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Robert J Smith - One of the best experts on this subject based on the ideXlab platform.

  • intestinal adaptation after extensive Small bowel Resection differential changes in growth and insulin like growth factor system messenger ribonucleic acids in jejunum and ileum
    Endocrinology, 1998
    Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J Smith
    Abstract:

    The distal Small bowel exhibits greater adaptive growth than proximal segments after partial Small Intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kg·day) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in ileum. Resection increased IGF-I mRNA in both jejunum (183%) and ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection ...

  • Intestinal Adaptation after Extensive Small Bowel Resection: Differential Changes in Growth and Insulin- Like Growth Factor System Messenger Ribonucleic Acids in Jejunum and Ileum*
    Endocrinology, 1998
    Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J Smith
    Abstract:

    The distal Small bowel exhibits greater adaptive growth than proximal segments after partial Small Intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kgXday) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in ileum. Resection increased IGF-I mRNA in both jejunum (183%) and ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection and Resection. These data confirm that bowel Resection induces greater adaptive growth in ileum than jejunum. IGF-I administration modestly increases ileal, but not jejunal, growth after Resection. Increased levels of intestinal IGF-I and IGFBP-4 mRNA suggest roles for IGF-I and IGFBP-4 in mediating Small bowel adaptation. Higher levels of jejunal IGFBP-3 mRNA may be related to limited jejunal vs. ileal growth after extensive jejuno-ileal Resection.

Thomas R Ziegler - One of the best experts on this subject based on the ideXlab platform.

  • intestinal adaptation after extensive Small bowel Resection differential changes in growth and insulin like growth factor system messenger ribonucleic acids in jejunum and ileum
    Endocrinology, 1998
    Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J Smith
    Abstract:

    The distal Small bowel exhibits greater adaptive growth than proximal segments after partial Small Intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kg·day) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in ileum. Resection increased IGF-I mRNA in both jejunum (183%) and ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection ...

  • Intestinal Adaptation after Extensive Small Bowel Resection: Differential Changes in Growth and Insulin- Like Growth Factor System Messenger Ribonucleic Acids in Jejunum and Ileum*
    Endocrinology, 1998
    Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J Smith
    Abstract:

    The distal Small bowel exhibits greater adaptive growth than proximal segments after partial Small Intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kgXday) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in ileum. Resection increased IGF-I mRNA in both jejunum (183%) and ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection and Resection. These data confirm that bowel Resection induces greater adaptive growth in ileum than jejunum. IGF-I administration modestly increases ileal, but not jejunal, growth after Resection. Increased levels of intestinal IGF-I and IGFBP-4 mRNA suggest roles for IGF-I and IGFBP-4 in mediating Small bowel adaptation. Higher levels of jejunal IGFBP-3 mRNA may be related to limited jejunal vs. ileal growth after extensive jejuno-ileal Resection.

G Mazzacca - One of the best experts on this subject based on the ideXlab platform.

  • Transglutaminase changes in intestinal mucosa after experimental Small bowel Resection in the rat.
    Clinical physiology and biochemistry, 1992
    Co-Authors: G D'argenio, C Ciacci, I Sorrentini, R Ventriglia, S Spagnuolo, D Mattera, M C Mellone, P Iovino, G Mazzacca
    Abstract:

    The low serum transglutaminase found in various intestinal disorders (celiac disease and IBD) suggested to us to study the serum and mucosal transglutaminase behaviour in an experimental model of Small Intestine Resection in rats to reduce cellular mass and induce enterocyte hyperproliferation in the proximal part left in continuity. Transglutaminase activity in the intestinal mucosa was significantly higher in resected rats than in control and sham operated animals from days 4 (121 +/- 10 v basal 94 +/- 3 mU/g protein, p < 0.01) to 10 (165 +/- 37 mU/g protein, p < 0.05) after surgery; no significant difference was observed at days 12 and 15 (110 +/- 15 and 105 +/- 23 respectively). Both serum alkaline phosphatase activity (partly produced in enterocytes) and serum transglutaminase were significantly lower in resected rats at each time-point beginning at day 6 (208 +/- 34 v 557 +/- 125 UI and 1.55 +/- 0.11 v 3.78 +/- 0.70 mU/ml, p < 0.001 respectively). These data suggest an involvement of transglutaminase in enterocyte proliferation and confirm the association between reduced intestinal mass and low levels of the enzyme in serum.

Sérgio Zucoloto - One of the best experts on this subject based on the ideXlab platform.

