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Eus J.w. Van Someren - One of the best experts on this subject based on the ideXlab platform.
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core body and Skin Temperature in type 1 narcolepsy in daily life effects of sodium oxybate and prediction of sleep attacks
Sleep, 2016Co-Authors: Astrid Van Der Heide, Claire E H M Donjacour, Eus J.w. Van Someren, Gert Jan Lammers, Robert H A M Reijntjes, Esther Werth, Christian R Baumann, Rolf FronczekAbstract:STUDY OBJECTIVES: Previous laboratory studies in narcolepsy patients showed altered core body and Skin Temperatures, which are hypothesised to be related to a disturbed sleep wake regulation. In this ambulatory study we assessed Temperature profiles in normal daily life, and whether sleep attacks are heralded by changes in Skin Temperature. Furthermore, the effects of three months of treatment with sodium oxybate (SXB) were investigated. METHODS: 25 narcolepsy patients and 15 healthy controls were included. Core body, proximal and distal Skin Temperatures, and sleep-wake state were measured simultaneously for 24 hours in ambulatory patients. This procedure was repeated in 16 narcolepsy patients after at least 3 months of stable treatment with SXB. RESULTS: Increases in distal Skin Temperature and distal-to-proximal Temperature gradient (DPG) strongly predicted daytime sleep attacks (P < 0.001). As compared to controls, patients had a higher proximal and distal Skin Temperature in the morning, and a lower distal Skin Temperature during the night (all P < 0.05). Furthermore, they had a higher core body Temperature during the first part of the night (P < 0.05), which SXB decreased (F = 4.99, df = 1, P = 0.03) to a level similar to controls. SXB did not affect Skin Temperature. CONCLUSIONS: This ambulatory study demonstrates that daytime sleep attacks were preceded by clear changes in distal Skin Temperature and DPG. Furthermore, changes in core body and Skin Temperature in narcolepsy, previously only studied in laboratory settings, were partially confirmed. Treatment with SXB resulted in a normalisation of the core body Temperature profile. Future studies should explore whether predictive Temperature changes can be used to signal or even prevent sleep attacks.
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the effects of sodium oxybate on core body and Skin Temperature regulation in narcolepsy
Sleep Medicine, 2015Co-Authors: Astrid Van Der Heide, Claire E H M Donjacour, Eus J.w. Van Someren, Gert Jan Lammers, Hanno Pijl, Robert H A M Reijntjes, Sebastiaan Overeem, Rolf FronczekAbstract:Patients suffering from narcolepsy type 1 show altered Skin Temperatures, resembling the profile that is related to sleep onset in healthy controls. The aim of the present study is to investigate the effects of sodium oxybate, a widely used drug to treat narcolepsy, on the 24-h profiles of Temperature and sleep-wakefulness in patients with narcolepsy and controls. Eight hypocretin-deficient male narcolepsy type 1 patients and eight healthy matched controls underwent Temperature measurement of core body and proximal and distal Skin twice, and the sleep-wake state for 24 h. After the baseline assessment, 2 × 3 g of sodium oxybate was administered for 5 nights, immediately followed by the second assessment. At baseline, daytime core body Temperature and proximal Skin Temperature were significantly lower in patients with narcolepsy (core: 36.8 ± 0.05 °C versus 37.0 ± 0.05 °C, F = 8.31, P = 0.01; proximal: 33.4 ± 0.26 °C versus 34.3 ± 0.26 °C, F = 5.66, P = 0.03). In patients, sodium oxybate administration increased proximal Skin Temperature during the day (F = 6.46, P = 0.04) to a level similar as in controls, but did not affect core body Temperature, distal Temperature or distal-proximal Temperature gradient. Sodium oxybate administration normalised the predictive value of distal Skin Temperature and distal-proximal Temperature gradient for the onset of daytime naps (P < 0.01). In conclusion, sodium oxybate administration resulted in a partial normalisation of the Skin Temperature profile, by increasing daytime proximal Skin Temperature, and by strengthening the known relationship between Skin Temperature and daytime sleep propensity. These changes seem to be related to the clinical improvement induced by sodium oxybate treatment. A causal relationship is not proven.
