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Takuya Watanabe - One of the best experts on this subject based on the ideXlab platform.

  • Role of Gallium-SPECT-CT in the Management of Patients With Ventricular Assist Device-Specific Percutaneous Driveline Infection.
    Journal of Cardiac Failure, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Emi Tateishi, Takuya Watanabe
    Abstract:

    ABSTRACT Background Percutaneous driveline infection is a major complication of left ventricular assist device (LVAD). This study evaluated the role of gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT in LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Primary outcomes were surgical intervention and readmission for driveline infection. Results Twenty-two patients had uptake on Ga-SPECT-CT. No significant differences were noted in patient characteristics, wound appearance, or laboratory results. The prevalence of positive Skin Culture at the driveline exit site (DLES), and usage and duration of antibiotics did not differ. However, the uptake group had higher 1-year event rates (surgical intervention: 39% vs 0%, P = .019; readmission: 74% vs 6.9%, P = .0016). In addition to positive Skin Culture at DLES and short duration of antibiotic therapy, uptake on Ga-SPECT-CT was a risk factor for surgical intervention (odds ratio 9.00; P = .018) and readmission (odds ratio 7.86; P = .0051). Conclusions Ga-SPECT-CT could be one of the clinical modalities for guiding the treatment of driveline infection in patients with a LVAD.

  • Role of Gallium-SPECT-CT in Predicting Outcomes of Patients with Ventricular Assist Device-Specific Percutaneous Driveline Infection
    The Journal of Heart and Lung Transplantation, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Takuya Watanabe, Hideki Mochizuki, Y. Matsumoto
    Abstract:

    Purpose Percutaneous driveline infection is a major complication after left ventricular assist device (LVAD) implantation, causing pump infection. Therefore, the precise diagnosis and evaluation of driveline infection are important. Recently, Fluor-18-fluorodeoxyglucose positron emission tomography is used for diagnosis of LVAD-specific and related infections. However, the role of Gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT has not been fully elucidated. We investigated whether Ga-SPECT-CT predicts outcomes of patients with LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to diagnose and evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Main outcomes were surgical intervention (debridement, translocation of driveline exit site or pump exchange) and driveline-infection-caused readmission. Results Uptake on Ga-SPECT-CT revealed in 22 patients and regions of uptake were 9 (41%) driveline exit site, 10 (45%) subcutaneous driveline tunnel, and 3 (14%) sub-rectus driveline tunnel. No significant differences were noted in patient characteristics, wound appearance, and blood test. The prevalence of positive Skin Culture of driveline exit site as well as usage and duration of antibiotics did not differ (uptake vs no-uptake: 21/22, 95% vs 12/14, 86%, P = 0.30; 20/22, 91%, vs 11/14, 79%, P = 0.30; 20 vs 17 days, P = 0.19, respectively). However, the uptake group had a higher 1-year event rate (surgical intervention: 32% vs 0%, P = 0.037; readmission: 74% vs 6.9%, P = 0.0016). Conclusion Ga-SPECT-CT predicts surgical intervention and readmission in patients with LVAD-specific percutaneous driveline infection. Driveline infections with uptake on Ga-SPECT-CT require aggressive treatment including early surgical treatment.

Yuki Kimura - One of the best experts on this subject based on the ideXlab platform.

  • Role of Gallium-SPECT-CT in the Management of Patients With Ventricular Assist Device-Specific Percutaneous Driveline Infection.
    Journal of Cardiac Failure, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Emi Tateishi, Takuya Watanabe
    Abstract:

    ABSTRACT Background Percutaneous driveline infection is a major complication of left ventricular assist device (LVAD). This study evaluated the role of gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT in LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Primary outcomes were surgical intervention and readmission for driveline infection. Results Twenty-two patients had uptake on Ga-SPECT-CT. No significant differences were noted in patient characteristics, wound appearance, or laboratory results. The prevalence of positive Skin Culture at the driveline exit site (DLES), and usage and duration of antibiotics did not differ. However, the uptake group had higher 1-year event rates (surgical intervention: 39% vs 0%, P = .019; readmission: 74% vs 6.9%, P = .0016). In addition to positive Skin Culture at DLES and short duration of antibiotic therapy, uptake on Ga-SPECT-CT was a risk factor for surgical intervention (odds ratio 9.00; P = .018) and readmission (odds ratio 7.86; P = .0051). Conclusions Ga-SPECT-CT could be one of the clinical modalities for guiding the treatment of driveline infection in patients with a LVAD.

