The Experts below are selected from a list of 171 Experts worldwide ranked by ideXlab platform

Wolfgang Weinmann - One of the best experts on this subject based on the ideXlab platform.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    Purpose The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. Methods An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. Results For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. Conclusions This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

Katharina Elisabeth Grafinger - One of the best experts on this subject based on the ideXlab platform.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    Purpose The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. Methods An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. Results For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. Conclusions This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

Jürg Gertsch - One of the best experts on this subject based on the ideXlab platform.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    Purpose The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. Methods An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. Results For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. Conclusions This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

Alain Broillet - One of the best experts on this subject based on the ideXlab platform.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    Purpose The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. Methods An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. Results For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. Conclusions This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

Harpreet Kaur Mandhair - One of the best experts on this subject based on the ideXlab platform.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    Purpose The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. Methods An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. Results For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. Conclusions This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.

  • Cytotoxicity of the synthetic cannabinoids 5C-AKB48, 5F-MDMB-PINACA, ADB-CHMINACA, MDMB-CHMICA and NM-2201 in A549 and TR146 cell lines
    Forensic Toxicology, 2019
    Co-Authors: Katharina Elisabeth Grafinger, Harpreet Kaur Mandhair, Alain Broillet, Jürg Gertsch, Wolfgang Weinmann
    Abstract:

    The aim of the present study was to evaluate the cytotoxicity of five synthetic cannabinoids in two cell lines, for which both reference standards and herbal blends were available. An in-house Smoking Device was developed to produce smoke condensates. The cell viability of reference standards, herbal blend extracts and smoke condensates was measured using an MTT assay in the A549 lung carcinoma cell line and the TR146 buccal carcinoma cell line. Damiana extracts and damiana smoke condensates were also tested for cytotoxicity. For the reference standards of 5F-MDMB-PINACA, ADB-CHMINACA and MDMB-CHMICA, a significant concentration-dependent decrease in cell viability was observed. ADB-CHMINACA and MDMB-CHMICA extracts were more potent than the damiana extract, whereas the NM-2201 blend extract abrogated the effects of the damiana leaves. Compared with damiana smoke condensate, MDMB-CHMICA smoke condensate had higher sensitivity, while ADB-CHMINACA smoke condensate was less potent. This is the first study to investigate the comparative cytotoxicity of reference standards, herbal blend extracts and smoke condensates of synthetic cannabinoids. The data showed that the presence of damiana plant contributed to enhancing the cytotoxicity of 5C-AKB48, 5F-MDMB-PINACA, and MDMB-CHMICA. The plant effects were generally more marked for smoke condensates. MDMB-CHMICA was the most potent substance. The NM-2201 reference standard and extract led to an increase in cell viability as compared to the control. This is of special interest, because the NM-2201 herbal blend extract seemed to abrogate the effects of the damiana leaf extracts. Further studies would be necessary to assess potential procarcinogenic or tumorigenic effects of NM-2201.