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Effects of artificial dawn on sleep inertia, Skin Temperature, and the awakening cortisol response
Journal of sleep research, 2010Co-Authors: Maan Van De Werken, Marina C. Gimenez, Bonnie De Vries, Domien G. M. Beersma, Eus J.w. Van Someren, Marijke C. M. GordijnAbstract:P>The effect of artificial dawn during the last 30 min of sleep on subsequent dissipation of sleep inertia was investigated, including possible involvement of cortisol and thermoregulatory processes. Sixteen healthy subjects who reported difficulty with waking up participated in random order in a control and an artificial dawn night. Sleep inertia severity was measured by subjective ratings of sleepiness and activation, and by performance on an addition and a reaction time task measured at 1, 15, 30, 45, 60, and 90 min after waking up at habitual wake up time at workdays. At all intervals, saliva samples were collected for cortisol analysis. Sleep electroencephalogram was recorded during the 30 min prior to waking up; core body Temperature and Skin Temperatures were recorded continuously until 90 min after waking up. Subjective sleepiness was significantly decreased and subjective activation increased after waking up in the artificial dawn condition as compared with control, in which lights were turned on at waking up. These effects can be explained by effects of artificial dawn on Skin Temperature and amount of wakefulness during the 30 min prior to the alarm. Artificial dawn accelerated the decline in Skin Temperature and in the distal-to-proximal Skin Temperature gradient after getting up. No significant effects of artificial dawn on performance, core body Temperature, and cortisol were found. These results suggest that the physiology underlying the positive effects of artificial dawn on the dissipation of sleep inertia involves light sleep and an accelerated Skin Temperature decline after awakening.
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Skin Temperature and sleep onset latency changes with age and insomnia
Physiology & Behavior, 2007Co-Authors: Roy J E M Raymann, Eus J.w. Van Someren, D F SwaabAbstract:Throughout the 24-hour day, the occurrence of sleep and wakefulness is closely related to changes in body Temperatures. Changes in Skin Temperature may causally affect the ability to initiate and maintain sleep. First, we briefly summarize a previously proposed neurobiological mechanism that couples Skin Temperature to sleep propensity. Next we review previous findings on the relation between Skin Temperature and sleep-onset latency, indicating that sleep propensity can be enhanced by warming the Skin to the level that normally occurs prior to and during sleep. Finally, we present new data indicating age- and insomnia-related changes in the sleep-onset latency response to foot warming, and evaluate whether different methods of foot warming could provide an applicable strategy to address sleep complaints. Foot Temperature manipulations included footbaths before sleep onset (1), and heatable bed socks applied either before (2) or after lights-off (3). In adults, sleep-onset was accelerated by warm and neutral bed socks after lights-off and correlated to the increase in foot Temperature. This increase was attenuated in elderly subjects. In elderly subjects without sleep difficulties, sleep onset could be accelerated with neutral bed socks after lights-off and a warm footbath prior to lights-off. In elderly insomniacs, none of the treatments accelerated sleep onset. We illustrate that elderly subjects show an attenuated increase in foot Temperature after lights-off and lose the relationship between pre-sleep heat-loss activation and sleep latency. The sensitivity of sleep propensity to foot warming changes with age and is attenuated in age-related insomnia. Keywords: Sleep electroencephalogram; Core body Temperature; Skin Temperature; Thermoregulation; Sleep-onset latency; Ageing; Insomnia; Foot warming
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evaluation of wireless determination of Skin Temperature using ibuttons