  • Role of Gallium-SPECT-CT in Predicting Outcomes of Patients with Ventricular Assist Device-Specific Percutaneous Driveline Infection
    The Journal of Heart and Lung Transplantation, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Takuya Watanabe, Hideki Mochizuki, Y. Matsumoto
    Abstract:

    Purpose Percutaneous driveline infection is a major complication after left ventricular assist device (LVAD) implantation, causing pump infection. Therefore, the precise diagnosis and evaluation of driveline infection are important. Recently, Fluor-18-fluorodeoxyglucose positron emission tomography is used for diagnosis of LVAD-specific and related infections. However, the role of Gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT has not been fully elucidated. We investigated whether Ga-SPECT-CT predicts outcomes of patients with LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to diagnose and evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Main outcomes were surgical intervention (debridement, translocation of driveline exit site or pump exchange) and driveline-infection-caused readmission. Results Uptake on Ga-SPECT-CT revealed in 22 patients and regions of uptake were 9 (41%) driveline exit site, 10 (45%) subcutaneous driveline tunnel, and 3 (14%) sub-rectus driveline tunnel. No significant differences were noted in patient characteristics, wound appearance, and blood test. The prevalence of positive Skin Culture of driveline exit site as well as usage and duration of antibiotics did not differ (uptake vs no-uptake: 21/22, 95% vs 12/14, 86%, P = 0.30; 20/22, 91%, vs 11/14, 79%, P = 0.30; 20 vs 17 days, P = 0.19, respectively). However, the uptake group had a higher 1-year event rate (surgical intervention: 32% vs 0%, P = 0.037; readmission: 74% vs 6.9%, P = 0.0016). Conclusion Ga-SPECT-CT predicts surgical intervention and readmission in patients with LVAD-specific percutaneous driveline infection. Driveline infections with uptake on Ga-SPECT-CT require aggressive treatment including early surgical treatment.

Y. Matsumoto - One of the best experts on this subject based on the ideXlab platform.

  • Role of Gallium-SPECT-CT in Predicting Outcomes of Patients with Ventricular Assist Device-Specific Percutaneous Driveline Infection
    The Journal of Heart and Lung Transplantation, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Takuya Watanabe, Hideki Mochizuki, Y. Matsumoto
    Abstract:

    Purpose Percutaneous driveline infection is a major complication after left ventricular assist device (LVAD) implantation, causing pump infection. Therefore, the precise diagnosis and evaluation of driveline infection are important. Recently, Fluor-18-fluorodeoxyglucose positron emission tomography is used for diagnosis of LVAD-specific and related infections. However, the role of Gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT has not been fully elucidated. We investigated whether Ga-SPECT-CT predicts outcomes of patients with LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to diagnose and evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Main outcomes were surgical intervention (debridement, translocation of driveline exit site or pump exchange) and driveline-infection-caused readmission. Results Uptake on Ga-SPECT-CT revealed in 22 patients and regions of uptake were 9 (41%) driveline exit site, 10 (45%) subcutaneous driveline tunnel, and 3 (14%) sub-rectus driveline tunnel. No significant differences were noted in patient characteristics, wound appearance, and blood test. The prevalence of positive Skin Culture of driveline exit site as well as usage and duration of antibiotics did not differ (uptake vs no-uptake: 21/22, 95% vs 12/14, 86%, P = 0.30; 20/22, 91%, vs 11/14, 79%, P = 0.30; 20 vs 17 days, P = 0.19, respectively). However, the uptake group had a higher 1-year event rate (surgical intervention: 32% vs 0%, P = 0.037; readmission: 74% vs 6.9%, P = 0.0016). Conclusion Ga-SPECT-CT predicts surgical intervention and readmission in patients with LVAD-specific percutaneous driveline infection. Driveline infections with uptake on Ga-SPECT-CT require aggressive treatment including early surgical treatment.

Kensuke Kuroda - One of the best experts on this subject based on the ideXlab platform.

  • Role of Gallium-SPECT-CT in the Management of Patients With Ventricular Assist Device-Specific Percutaneous Driveline Infection.
    Journal of Cardiac Failure, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Emi Tateishi, Takuya Watanabe
    Abstract:

    ABSTRACT Background Percutaneous driveline infection is a major complication of left ventricular assist device (LVAD). This study evaluated the role of gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT in LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Primary outcomes were surgical intervention and readmission for driveline infection. Results Twenty-two patients had uptake on Ga-SPECT-CT. No significant differences were noted in patient characteristics, wound appearance, or laboratory results. The prevalence of positive Skin Culture at the driveline exit site (DLES), and usage and duration of antibiotics did not differ. However, the uptake group had higher 1-year event rates (surgical intervention: 39% vs 0%, P = .019; readmission: 74% vs 6.9%, P = .0016). In addition to positive Skin Culture at DLES and short duration of antibiotic therapy, uptake on Ga-SPECT-CT was a risk factor for surgical intervention (odds ratio 9.00; P = .018) and readmission (odds ratio 7.86; P = .0051). Conclusions Ga-SPECT-CT could be one of the clinical modalities for guiding the treatment of driveline infection in patients with a LVAD.

