The Experts below are selected from a list of 51 Experts worldwide ranked by ideXlab platform

Eunson Hwang - One of the best experts on this subject based on the ideXlab platform.

  • a comparative study of baby immature and adult shoots of aloe vera on uvb induced Skin photoaging in vitro
    Phytotherapy Research, 2013
    Co-Authors: Eunson Hwang, Su Hyeon Kim, Sarah Lee, Choong Hwan Lee, Jinwan Kim, Sun Yeou Kim
    Abstract:

    Ultraviolet (UV) irradiation induces photo-damage of the Skin, which in turn causes depletion of the dermal extracellular matrix and chronic alterations in Skin structure. Skin Wrinkle formations are associated with collagen synthesis and matrix metalloproteinase (MMP) expression. The production of type I procollagen is regulated by transforming growth factor-β1 (TGF-β1) expression; the activation of MMP is also correlated with an increase of interleukin-6 (IL-6). Aloe barbadensis M. (Aloe vera) is widely used in cosmetic and pharmaceutical products. In this study, we examined whether baby aloe shoot extract (BAE, immature aloe extract), which is from the one-month-old shoots of Aloe vera, and adult aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, have a protective effect on UVB-induced Skin photoaging in normal human dermal fibroblasts (NHDFs). The effects of BAE and AE on UVB-induced photoaging were tested by measuring the levels of reactive oxygen species, MMP-1, MMP-3, IL-6, type I procollagen, and TGF-β1 after UVB irradiation. We found that NHDF cells treated with BAE after UVB-irradiation suppressed MMP-1, MMP-3, and IL-6 levels compared to the AE-treated cells. Furthermore, BAE treatment elevated type I procollagen and TGF-β1 levels. Our results suggest that BAE may potentially protect the Skin from UVB-induced damage more than AE.

  • a comparative study of baby immature and adult shoots of aloe vera on uvb induced Skin photoaging in vitro
    Phytotherapy Research, 2013
    Co-Authors: Eunson Hwang, Seongil Do
    Abstract:

    Ultraviolet (UV) irradiation induces photo-damage of the Skin, which in turn causes depletion of the dermal extracellular matrix and chronic alterations in Skin structure. Skin Wrinkle formations are associated with collagen synthesis and matrix metalloproteinase (MMP) expression. The production of type I procollagen is regulated by transforming growth factor-β1 (TGF-β1) expression; the activation of MMP is also correlated with an increase of interleukin-6 (IL-6). Aloe barbadensis M. (Aloe vera) is widely used in cosmetic and pharmaceutical products. In this study, we examined whether baby aloe shoot extract (BAE, immature aloe extract), which is from the one-month-old shoots of Aloe vera, and adult aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, have a protective effect on UVB-induced Skin photoaging in normal human dermal fibroblasts (NHDFs). The effects of BAE and AE on UVB-induced photoaging were tested by measuring the levels of reactive oxygen species, MMP-1, MMP-3, IL-6, type I procollagen, and TGF-β1 after UVB irradiation. We found that NHDF cells treated with BAE after UVB-irradiation suppressed MMP-1, MMP-3, and IL-6 levels compared to the AE-treated cells. Furthermore, BAE treatment elevated type I procollagen and TGF-β1 levels. Our results suggest that BAE may potentially protect the Skin from UVB-induced damage more than AE. Copyright © 2013 John Wiley & Sons, Ltd.

Sun Yeou Kim - One of the best experts on this subject based on the ideXlab platform.

  • a comparative study of baby immature and adult shoots of aloe vera on uvb induced Skin photoaging in vitro
    Phytotherapy Research, 2013
    Co-Authors: Eunson Hwang, Su Hyeon Kim, Sarah Lee, Choong Hwan Lee, Jinwan Kim, Sun Yeou Kim
    Abstract:

    Ultraviolet (UV) irradiation induces photo-damage of the Skin, which in turn causes depletion of the dermal extracellular matrix and chronic alterations in Skin structure. Skin Wrinkle formations are associated with collagen synthesis and matrix metalloproteinase (MMP) expression. The production of type I procollagen is regulated by transforming growth factor-β1 (TGF-β1) expression; the activation of MMP is also correlated with an increase of interleukin-6 (IL-6). Aloe barbadensis M. (Aloe vera) is widely used in cosmetic and pharmaceutical products. In this study, we examined whether baby aloe shoot extract (BAE, immature aloe extract), which is from the one-month-old shoots of Aloe vera, and adult aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, have a protective effect on UVB-induced Skin photoaging in normal human dermal fibroblasts (NHDFs). The effects of BAE and AE on UVB-induced photoaging were tested by measuring the levels of reactive oxygen species, MMP-1, MMP-3, IL-6, type I procollagen, and TGF-β1 after UVB irradiation. We found that NHDF cells treated with BAE after UVB-irradiation suppressed MMP-1, MMP-3, and IL-6 levels compared to the AE-treated cells. Furthermore, BAE treatment elevated type I procollagen and TGF-β1 levels. Our results suggest that BAE may potentially protect the Skin from UVB-induced damage more than AE.

Seongil Do - One of the best experts on this subject based on the ideXlab platform.