Physiology & Behavior, 2006Co-Authors: Wouter D Van Marken Lichtenbelt, Eus J.w. Van Someren, Roy J E M Raymann, Rolf Fronczek, H A M Daanen, Loek Wouters, Natascha M W SeverensAbstract:Measurements of Skin Temperatures are often complicated because of the use of wired sensors. This is so in field studies, but also holds for many laboratory conditions. This article describes a wireless Temperature system for human Skin Temperature measurements, i.e. the Thermochron iButton DS1291H. The study deals with validation of the iButton and its application on the human Skin, and describes clinical and field measurements. The validation study shows that iButtons have a mean accuracy of .0.09 °C (.0.4 °C at most) with a precision of 0.05 °C (0.09 °C at most). These properties can be improved by using calibration. Due to the size of the device the response time is longer than that of conventional sensors, with a o in water of 19 s. On the human Skin under transient conditions the response time is significantly longer, revealing momentary deviations with a magnitude of 1 °C. The use of iButtons has been described in studies on circadian rhythms, sleep and cardiac surgery. With respect to circadian rhythm and sleep research, Skin Temperature assessment by iButtons is of significant value in laboratory, clinical and home situations. We demonstrate that differences in laboratory and field measurements add to our understanding of thermophysiology under natural living conditions. The advantage of iButtons in surgery research is that they are easy to sterilize and wireless so that they do not hinder the surgical procedure. In conclusion, the application of iButtons is advantageous for measuring Skin Temperatures in those situations in which wired instruments are unpractical and fast responses are not required. Keywords: Thermoregulation; Temperature sensor validation; Sleep research; Surgery
Takayuki Matsushita - One of the best experts on this subject based on the ideXlab platform.
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Prediction of whole-body thermal sensation in the non-steady state based on Skin Temperature
Building and Environment, 2013Co-Authors: Satoru Takada, Sho Matsumoto, Takayuki MatsushitaAbstract:Abstract The goal of this study is to propose a new model for predicting thermal sensation in the non-steady state based on Skin Temperature and its time differential. A multiple regression equation for the prediction of the transient thermal sensation as a function of mean Skin Temperature and its time differential is determined based on the data obtained in subject experiments involving various non-steady state patterns during sedentary conditions. The results indicate a high correlation and a trend in good agreement between the predicted and experimental thermal sensations in a non-steady state, and showed that the proposed equation can predict transient whole-body thermal sensation with high precision. In addition, experiments incorporating processes with changes in metabolic rate (walking) were conducted on the subjects, and the applicability of the proposed equation, which was based on the data for sedentary conditions, to the conditions involving such a change in metabolic rate was studied. When the Skin Temperatures of all the body segments increase or decrease simultaneously, the predicted thermal sensation agrees well with the experimental results, allowing for the use of the proposed equation, while the application of the equation is more difficult for the cases in which Skin Temperature increases and decreases coexist over the segments of the body.
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re evaluation of stolwijk s 25 node human thermal model under thermal transient conditions prediction of Skin Temperature in low activity conditions
Building and Environment, 2009Co-Authors: Abdul Munir, Satoru Takada, Takayuki MatsushitaAbstract:Abstract The performance of Stolwijk's 25-node thermal model of the human body was evaluated for the prediction of the Skin Temperature of a sedentary person in a thermal-transient state. The Skin Temperature calculated by the original Stolwijk model was compared to experimental data obtained systematically from a large number of subjects exposed to stepwise changes in environmental conditions, including neutral (29.4 °C), low (19.5 °C), and high (38.9 °C) ambient Temperatures. The results show that the original Stolwijk model accurately predicts both the absolute value and the tendency in the transient mean Skin Temperature. This suggests that the Stolwijk model is valid for the prediction of the transient mean Skin Temperature for the “average” person under low-activity conditions. Discrepancies are observed in the local Skin Temperature for some segments. However, these discrepancies can be significantly reduced through modification of the basal Skin blood flow distributions and the distributions of vasoconstriction and workload in the model.
Qingyan Chen - One of the best experts on this subject based on the ideXlab platform.