  • Role of Gallium-SPECT-CT in Predicting Outcomes of Patients with Ventricular Assist Device-Specific Percutaneous Driveline Infection
    The Journal of Heart and Lung Transplantation, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Takuya Watanabe, Hideki Mochizuki, Y. Matsumoto
    Abstract:

    Purpose Percutaneous driveline infection is a major complication after left ventricular assist device (LVAD) implantation, causing pump infection. Therefore, the precise diagnosis and evaluation of driveline infection are important. Recently, Fluor-18-fluorodeoxyglucose positron emission tomography is used for diagnosis of LVAD-specific and related infections. However, the role of Gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT has not been fully elucidated. We investigated whether Ga-SPECT-CT predicts outcomes of patients with LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to diagnose and evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Main outcomes were surgical intervention (debridement, translocation of driveline exit site or pump exchange) and driveline-infection-caused readmission. Results Uptake on Ga-SPECT-CT revealed in 22 patients and regions of uptake were 9 (41%) driveline exit site, 10 (45%) subcutaneous driveline tunnel, and 3 (14%) sub-rectus driveline tunnel. No significant differences were noted in patient characteristics, wound appearance, and blood test. The prevalence of positive Skin Culture of driveline exit site as well as usage and duration of antibiotics did not differ (uptake vs no-uptake: 21/22, 95% vs 12/14, 86%, P = 0.30; 20/22, 91%, vs 11/14, 79%, P = 0.30; 20 vs 17 days, P = 0.19, respectively). However, the uptake group had a higher 1-year event rate (surgical intervention: 32% vs 0%, P = 0.037; readmission: 74% vs 6.9%, P = 0.0016). Conclusion Ga-SPECT-CT predicts surgical intervention and readmission in patients with LVAD-specific percutaneous driveline infection. Driveline infections with uptake on Ga-SPECT-CT require aggressive treatment including early surgical treatment.

Osamu Seguchi - One of the best experts on this subject based on the ideXlab platform.

  • Role of Gallium-SPECT-CT in the Management of Patients With Ventricular Assist Device-Specific Percutaneous Driveline Infection.
    Journal of Cardiac Failure, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Hiroki Mochizuki, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Emi Tateishi, Takuya Watanabe
    Abstract:

    ABSTRACT Background Percutaneous driveline infection is a major complication of left ventricular assist device (LVAD). This study evaluated the role of gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT in LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Primary outcomes were surgical intervention and readmission for driveline infection. Results Twenty-two patients had uptake on Ga-SPECT-CT. No significant differences were noted in patient characteristics, wound appearance, or laboratory results. The prevalence of positive Skin Culture at the driveline exit site (DLES), and usage and duration of antibiotics did not differ. However, the uptake group had higher 1-year event rates (surgical intervention: 39% vs 0%, P = .019; readmission: 74% vs 6.9%, P = .0016). In addition to positive Skin Culture at DLES and short duration of antibiotic therapy, uptake on Ga-SPECT-CT was a risk factor for surgical intervention (odds ratio 9.00; P = .018) and readmission (odds ratio 7.86; P = .0051). Conclusions Ga-SPECT-CT could be one of the clinical modalities for guiding the treatment of driveline infection in patients with a LVAD.

  • Role of Gallium-SPECT-CT in Predicting Outcomes of Patients with Ventricular Assist Device-Specific Percutaneous Driveline Infection
    The Journal of Heart and Lung Transplantation, 2019
    Co-Authors: Yuki Kimura, Osamu Seguchi, Kensuke Kuroda, Keiichiro Iwasaki, Koichi Toda, Yuto Kumai, Seiko Nakajima, Takuya Watanabe, Hideki Mochizuki, Y. Matsumoto
    Abstract:

    Purpose Percutaneous driveline infection is a major complication after left ventricular assist device (LVAD) implantation, causing pump infection. Therefore, the precise diagnosis and evaluation of driveline infection are important. Recently, Fluor-18-fluorodeoxyglucose positron emission tomography is used for diagnosis of LVAD-specific and related infections. However, the role of Gallium-67 single-photon emission computed tomography (Ga-SPECT)-CT has not been fully elucidated. We investigated whether Ga-SPECT-CT predicts outcomes of patients with LVAD-specific percutaneous driveline infection. Methods Thirty-six patients with implantable continuous-flow LVAD, who underwent Ga-SPECT-CT to diagnose and evaluate percutaneous driveline infections, were enrolled and divided into uptake and no-uptake groups based on tracer concentration uptake on Ga-SPECT-CT. Main outcomes were surgical intervention (debridement, translocation of driveline exit site or pump exchange) and driveline-infection-caused readmission. Results Uptake on Ga-SPECT-CT revealed in 22 patients and regions of uptake were 9 (41%) driveline exit site, 10 (45%) subcutaneous driveline tunnel, and 3 (14%) sub-rectus driveline tunnel. No significant differences were noted in patient characteristics, wound appearance, and blood test. The prevalence of positive Skin Culture of driveline exit site as well as usage and duration of antibiotics did not differ (uptake vs no-uptake: 21/22, 95% vs 12/14, 86%, P = 0.30; 20/22, 91%, vs 11/14, 79%, P = 0.30; 20 vs 17 days, P = 0.19, respectively). However, the uptake group had a higher 1-year event rate (surgical intervention: 32% vs 0%, P = 0.037; readmission: 74% vs 6.9%, P = 0.0016). Conclusion Ga-SPECT-CT predicts surgical intervention and readmission in patients with LVAD-specific percutaneous driveline infection. Driveline infections with uptake on Ga-SPECT-CT require aggressive treatment including early surgical treatment.