The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform
Takashi Miura - One of the best experts on this subject based on the ideXlab platform.
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Noise-induced scaling in Skull Suture interdigitation.
PloS one, 2020Co-Authors: Yutoh Naroda, Kenji Yoshimura, Yoshie Endo, Hiroshi S. Ishii, Takashi MiuraAbstract:Sutures, the thin, soft tissue between Skull bones, serve as the major craniofacial growth centers during postnatal development. In a newborn Skull, the Sutures are straight; however, as the Skull develops, the Sutures wind dynamically to form an interdigitation pattern. Moreover, the final winding pattern had been shown to have fractal characteristics. Although various molecules involved in Suture development have been identified, the mechanism underlying the pattern formation remains unknown. In a previous study, we reproduced the formation of the interdigitation pattern in a mathematical model combining an interface equation and a convolution kernel. However, the generated pattern had a specific characteristic length, and the model was unable to produce a fractal structure with the model. In the present study, we focused on the anterior part of the sagittal Suture and formulated a new mathematical model with time-space-dependent noise that was able to generate the fractal structure. We reduced our previous model to represent the linear dynamics of the centerline of the Suture tissue and included a time-space-dependent noise term. We showed theoretically that the final pattern from the model follows a scaling law due to the scaling of the dispersion relation in the full model, which we confirmed numerically. Furthermore, we observed experimentally that stochastic fluctuation of the osteogenic signal exists in the developing Skull, and found that actual Suture patterns followed a scaling law similar to that of the theoretical prediction.
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Noise-induced scaling in Skull Suture interdigitation
2020Co-Authors: Yutoh Naroda, Kenji Yoshimura, Yoshie Endo, Hiroshi S. Ishii, Takashi MiuraAbstract:Abstract Sutures, the thin, soft tissue between Skull bones, serve as the major craniofacial growth centers during postnatal development. In a newborn Skull, the Sutures are straight; however, as the Skull develops, the Sutures wind dynamically to form an interdigitation pattern. Moreover, the final winding pattern had been shown to have fractal characteristics. Although various molecules involved in Suture development have been identified, the mechanism underlying the pattern formation remains unknown. In a previous study, we reproduced the formation of the interdigitation pattern in a mathematical model combining an interface equation and a convolution kernel. However, the generated pattern had a specific characteristic length, and the model was unable to produce a fractal structure with the model. In the present study, we focused on the anterior part of the sagittal Suture and formulated a new mathematical model with time–space-dependent noise that was able to generate the fractal structure. We reduced our previous model to represent the linear dynamics of the centerline of the Suture tissue and included a time–space-dependent noise term. We showed theoretically that the final pattern from the model follows a scaling law due to the scaling of the dispersion relation in the full model, which we confirmed numerically. Furthermore, we observed experimentally that stochastic fluctuation of the osteogenic signal exists in the developing Skull, and found that actual Suture patterns followed a scaling law similar to that of the theoretical prediction. Author summary Skull Sutures (thin, undifferentiated tissue between bones) act as the growth centers for the Skull. Sutures are straight at birth but later develop an interdigitated pattern that ultimately becomes a fractal structure. While our previous mathematical model of Sutures generated a periodic pattern, the mechanism underlying the fractal structure formation remained to be elucidated. Here, we focused only on the anterior part of the sagittal Suture and formulated a reduced model representing the initial linear phase of pattern formation with the addition of a time–space-dependent noise term. We showed analytically that the model generates patterns with a scaling law. This result was confirmed numerically and experimentally.
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Fractality of Cranial Sutures
Springer Series in Computational Neuroscience, 2016Co-Authors: Takashi MiuraAbstract:It has long been known that Skull Suture has a typical fractal structure. Although the fractal dimensions have been measured, the generation mechanism of the fractal structure remains to be elucidated. Recent advances in the mathematical modeling of biological pattern formation have provided useful frameworks for understanding this mechanism. Applying a simple fractal principle, which the same rule appears on different scales, this chapter shows how various mechanisms lead to the formation of fractal structures in cranial Sutures.
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Mechanism of Skull Suture maintenance and interdigitation.
Journal of anatomy, 2009Co-Authors: Takashi Miura, Chad A. Perlyn, Masato Kinboshi, Naomichi Ogihara, Mikiko Kobayashi-miura, Gillian M. Morriss-kay, Kohei ShiotaAbstract:Skull Sutures serve as growth centers whose function involves multiple molecular pathways. During periods of brain growth the Sutures remain thin and straight, later developing complex fractal interdigitations that provide interlocking strength. The nature of the relationship between the molecular interactions and Suture pattern formation is not understood. Here we show that by classifying the molecules involved into two groups, stabilizing factors and substrate molecules, complex molecular networks can be modeled by a simple two-species reaction–diffusion model that recapitulates all the known behavior of Suture pattern formation. This model reproduces the maintenance of thin sutural tissue at early stages, the later modification of the straight Suture to form osseous interdigitations, and the formation of fractal structures. Predictions from the model are in good agreement with experimental observations, indicating that the model captures the essential nature of the interdigitation process.
