenium Chandler, 1961 is confirmed through the obliquity of its endocarp, but all species are found to be synonymous. Menispermicarpum rariforme Chandler, 1961 is also included in PalaeoSinomenium.
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Sinomenium macrocarpum sp nov menispermaceae from the miocene pliocene transition of gray northeast tennessee usa
Review of Palaeobotany and Palynology, 2010Co-Authors: Frédéric M.b. JacquesAbstract:article i nfo The present study documents the first confirmed fossil record of Sinomenium in Menispermaceae, Sinome- nium macrocarpum sp. nov., from the recently discovered Gray Fossil Site in Tennessee, southeastern USA. The fossil species is represented by more than 120 endocarps, all of which are characterized by their horseshoe-shaped form and occurrence of highly ornamented protuberances on both dorsal and lateral crests. A combination of their relatively large size and highly developed of protuberances on the surface of endocarp warrants the new species. The new species is justified through a detailed comparison with the related and published extant and fossil species. The discovery of the genus in North America appears to support that the Gray site in southern Appalachian region represented a forest refugium during the late Neogene when the global cooling was intensified and grasslands were globally expanded.
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Sinomenium macrocarpum sp. nov. (Menispermaceae) from the Miocene–Pliocene transition of Gray, northeast Tennessee, USA
Review of Palaeobotany and Palynology, 2010Co-Authors: Frédéric M.b. JacquesAbstract:article i nfo The present study documents the first confirmed fossil record of Sinomenium in Menispermaceae, Sinome- nium macrocarpum sp. nov., from the recently discovered Gray Fossil Site in Tennessee, southeastern USA. The fossil species is represented by more than 120 endocarps, all of which are characterized by their horseshoe-shaped form and occurrence of highly ornamented protuberances on both dorsal and lateral crests. A combination of their relatively large size and highly developed of protuberances on the surface of endocarp warrants the new species. The new species is justified through a detailed comparison with the related and published extant and fossil species. The discovery of the genus in North America appears to support that the Gray site in southern Appalachian region represented a forest refugium during the late Neogene when the global cooling was intensified and grasslands were globally expanded.
Xiaoling Wang - One of the best experts on this subject based on the ideXlab platform.
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Two new morphinane alkaloids from Sinomenium acutum.
Journal of Asian natural products research, 2020Co-Authors: Xiaoling Wang, Junru Wang, Chienkuang ChenAbstract:Two new morphinane alkaloids, 1-hydroxy-10-oxo-sinomenine (1) and 4,5-epoxy-14-hydroxy sinomenine N-oxide (2), have been isolated from the stems of Sinomenium acutum. Their structures were established by various spectral analyses, especially 2D NMR experiments. The structure of 2 was confirmed by single crystal X-ray diffraction. The absolute configurations of 1 and 2 were deduced by comparison of CD spectra with the known alkaloid sinomenine (3). Compound 1 was tested for DPPH inhibition and gave IC(50) of 27.9 μM. Compound 2 was tested for neuroprotective effect and showed significant activity against β-amyloid(25-35)-induced oxidative injury (*P
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Sinopestalotiollides A–D, cytotoxic diphenyl ether derivatives from plant endophytic fungus Pestalotiopsis palmarum
Bioorganic & Medicinal Chemistry Letters, 2017Co-Authors: Jian Xiao, Jia-yao Hu, Xiang Zhao, Wang-tong Zhong, Dong-zhu Duan, Le Wang, Xiaoling WangAbstract:Abstract Four new diphenyl ether derivatives, sinopestalotiollides A–D ( 1 – 4 ), one new natural α-pyrone product ( 11 ), as well as twelve known compounds ( 5 – 1 7 ), were obtained from the ethyl acetate extract of the endophytic fungus Pestalotiopsis palmarum isolated from the leaves of medicinal plant Sinomenium acutum (Thunb.) Rehd et Wils. The structures were elucidated by HR-ESI-MS and NMR spectrometry data. Bioassay experiments revealed that compounds 1–4 and 11 exhibited strong to weak cytotoxicities against three human tumor cell lines Hela, HCT116 and A549.
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sinoscrewtine an alkaloid with novel skeleton from the roots of Sinomenium acutum
Fitoterapia, 2013Co-Authors: Xiaoling Wang, Chienkuang ChenAbstract:Abstract An alkaloid with novel skeleton, sinoscrewtine ( 1 ), has been isolated from the roots of Sinomenium acutum . Its structure was established by spectral analysis and X-ray crystallographic study, and its possible biosynthetic pathway was delivered. In vitro experiments, 1 showed weak injurious effects against H 2 O 2 /Aβ 25–35 induced oxidative injury in PC-12 cells and DPPH radical scavenging activity with IC 50 of 32.6 μM.