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measurements and predictions of the Skin Temperature of human subjects on outdoor environment
Energy and Buildings, 2017Co-Authors: Xiaojie Zhou, Qingyan ChenAbstract:Abstract Thermal comfort in outdoor spaces is strongly associated with the quality of social life in an urban community. This study investigated dynamic outdoor thermal comfort under cold, mild, and hot climatic conditions with air Temperature ranging from −0.1 to 35.0 °C. Using a total of 26 human subjects in 94 tests under these climatic conditions, this study measured outdoor thermal environmental parameters, monitored subjects’ Skin Temperature, and recorded subjects’ thermal sensation. The study found that fluctuations in wind speed and solar radiation led to changes in convective and radiative thermal loads on the human subjects. Their Skin Temperature and thermal sensation changed accordingly. In the cold conditions, the Skin Temperature of the trunk was stable at around 34 °C, while the Skin Temperature of the face decreased to 19 °C. This investigation developed a human heat transfer model that considers outdoor radiative heat exchange and transient heat transfer in clothing. The mean Skin Temperatures predicted by the model agree reasonably well with the measured data. However, the discrepancy between the predicted and measured local Skin Temperature under extremely cold conditions can be as large as 6 K.
Rolf Fronczek - One of the best experts on this subject based on the ideXlab platform.
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core body and Skin Temperature in type 1 narcolepsy in daily life effects of sodium oxybate and prediction of sleep attacks
Sleep, 2016Co-Authors: Astrid Van Der Heide, Claire E H M Donjacour, Eus J.w. Van Someren, Gert Jan Lammers, Robert H A M Reijntjes, Esther Werth, Christian R Baumann, Rolf FronczekAbstract:STUDY OBJECTIVES: Previous laboratory studies in narcolepsy patients showed altered core body and Skin Temperatures, which are hypothesised to be related to a disturbed sleep wake regulation. In this ambulatory study we assessed Temperature profiles in normal daily life, and whether sleep attacks are heralded by changes in Skin Temperature. Furthermore, the effects of three months of treatment with sodium oxybate (SXB) were investigated. METHODS: 25 narcolepsy patients and 15 healthy controls were included. Core body, proximal and distal Skin Temperatures, and sleep-wake state were measured simultaneously for 24 hours in ambulatory patients. This procedure was repeated in 16 narcolepsy patients after at least 3 months of stable treatment with SXB. RESULTS: Increases in distal Skin Temperature and distal-to-proximal Temperature gradient (DPG) strongly predicted daytime sleep attacks (P < 0.001). As compared to controls, patients had a higher proximal and distal Skin Temperature in the morning, and a lower distal Skin Temperature during the night (all P < 0.05). Furthermore, they had a higher core body Temperature during the first part of the night (P < 0.05), which SXB decreased (F = 4.99, df = 1, P = 0.03) to a level similar to controls. SXB did not affect Skin Temperature. CONCLUSIONS: This ambulatory study demonstrates that daytime sleep attacks were preceded by clear changes in distal Skin Temperature and DPG. Furthermore, changes in core body and Skin Temperature in narcolepsy, previously only studied in laboratory settings, were partially confirmed. Treatment with SXB resulted in a normalisation of the core body Temperature profile. Future studies should explore whether predictive Temperature changes can be used to signal or even prevent sleep attacks.
