The Experts below are selected from a list of 309 Experts worldwide ranked by ideXlab platform
S.s. Wynn - One of the best experts on this subject based on the ideXlab platform.
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Late‐onset warfarin‐induced Skin Necrosis: case report and review of the literature
American Journal of Hematology, 1998Co-Authors: D.w. Essex, S.s. WynnAbstract:Warfarin-induced Skin Necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced Skin Necrosis and review the literature on this rarely reported variant of warfarin-induced Skin Necrosis. The Skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C. Am. J. Hematol. 57:233–237, 1998. © 1998 Wiley-Liss, Inc.
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late onset warfarin induced Skin Necrosis case report and review of the literature
American Journal of Hematology, 1998Co-Authors: D.w. Essex, S.s. WynnAbstract:Warfarin-induced Skin Necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced Skin Necrosis and review the literature on this rarely reported variant of warfarin-induced Skin Necrosis. The Skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C. Am. J. Hematol. 57:233–237, 1998. © 1998 Wiley-Liss, Inc.
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Warfarin-Induced Skin Necrosis Occurring Four Days after Discontinuation of Warfarin
Pathophysiology of Haemostasis and Thrombosis, 1997Co-Authors: S.s. Wynn, D.w. EssexAbstract:Warfarin-induced Skin Necrosis is a rare complication of warfarin therapy. It appears between days 1 and 10 of therapy while the patient is receiving warfarin. Warfarin-induced Skin Necrosis occurring
David Lillicrap - One of the best experts on this subject based on the ideXlab platform.
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multicentric warfarin induced Skin Necrosis complicating heparin induced thrombocytopenia
American Journal of Hematology, 1999Co-Authors: Theodore E Warkentin, William M Sikov, David LillicrapAbstract:Two patients developed catastrophic multicentric Skin Necrosis while receiving warfarin to treat venous thromboembolism complicated by immune-mediated heparin-induced thrombocytopenia (HIT). Patient 1 developed Skin Necrosis involving the breasts, thighs, and face, as well as venous limb gangrene and bilateral hemorrhagic Necrosis of the adrenal glands, resulting in death. The second patient developed bilateral mammary Necrosis necessitating mastectomies, as well as Skin Necrosis involving the thigh. Neither patient had an identifiable hypercoagulable syndrome, other than HIT. HIT may represent a risk factor for the development of multicentric warfarin-induced Skin Necrosis (WISN).
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Multicentric warfarin‐induced Skin Necrosis complicating heparin‐induced thrombocytopenia
American Journal of Hematology, 1999Co-Authors: Theodore E Warkentin, William M Sikov, David LillicrapAbstract:Two patients developed catastrophic multicentric Skin Necrosis while receiving warfarin to treat venous thromboembolism complicated by immune-mediated heparin-induced thrombocytopenia (HIT). Patient 1 developed Skin Necrosis involving the breasts, thighs, and face, as well as venous limb gangrene and bilateral hemorrhagic Necrosis of the adrenal glands, resulting in death. The second patient developed bilateral mammary Necrosis necessitating mastectomies, as well as Skin Necrosis involving the thigh. Neither patient had an identifiable hypercoagulable syndrome, other than HIT. HIT may represent a risk factor for the development of multicentric warfarin-induced Skin Necrosis (WISN).
D.w. Essex - One of the best experts on this subject based on the ideXlab platform.
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Late‐onset warfarin‐induced Skin Necrosis: case report and review of the literature
American Journal of Hematology, 1998Co-Authors: D.w. Essex, S.s. WynnAbstract:Warfarin-induced Skin Necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced Skin Necrosis and review the literature on this rarely reported variant of warfarin-induced Skin Necrosis. The Skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C. Am. J. Hematol. 57:233–237, 1998. © 1998 Wiley-Liss, Inc.
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late onset warfarin induced Skin Necrosis case report and review of the literature
American Journal of Hematology, 1998Co-Authors: D.w. Essex, S.s. WynnAbstract:Warfarin-induced Skin Necrosis is a rare complication of therapy with warfarin or other coumarin derivatives. When it occurs it usually appears 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiation of therapy) warfarin-induced Skin Necrosis and review the literature on this rarely reported variant of warfarin-induced Skin Necrosis. The Skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein C. Am. J. Hematol. 57:233–237, 1998. © 1998 Wiley-Liss, Inc.
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Warfarin-Induced Skin Necrosis Occurring Four Days after Discontinuation of Warfarin
Pathophysiology of Haemostasis and Thrombosis, 1997Co-Authors: S.s. Wynn, D.w. EssexAbstract:Warfarin-induced Skin Necrosis is a rare complication of warfarin therapy. It appears between days 1 and 10 of therapy while the patient is receiving warfarin. Warfarin-induced Skin Necrosis occurring
Gerard Stansby - One of the best experts on this subject based on the ideXlab platform.
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warfarin induced Skin Necrosis
British Journal of Surgery, 2000Co-Authors: Y C Chan, D Valenti, A O Mansfield, Gerard StansbyAbstract:ral anticoagulation therapy with warfarin may cause injury to the Skin. Cutaneous injury from warfarin begins as localized paresthesias with an erythematous flush, progresses to petechiae and hemorrhagic bullae, and may eventually result in full-thickness Skin Necrosis. Patients typically experience pain in affected areas. The onset of disease is usually between the third and sixth day of therapy. Early recognition and treatment are important to avoid substantial morbidity. This article describes the clinical course of a patient who developed warfarin-induced Skin Necrosis (WISN) and discusses the clinical manifestations, diagnosis, treatment, and prevention of this condition.
Lyn M Duncan - One of the best experts on this subject based on the ideXlab platform.
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warfarin induced Skin Necrosis
Journal of The American Academy of Dermatology, 2009Co-Authors: Rosalynn M Nazarian, Elizabeth M Van Cott, Artur Zembowicz, Lyn M DuncanAbstract:Warfarin-induced Skin Necrosis is a rare complication of anticoagulant therapy with a high associated morbidity and mortality requiring immediate drug cessation. Cutaneous findings include petechiae that progress to ecchymoses and hemorrhagic bullae. Characteristic dermatopathological findings are diffuse dermal microthrombi with endothelial cell damage and red cell extravasation with progression to full-thickness coagulative Necrosis. The lesions of warfarin-induced Skin Necrosis may be difficult to differentiate from mimickers, but Skin biopsy in conjunction with careful consideration of the clinical history, including time of onset, cutaneous distribution of the lesions, and laboratory findings, are essential for prompt diagnosis and patient treatment. Herein, we review the clinical and histologic features helpful for differentiating warfarin-induced Skin Necrosis and report a case illustrative of the diagnostic difficulty that may at times be encountered in clinical practice.
