The Experts below are selected from a list of 9189 Experts worldwide ranked by ideXlab platform
Rudi M H Roumen - One of the best experts on this subject based on the ideXlab platform.
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lateral cutaneous nerve entrapment syndrome lacnes a previously unrecognized cause of intractable flank pain
Scandinavian Journal of Pain, 2017Co-Authors: Robbert C Maatman, Nicole E Papenbotterhuis, Marc R Scheltinga, Rudi M H RoumenAbstract:Abstract Background and aims Chronic abdominal pain may occasionally be due to terminal endings of intercostal nerves (ACNES, abdominal cutaneous nerve entrapment syndrome) that are entrapped in the abdominal wall. Spontaneous neuropathic flank pain may also be caused by involvement of branches of these intercostal nerves. Aim is to describe a series of patients with flank pain due to nerve entrapment and to increase awareness for an unknown condition coined Lateral Cutaneous Nerve Entrapment Syndrome (LACNES). Methods Patients possibly having LACNES (constant area of flank tenderness, small point of maximal pain with neuropathic characteristics, locoregional altered Skin Sensation) presenting between January 2007 and May 2016 received a diagnostic 5–10 mL 1% lidocaine injection. Pain levels were recorded using a numerical rating scale (0, no pain to 10, worst possible). A >50% pain reduction was defined as success. Long term effect of injections and alternative therapies were determined using a satisfaction scale (1, very satisfied, no pain – 5, pain worse). Results 30 patients (21 women, median age 52, range 13–78) were diagnosed with LACNES. Pain following one injection dropped from 6.9 ± 1.4 to 2.4 ± 1.9 (mean, p Conclusions and implications LACNES should be considered in patients with chronic flank pain. Injection therapy is long term effective in more than half of the population.
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prevalence of anterior cutaneous nerve entrapment syndrome in a pediatric population with chronic abdominal pain
Journal of Pediatric Gastroenterology and Nutrition, 2016Co-Authors: Murid Siawash, Rudi M H Roumen, Jenneke W A J De Jagerkievit, Walther Tjon A Ten, Marc R ScheltingaAbstract:Objective Anterior cutaneous nerve entrapment syndrome (ACNES) is a frequently overlooked condition causing chronic abdominal pain (CAP). The objective of the present study was to investigate the rate of ACNES in a pediatric outpatient cohort with CAP. Methods A cross-sectional cohort study was conducted in a population 10 to 18 years of age consulting a pediatric outpatient department with new-onset CAP during a 2 years' time period. All individuals were identified through a standard hospital registration system. History, physical examination, diagnosis, and success of treatment were obtained in patients who were diagnosed as having ACNES. Results Twelve of 95 adolescents with CAP were found to be experiencing ACNES. Carnett sign was positive at the lateral border of the rectus abdominus muscle in all 12. Altered Skin Sensation was present in 11 of 12 patients with ACNES. Six weeks after treatment (1-3 injections, n = 5; neurectomy, n = 7), pain was absent in 11 patients. Conclusions ACNES is present in 1 of 8 adolescents presenting with CAP to a pediatric outpatient department of a teaching hospital. Simple physical examinational testing allows for the diagnosis. Treatments including nerve blocks or surgery are beneficial in most.
Simon C Gandevia - One of the best experts on this subject based on the ideXlab platform.