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the effects of sodium oxybate on core body and Skin Temperature regulation in narcolepsy
Sleep Medicine, 2015Co-Authors: Astrid Van Der Heide, Claire E H M Donjacour, Eus J.w. Van Someren, Gert Jan Lammers, Hanno Pijl, Robert H A M Reijntjes, Sebastiaan Overeem, Rolf FronczekAbstract:Patients suffering from narcolepsy type 1 show altered Skin Temperatures, resembling the profile that is related to sleep onset in healthy controls. The aim of the present study is to investigate the effects of sodium oxybate, a widely used drug to treat narcolepsy, on the 24-h profiles of Temperature and sleep-wakefulness in patients with narcolepsy and controls. Eight hypocretin-deficient male narcolepsy type 1 patients and eight healthy matched controls underwent Temperature measurement of core body and proximal and distal Skin twice, and the sleep-wake state for 24 h. After the baseline assessment, 2 × 3 g of sodium oxybate was administered for 5 nights, immediately followed by the second assessment. At baseline, daytime core body Temperature and proximal Skin Temperature were significantly lower in patients with narcolepsy (core: 36.8 ± 0.05 °C versus 37.0 ± 0.05 °C, F = 8.31, P = 0.01; proximal: 33.4 ± 0.26 °C versus 34.3 ± 0.26 °C, F = 5.66, P = 0.03). In patients, sodium oxybate administration increased proximal Skin Temperature during the day (F = 6.46, P = 0.04) to a level similar as in controls, but did not affect core body Temperature, distal Temperature or distal-proximal Temperature gradient. Sodium oxybate administration normalised the predictive value of distal Skin Temperature and distal-proximal Temperature gradient for the onset of daytime naps (P < 0.01). In conclusion, sodium oxybate administration resulted in a partial normalisation of the Skin Temperature profile, by increasing daytime proximal Skin Temperature, and by strengthening the known relationship between Skin Temperature and daytime sleep propensity. These changes seem to be related to the clinical improvement induced by sodium oxybate treatment. A causal relationship is not proven.
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evaluation of wireless determination of Skin Temperature using ibuttons
Physiology & Behavior, 2006Co-Authors: Wouter D Van Marken Lichtenbelt, Eus J.w. Van Someren, Roy J E M Raymann, Rolf Fronczek, H A M Daanen, Loek Wouters, Natascha M W SeverensAbstract:Measurements of Skin Temperatures are often complicated because of the use of wired sensors. This is so in field studies, but also holds for many laboratory conditions. This article describes a wireless Temperature system for human Skin Temperature measurements, i.e. the Thermochron iButton DS1291H. The study deals with validation of the iButton and its application on the human Skin, and describes clinical and field measurements. The validation study shows that iButtons have a mean accuracy of .0.09 °C (.0.4 °C at most) with a precision of 0.05 °C (0.09 °C at most). These properties can be improved by using calibration. Due to the size of the device the response time is longer than that of conventional sensors, with a o in water of 19 s. On the human Skin under transient conditions the response time is significantly longer, revealing momentary deviations with a magnitude of 1 °C. The use of iButtons has been described in studies on circadian rhythms, sleep and cardiac surgery. With respect to circadian rhythm and sleep research, Skin Temperature assessment by iButtons is of significant value in laboratory, clinical and home situations. We demonstrate that differences in laboratory and field measurements add to our understanding of thermophysiology under natural living conditions. The advantage of iButtons in surgery research is that they are easy to sterilize and wireless so that they do not hinder the surgical procedure. In conclusion, the application of iButtons is advantageous for measuring Skin Temperatures in those situations in which wired instruments are unpractical and fast responses are not required. Keywords: Thermoregulation; Temperature sensor validation; Sleep research; Surgery
Kenichi Kameyama - One of the best experts on this subject based on the ideXlab platform.
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Estimation of thermal sensation using human peripheral Skin Temperature
2009 IEEE International Conference on Systems Man and Cybernetics, 2009Co-Authors: Kanako Nakayama, Takuji Suzuki, Kenichi KameyamaAbstract:Control of indoor thermal environments in accordance with people's preferences, makes an important contribution to comfort. To keep a suitably temperate environment, we tried to estimate a subject's thermal sensation using biologic signals. We focused on peripheral Skin Temperature to estimate individual thermal sensation. First we carried out an experiment involving an alteration of environmental Temperatures to reveal the relationship between peripheral Skin Temperature and thermal sensation votes. Next we made an algorithm of estimating thermal sensation and assessed the algorithm. When thermal sensation indices estimated by our algorithm were compared with the subject's votes, error of mean squares was 1 or less in most cases. As a result, the possibility of thermal sensation measurement using peripheral Skin Temperatures is confirmed. Furthermore, we implemented the Temperature control system using a household air conditioner and a thermal sensor.