  • Intrinsic myenteric denervation: a new model to increase the intestinal absorptive surface in short-bowel syndrome.
    The Journal of surgical research, 1999
    Co-Authors: Sérgio Britto Garcia, M.c. Kawasaky, Julio César Fernandes Da Silva, A.c. Garcia-rodrigues, T.j. Borelli-bovo, A.c. Iglesias, Sérgio Zucoloto
    Abstract:

    Introduction. Short-bowel syndrome (SBS) is caused by Resection of massive portions of the Small Intestine and is characterized by symptoms related to malabsorption, of which severe weight loss is the most apparent. Surgical treatments for SBS are not yet satisfactory. In rats, the myenteric denervation by benzalkonium chloride (BAC) leads to development of megaileum with visceral dilatation and mucosal hyperplasia and increases the intestinal transit time. Such operation in the remaining intestinal segment after massive Small bowel Resection could increase the duration of contact between luminal nutrients and ileal mucosal epithelium, and furthermore, it could increase the superficial area of the mucosa. Thus, our aim in this study was to evaluate the epithelial morphology and body weight changes of animals after intrinsic ileal denervation associated with extensive Small Intestine Resection. Material and methods. Wistar rats were submitted to Resection of 80% of Small intestinal length (Group R). Another group (B) of animals also received topical serosal application of BAC 0.3%. Control animals were submitted to simulated surgery (Group C). Animals were weighed weekly and sacrificed after 90 days. Intestinal walls were collected for histological procedure and morphometry. Results. At the end of the experimental period all groups showed weight increase, which was reduced in the R group (P < 0.01). Interestingly, the denervated Group B showed a marked increase in weight, similar to the control animals. Morphometric analysis of the mucosal layer area showed a major increase in mucosal surface area, mainly in Group B. Conclusions. Our results showed that the ileal intrinsic denervation associated with massive intestinal Resection induced an increase in the superficial absorptive area and was able to improve the postsurgical conditions for the animals, with accentuated weight increase. This procedure may be a useful model for further studies related to the role of the enteric nervous system on intestinal adaptations after extensive Resections and may provide a new approach for the surgical treatment of short-bowel syndrome.

Mark P Mantell - One of the best experts on this subject based on the ideXlab platform.

  • intestinal adaptation after extensive Small bowel Resection differential changes in growth and insulin like growth factor system messenger ribonucleic acids in jejunum and ileum
    Endocrinology, 1998
    Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J Smith
    Abstract:

    The distal Small bowel exhibits greater adaptive growth than proximal segments after partial Small Intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kg·day) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in ileum. Resection increased IGF-I mRNA in both jejunum (183%) and ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection ...

  • Intestinal Adaptation after Extensive Small Bowel Resection: Differential Changes in Growth and Insulin- Like Growth Factor System Messenger Ribonucleic Acids in Jejunum and Ileum*
    Endocrinology, 1998
    Co-Authors: Thomas R Ziegler, Mark P Mantell, Jessie C Chow, John L Rombeau, Robert J Smith
    Abstract:

    The distal Small bowel exhibits greater adaptive growth than proximal segments after partial Small Intestine Resection. To explore this process, we evaluated adaptive cellularity, intestinal insulin-like growth factor (IGF) system messenger RNA (mRNA) transcripts, and effects of recombinant IGF-I treatment in jejunum and ileum of adult rats. Gastrostomy-fed animals underwent 80% jejuno-ileal Resection or intestinal transection and reanastomosis without Resection, followed by infusion of human recombinant IGF-I (2.4 mg/kgXday) or vehicle. After 7 days, resected rats demonstrated modest adaptive growth in jejunum and marked cell proliferation in ileum. Resection increased IGF-I mRNA in both jejunum (183%) and ileum (249%) and up-regulated IGFBP-4 mRNA levels in both tissues. IGFBP-3 mRNA fell significantly in ileum after Resection. IGF-I infusion modestly increased ileal cellularity after Resection, but had no effect in jejunum. IGF-I markedly increased IGFBP-3 mRNA levels in jejunum after both transection and Resection. These data confirm that bowel Resection induces greater adaptive growth in ileum than jejunum. IGF-I administration modestly increases ileal, but not jejunal, growth after Resection. Increased levels of intestinal IGF-I and IGFBP-4 mRNA suggest roles for IGF-I and IGFBP-4 in mediating Small bowel adaptation. Higher levels of jejunal IGFBP-3 mRNA may be related to limited jejunal vs. ileal growth after extensive jejuno-ileal Resection.