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Quantifying upper limb motor impairment in people with Parkinson's disease: A physiological profiling approach
'PeerJ', 2021Co-Authors: La Ingram, Vk Carroll, Aa Butler, Simon C GandeviaAbstract:Background. Upper limb motor impairments, such as slowness of movement and difficulties executing sequential tasks, are common in people with Parkinson's disease (PD). Objective. To evaluate the validity of the upper limb Physiological Profile Assessment (PPA) as a standard clinical assessment battery in people with PD, by determining whether the tests, which encompass muscle strength, dexterity, arm stability, position sense, Skin Sensation and bimanual coordination can (a) distinguish people with PD from healthy controls, (b) detect differences in upper limb test domains between "off"and "on"anti-Parkinson medication states and (c) correlate with a validated measure of upper limb function. Methods. Thirty-four participants with PD and 68 healthy controls completed the upper limb PPA tests within a single session. Results. People with PD exhibited impaired performance across most test domains. Based on validity, reliability and feasibility, six tests (handgrip strength, finger-press reaction time, 9-hole peg test, bimanual pole test, arm stability, and shirt buttoning) were identified as key tests for the assessment of upper limb function in people with PD. Conclusions. The upper limb PPA provides a valid, quick and simple means of quantifying specific upper limb impairments in people with PD. These findings indicate clinical assessments should prioritise tests of muscle strength, unilateral movement and dexterity, bimanual coordination, arm stability and functional tasks in people with PD as these domains are the most commonly and significantly impaired
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the upper limb physiological profile assessment description reliability normative values and criterion validity
PLOS ONE, 2019Co-Authors: Lewis A Ingram, Annie A Butler, Lee D Walsh, Matthew A Brodie, Stephen R Lord, Simon C GandeviaAbstract:A progressive decline in upper limb function is associated with ageing and disease. In this cross-sectional study we assessed the performance of 367 healthy individuals aged of 20 to 95 years across a battery of upper limb clinical tests, which we have termed the upper limb Physiological Profile Assessment (PPA). The upper limb PPA was designed to quantify the performance of the multiple physiological domains important for adequate function in the upper extremities. Included are tests of muscle strength, unilateral movement and dexterity, position sense, Skin Sensation, bimanual coordination, arm stability, along with a functional task. We report age and gender normative values for each test. Test-retest reliability ranged from good to excellent in all tests (intra-class correlation coefficients from 0.65 to 0.98) with the exception of position sense (0.31). Ten of the thirteen tests revealed differences in performance between males and females, twelve showed a decline in performance with increasing age, and eight discriminated between older people with and without upper limb functional impairment. Furthermore, most tests showed good external validity with respect to age, an upper limb functional test and self-reported function. This profiling approach provides a reference range for clinical groups with upper limb sensory and motor impairments and may assist in identifying undiagnosed deficits in the general population. Furthermore, the tests are sufficiently reliable to detect motor impairments in people with compromised upper limb function and evaluate the effectiveness of interventions.
Marc R Scheltinga - One of the best experts on this subject based on the ideXlab platform.
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lateral cutaneous nerve entrapment syndrome lacnes a previously unrecognized cause of intractable flank pain
Scandinavian Journal of Pain, 2017Co-Authors: Robbert C Maatman, Nicole E Papenbotterhuis, Marc R Scheltinga, Rudi M H RoumenAbstract:Abstract Background and aims Chronic abdominal pain may occasionally be due to terminal endings of intercostal nerves (ACNES, abdominal cutaneous nerve entrapment syndrome) that are entrapped in the abdominal wall. Spontaneous neuropathic flank pain may also be caused by involvement of branches of these intercostal nerves. Aim is to describe a series of patients with flank pain due to nerve entrapment and to increase awareness for an unknown condition coined Lateral Cutaneous Nerve Entrapment Syndrome (LACNES). Methods Patients possibly having LACNES (constant area of flank tenderness, small point of maximal pain with neuropathic characteristics, locoregional altered Skin Sensation) presenting between January 2007 and May 2016 received a diagnostic 5–10 mL 1% lidocaine injection. Pain levels were recorded using a numerical rating scale (0, no pain to 10, worst possible). A >50% pain reduction was defined as success. Long term effect of injections and alternative therapies were determined using a satisfaction scale (1, very satisfied, no pain – 5, pain worse). Results 30 patients (21 women, median age 52, range 13–78) were diagnosed with LACNES. Pain following one injection dropped from 6.9 ± 1.4 to 2.4 ± 1.9 (mean, p Conclusions and implications LACNES should be considered in patients with chronic flank pain. Injection therapy is long term effective in more than half of the population.
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prevalence of anterior cutaneous nerve entrapment syndrome in a pediatric population with chronic abdominal pain
Journal of Pediatric Gastroenterology and Nutrition, 2016Co-Authors: Murid Siawash, Rudi M H Roumen, Jenneke W A J De Jagerkievit, Walther Tjon A Ten, Marc R ScheltingaAbstract:Objective Anterior cutaneous nerve entrapment syndrome (ACNES) is a frequently overlooked condition causing chronic abdominal pain (CAP). The objective of the present study was to investigate the rate of ACNES in a pediatric outpatient cohort with CAP. Methods A cross-sectional cohort study was conducted in a population 10 to 18 years of age consulting a pediatric outpatient department with new-onset CAP during a 2 years' time period. All individuals were identified through a standard hospital registration system. History, physical examination, diagnosis, and success of treatment were obtained in patients who were diagnosed as having ACNES. Results Twelve of 95 adolescents with CAP were found to be experiencing ACNES. Carnett sign was positive at the lateral border of the rectus abdominus muscle in all 12. Altered Skin Sensation was present in 11 of 12 patients with ACNES. Six weeks after treatment (1-3 injections, n = 5; neurectomy, n = 7), pain was absent in 11 patients. Conclusions ACNES is present in 1 of 8 adolescents presenting with CAP to a pediatric outpatient department of a teaching hospital. Simple physical examinational testing allows for the diagnosis. Treatments including nerve blocks or surgery are beneficial in most.