Bruno Della Pietra - One of the best experts on this subject based on the ideXlab platform.
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Undetected traumatic diastasis of cranial Sutures: a case of child abuse.
Forensic Science International, 2019Co-Authors: Carlo Pietro Campobasso, Francesco De Micco, Valentina Bugelli, Antonio Cavezza, William C. Rodriguez, Bruno Della PietraAbstract:Traumatic diastasis of cranial Sutures is a type of bone fracture more common in children than in adults, but little attention has been paid to this Skull damage. Differentiation between inflicted and accidental traumatic head injury is still a challenge in forensic pathology, particularly in pediatric population. In fact, diastasis of cranial Sutures may occur with or without other Skull fractures and may be the only evidence of an abusive head trauma (AHT). This is a case study dealing with undetected traumatic diastasis of cranial Sutures in child abuse. The skeletonized juvenile remains were found inside a suitcase. A diastasis of the coronal and sagittal Sutures was the only finding recorded at the autopsy with no other relevant bone defects. The diastasis was originally attributed by the medical examiner to a physiological unfused stage of the calvarial bones. Therefore, the cause of death was undetermined. Twelve years later an anthropological revision of the cold case showed that diastasis of the coronal and sagittal Sutures was assessed as the evidence of an AHT. Analysis of Skull fractures in child abuse can be challenging as normal Skull Suture variants mimicking intentional injury are reported. Diastasis of the cranial Sutures can be also a post-mortem effect of burning or freezing. Therefore, a differential diagnosis between natural, accidental or inflicted Skull defects is mandatory in death investigation. A multidisciplinary approach in such circumstances is strongly recommended in order to reduce the risk of misdiagnosis.
Carlo Pietro Campobasso - One of the best experts on this subject based on the ideXlab platform.
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Undetected traumatic diastasis of cranial Sutures: a case of child abuse.
Forensic Science International, 2019Co-Authors: Carlo Pietro Campobasso, Francesco De Micco, Valentina Bugelli, Antonio Cavezza, William C. Rodriguez, Bruno Della PietraAbstract:Traumatic diastasis of cranial Sutures is a type of bone fracture more common in children than in adults, but little attention has been paid to this Skull damage. Differentiation between inflicted and accidental traumatic head injury is still a challenge in forensic pathology, particularly in pediatric population. In fact, diastasis of cranial Sutures may occur with or without other Skull fractures and may be the only evidence of an abusive head trauma (AHT). This is a case study dealing with undetected traumatic diastasis of cranial Sutures in child abuse. The skeletonized juvenile remains were found inside a suitcase. A diastasis of the coronal and sagittal Sutures was the only finding recorded at the autopsy with no other relevant bone defects. The diastasis was originally attributed by the medical examiner to a physiological unfused stage of the calvarial bones. Therefore, the cause of death was undetermined. Twelve years later an anthropological revision of the cold case showed that diastasis of the coronal and sagittal Sutures was assessed as the evidence of an AHT. Analysis of Skull fractures in child abuse can be challenging as normal Skull Suture variants mimicking intentional injury are reported. Diastasis of the cranial Sutures can be also a post-mortem effect of burning or freezing. Therefore, a differential diagnosis between natural, accidental or inflicted Skull defects is mandatory in death investigation. A multidisciplinary approach in such circumstances is strongly recommended in order to reduce the risk of misdiagnosis.
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Undetected Traumatic Diastasis in a case of Child Abuse
2019Co-Authors: Carlo Pietro Campobasso, De Micco F, Cavezza A, Wc Rodriguez, Della Pietra BAbstract:Traumatic diastasis of cranial Sutures is a type of bone fracture more common in children than in adults, but little attention has been paid to this Skull damage. Differentiation between inflicted and accidental traumatic head injury is still a challenge in forensic pathology, particularly in pediatric population. In fact, diastasis of cranial Sutures may occur with or without other Skull fractures and may be the only evidence of an abusive head trauma (AHT). This is a case study dealing with undetected traumatic diastasis of cranial Sutures in child abuse. The skeletonized juvenile remains were found inside a suitcase. A diastasis of the coronal and sagittal Sutures was the only finding recorded at the autopsy with no other relevant bone defects. The diastasis was originally attributed by the medical examiner to a physiological unfused stage of the calvarial bones. Therefore, the cause of death was undetermined. Twelve years later an anthropological revision of the cold case showed that diastasis of the coronal and sagittal Sutures was assessed as the evidence of an AHT. Analysis of Skull fractures in child abuse can be challenging as normal Skull Suture variants mimicking intentional injury are reported. Diastasis of the cranial Sutures can be also a post-mortem effect of burning or freezing. Therefore, a differential diagnosis between natural, accidental or inflicted Skull defects is mandatory in death investigation. A multidisciplinary approach in such circumstances is strongly recommended in order to reduce the risk of misdiagnosis
Yutoh Naroda - One of the best experts on this subject based on the ideXlab platform.
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Noise-induced scaling in Skull Suture interdigitation.