  • a comparative study of baby immature and adult shoots of aloe vera on uvb induced Skin photoaging in vitro
    Phytotherapy Research, 2013
    Co-Authors: Eunson Hwang, Seongil Do
    Abstract:

    Ultraviolet (UV) irradiation induces photo-damage of the Skin, which in turn causes depletion of the dermal extracellular matrix and chronic alterations in Skin structure. Skin Wrinkle formations are associated with collagen synthesis and matrix metalloproteinase (MMP) expression. The production of type I procollagen is regulated by transforming growth factor-β1 (TGF-β1) expression; the activation of MMP is also correlated with an increase of interleukin-6 (IL-6). Aloe barbadensis M. (Aloe vera) is widely used in cosmetic and pharmaceutical products. In this study, we examined whether baby aloe shoot extract (BAE, immature aloe extract), which is from the one-month-old shoots of Aloe vera, and adult aloe shoot extract (AE), which is from the four-month-old shoots of Aloe vera, have a protective effect on UVB-induced Skin photoaging in normal human dermal fibroblasts (NHDFs). The effects of BAE and AE on UVB-induced photoaging were tested by measuring the levels of reactive oxygen species, MMP-1, MMP-3, IL-6, type I procollagen, and TGF-β1 after UVB irradiation. We found that NHDF cells treated with BAE after UVB-irradiation suppressed MMP-1, MMP-3, and IL-6 levels compared to the AE-treated cells. Furthermore, BAE treatment elevated type I procollagen and TGF-β1 levels. Our results suggest that BAE may potentially protect the Skin from UVB-induced damage more than AE. Copyright © 2013 John Wiley & Sons, Ltd.

Young-hee Kang - One of the best experts on this subject based on the ideXlab platform.

  • Dietary compound ellagic acid alleviates Skin Wrinkle and inflammation induced by UV-B irradiation
    Experimental Dermatology, 2010
    Co-Authors: Ji Young Bae, Jung Suk Choi, Jinseu Park, Sang Wook Kang, Yong Jin Lee, Young-hee Kang
    Abstract:

    Ellagic acid, a polyphenol compound present in berries and pomegranate, has received attention as an agent that may have potential bioactivities preventing chronic diseases. This study examined photoprotective effects of ellagic acid on collagen breakdown and inflammatory responses in UV (ultraviolet)-B irradiated human Skin cells and hairless mice. Ellagic acid attenuated the UV-B-induced toxicity of HaCaT keratinocytes and human dermal fibroblasts. Non-toxic ellagic acid markedly prevented collagen degradation by blocking matrix metalloproteinase production in UV-B-exposed fibroblasts. Anti-Wrinkle activity of ellagic acid was further investigated in hairless mice exposed to UV-B, in which it attenuated UV-B-triggered Skin Wrinkle formation and epidermal thickening. Topical application of 10 micromol/l ellagic acid diminished production of pro-inflammatory cytokines IL-1beta and IL-6, and blocked infiltration of inflammatory macrophages in the integuments of SKH-1 hairless mice exposed to UV-B for 8 weeks. In addition, this compound mitigated inflammatory intracellular cell adhesion molecule-1 expression in UV-B-irradiated keratinocytes and photoaged mouse epidermis. These results demonstrate that ellagic acid prevented collagen destruction and inflammatory responses caused by UV-B. Therefore, dietary and pharmacological interventions with berries rich in ellagic acid may be promising treatment strategies interrupting Skin Wrinkle and inflammation associated with chronic UV exposure leading to photoageing.

Ji Young Bae - One of the best experts on this subject based on the ideXlab platform.

  • Dietary compound ellagic acid alleviates Skin Wrinkle and inflammation induced by UV-B irradiation
    Experimental Dermatology, 2010
    Co-Authors: Ji Young Bae, Jung Suk Choi, Jinseu Park, Sang Wook Kang, Yong Jin Lee, Young-hee Kang
    Abstract:

    Ellagic acid, a polyphenol compound present in berries and pomegranate, has received attention as an agent that may have potential bioactivities preventing chronic diseases. This study examined photoprotective effects of ellagic acid on collagen breakdown and inflammatory responses in UV (ultraviolet)-B irradiated human Skin cells and hairless mice. Ellagic acid attenuated the UV-B-induced toxicity of HaCaT keratinocytes and human dermal fibroblasts. Non-toxic ellagic acid markedly prevented collagen degradation by blocking matrix metalloproteinase production in UV-B-exposed fibroblasts. Anti-Wrinkle activity of ellagic acid was further investigated in hairless mice exposed to UV-B, in which it attenuated UV-B-triggered Skin Wrinkle formation and epidermal thickening. Topical application of 10 micromol/l ellagic acid diminished production of pro-inflammatory cytokines IL-1beta and IL-6, and blocked infiltration of inflammatory macrophages in the integuments of SKH-1 hairless mice exposed to UV-B for 8 weeks. In addition, this compound mitigated inflammatory intracellular cell adhesion molecule-1 expression in UV-B-irradiated keratinocytes and photoaged mouse epidermis. These results demonstrate that ellagic acid prevented collagen destruction and inflammatory responses caused by UV-B. Therefore, dietary and pharmacological interventions with berries rich in ellagic acid may be promising treatment strategies interrupting Skin Wrinkle and inflammation associated with chronic UV exposure leading to photoageing.