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two new morphinane alkaloids from Sinomenium acutum
Journal of Asian Natural Products Research, 2011Co-Authors: Xiaoling Wang, Junru Wang, Chienkuang ChenAbstract:Two new morphinane alkaloids, 1-hydroxy-10-oxo-sinomenine (1) and 4,5-epoxy-14-hydroxy sinomenine N-oxide (2), have been isolated from the stems of Sinomenium acutum. Their structures were established by various spectral analyses, especially 2D NMR experiments. The structure of 2 was confirmed by single crystal X-ray diffraction. The absolute configurations of 1 and 2 were deduced by comparison of CD spectra with the known alkaloid sinomenine (3). Compound 1 was tested for DPPH inhibition and gave IC50 of 27.9 μM. Compound 2 was tested for neuroprotective effect and showed significant activity against β-amyloid25–35-induced oxidative injury (*P < 0.05) at 10 μM in PC-12 cells.
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sinoracutine a novel skeletal alkaloid with cell protective effects from Sinomenium acutum
Tetrahedron Letters, 2009Co-Authors: Xiaoling Wang, Xican Tang, Pauline ChiuAbstract:From the stems of Sinomenium acutum, sinoracutine (1) has been isolated, an alkaloid with a structurally novel skeletal framework, whose structure has been established by spectral and single crystal X-ray diffraction analysis. In vitro experiments show that sinoracutine increases cell viability against Hydrogen peroxide-induced oxidative injury.
Hee Jung Sim - One of the best experts on this subject based on the ideXlab platform.
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Simultaneous determination of structurally diverse compounds in different fangchi species by UHPLC-DAD and UHPLC-ESI-MS/MS
Molecules, 2013Co-Authors: Hee Jung Sim, Kang Ro Lee, Ji-hee Kim, Jongki HongAbstract:Two bisbenzylisoquinoline alkaloids, two morphine alkaloids, one aporphine alkaloid, syringaresinol and aristolochic acid І were selected as marker compounds and simultaneously analyzed using an ultra-high pressure liquid chromatography-diode array detection (UHPLC-DAD) method. These marker compounds were used for the quality control of Fangchi species of different origins, including Sinomenium acutum, Stephania tetrandra, Cocculus trilobus and Aristolochia fangchi. A reversed-phase UHPLC-DAD method was developed and validated for the simultaneous quantification of structurally diverse markers in different Fangchi species. In addition, an UHPLC-electrospray ionization tandem mass spectrometry (ESI-MS/MS) method was used for marker identification in Fangchi species, which provided diagnostic MS/MS spectral patterns that were dependent upon the marker structures. The UHPLC-MS/MS data were used to confirm and complement the UHPLC-DAD quality evaluation results. Additionally, magnoflorine and syringaresinol were observed for the first time in S. tetrandra and C. trilobus, respectively. Twenty different Fangchi species samples were analyzed for aristolochic acid I, syringaresinol and the alkaloids using the UHPLC-DAD and MS/MS method. Based on the levels of markers and principal component analysis (PCA), this method allowed for the clear classification of the samples into four different groups representing samples originating from the four species.
Ji-hee Kim - One of the best experts on this subject based on the ideXlab platform.
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Simultaneous determination of structurally diverse compounds in different fangchi species by UHPLC-DAD and UHPLC-ESI-MS/MS
Molecules, 2013Co-Authors: Hee Jung Sim, Kang Ro Lee, Ji-hee Kim, Jongki HongAbstract:Two bisbenzylisoquinoline alkaloids, two morphine alkaloids, one aporphine alkaloid, syringaresinol and aristolochic acid І were selected as marker compounds and simultaneously analyzed using an ultra-high pressure liquid chromatography-diode array detection (UHPLC-DAD) method. These marker compounds were used for the quality control of Fangchi species of different origins, including Sinomenium acutum, Stephania tetrandra, Cocculus trilobus and Aristolochia fangchi. A reversed-phase UHPLC-DAD method was developed and validated for the simultaneous quantification of structurally diverse markers in different Fangchi species. In addition, an UHPLC-electrospray ionization tandem mass spectrometry (ESI-MS/MS) method was used for marker identification in Fangchi species, which provided diagnostic MS/MS spectral patterns that were dependent upon the marker structures. The UHPLC-MS/MS data were used to confirm and complement the UHPLC-DAD quality evaluation results. Additionally, magnoflorine and syringaresinol were observed for the first time in S. tetrandra and C. trilobus, respectively. Twenty different Fangchi species samples were analyzed for aristolochic acid I, syringaresinol and the alkaloids using the UHPLC-DAD and MS/MS method. Based on the levels of markers and principal component analysis (PCA), this method allowed for the clear classification of the samples into four different groups representing samples originating from the four species.