PloS one, 2020Co-Authors: Yutoh Naroda, Kenji Yoshimura, Yoshie Endo, Hiroshi S. Ishii, Takashi MiuraAbstract:Sutures, the thin, soft tissue between Skull bones, serve as the major craniofacial growth centers during postnatal development. In a newborn Skull, the Sutures are straight; however, as the Skull develops, the Sutures wind dynamically to form an interdigitation pattern. Moreover, the final winding pattern had been shown to have fractal characteristics. Although various molecules involved in Suture development have been identified, the mechanism underlying the pattern formation remains unknown. In a previous study, we reproduced the formation of the interdigitation pattern in a mathematical model combining an interface equation and a convolution kernel. However, the generated pattern had a specific characteristic length, and the model was unable to produce a fractal structure with the model. In the present study, we focused on the anterior part of the sagittal Suture and formulated a new mathematical model with time-space-dependent noise that was able to generate the fractal structure. We reduced our previous model to represent the linear dynamics of the centerline of the Suture tissue and included a time-space-dependent noise term. We showed theoretically that the final pattern from the model follows a scaling law due to the scaling of the dispersion relation in the full model, which we confirmed numerically. Furthermore, we observed experimentally that stochastic fluctuation of the osteogenic signal exists in the developing Skull, and found that actual Suture patterns followed a scaling law similar to that of the theoretical prediction.
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Noise-induced scaling in Skull Suture interdigitation
2020Co-Authors: Yutoh Naroda, Kenji Yoshimura, Yoshie Endo, Hiroshi S. Ishii, Takashi MiuraAbstract:Abstract Sutures, the thin, soft tissue between Skull bones, serve as the major craniofacial growth centers during postnatal development. In a newborn Skull, the Sutures are straight; however, as the Skull develops, the Sutures wind dynamically to form an interdigitation pattern. Moreover, the final winding pattern had been shown to have fractal characteristics. Although various molecules involved in Suture development have been identified, the mechanism underlying the pattern formation remains unknown. In a previous study, we reproduced the formation of the interdigitation pattern in a mathematical model combining an interface equation and a convolution kernel. However, the generated pattern had a specific characteristic length, and the model was unable to produce a fractal structure with the model. In the present study, we focused on the anterior part of the sagittal Suture and formulated a new mathematical model with time–space-dependent noise that was able to generate the fractal structure. We reduced our previous model to represent the linear dynamics of the centerline of the Suture tissue and included a time–space-dependent noise term. We showed theoretically that the final pattern from the model follows a scaling law due to the scaling of the dispersion relation in the full model, which we confirmed numerically. Furthermore, we observed experimentally that stochastic fluctuation of the osteogenic signal exists in the developing Skull, and found that actual Suture patterns followed a scaling law similar to that of the theoretical prediction. Author summary Skull Sutures (thin, undifferentiated tissue between bones) act as the growth centers for the Skull. Sutures are straight at birth but later develop an interdigitated pattern that ultimately becomes a fractal structure. While our previous mathematical model of Sutures generated a periodic pattern, the mechanism underlying the fractal structure formation remained to be elucidated. Here, we focused only on the anterior part of the sagittal Suture and formulated a reduced model representing the initial linear phase of pattern formation with the addition of a time–space-dependent noise term. We showed analytically that the model generates patterns with a scaling law. This result was confirmed numerically and experimentally.
Valentina Bugelli - One of the best experts on this subject based on the ideXlab platform.
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Undetected traumatic diastasis of cranial Sutures: a case of child abuse.
Forensic Science International, 2019Co-Authors: Carlo Pietro Campobasso, Francesco De Micco, Valentina Bugelli, Antonio Cavezza, William C. Rodriguez, Bruno Della PietraAbstract:Traumatic diastasis of cranial Sutures is a type of bone fracture more common in children than in adults, but little attention has been paid to this Skull damage. Differentiation between inflicted and accidental traumatic head injury is still a challenge in forensic pathology, particularly in pediatric population. In fact, diastasis of cranial Sutures may occur with or without other Skull fractures and may be the only evidence of an abusive head trauma (AHT). This is a case study dealing with undetected traumatic diastasis of cranial Sutures in child abuse. The skeletonized juvenile remains were found inside a suitcase. A diastasis of the coronal and sagittal Sutures was the only finding recorded at the autopsy with no other relevant bone defects. The diastasis was originally attributed by the medical examiner to a physiological unfused stage of the calvarial bones. Therefore, the cause of death was undetermined. Twelve years later an anthropological revision of the cold case showed that diastasis of the coronal and sagittal Sutures was assessed as the evidence of an AHT. Analysis of Skull fractures in child abuse can be challenging as normal Skull Suture variants mimicking intentional injury are reported. Diastasis of the cranial Sutures can be also a post-mortem effect of burning or freezing. Therefore, a differential diagnosis between natural, accidental or inflicted Skull defects is mandatory in death investigation. A multidisciplinary approach in such circumstances is strongly recommended in order to reduce the risk of misdiagnosis.