The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Thaís R. Sudbrack - One of the best experts on this subject based on the ideXlab platform.
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Effects of sildenafil and tadalafil on Skin Flap viability
Archives of Dermatological Research, 2021Co-Authors: Rafael A. C. Souza, Carla Patrícia Martinelli-kläy, Armando J. D’acampora, Geraldo J. S. Bernardes, Sandro M. Sgrott, Laila A. C. Souza, Tommaso Lombardi, Thaís R. SudbrackAbstract:Vascular complication is one of the causes of Skin Flap healing failure. Sildenafil and tadalafil, a type-5 phosphodiesterase inhibitor, can improve Flap viability, however, the action mechanisms involved in this process are still unclear. To assess the effects of orally administered sildenafil and tadalafil on the healing kinetics and Skin Flap viability, sixty-two Wistar rats were divided into three groups: control ( n = 22), sildenafil ( n = 20), and tadalafil ( n = 20). The solutions were administered orally (dose: 10 mg/kg) immediately after the surgical procedure and then every 24 h. At postoperative days 7 and 14, the Skin Flap samples were collected, submitted to histological processing and evaluated under optical microscopy. In experimental groups (sildenafil and tadalafil), we found an increased vascularization ( p
Yuguang Zhang - One of the best experts on this subject based on the ideXlab platform.
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self healing and injectable hydrogel for matching Skin Flap regeneration
Advanced Science, 2019Co-Authors: Xiyuan Mao, Lu Zhang, Ruoyu Cheng, Hongbo Zhang, Jinhong Bae, Liying Cheng, Lianfu Deng, Wenguo Cui, Yuguang ZhangAbstract:The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing-promoting properties that match the dynamic healing process of Skin Flap regeneration, is currently a research challenge. Here, a multifunctional and dynamic coordinative polyethylene glycol (PEG) hydrogel with mangiferin liposomes (MF-Lip@PEG) is developed for clinical applications through Ag-S coordination of four-arm-PEG-SH and Ag+. Compared to MF-PEG, MF-Lip@PEG exhibits self-healing properties, lower swelling percentages, and a longer endurance period. Moreover, the hydrogel exhibits excellent drug dispersibility and release characteristics for slow and persistent drug delivery. In vitro studies show that the hydrogel is biocompatible and nontoxic to cells, and exerts an outstanding neovascularization-promoting effect. The MF-Lip@PEG also exhibits a strong cytoprotective effect against hypoxia-induced apoptosis through regulation of the Bax/Bcl-2/caspase-3 pathway. In a random Skin Flap animal model, the MF-Lip@PEG is injectable and convenient to deliver into the Skin Flap, providing excellent anti-inflammation, anti-infection, and proneovascularization effects and significantly reducing the Skin Flap necrosis rate. In general, the MF-Lip@PEG possesses outstanding multifunctionality for the dynamic healing process of Skin Flap regeneration.
D. A. Degner - One of the best experts on this subject based on the ideXlab platform.
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The cranial superficial epigastric Skin Flap in the dog
Veterinary and Comparative Orthopaedics and Traumatology, 1994Co-Authors: D. A. Degner, M. S. Bauer, P. F. Steyn, Wanda Toombs, E.c. OrtonAbstract:This study evaluated the angio-some of the cranial superficial epigastric artery and perfusion of the cranial superficial epigastric Skin Flap using scintigraphy. The results from this study indicate the cranial superficial epigastric Skin Flap may remain viable in a chronic model.
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The Cranial Superficial Epigastric Skin Flap in the Dog
Veterinary and Comparative Orthopaedics and Traumatology, 1994Co-Authors: M. S. Bauer, P. F. Steyn, Wanda Toombs, E.c. Orton, D. A. DegnerAbstract:SummaryThis study evaluated the angiosome of the cranial superficial epigastric artery and perfusion of the cranial superficial epigastric Skin Flap using scintigraphy. The results from this study indicate the cranial superficial epigastric Skin Flap may remain viable in a chronic model.Anastomoses were noted between the cranial and caudal superficial epigastric arterial beds of all Skin Flaps. The scintigraphic study demonstrated that perfusion of the entire Skin Flap was maintained, with only the cranial superficial artery and vein intact.
Wenguo Cui - One of the best experts on this subject based on the ideXlab platform.
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self healing and injectable hydrogel for matching Skin Flap regeneration
Advanced Science, 2019Co-Authors: Xiyuan Mao, Lu Zhang, Ruoyu Cheng, Hongbo Zhang, Jinhong Bae, Liying Cheng, Lianfu Deng, Wenguo Cui, Yuguang ZhangAbstract:The fabrication of highly biocompatible hydrogels with multiple unique healing abilities for the whole healing process, for example, multifunctional hydrogels with injectable, degradation, antibacterial, antihypoxic, and wound healing-promoting properties that match the dynamic healing process of Skin Flap regeneration, is currently a research challenge. Here, a multifunctional and dynamic coordinative polyethylene glycol (PEG) hydrogel with mangiferin liposomes (MF-Lip@PEG) is developed for clinical applications through Ag-S coordination of four-arm-PEG-SH and Ag+. Compared to MF-PEG, MF-Lip@PEG exhibits self-healing properties, lower swelling percentages, and a longer endurance period. Moreover, the hydrogel exhibits excellent drug dispersibility and release characteristics for slow and persistent drug delivery. In vitro studies show that the hydrogel is biocompatible and nontoxic to cells, and exerts an outstanding neovascularization-promoting effect. The MF-Lip@PEG also exhibits a strong cytoprotective effect against hypoxia-induced apoptosis through regulation of the Bax/Bcl-2/caspase-3 pathway. In a random Skin Flap animal model, the MF-Lip@PEG is injectable and convenient to deliver into the Skin Flap, providing excellent anti-inflammation, anti-infection, and proneovascularization effects and significantly reducing the Skin Flap necrosis rate. In general, the MF-Lip@PEG possesses outstanding multifunctionality for the dynamic healing process of Skin Flap regeneration.
E.c. Orton - One of the best experts on this subject based on the ideXlab platform.
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The cranial superficial epigastric Skin Flap in the dog
Veterinary and Comparative Orthopaedics and Traumatology, 1994Co-Authors: D. A. Degner, M. S. Bauer, P. F. Steyn, Wanda Toombs, E.c. OrtonAbstract:This study evaluated the angio-some of the cranial superficial epigastric artery and perfusion of the cranial superficial epigastric Skin Flap using scintigraphy. The results from this study indicate the cranial superficial epigastric Skin Flap may remain viable in a chronic model.
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The Cranial Superficial Epigastric Skin Flap in the Dog
Veterinary and Comparative Orthopaedics and Traumatology, 1994Co-Authors: M. S. Bauer, P. F. Steyn, Wanda Toombs, E.c. Orton, D. A. DegnerAbstract:SummaryThis study evaluated the angiosome of the cranial superficial epigastric artery and perfusion of the cranial superficial epigastric Skin Flap using scintigraphy. The results from this study indicate the cranial superficial epigastric Skin Flap may remain viable in a chronic model.Anastomoses were noted between the cranial and caudal superficial epigastric arterial beds of all Skin Flaps. The scintigraphic study demonstrated that perfusion of the entire Skin Flap was maintained, with only the cranial superficial artery and vein intact.