Lewis A Ingram - One of the best experts on this subject based on the ideXlab platform.
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the upper limb physiological profile assessment description reliability normative values and criterion validity
PLOS ONE, 2019Co-Authors: Lewis A Ingram, Annie A Butler, Lee D Walsh, Matthew A Brodie, Stephen R Lord, Simon C GandeviaAbstract:A progressive decline in upper limb function is associated with ageing and disease. In this cross-sectional study we assessed the performance of 367 healthy individuals aged of 20 to 95 years across a battery of upper limb clinical tests, which we have termed the upper limb Physiological Profile Assessment (PPA). The upper limb PPA was designed to quantify the performance of the multiple physiological domains important for adequate function in the upper extremities. Included are tests of muscle strength, unilateral movement and dexterity, position sense, Skin Sensation, bimanual coordination, arm stability, along with a functional task. We report age and gender normative values for each test. Test-retest reliability ranged from good to excellent in all tests (intra-class correlation coefficients from 0.65 to 0.98) with the exception of position sense (0.31). Ten of the thirteen tests revealed differences in performance between males and females, twelve showed a decline in performance with increasing age, and eight discriminated between older people with and without upper limb functional impairment. Furthermore, most tests showed good external validity with respect to age, an upper limb functional test and self-reported function. This profiling approach provides a reference range for clinical groups with upper limb sensory and motor impairments and may assist in identifying undiagnosed deficits in the general population. Furthermore, the tests are sufficiently reliable to detect motor impairments in people with compromised upper limb function and evaluate the effectiveness of interventions.
Chara Koutsioumpa - One of the best experts on this subject based on the ideXlab platform.
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mechanoreceptor synapses in the brainstem shape the central representation of touch
Social Science Research Network, 2021Co-Authors: Brendan P Lehnert, Celine Santiago, Erica L Huey, Alan J Emanuel, Sophia Renauld, Nusrat Africawala, Ilayda Alkislar, Yongping Zheng, Ling Bai, Chara KoutsioumpaAbstract:Mammals use the glabrous (hairless) Skin of their hands and feet to navigate and manipulate their environment. Cortical maps of the body surface across species contain disproportionately large numbers of neurons dedicated to glabrous Skin Sensation, potentially reflecting a higher density of mechanoreceptors that innervate these Skin regions. Here, we find that disproportionate representation of glabrous Skin emerges over postnatal development at the first synapse between peripheral mechanoreceptors and their central targets in the brainstem. Mechanoreceptor synapses undergo developmental refinement that depends on proximity of their terminals to glabrous Skin, such that those innervating glabrous Skin make synaptic connections that expand their central representation. In mice that do not sense gentle touch, mechanoreceptors innervating glabrous Skin still make more powerful synapses in the brainstem. We propose that the Skin region a mechanoreceptor innervates controls refinement of its central synapses over development to shape the representation of touch in the brain.
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mechanoreceptor synapses in the brainstem shape the central representation of touch
bioRxiv, 2021Co-Authors: Brendan P Lehnert, Celine Santiago, Erica L Huey, Alan J Emanuel, Sophia Renauld, Nusrat Africawala, Ilayda Alkislar, Yongping Zheng, Ling Bai, Chara KoutsioumpaAbstract:Mammals use glabrous (hairless) Skin of their hands and feet to navigate and manipulate their environment. Cortical maps of the body surface across species contain disproportionately large numbers of neurons dedicated to glabrous Skin Sensation, potentially reflecting a higher density of mechanoreceptors that innervate these Skin regions. Here, we find that disproportionate representation of glabrous Skin emerges over postnatal development at the first synapse between peripheral mechanoreceptors and their central targets in the brainstem. Mechanoreceptor synapses undergo developmental refinement that depends on proximity of their terminals to glabrous Skin, such that those innervating glabrous Skin make synaptic connections that expand their central representation. In mice that do not sense gentle touch, mechanoreceptors innervating glabrous Skin still make more powerful synaptic connections in the brainstem. We propose that the Skin region a mechanoreceptor innervates controls refinement of its central synapses over development to shape the representation of touch in the brain.